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drug information from phase i ii and iii studies the new drug application and product approval launch

Reproductive and Child Health Project Rapid Household Survey (Phase I & II) 1998-1999 ppt

Reproductive and Child Health Project Rapid Household Survey (Phase I & II) 1998-1999 ppt

Sức khỏe trẻ em

... these agencies Region No I II III IV V VI VII VIII IX X XI XII XIII XIV XV 1.2 Name of States/Union Territories in the Region Andhra Pradesh and A & N Islands Tamil Nadu, Lakshdweep and Pondicherry ... deliveries took place in health xix institutions In other districts- from Kerala and Chennai from Tamil Nadu- institutional deliveries constituted 99 percent of the total deliveries In India 63, ... district level indicators The weight is the proportion of the district population in the total population of the state ∑ Wi CPR = CPR (i ) Each district level indicator i is assigned a weight wi...
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Báo cáo sinh học:

Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt

Hóa học - Dầu khí

... Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)-Good Clinical Practice (GCP)-registered phase I/ II clinical trial of rh-HGF As this application is the first clinical ... renal involvement, including serum creatinine and histological findings A phase I/ II clinical trial for patients with acute liver failure Overview This single-arm, open-labeled, and dose-escalation ... confirmed reversibility of renal toxicity through additional preclinical studies In this clinical trial, rh-HGF was administered intravenously for 12 to 14 days, and severe side effects and Ido...
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Báo cáo khoa học:

Báo cáo khoa học: " Hypofractionated intensity modulated irradiation for localized prostate cancer, results from a phase I/II feasibility study" ppsx

Báo cáo khoa học

... maximum of Grade I and 26% (n = 10) Grade II during RT None developed a grade III/ IV acute GU toxicity Acute GU toxicity reached its maximum in weeks and and resolved within weeks after RT in ... until now (Grade II toxicity) No Grade III toxicity was seen with a median follow up of 20 months At 24 and 36 months there were still respectively 3/10 and 2/6 patients with Grade I toxicity ... in their randomized trial somewhat higher figures of grade II (40%) and grade III (8%) acute GU toxicity in the H-IMRT arm (70.2 Gy in 26 fractions of 2.7 Gy) although PTV margins were slightly...
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Báo cáo y học:

Báo cáo y học: " Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study" pot

Báo cáo khoa học

... of IgG positive antibody secreting cells in the lamina propria [21] The weak correlation of IgG antibodies in IS to serum IgG is consistent with this dual origin of bronchial IgG antibodies IgA ... 8:57 remains to be shown whether the OprF-OprI vaccine can be effective in patients with CF and other conditions Recent data of a phase III clinical trial with CF patients evaluating a bivalent ... OprFOprI vaccine Recent data of a phase III clinical trial with a flagella vaccine support both the promise of protein based vaccines and the need for further optimization of the vaccine strategy...
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Báo cáo khoa học:

Báo cáo khoa học: "A Machine Learning Approach to Extract Temporal Information from Texts in Swedish and Generate Animated 3D Scenes" docx

Báo cáo khoa học

... overwhelming in some reports, while in others most of the information is implicit The complexity of the accidents described ranges from simple accidents with only one vehicle to multiple collisions with ... reorganizes them and discards the temporal loops The initial step of the loop resolution assigns each link with a score This score is created by the decision trees and is derived from the C4.5 metrics ... semantics will be a proposition paired with a point or interval in time during which the proposition is true • Relations and Quantities They describe specific features of objects and events and...
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báo cáo hóa học:

báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx

Hóa học - Dầu khí

... for further clinical evaluation because the toxicity increased with higher doses in the prior phase I/ II clinical trials, whereas there was evidence of reproducible immune activation at this dose ... study and performed the statistical analysis AK participated in the study design and coordination SDG participated in the study design and coordination OK participated in the study design and coordination ... participated in the study design and coordination TLW carried out and interpreted the immunoassay and drafted portions of the manuscript describing the assays WG participated in the design of the...
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Báo cáo y học:

Báo cáo y học: " Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren''''s syndrome: an open-label phase I/II study" docx

Báo cáo khoa học

... subsided within hour (the fourth infusion was not administered to this patient) Overall, the infusions were administered in a median infusion time Figure Autoantibodies There were no changes in the ... regeneration of glandular tissue, suggesting the need for pre- and post-therapy biopsies of minor salivary glands Additional findings in terms of statistically significant improvement from baseline in ... mechanism of action is believed to be the downregulation of the BCR, with mechanisms of action differing from rituximab (by CD22 phosphorylation and BCR effects via immobilised Ig crosslinking) [18,21]...
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Báo cáo khoa học:

Báo cáo khoa học: "Toxicity report of once weekly radiation therapy for low-risk prostate adenocarcinoma: preliminary results of a phase I/II trial" pdf

