drug therapy in neonates and pediatric patients
Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... monitoring in these patients however are running behind A random sample survey is often the only way to assess treatment efficacy and the selection of drug resistance in treatment programs in Africa ... molecular work and sequence analysis and prepared the manuscript SL and CV assisted in designing the study and drafting the manuscript KD and JR performed viral loads and genotyping KM supervised...
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Báo cáo khoa học: "Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients" ppsx
... the initial clinical experience with head and neck RapidArc patients, in terms of dosimetric analysis and acute toxicity results Methods and materials Patients selection This is a single-Institute ... contoured by the planner and included as follow: spinal cord, brain stem, left and right parotids; larynx and uninvolved oral cavity were outlined whenever not heavily included in the target Whenever ... performed in patients Patients were stratified into three groups: - Group A: 36 patients treated with exclusive curative intent - Group B: patients treated in a postoperative regimen - Group C: patients...
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Báo cáo y học: "Gastroesophageal reflux in mechanically ventilated pediatric patients and its relation to ventilator-associated pneumonia" ppt
... disposing factors of GER and aspiration in mechanically ventilated patients [6] We hypothesized that GER occurs in ventilated non-pneumonic infants and children and is possibly a predisposing factor ... non-survivors indicating a strong relation between acidic reflux and high mortality rate in VAP patients Acid and pepsin are the major factors responsible for symptoms and esophageal mucosal damage in gastroesophageal ... aureus (2/ 16) and Enterococci (2/16) GER was demonstrated in all patients with VAP (100%) compared with non-VAP (75%) patients Alkaline reflux was the most frequent finding seen in both groups...
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Báo cáo y học: "Binge eating symptomatology in overweight and obese patients with schizophrenia: a case control study" ppt
... leptin levels increase rapidly after initiation of clozapine therapy Mol Psychiatry 1998, 3:76-80 Theisen FM, Linden A, Konig IR, Martin M, Remschmidt H, Hebebrand J: Spectrum of binge eating ... controls have binge eating symptomatology ation and maintenance of the WG phenomenon observed in at least part of patients with schizophrenia Finally, management of AP induced WG should take into account ... Freeman LM, Gil KM: Daily stress, coping, and dietary restraint in binge eating Int J Eat Disord 2004, 36:204-212 MB F, Spitzer RL, M G, J W: Structured clinical interview for DSM-IV-TR Axis I disorders-...
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Báo cáo y học: "The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics" pot
... with recombinant adenoviruses carrying BMP-2 and insulinlike growth factor-1 cDNAs [29] The modified cells were incorporated into fibrin glue and placed into partial thickness lesions in the patellar ... methods for delivering proteins efficiently into cells by attaching protein transduction domains to their amino-termini One such protein transduction domain is derived from the TAT protein of HIV; Jeffrey ... confirming the remarkable potency of genetically modified dendritic cells as antiarthritic agents in murine, collagen-induced arthritis A variety of transgenes, including interleukin-4 and Fas ligand,...
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Báo cáo y học: "Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia" docx
... norepinephrine, epinephrine, and dopamine All three substances act within the central nervous system Norepinephrine acts also in peripheral postganglionic nerve endings and exerts local effects in close ... widespread pain and allodynia) could be explained by a pathogenesis known as 'sympathetically maintained pain' [5] Naturally occurring sympathetic neurotransmitters are catecholamines known as norepinephrine, ... inhibition in rats results in a dramatic increase in sensitivity to pain Low COMT activity may increase pain sensitivity by activating beta (2/3)-adrenergic receptors The objective of our investigation...
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Báo cáo y học: "Generic and low dose antiretroviral therapy in adults and children: implication for scaling up treatment in resource limited settings" ppsx
... anemia in 16 (25.8%) patients and polyneuropathy in 12 (19.4%) of the patients In this cohort, 76% of the patients were started on a d4T-containing regimen Moreover, 70% of the patients had WHO clinical ... Hassink E, van Leeuwen R, Robinson P, Wit FW, Lange JM: Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: ... once daily has been suggested when co-administering with rifampicin A study in Thailand comparing EFV 600 mg with EFV 800 mg in patients using rifampicin showed that EFV plasma concentrations...
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Báo cáo y học: "Prevalence of and risk factors for perioperative arrhythmias in neonates and children after cardiopulmonary bypass: continuous holter" docx
... different in magnitude between the two groups (73.4% and 79.1% in neonates and in older children, respectively, p = 0.73), albeit occurring later in neonates than in older children Within 24 hours ... priming solution within the extracorporeal circuit and the circulating blood volume using a heat exchanger Aortic cross clamping was undertaken and cardioplegia induced by a single aortic injection ... frequent in infants and older children than in neonates (79.1% vs 58.0%, p < 0.0001) In contrast, 72 hours after surgery, arrhythmias were less frequent in Page of the older children than in neonates...
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Advanced Therapy in Gastroenterology and Liver Disease - part 4 pps
... cognitions include ignoring pain, using coping selfstatements, and indicating acceptance of pain Negative processes include catastrophizing (ie, viewing the pain as the worst thing in the world and ... common in women, even in the absence of prior surgery and are found in equal proportion in patients complaining of pelvic pain and those with other complaints Indeed, laparoscopy for chronic pain ... skills and our time Nonetheless, these are patients in pain and in peril, and a careful and collaborative approach can make their care an interesting and rewarding process Supplemental Reading Asher...
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Advanced Therapy in Gastroenterology and Liver Disease - part 5 ppsx
... obscure origin There is a separate chapter (Chapter 60, “Nonsteroidal Antiinflammatory DrugInduced Small and large Intestinaal Injury”) on NSAIDinduced injury to the small and large intestine 357 ... antiinflammatory drug induced intestinal in ammation in humans Gastroenterol 1987;93:480–9 Bjarnason I, Zanelli G, Prouse P, et al Blood and protein loss via small intestinal in ammation induced ... Effects /Drug Interventions Herb Contraindications and Drug Interactions (F Brinker, Eclectic Medical Publications) This book describes known and speculated side effects, contraindications, and drug interactions...
