... emerging targets for treatment of obesity and related metabolic diseasesTsuyoshi Kadomatsu, Mitsuhisa Tabata and Yuichi OikeDepartment of Molecular Genetics, Graduate School of Medical Sciences, ... with increased risk of cardiovascular disease, the leading cause of death. Therefore, it is important to understand the molecular basis underly-ing obesity and related metabolic diseases in order ... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity andrelated metabolic diseases, and discuss the possibility that both could func-tion as molecular targets for the prevention and treatmentof obesity...
... effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in the treatmentof any disease, and the barriers to the treatmentof sickle cell disease with hydroxyurea ... of hydroxyurea for sickle cell disease. The dosing of hydroxyurea for sickle cell disease is comparable to that in other diseases, although in the case of malignant disease, more drug is often ... with Treatmentfor Patients with Sickle Cell Disease 61 Table 9. Summary of Barriers to Treatmentof Sickle Cell Disease Reported by Patients and Providers 63 Table 10. Results of Studies...
... therapeuticstrategy for the treatmentof Alzheimer’s disease Peter J. Crouch1, Anthony R. White1and Ashley I. Bush2,31 Department of Pathology and Centre for Neuroscience, The University of Melbourne, ... ameliorate several of the dysfunctional events characteristic of Alzheimer’s disease. Metal-basedtherapeutics have already provided promising results for the treatment of Alzheimer’s disease, and ... is no cure for AD,and the development of effective therapeutic strategiesis hampered by a paucity of information on the biolo-gical mechanisms underlying the disease. The severity of AD relates...
... considered in patients before treatment withbisphosphonates, because bone biopsy is the most accuratetest for the diagnosis of adynamic bone disease, and thepresence of adynamic bone disease is a contraindication ... year (i.e., 1950 onward). For the question of bisphosphonates as a treatment for CKD–MBD, one RCT was identified that evaluated the use of bisphosphonates for the prevention of glucocorticoid-induced ... assessed for each outcome.The evaluation of questions of interventions includedRCTs. The grading of the outcomes of these studies included aconsideration of the methods (that is, duration, type of blinding,...
... trial of endoscopic laminoforaminoplasty for the treatmentof foraminal spinal stenosis. Methods This was a prospective study of 64 patients who underwent endoscopic laminoforaminoplasty for ... International Publisher. All rights reserved Research Paper Endoscopic laminoforaminoplasty success rates fortreatmentof foraminal spinal stenosis: report on sixty-four cases Scott M.W. Haufe ... rates of complication, postoperative pain, and shorter duration of hospital stay. Methods: We performed a prospective, open, uncontrolled trial of 64 patients to evaluate endoscopic laminoforaminoplasty...
... number of patients and short period of time studied. As the fucose/galactose inhalation is a novel treatment, an important question concerns the obser-vation of adverse effects of this treatment. ... Chronic infection of the airways with P. aerugi-nosa is the leading cause of morbidity and mortality in the majority of CF patients (1). This pathogen colonises the airways and lungs often in the ... information available on the clinical effect of fucose/galacatose when given to CF patients. In the present study both inhalation of fucose/galactose solution alone and combined therapy of...
... acceptability of misoprostol fortreatmentof incomplete abortion, while Chapters III through V outline who can be offered the method, recommended regimens, schedule of clinic visits, management of side ... taken it before presenting at the health facility. Misoprostol can be offered fortreatment even if the drug was used to induce the abortion. Repeated misoprostol doses fortreatmentof incomplete ... with misoprostol fortreatmentof incomplete abortion, success rates will generally rise.25C. Schedule of clinic visitsA woman who chooses misoprostol fortreatmentof her incomplete abortion...
... Collateralization of Striatofugal Neuronsand Co-localization of Dopamine ReceptorsOne of the important series of data that challenged the concept of segregated direct and indirectstriatofugal pathways ... mediolateral extent of the SNr and form the largest pop-ulation of nigrofugal neurons (131). Inputs from the medial part of the SNr terminate mostly in themedial magnocellular division of the VA (VAmc) ... evidence for the exist-ence of the indirect pathway, they suggest that the so-called direct striatofugal neurons display a highdegree of collateralization and that none of the striatofugal neurons...
... monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Phar-macists, the Infectious Diseases Society of America, and the Society of Infectious Diseases ... experienced CPK elevation of .500 IU/L compared to standard treatment (9.5% of 116 vs. 1.5% of 111, P = 0.04). However, only three of these patients required discontinuation of daptomycin.62A ... and ef-cacy of doses up to 12 mg/kg57,63 However, clinical Daptomycin fortreatmentof cSSSIHealthy Aging & Clinical Care in the Elderly 2012:4 15antibiotic of choice for many clinicians...
... it. This is because of lack of awareness, shyness and lack of modern medical facilities available in their region and the high cost of medical system fortreatment are unaffordable by tribal. ... utilization of plants available with the people of Chhattisgarh, they are using the traditional knowledge for the treatmentof gynecological disorders. There is an urgent need for systematic ... Ethnomedicinal practices of tribal and non tribal relating with human health. Ethnomedicine means the medical practices for the treatmentof ethnic or aborigine people for their health care needs....
... trial designs fordrugs to support an indication fortreatmentof ABS. This guidance does not address the development of drugs for other purposes such as prevention of ABS or treatmentof chronic ... review of previous ABS trials has not been able to establish a reliable estimate of the magnitude of benefit fortreatmentof ABS by antimicrobial drugs. Therefore, we do not recommend the use of ... Guidance for Industry Acute Bacterial Sinusitis: Developing Drugsfor Treatment Additional copies are available from: Office of Communications, Division of Drug Information Center for Drug...