dose dependent training dose stimulus effects
Effects of longterm ingestion of cd polluted rice or low dose cd supplemented diet on the endogenous cop
... the concentrations increased in a dose dependent manner for the first 18 months and remained the same thereafter The concentrations of Cu increased in a dose dependent manner at 12 and 18 months, ... the Cd concentration increased in a dose dependent manner for the first 18 months of exposure After 18 months, the concentration remained stationary in the low -dose groups, increased in the 5-ppm ... treatment group and control group (group I), p < 0.05 10 µg/g) The Zn concentration increased in a dose dependent manner Correlation coefficients between Cd and Zn are shown in Table Although a correlation...
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Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway pdf
... of Bim expression in a timedependent and dose- dependent manner (Fig 5A,B) Bcl-2 prevents release of cytochrome c by heterodimerizing with Bax [51,52] Therefore, the effects of treatment with morphine ... representative of three independent experiments yielding similar results Data are means ± SEMs for three independent experiments *P < 0.05 as compared with morphine dependent apoptosis, caspase ... X Lin et al promoting effects occur at low concentrations or single doses of opioids, whereas growth-inhibitory effects occur with chronic opioid treatment or relatively...
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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... meta-analysis of randomized melanoma trials, covering a wide range of IFN dose regimens, suggested that the benefits of IFN are independent of dose or therapy duration, and translate into an absolute OS benefit ... signaling in melanoma by high -dose IFNa2b Clin Cancer Res 2007, 13:1523-1531 Wang W, Edington HD, Rao UN, Jukic DM, Radfar A, Wang H, Kirkwood JM: Effects of high -dose IFNa2b on regional lymph ... administration of the first dose it was essential that all blood examinations, electrocardiography, and cardiac ultrasound were normal IFN-a 2b was administered iv at a dose of 20 MU/m2 each day...
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báo cáo hóa học: " Effects of low dose GM-CSF on microglial inflammatory profiles to diverse pathogen-associated molecular patterns (PAMPs)" potx
... 2007, 4:10 effects of GM-CSF on microglial activation and bacterial phagocytosis are negligible at the low doses used as a culture medium supplement in our studies Effects of low dose GM-CSF ... microglial responsiveness to a downstream CpG-ODN (TLR9) stimulus Low dose GM-CSF influences microglial responsiveness to a downstream CpG-ODN (TLR9) stimulus Primary microglia expanded with (+) or without ... represents the first report investigating the effects of low dose GMCSF on microglial responses to TLR4 and TLR3 ligands Importantly, based on the finding that low dose GM-CSF does not dramatically alter...
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Báo cáo toán học: " Effects of internal low-dose irradiation from 131 I on gene expression in normal tissues in Balb/c mice" ppt
... the dose- response relationships for transcripts regulated at all doses in a certain tissue type showed that few transcripts could potentially serve as biomarkers for the absorbed dose in the dose ... present study; the absorbed dose was delivered at varying dose rates with time (including effects of biokinetics and physical decay of the radionuclide) as well as with dose, which is an unavoidable ... the overall side effect (both acute and late effects) on normal tissues from high -dose exposures is relatively well known, the effects in the low -dose range is still to be explored Notably, firm...
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Báo cáo y học: "An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects" ppsx
... some of the patients not responding at week 12 on duloxetine fixed -dose monotherapy may have responded if treated with higher doses of antidepressant (for example, 120 mg/day) and/or if treated ... ones, could be part of MDD rather than side effects due to treatment) What should be noted is that zonisamide apparently did not produce negative effects compared with the start of treatment ... augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects Annals of General Psychiatry 2011 10:23 Submit your...
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Báo cáo khoa học: "Choline PET based dose-painting in prostate cancer - Modelling of dose effects" potx
... a, a/b, g50, whole prostate dose, SIB dose and dose per fraction In order to present the calculations different representative scenarios have been tested: All these effects may be in place but ... sensitivity of choline PET, low whole prostate dose, high g50(ASTRO consensus) and Fowler’s a/b a [Gy-1] 0.04 a/b [Gy] g50 Det rate PET [%] Dose [Gy] SIB [Gy] Single dose [Gy] TCPconv [%] TCP Increase [%] ... sensitivity of choline PET, low whole prostate dose, low g50(CN + definition) and Fowler’s a/b a [Gy-1] 0.04 a/b [Gy] g50 Det rate PET [%] Dose [Gy] SIB [Gy] Single dose [Gy] TCPconv [%] TCP Increase [%]...