Báo cáo khoa học

... Appendix - RTOG late toxicity scale RTOG GRADE I II III IV None Slight epithelial atrophy; minor telangiectasia (microscopic hematuria) Moderate frequency; generalized telangiectasia; intermittent ... Arcangeli G, Saracino B, Gomellini S, et al: A Prospective Phase III Randomized Trial of Hypofractionation Versus Conventional Fractionation in Patients With High-Risk Prostate Cancer International ... published data from phase I/ II trial not have sufficient follow-up to draw conclusions Table Acute urinary and rectal toxicity after prostate EBRT RTOG GRADE I II III IV GENITOURINARY On-treatment...
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Báo cáo khoa học:

Báo cáo khoa học: "Combining information from surveys of several species to estimate the probability of freedom from Echinococcus multilocularis in Sweden, Finland and mainland Norway" docx

Báo cáo khoa học

... 1) Where PriorPInfy+1 is the prior probability of infection in year y+1, PostInfy is the posterior probability of infection in year y and PIntro y+1 is the probability of introduction in year y+1 ... Positive Positive Negative Negative Positive Positive Terminal nodes Negative outcome Positive outcome PR TAKE SAMPLE Negative Negative Positive Positive Negative Negative Positive Negative Positive ... Infection node Detection nod MEAT INSPECTION Negative Negative Positive SCT Negative Positive Negative PCR Positive Negative Negative Positive Positive SCT Positive PCR Negative Negative Positive...
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Đề kiểm tra 01 tiết sinh học lớp 8 tham khảo hết nội dung chương trình chương i, II và III

Đề kiểm tra 01 tiết sinh học lớp 8 tham khảo hết nội dung chương trình chương i, IIIII

Đề thi lớp 8

... h i viết câu h i trả l i) ĐỀ KIỂM TRA GIỮA HỌC KỲ I MÔN SINH HỌC LỚP Đề số Th i gian làm b i: 45 phút Câu 1: ( i m) Cấu tạo nơron thần kinh? Chức nơron? Câu 2: (2 i m) Tìm đặc i m chứng minh ... Câu ( i m) Để xương phát triển cân đ i cần làm ? ( Không gập, viết vẽ vào đề kiểm tra, làm câu h i viết câu h i trả l i) ĐỀ KIỂM TRA GIỮA HỌC KỲ I MÔN SINH HỌC LỚP Đề số Th i gian làm b i: 45 ... i m) Để chống cong vẹo cột sống lao động học tập ph i ý i m ? ( Không gập, viết vẽ vào đề kiểm tra, làm câu h i viết câu h i trả l i) ĐỀ KIỂM TRA GIỮA HỌC KỲ I MÔN SINH HỌC LỚP Đề số Th i gian...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot

Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot

Báo cáo khoa học

... the binding between decorin and collagens or their CNBr peptides is quite sensitive to the ionic strength of the buffer, suggesting an ionic character of the binding The main decorin region implicated ... of their positive charge eliminates the interaction On the contrary, the chemical modification preserving the ionic character modulates the binding to decorin This leads to a differential behaviour ... binding of chemical modification of Lys and Hyl side chains of collagens and peptides Derivatizations that eliminate the positive charge of Lys/Hyl eliminate the binding to decorin, whereas the binding...
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Mixed mode i II III fracture criterion and its application to cement mortar 1

Mixed mode i II III fracture criterion and its application to cement mortar 1

Thạc sĩ - Cao học

... unified modes I, II and III stress intensity factors, KIθ/KIC, KIIθ/KIIC and KIIIθ/KIIIC, respectively (Lo et al., 2000) The application of the finite element (FE) method to LEFM, and numerical methods ... data from mixed mode I II III loading, as shown in Figure 1.6 Modes I and II crack tip loading conditions were created in the specimen by subjecting it to an axial load, while mode III crack tip ... Depending on the values of h and a, it is possible to induce mixed mode I II, I III, or I II III, loading at the fronts of the corresponding main notches By using four failure planes in different...
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Mixed mode i II III fracture criterion and its application to cement mortar 2

Mixed mode i II III fracture criterion and its application to cement mortar 2

Thạc sĩ - Cao học

... I, II and III fracture toughness, KIC, KIIC and KIIIC, respectively, of the test material The evaluation of KIC and KIIC will be dealt with in the following discussion, while that of KIIIC will ... K IC = K I0 ⋅ FIC , (4.1) K IIC = K II0 ⋅ FIIC , (4.2) while for pure mode II loading, where KI0 and KII0 are the respective stress intensity factors obtained from K-calibration curves shown in ... Modes I and II Fracture Testing Before verification of the proposed mixed mode I II III fracture criterion, given by foregoing equation (2.80) of §2.4, it would be necessary to evaluate the pure...
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Mixed mode i II III fracture criterion and its application to cement mortar 3

