drug drug interactions between non nucleoside reverse transcriptase inhibitors nnrtis and protease inhibitors
Báo cáo y học: "Rapid CD4 decline after interruption of non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy in a resource-limited setting" ppt
Ngày tải lên :
10/08/2014, 05:20
... TI between NNRTI group and PI group, ii) define the predictors for early resumption of ART, iii) compare change of CD4 and HIV-related symptoms after TI between NNRTI group and PI group, and ... cell count to guide when to interrupt and recommence ART [11-14] However, there is none study reporting the difference outcomes of TI between NNRTI-based and protease inhibitor (PI)-based ART From ... available or are not affordable in resource-limited settings Non- nucleoside reverse transcriptase inhibitor (NNRTI) with stavudine and lamivudine is widely used as the first-line antiretroviral...
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Báo cáo y học: " Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen" doc
Ngày tải lên :
10/08/2014, 05:21
... Central and Southern Africa; the ‘light skin” group included 68 Caucasians, one Moroccan and one Ecuadorian NNRTI Viral Load (log10) HIV stage (CDC) PI: Protease inhibitors; NNRTI: non- nucleoside reverse ... STATA and R software Pre-HAART data was summarized using counts and percentages, means and standard deviations for normally distributed data, and median (interquartile range, IQR) for non- normal ... with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen AIDS Research and Therapy 2010 7:40 Submit your next manuscript to BioMed Central and take full advantage...
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Báo cáo y học: "Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV proteas" doc
Ngày tải lên :
13/08/2014, 01:20
... Tachedjian G: Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol PLoS Pathog 2006, 2:e119 de Bethune MP: Non- nucleoside reverse transcriptase inhibitors (NNRTIs) , their discovery, ... described for one class of currently used antiretroviral drugs, namely non- nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) [27] NNRTIs are an integral part of modern HAART regimens ... precursor and reverse transcriptase homodimer formation FEBS Lett 2005, 579:379-384 34 Tachedjian G, Orlova M, Sarafianos SG, Arnold E, Goff SP: Nonnucleoside reverse transcriptase inhibitors...
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Báo cáo y học: "Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 33." pptx
Ngày tải lên :
10/08/2014, 05:20
... brand new class of drugs Friedland and Williams [10] have suggested that the relationship between the development of resistance and adherence to the drugs is bell-shaped, such that both high and ... Research and Therapy 2007, 4:2 pViral RNA Mini Kit (Qiagen Inc., Valencia, CA) Reverse transcriptase polymerase chain reaction (RT-PCR) and direct DNA sequencing of protease and reverse transcriptase ... AIDS Research and Therapy 2007, 4:2 Background Nucleoside reverse transcriptase inhibitors (NRTI) were the first antiretroviral drugs available and continue to be a component...
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Báo cáo y học: " Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report" pot
Ngày tải lên :
11/08/2014, 10:22
... data and revised the manuscript LB and MG analyzed the liver biopsy and revised the manuscript CT conceived the study and participated in the drafting of the manuscript All authors read and approved ... incidence, liver histology, and outcome J Acquir Immune Defic Syndr 2003, 32:259-267 Brinkman K, Kakuda TN: Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: a looming ... mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors Antimicrob Agents Chemother 2002, 46:716-723 den BM, Wit FW, Wertheim-van...
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Báo cáo y học: "Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors" pps
Ngày tải lên :
12/08/2014, 19:22
... was significantly different between survivors and nonsurvivors The mean values of the initial blood lactate level in survivors and in nonsurvivors were 7.3 ± 3.8 and 18.6 ± 8.8 mmol/l, respectively ... proapoptotic and antiapoptotic signals The imbalance in 227 Critical Care June 2003 Vol No Claessens et al Table Cellular effects of nucleosidic reverse transcriptase inhibitors (NRTIs) and carnitine ... Brinkman K: Editorial response: hyperlactatemia and hepatic steatosis as features of mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors Clin Infect Dis 2000, 31:167-169...
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Scientific report: "Biological interactions between spiders catch prey Amblyseius cucumeris (Oudermans) and Orius bugs prey sauteri (Poppius) in each animal prey truongco Thrip thrips palmi (Karny)" ppt
Ngày tải lên :
06/08/2014, 18:21
... the hypothesis that A cucumeris and O sauteri discriminate between patches with prey only and patches with prey and the other predator Response of A cucumeris and O sauteri are studied in the ... non - parametric binomial test) When O sauteri was given a choice between the bean leaf with T palmi and A cucumeris and the bean leaf with T palmi only, O sauteri also did not discriminate between ... offered a choice between odours from leaves with thrips and leaves with thrips and the other predator O sauteri in an olfactometer and the response of O sauteri when offered a choice between odours...