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DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and a2-adrenergic receptors potx
... intensity -dependent analgesia on the tail reflex and showed maximal DNIC effects within the stimulation period Notably, E50 elicited a strong and long analgesic effect (B) (C, D) A high -dose formalin ... through NA- and opioid -dependent actions (left upper panel), whereas the analgesic effect of noxious electrical stimulus may not depend on activation of opioid receptors (opioid-independent, right ... = 3) but longer hind paw elevation (pain score = 1-2) compared to those after i.pl injections Dose- dependent hyperalgesic responses were shown in the i.m formalin groups from concentrations of...
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Báo cáo y học: "Dose dependent effect of statins on postoperative atrial fibrillation after cardiac surgery among patients treated with beta blockers" docx
... board, higher doses of statins were required to reduce the incidence of postoperative AF Previously, Lertsburapa et al [17] and Kourliouros et al [18] had also found that higher dose statins were ... 2008, 135:405-411 Kourliouros A, De Souza A, Roberts N, Marciniak A, Tsiouris A, et al.: Dose- related effects of statins on atrial fibrillation after cardiac surgery Ann Thorac Surg 2008, 85:1515-20 ... (i.e > 20 mg/ day) of statins However the incidence of postoperative AF was not influenced by low dose statin treatment There has been a recent interest in using statins for preventing postoperative...
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Báo cáo y học: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered" pptx
... dysfunction and atrophy None of these effects were observed with the higher dose of methylprednisolone (30 mg/kg), a dose that fully protected the diaphragm against the effects of CMV Corticosteroids ... data indicate that the effects of MP on caspase-3 activity during CMV were independent of the dose administered Our data also clearly show that MP can minimize the deleterious effects of CMV on the ... corticosteroids was shown to be dependent on the dose administered Surprisingly, our data showed a prevention of the CMV-induced increase in 20S proteasome activity with both doses of MP This is in contrast...
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Báo cáo y học: " Real time analysis of b2-adrenoceptor-mediated signaling kinetics in Human Primary Airway Smooth Muscle Cells reveals both ligand and dose dependent differences" ppt
... curves to isoproterenol by perfusing a single cell with increasing doses of drug, allowing time for cellular recovery after each dose [17] We extended these studies to see whether a full concentration ... 0.05, n = 6-19) This does not appear to be a non-specific effect seen only at high doses as a further concentration -dependent decrease in the rate of onset of Lower concentrations of isoproterenol ... Gsmediated effects were quantified [21] As this phenomenon has become more widely reported it has attracted Page of 10 a variety of labels including biased agonism, conformational selection, stimulus...
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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx
... mitochondrial membrane potential is both GPS dose- dependent and time -dependent Loss of mitochondrial membrane potential is both GPS dose- dependent and time -dependent m depolarization monitored by ... a dosedependent manner in A549 [34], HFL-1 [38], U937 human premonocytic [39] and BEAS-2B cells [40] Figure tein causes GPS levels a dose- dependent change in active caspase-3 proGPS causes a dose- dependent ... of T cells in response to various doses of tobacco smoke in vitro Our results clearly demonstrate that the effects of CS administration are both dose- and time -dependent and that apoptosis is an...
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Báo cáo y học: " The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose" ppt
... http://respiratory-research.com/content/5/1/15 Figure Dose response curves to inhaled methacholine Dose response curves to inhaled methacholine Dose response curves (expressed as a % of the response ... the dose of antigen at challenge has an influence on the timing of peak responsiveness to bronchoconstricting agents The aim of this study was to systemically investigate the effect of antigen dose ... to the level seen in naive mice, 48 hours after the OVA aerosol Response 99% CI { MCh dose Saline Threshold dose (Sensitivity) Figure Technique for sensitivity calculation Technique for sensitivity...