Mixed mode i II III fracture criterion and its application to cement mortar 3

Thạc sĩ - Cao học

... loading (in which α=90° and α=0, respectively), as K IC = K I0 ⋅ FIC (4.3) K IIIC = K III0 ⋅ FIIIC (4.4) and The respective stress intensity factors, KI0 and KIII0, were obtained from the K-calibration ... are depicted in the plot between the normalized unified pure mode I and III stress intensity factors, KIθ /KIC and KIIIθ /KIIIC, respectively, of Figure 4.29 The figure also shows the unified fracture ... concentration Figure 4.19 shows the application of mixed mode I- III loading at an angle of α=45° The main advantage of the test configuration is that the entire mixed mode I- III 95 F le α ang ing load...
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Mixed mode i II III fracture criterion and its application to cement mortar 4

Mixed mode i II III fracture criterion and its application to cement mortar 4

Thạc sĩ - Cao học

... of beam group D Figure 4.39 Failure of mixed mode IIIIII fracture test specimens 133 KIIθ KIθ KIIIθ ( KIC )2+ ( KIIC ) + ( KIIIIC )=1 2 √(K II θ / KIIC)2 + (KIIIθ / KIIIC) 1.0 0.8 0.6 0.4 ... as K I = K I0 ⋅ FC , (4.7) K II = K II0 ⋅ FC (4.8) K III = K III0 ⋅ FC , (4.9) and where KI0, KII0 and KIII0 are the stress intensity factors, due to unit loading, obtained according to the ... testing machine In order to achieve differing mode I/ mode II and mode I/ mode III loading ratios, each beam group (according to §4.4.1) was subjected to various loading cases, as depicted in Figure...
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Kế hoạch Triển khai thực hiện xác định thôn đặc biệt khó khăn, xã khu vực I,II,III vùng dân tộc và miền núi giai đoạn 2012 -2015

Kế hoạch Triển khai thực hiện xác định thôn đặc biệt khó khăn, xã khu vực I,II,III vùng dân tộc và miền núi giai đoạn 2012 -2015

Tài liệu khác

... đ i chiếu v i tiêu để xác định xã thuộc khu vực I, II III (theo biểu 02 Thông tư số 01/2012/TTUBDT); đồng th i tổ chức họp thông qua kết xác định thôn đặc biệt khó khăn xã thuộc khu vực I, II III; ... biệt khó khăn xã xếp xã vào khu vực I, II III; trình UBND tỉnh kết xét duyệt thôn đặc biệt khó khăn danh sách xã thuộc khu vực I, II III (theo biểu 04, 05 Thông tư số 01/2012/TT-UBDT) kèm Biên ... Rà soát đ i chiếu v i số liệu, t i liệu thực trạng kinh tế - xã h i để xác định thôn đặc biệt khó khăn xã thuộc khu vực I, II, III Th i gian thực xong trước ngày 20/01/2013 Tổ chức i u tra xét...
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Giáo án Hình học 11 chương I, II, III

Giáo án Hình học 11 chương I, II, III

Toán học

... không hợp lệ file bị xóa (violet.vn/uploads/resources/307/25613//Baisoan_Hinh11chuongI %20chuongII%2 0III. doc) Quay trở http://violet.vn ...
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ôn tập chương I-II-III

ôn tập chương I-II-III

Hóa học

... natri hiđroxit hợp chất ion C glixerol chất lỏng, natri hiđroxit chất rắn D glixerol chất không i n li, natri hiđroxit chất i n li Câu 2: Các mu i, axít, hiđroxit tan chất i n li vì: A chúng ... A orbital s v i orbital p tạo thành orbital lai hoá sp2 B orbital s v i orbital p tạo thành orbital lai hoá sp2 C orbital s v i orbital p tạo thành orbital lai hoá sp2 D orbital s v i orbital ... trúc C góc không gian D góc hóa trị Câu 6: Liên kết hóa học ion đợc g i A liên kết anion cation B liên kết ion hóa C liên kết tĩnh i n D liên kết ion Câu 7: Liên kết ion khác liên kết cộng hóa...
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Chương I, II, III(Chuẩn)

Chương I, II, III(Chuẩn)

Vật lý

... ng ca hc sinh Yờu cu hs gii thớch ti chn D Gii thớch la chn Yờu cu hs gii thớch ti chn D Gii thớch la chn Yờu cu hs gii thớch ti chn D Gii thớch la chn Yờu cu hs gii thớch ti chn A Gii thớch la ... cỏc i lng dng ca cỏc i lng bin Nhng i lng in v t bin thiờn bin thiờn theo hm sin hay thiờn theo hm sin hay cụsin theo hm sin hay cụsin theo thi gian u cụsin theo thi gian theo thi gian cú giỏ ... b ca giỏo viờn: Gii bi theo nhiu cỏch khỏc Chun b ca hc sinh: Hc bi c, ụn li kin thc lng giỏc, lm bi III - Hot ng dy - hc: ngy son: - 2008 Hot ng 1: Gii bi 7-9 Hot ng ca giỏo viờn Nhc li nh ngha...
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