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Báo cáo khoa học: "Immunohistochemical expression of h-telomerase reverse transcriptase in canine and feline meningiomas" pptx
Ngày tải lên :
07/08/2014, 20:23
... gnisylana rof ,eulb enidiulot gnisu ,dohtem gniniats elpmis dna dipar A C irroihcleM ,E ilongamoR ,M inongaP ,P oceihC secnerefeR )5002 NIRP ,tseretnI lanoitaN tnaveleR fo smargorP hcraeseR cifitneicS(...
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Báo cáo y học: "Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture" potx
Ngày tải lên :
10/08/2014, 05:21
... infection and incubated for 24 h (black triangle); and percent inhibition when cells were pre-incubated with drugs for 24 h and then the media was changed to remove drug at and 24 h without drug replacement ... "forgiving" if a patient inadvertently takes drug holidays Most current HAART regimens comprise of two nucleoside analogs and a non nucleoside analog or a protease inhibitor [1] Therefore, NRTIs continue ... Safrit JT, Stringer JS: Single-dose tenofovir and emtricitabine for reduction of viral resistance to non- nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for...
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Báo cáo y học: " RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models" ppt
Ngày tải lên :
10/08/2014, 05:21
... markedly inhibited by all three NNRTIs (UC781, efavirenz, and nevirapine), and also by a number of NRTIs (AZT and D4T), and protease inhibitors (PIs: indinavir and saquinavir) The antiviral effect ... NNRTIs: Non- nucleoside reverse transcriptase inhibitors; NRTIs: nucleoside RT inhibitors; PIs: protease inhibitors EC50: Effective concentration of antiretroviral drug inhibited 50% virus replication ... Anti-HIV drugs NNRTIs Efavirenz Nevirapine UC781 ZIdovudine (AZT) Lamivudine (3TC) Stavudine (D4T) Emtricitabine (FTC) Tenofovir Ritonavir Indinavir Saquinavir NRTIs PIs NNRTIs: Non- nucleoside reverse...
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Báo cáo y học: " Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study" ppt
Ngày tải lên :
10/08/2014, 05:21
... HCV HBV HCV + HVB Cirrhosis ART: antiretroviral treatment PIs: protease inhibitors NNRTIs: non- nucleos(t)ide reverse transcriptase inhibitors M: median Group A: naive patients Group B: patients ... patients with virological failure to a preceding protease inhibitor (PI)- or nonnucleoside reverse transcriptase inhibitors (NNRTI)based regimen, and D) those with an undetectable viral load who ... K65R mutation was present in 5, the L74V in 6, and the M184I/V in 44; other mutations which confer resistance to non- nucleoside reverse transcriptase inhibitors was observed in 53 patients) Sixty...
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Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
Ngày tải lên :
16/03/2014, 13:20
... (PETT) nonnucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases: structural and biochemical analyses J Biol Chem 275, 5633–5639 Das K, Ding J, Hsiou Y, Clark AD, Moereels H, Koymans L, Andries ... Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non- nucleoside inhibitors J Mol Biol ... viral reverse transcriptase Med Res Rev 13, 229–258 Esnouf R, Ren J, Ross C, Jones Y, Stammers D & Stuart D (1995) Mechanism of inhibition of HIV-1 reverse transcriptase by non- nucleoside inhibitors...
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Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
Ngày tải lên :
22/03/2014, 16:20
... HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding Curr HIV Res 2, 323332 30 Pata JD, Stirtan WG, Goldstein SW & Steitz TA (2004) Structure of HIV-1 reverse ... LM (2000) Mutants of human immunodeciency virus type (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that ... M, Bambara RA & Demeter LM (2001) The Y181C mutant of HIV-1 reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors alters the size distribution of RNase H cleavages...
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Báo cáo y học: " ytotoxic T cell recognition of an HIV-1 reverse transcriptase variant peptide incorporating the K103N drug resistance mutation" pot
Ngày tải lên :
10/08/2014, 05:20
... complex NRTI: nucleoside reverse transcriptase inhibitor ELISPOT: enzyme-linked spot assay NNRTI: non- nucleoside reverse transcriptase inhibitor PBMC: peripheral blood mononuclear cells IFN-γ: ... switching drug therapy HIV: human immunodeficiency virus HLA: human lymphocyte antigen CTL: cytotoxic T cell lymphocyte RT: reverse transcriptase MHC: major histocompatibility complex NRTI: nucleoside ... The emergence of K103N and other drug resistant variants may be a dynamic process influenced by patient-specific anti-HIV CTL activity In support of this idea, interactions between certain HLA subtypes,...