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Báo cáo y học: "A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose" pptx
... radiation-independent drug effects and enabled assessment of the relationship of this variable to radiationdependent effects Conclusion Measurement of radiation responses over a wide range of doses ... survival and dose is more complex than that predicted by the LQ equation Secondly, cytotoxic effects of sensitising agents that are independent of radiation are not taken into account Such effects ... sensitising effects over different radiation dose ranges http://www.tbiomed.com/content/4/1/25 significance of the cytotoxic and radiosensitising effects, and to ascertain whether the two are interdependent...
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Báo cáo sinh học: "Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery" docx
... injection was done with the higher dose but not with the lower doses (Table 2) Moreover, it was possible to rescue plasmid DNA from mice injected with the higher plasmid dose in all tissue analyzed ... colonies obtained after transformation of tissue DNA after immunization with different doses pcDNA3hsp65 doses Number of colonies/µg total DNAa Time after immunization Muscle DLN BM Liver Spleen ... biodistribution can also be correlated with the plasmid dose injected To evaluate this possibility, some mice were immunized with lower doses of plasmid DNA-Hsp65 (4 and 20 µg/mouse) The results...
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DOSE RESPONSE ASSESSMENT (threshold effects)
... POINT ON DOSEDOSE-RESPONSE CURVE ONLY 12/5/2010 ACCURACY ISSUES Dose spacing Information at different exposure levels Slope of the dose- response curve Shape of the dose- response curve: dose response ... CONTAMINATS ADI/TDI Exceeders ABOVE “ADi” DOSE FOG OF UNCERTAINTY "SAFE" REGION OF NO EFFECTS "NOT SAFE" REGION OF ADVERSE EFFECTS “ADI” DOSE INCREASING DOSE 10 12/5/2010 MATHEMATICAL MODELS WHY? ... ⌧More accurate d i derivation of “ O / O ” i f “NOEL/LOEL” Effects at various exposure levels BENCHMARK DOSE BIOLOGICALLY BASED DOSEDOSERESPONSE MODELS (BBDR) ⌧Pharmacokinetics ⌧Mechanisms of...
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Báo cáo y học: " Effect of dose-escalation of 5-fluorouracil on circadian variability of it"
... Standard dose a) 27 High dose p c) (22.2 %) (37.5 %) 0.396 10 (37.0 %) (50.0 %) 0.685 (14.8 %) (12.5 %) 1.000 (18.5 %) (25.0 %) 0.648 a) Standard dose group: 400 mg/m2/day of 5-fluorouracil; High dose ... b) Two of patients with Stage IVa had a CR in the high dose group, but no patient in the standard dose group c) Standard dose group vs high dose group (Fisher’s exact test) http://www.medsci.org ... 5-Fluorouracil in the Standard dose and High dose groups Group Stage III Stage IVa Stage III/ IVa Standard dose a) 19 0.117±0.031 b) 0.101±0.027 27 0.112±0.030 High dose 0.131±0.036 0.144±0.029...
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Tài liệu 101 Motivational Quotes Your daily dose of motinvation pptx
... the reprint and redistribution rights to this FREE ebook: “101 Motivational Quotes –Your Daily Dose of Motivation” This means you may freely redistribute this ebook to whom ever you wish The ... That way at any time wherever you are and whatever you are doing you will always have your daily dose of motivation Steven Grabek 101 Motivational Quotes Quotes – The world has the habit of making ... are Anthony Robbins Quotes 25 – 30 Every human has four endowments- self-awareness, conscience, independent will and creative imagination These give us the ultimate human freedom The power to choose,...
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Tài liệu Báo cáo " Determination of the annual beta dose by meaming beta activity using the liquid scintillation technique " ppt
... Fig The additive dose method for evaluation of the paleodose The paleodose P that the sample has received during antiquity is usually greater than Q because of the pre -dose effects [1,2] The ... of pottery (in years -yr); P is the paleodose in sample (Gy); Dβ is annual beta dose (Gy/yr); Dγ is annual gamma dose (Gy/yr); and DC is anual cosmic dose, which is around 175 µGy/yr) [1-3] Presently, ... ThapBa Annual beta dose rate (Dβ) (mGy/yr) 2.344 ± 0.089 1.925 ± 0.092 2.451 ± 0.085 Annual gamma dose rate (Dγ) (mGy/yr) 2.283 ± 0.073 1.284 ± 0.073 2.283 ± 0.073 The equivalent dose (Q) was evaluated...
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