drug distribution and clearance
Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... extracorporeal clearance, ClNR is the nonrenal clearance, and ClR is the renal clearance Because AKI changes renal clearance and potentially nonrenal clearance, AKI could alter the FrEC of drugs during ... activity of P-gp and OATs in AKI would contribute to decreased drug clearance and may potentially result in increased drug exposure Disposition of formed metabolites in AKI Once formed, drug metabolites, ... parent drug and metabolite in impaired metabolite clearance Presented is a schematic of the serum concentration profile of parent drug and metabolite that may occur with impaired metabolite clearance...
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Báo cáo y học: " Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination" pps
... H and Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs Int J Pharm 2003, 263:113– 122 Pang KS and Rowland M: Hepatic clearance of drugs ... role of P-gp in drug absorption and excretion in intestine, kidney and liver, has been revealed through reduction of absorption of orally administered drugs and promotion of urinary and biliary excretion ... P-gp activity on drug distribution, we had access to WT and KO tissue concentrations of domperidone, an antiemetic drug associated with cardiac toxicity [15-17] The choice of this drug model was...
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Tài liệu Module 3: Designing a Software Distribution and Management Strategy ppt
... software distribution and management options based on business needs, and the current and planned environment Determining Current Software Distribution Strategy Determining Software Distribution and ... Current Software Distribution Strategy Determining Software Distribution and Management Needs Evaluating Software Distribution and Management Options Selecting Software Distribution and Management ... Software Distribution and Management Strategy 17 Selecting Software Distribution and Management Options Topic Objective To identify the appropriate options for software distribution and management...
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Tài liệu Báo cáo khoa học: Neuropeptide Y-family receptors Y6and Y7in chicken Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region docx
... ligand affinity between Y7 and Y2 may prove very useful for studies of ligand–receptor interactions and 3D modeling, and we have previously been able to utilize differences between chicken and ... radioligand This radioligand had iodinated tyrosines at positions 21 and 27 and a specific activity of 4000 CiÆmmol)1 Saturation experiments were carried out with serial dilutions of radioligand, and ... tissue distribution and phylogeny of the chicken Y6 and Y7 receptors and performed the initial pharmacological characterization of the latter It is clear, from these studies, that the Y6 and Y7...
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Tài liệu Growth, Distribution, and Tax Reform: Thoughts on the Romney Proposal pdf
... Gale, and Looney [2012a] See Cronin [1999] for a thorough discussion of the conventions used by the Treasury to estimate the distributional effects of tax policy 5 revenue collected and its distribution ... state and local taxes, I only include half the reported state and local taxes 9 Although both economic theory and historical experience suggest that a tax system with lower marginal rates and ... possible effects of the Romney proposal on See Brown, Gale, and Looney [2012a] See, for example, the critique by Feldstein [2012] and Brown, Gale and Looney’s[2012b] responses to their various critics...
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The Geographic Distribution and Characteristics of U.S. Bank Failures, 2007-2010: Do Bank Failures Still Reflect Local Economic Conditions? pptx
... Rhode Island, and Vermont), four southeastern states (Kentucky, Mississippi, South Carolina, and Tennessee), and two Great Plains states (Montana and North Dakota) Figure shows the distribution ... agricultural incomes and caused the failure of thousands of banks located in farm states and other rural areas States where farm land values and cultivated acreage had expanded the most during ... million and $204 million, respectively By comparison, among non-failing banks, mean total assets and deposits were $1.2 billion and $695 million, respectively, and median total assets and deposits...
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Báo cáo khoa học: A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic inverted repeats pptx
... similarity and a short internal spacer in the human genome They were termed as recombinogenic LIRs in our previous study on human chromosomes 21 and 22 [33], although their distribution and frequency ... orthologs Results Characters and distribution of LIRs in human autosomes We identified 2551 LIRs in human autosomes and approximately 87% of them have a short spacer (0–9 bp) and arm (31–59 bp) (Fig ... center, and was divided into five ranges We calculated the percentage of LIRs falling within the ranges and observed a small percentage difference between the ranges, suggesting a random distribution...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
... between east and west in Europe facilitated contacts and communication that were also used by drug traffickers, increasing the number of transit routes for drugs and markets for drug consumption.21 ... Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country profiles United States Department of Health and Human Services (Substance Abuse and Mental Health ... widely abused synthetic drug, cutting across all social classes 11 II Economic consequences of drug abuse and trafficking A Apparent "benefits" and costs of drug abuse and trafficking “Benefits”...
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The Distribution and Reproductive Success of the Western Snowy Plover along the Oregon Coast - 2010 potx
... 1993-2009 (79%) A minimum of 70 banded females and 18 unbanded females nested and 84 banded males and unbanded males nested An additional 24 banded females and 17 banded males were present during ... banded adult plovers was 78%, above the 1994 – 2009 mean of 63% During the 2010 season, we captured and rebanded 33 banded adult plovers - 21 were males and 12 were females; we banded six unbanded ... violations and educate the public about plovers and dog related issues, and we recommend that these aspects of management continue and be funded At Siltcoos and Bandon Beach where parking lots and recreational...