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Báo cáo y học: ": Prevalence of reverse transcriptase and protease mutations associated with antiretroviral drug resistance among drug-naïve HIV-1 infected pregnant women in Kagera and Kilimanjaro regions, Tanzania" pptx
Ngày tải lên :
10/08/2014, 05:21
... includes Triomune, a combination of two nucleoside reverse transcriptase inhibitors (NRTI) Stavudine (d4T) and Lamivudine (3TC), and a non- nucleoside reverse transcriptase inhibitor (NNRTI) Nevirapine ... Delaporte E, Peeters M: Natural polymorphism in protease and reverse transcriptase genes and in vitro antiretroviral drug susceptibilities of non- B HIV-1 strains from treatment-naive patients ... antiretroviral drug resistance It is imperative to investigate and describe mutations associated with resistance to antiretroviral drugs in the RT and PR genes of HIV1 non- B subtypes and CRF among...
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Báo cáo y học: " A comparative analysis of HIV drug resistance interpretation based on short reverse transcriptase sequences versus full sequences" pps
Ngày tải lên :
10/08/2014, 05:21
... region of interest ROI ARV drugs Stanford 3TC none 7, 8, 13, 35, 36, 40 (n = 6) ABC none 3, 13, 21, 33, 35, 39, 40 (n = 7) AZT d4T RT codon 1-40 virco®TYPE none none none 3, 13, 33, 35, 36, 40 ... 39, 40 (n = 7) ddI none TDF none 4, 7, 13, 21, 33, 40 (n = 6) EFV none 16, 20, 22, 27, 28, 31, 33, 34 (n = 8) NVP none 21, 31, 35 (n = 3) 3TC none 240, 248, 277, 313 (n = 4) ABC none 334, 348 (n ... resistance testing is based on amplifying and sequencing of the viral protease and reverse transcription genes This requires multiple rounds of amplification and at least 6-8 sequencing reactions...
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Báo cáo y học: "The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains" ppt
Ngày tải lên :
13/08/2014, 01:20
... Antiretroviral drugs The NRTIs ABC, AZT, ddI, emtricitabine (FTC), 3TC and d4T; and the NNRTIs efavirenz (EFV), etravirine (ETV), and NVP were obtained from the NIH AIDS Research and Reference ... in adults and adolescents: recommendations for a public health approach 2010, 20-7-2010 Ren J, Stammers DK: HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms ... Techasathit W, Ubolyam S, Chuenyam T, et al: Nucleoside analogue mutations and Q151M in HIV-1 subtype A/E infection treated with nucleoside reverse transcriptase inhibitors AIDS 2003, 17:1889-1896 Sungkanuparph...
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Báo cáo y học: " Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance" pps
Ngày tải lên :
13/08/2014, 05:21
... Update of the Drug Resistance Mutations in HIV-1: Spring 2008 Top HIV Med 2008, 16:62-68 Menendez-Arias L: Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase ... resistance to human immunodeficiency virus type with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity Antimicrob Agents Chemother ... activity and processivity Mol Pharmacol 1998, 54:291-297 Frankel FA, Invernizzi CF, Oliveira M, Wainberg MA: Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
Ngày tải lên :
06/03/2014, 04:20
... rifamycin antibiotics and four classes of antiretroviral drugs: protease inhibitors, non- nucleoside reverse- transcriptase inhibitors [NNRTI], CCR5-receptor antagonists, and integrase inhibitors Only ... antituberculosis drugs and antiretroviral drugs, immune reconstitution inflammatory syndrome, and drug- drug interactions The key interactions, and the focus of this document, are those between the ... antiretroviral drug Single protease inhibitors None (some experts recommend 800 mg for patients > 60 kg) Efavirenz Recommended change in dose of antiretroviral drug Non- nucleoside reverse transcriptase inhibitors...
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Báo cáo y học: "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation" docx
Ngày tải lên :
10/08/2014, 09:22
... The incidence of FK506associated thrombotic microangiopathy (TMA) is between 1% and 4.7% and the prevalence is between 0.14 and 0.7% [9] Tacrolimus-associated HUS following lung transplantation ... rate and increases renal vascular resistance via Endothelin-1 The net effect is ischemia and endothelial cell injury That triggers inflammation and platelet aggregation, resulting in thrombi and ... coordination and overlooked the progress of the manuscript and advised on valuable amendments All authors read and approved the final manuscript Submit your next manuscript to BioMed Central and take...
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