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Advanced Therapy in Gastroenterology and Liver Disease - part 6 pdf
... maintain perineal hygiene in the presence of diarrhea often leads to physical trauma of the perineal cleansing Patients should be instructed in proper perineal hygiene including gentle cleansing ... include increasing fluid and fiber intake, and reducing excessive or incorrect use of laxatives and cathartics Taking advantage of normal postprandial increases in colonic motility, patients should ... antihistamines are useful in decreasing the perineal soiling and injury.§ Tenesmus occurs with rectal contraction and IAS relaxation In IBD patients, tenesmus is related to rectal in ammation and often...
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Advanced Therapy in Gastroenterology and Liver Disease - part 7 pptx
... reversibility in 75% of patients within to months of treatment discontinuation In a randomized trial comparing infusional 5-FU/LV (LV5FU2), single-agent oxaliplatin and the combination (FOLFOX) in 459 patients ... fluorpyrimadine-based, including 5fluorouracil and leucovorin Newer agents that have shown benefit in advanced CRC, including irinotecan and oxaliplatin, are currently being studied in the adjuvant setting Unlike ... effects Chemotherapy and Radiation Therapy Chemotherapy and radiation therapy are important instruments in the palliation of incurable rectal cancer and are generally indicated in patients with...
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Advanced Therapy in Gastroenterology and Liver Disease - part 9 potx
... retinol due to deficiency in transhyretin, a thyroxine binding globulin to which retinol binding globulin is bound in the circulation, may also occur Deficiency in vitamin A usually manifests itself ... attacks and well if they avoid precipitating factors such as certain drugs (Moore and Hift, 1997), diminished food intake, excessive alcohol intake, and prolonged infections Information regarding drugs ... by demonstrating a marked increase in the excretion of octacarboxyl porphyrin (uroporphyrin) and hepatcarboxyl porphyrin in the urine In patients in whom the history indicates there is the familial...
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Advanced Therapy in Gastroenterology and Liver Disease - part 10 doc
... significant grade and gastrointestinal (GI) toxicities, including vomiting, mucositis, diarrhea, and GI bleeding in the IFN-based chemotherapy, requiring hospitalization in 43% of patients However, ... nonspecific in its clinical presentation The pain can be constant or intermittent and there may be frequent pain-free intervals Eating may exacerbate the pain, leading to fear of eating and weight loss ... pancreatic ducts and the parenchyma We are continuing to evaluate EUS and secretin against each other in patients with suspected small duct disease who present with chronic abdominal pain and negative...
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báo cáo khoa học:" Barriers towards insulin therapy in type 2 diabetic patients: results of an observational longitudinal study" pps
... patients who remained insulin-naïve” and patients switched to insulin treatment"; b = p < 05 between patients switched to insulin treatment” and patients who remained on insulin therapy" ; c = ... appraisal of insulin in insulin-naïve and insulin-treated type diabetic patients Of the insulin-naïve patients, 60% were switched to insulin treatment At baseline, those type diabetic patients who ... previous findings, insulin-naïve patients Page of had a significantly more negative appraisal of insulin therapy than patients who already were being treated with insulin The insulin-treated patients...
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Báo cáo y học: " G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children – safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847]" pps
... victims and high-risk surgical patients Unit B predominantly cares for infants and children who have undergone cardiac surgery Intervention and controls Control strategy For patients randomized ... (R&D Systems, Abington, UK) marked after incubation and coupling with a second phycoerythrin monoclonal antibody (sandwich technique) (R&D Systems, Abington, UK) Final measurement and analysis is ... diagnosis reduces the morbidity and costs associated with hospital acquired infection Ascertaining relevant indicators of morbidity and costs in all patients Available online http://ccforum.com/content/8/6/R443...
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Báo cáo khoa học: "The role of thyroid hormone therapy in acutely ill cardiac patients" pot
... randomized trial Competing interests The author(s) declare that they have no competing interests References 334 Wartofsky L, Burman KD: Alterations in thyroid function in patients with systemic ... sick syndrome J Clin Invest 2000, 106:393-402 De Groot LJ: Dangerous dogmas in medicine: the nonthyroidal illness syndrome J Clin Endocrinol Metab 1999, 84:151-164 Carrel T, Eckstein F, Englberger ... Mohacsi P: Thyronin treatment in adult and pediatric heart surgery: clinical experience and review of the literature Eur J Heart Fail 2002, 4:577582 Klemperer JD: Thyroid hormone and cardiac surgery...
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Báo cáo y học: "Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy" pdf
... rate ↑ Protein binding ↓ Gastro-intestinal resorption ↑ Increased drug metabolism Reduced storage of lipophilic drugs Faster urinary excretion Increased drug availability Increased drug availability ... parameter Influencing factors Absorption Gastrointestinal function (for example gastric emptying and intestinal motility; hydrochloric acid production, bile acid secretion, intestinal and body ... Therapeutic Drug Monitoring in Child and Adolescent Psychiatry" in December 2007 [1], including 12 Departments of Child and Adolescent Psychiatry in Germany, Austria and Switzerland The Network...
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Báo cáo y học: "A proposed algorithm for initiation of renal replacement therapy in adult critically ill patients" pps
... C, Kellum JA; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe ... JA; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes Clin J Am ... of clinical and/ or biochemical changes (including urea and creatinine) [16] The objective of this algorithm is to provide a starting point to guide clinicians on when to consider use of RRT in...
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