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The Distribution and Reproductive Success of the Western Snowy Plover along the Oregon Coast - 2008 pptx
... 1993-2007 (80%) A minimum of 54 banded females and 12 unbanded females nested and 57 banded males and unbanded males nested An additional 17 banded females and 17 banded males were present during ... based on returning banded adult plovers was 62% During the 2008 season, we captured and rebanded 30 banded adult plovers - 18 were males and 12 were females; we banded 10 unbanded adult plovers ... Portland, OR Prepared for U.S Fish and Wildlife Service and Oregon Parks and Recreation Department Lauten, D.J., K.A Castelein, B.V Smithers, K.C Jander, E Elliot-Smith, and E.P Gaines 2003 The Distribution...
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Distribution and mobility of heavy metals
... (for A17) and Zn (for A18) A21 and A23 form a separate group due to the high content of Al, Fe, Pb, La, Zn and Zr (for A21), and Al, Fe, Cd, Ni, Ti, V and Zn (for A23) No significant distribution ... chromium and nickel contents at site B are above both limits in many samples, whereas lead and zinc, and in some cases cadmium, are between ‘‘A’’ and ‘‘B’’ values All samples exceeding ‘‘A’’ and some ... sites and with Dutch intervention values (Ministry of Housing, 1994), formerly known as C values (Table 5) Italian limits depend on land use, and are lower for public and private green areas and...
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Báo cáo khoa học: Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5¢-phosphate oxidase pptx
... (A) and mouse (B) PNPO gene Exons are designated by closed boxes, and introns by bold lines The ORF is marked black, and grey boxes denote the 5¢- and 3¢-UTR sequences The locations of CpG islands ... contains CpG islands with a CGobs/CGexp ratio in excess of 0.6 and a G + C content of 62% spanning two regions from )377 to )158 and from )137 to +136 of the start codon Such a CpG island is indicative ... gel, and the product band was extracted from the gel, purified, and ligated into the pGEM vector Then a BamHI digested fragment was subcloned into pET28a expression vector (pET28a/PNPOx) and used...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... Chemistry 43 Amit S Kalgutkar Drug- Metabolizing Enzymes, Transporters, and Drug Drug Interactions 83 Steven W Louie and Magang Shou Experimental Models of Drug Metabolism and Disposition 151 Gang ... of drug metabolism and disposition These concepts are intended to build a unique foundation of knowledge for drug metabolism and the subsequent studies performed during drug discovery and drug ... White RE Short and long-term projections about the involvement of drug metabolism in drug discovery and development Drug Metab and Dispos 1998;26:1213À1216 Wu CY, Benet LZ Predicting Drug Disposition...
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The Distribution and Reproductive Success of the Western Snowy Plover along the Oregon Coast - 2011 ppt
... 1993-2010 (78%) A minimum of 90 banded females and 17 unbanded females nested and 104 banded males and unbanded males nested An additional 11 banded females and banded males were present during ... breeding season we observed 107 banded females, 113 banded males, 15-17 unbanded females, and 12-13 unbanded males The totals include six banded male and two banded female plovers that were most ... banded adult plovers was 75%, above the 1994-2010 mean of 64% During the 2011 season, we captured and rebanded 33 banded adult plovers - 22 were males and 11 were females; we banded three unbanded...
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AUDIT OF THE CONTROL SYSTEM GOVERNING THE PRODUCTION, PROCESSING, DISTRIBUTION AND IMPORTS OF ORGANIC PRODUCTS potx
... use of synthetic pesticides and fertilisers, antibiotics, certain food additives and processing aids Stages of production, preparation and distribution: Any stage from and including the primary ... import regimes, and meetings with the services of the Directorate-General for Agriculture and Rural Development and of the Directorate-General for Health and Consumers — Food and Veterinary Office ... processing, distribution and imports of organic products 38 61 The Commission’s analysis of annual reports is not standardised (e.g no checklists or standard report formats are used) and the analysis...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... incoming drugs before they reach the cytoplasm and at a transient high local concentration Moreover, in the latter case, Pgp is expected to handle incoming drugs more efficiently compared to drugs ... By contrast, in the case where drug concentrations in the cytoplasm and the cytoplasmic leaflet are in equilibrium, Pgp is expected to treat incoming drugs and drugs already present within the ... only transports a variety of drugs conjugated to glutathione, sulfate or glucuronate, as well as anionic drugs and dyes, but also neutral ⁄ basic amphipathic drugs and even oxyanions Previously,...
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DISTRIBUTION AND PACKAGING OF STUDENT FINANCI AIDI,: SOMEr EVIDEN~C FROM THE SURVEY 0F THE HIGH SCHOOL CLASS.OF 1972 potx
... education in the United States; conduct, and~ ~ publish reports on specialized analses of the meaning and significance of such, statistics; and review and report on education activities in foreign, ... postsecondary education in the academic year 197273, (2) the distribution of Federal aid by various student and institutional characteristics, and (3) the distribution of non-Federal aid that students may ... "package" consisting of different types and sources of aid Such a package may result in funds from Federal and/ or non-Federal sources, and from grants, jobs, loans, and transfer benefits in various...
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For Medicare Advantage Plans, Medicare Advantage Prescription Drug Plans, Prescription Drug Plans, and 1876 Cost Plans ppt
... management restrictions, drugs that are available via mail-order, excluded drugs, free first fill drugs, limited access drugs, drugs covered in the coverage gap, and drugs covered under the medical ... and generic drugs A generic drug is approved by the FDA as having the same active ingredient as the brand name drug Generally, generic drugs cost less than brand name drugs A statement describing ... below Drug Name: We suggest capitalizing brand name drugs, (e.g., LIPITOR), and listing generic drugs in lowercase italics, (e.g., penicillin) Part D plans may include the generic name of a drug...
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