dopamine independent inhibition of hippocampal ca1 neurons produced by nanomolar levodopa with facilitation of noradrenaline and gaba release in rats
Báo cáo khoa học: "Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum" ppsx
Ngày tải lên :
12/08/2014, 04:21
... whereas inhibition of HIV infectivity in the absence of cell cytotoxicity was evident in subfraction E4 that was eluted with a 1:1 mixture of acetonitrile/methanol Results Inhibition of HIV infection ... anti-depressive activity of the extract [1] The constituents hypericin and pseudohypericin effectively inhibit infection by a number of enveloped viruses of medical importance, including human immunodeficiency ... present in H perforatum extracts, we began by extracting dried aerial material with chloroform Chloroform Subsequent fractionation of E4 into eight subfractions was performed by using an initial...
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Tài liệu Environmental impacts of petroleum production: Fate of inorganic and organic chemicals in produced water from the Osage-Skiatook Petroleum Environmental Research sites, Osage County, Oklahoma doc
Ngày tải lên :
14/02/2014, 03:20
... produced with oil and gas, and from hydrocarbon and produced water releases caused by equipment failures, vandalism, flooding, and accidents In 1993, about 25 billion and 0.3 billion bbl of produced ... ‘A’ and ‘B’ sites, respectively The impacts include salt scarring, soil salinization and oil contamination, and brine and petroleum contamination of ground water and surface water, including ... Issues and Solutions in Exploration, Production and Refining, Albuquerque, NM: Integrated Petroleum Environmental Consortium (IPEC) and the University of Tulsa, Continuing Engineering and Science...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
Ngày tải lên :
07/03/2014, 03:20
... co-expressed in SGC7901/ADR cells The yellow staining in dual-labeling experiments indicated overlapping areas of red and green fluorescence, suggesting co-expression of p-Akt with PrPC in the cytoplasm of ... maintained in RPMI-1640 containing 10% heat-inactivated newborn bovine serum (SiJiQing, Hangzhou China) at 37° C in a humidified atmosphere of 5% CO2 and 95% air Double immunofluorescence staining ... activation of PI3K/Akt signaling pathway plays an essential role in PrP-induced MDR in gastric cancer cells Inhibition of the PI3K/Akt signaling pathway by LY2940002 or Akt siRNA leads to inhibition of...
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
Ngày tải lên :
08/03/2014, 08:20
... containing inactive versions of Rz-1 and Rz-2 were obtained in the same way by using templates as described above but in which the guanosine nucleotides, marked in bold, had been replaced by adenosine ... treated with RNase-free DNase I and used in RT/PCR At postincubation time h (12 h after the beginning of transfection, see Materials and methods) only a minimal amount of ribozyme RNA was present in ... Asp2, also called BACE protein or memapsin [9–13] This protein is involved in proteolytic cleavage of an amyloid precursor protein APP, and directly in uences the release of the toxic b-amyloid peptide...
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báo cáo hóa học: " Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia" potx
Ngày tải lên :
19/06/2014, 22:20
... prostaglandin (PG) E2 and PGD2 Findings We show that inhibition of Akt by the Akt inhibitor X enhanced the production of PGE2 and PGD2 without affecting the expression of COX-2, mPGES-1, mPGES-2 and cytosolic ... by pharmacological inhibition of these pathways in regard to the expression of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES-1) and to the production of prostaglandin ... phosphatidylinositol 3-kinase, mammalian target of rapamycin, glycogen synthase kinase-3, Akt, prostaglandins FINDINGS Inflammation has been recognized not only as a mere bystander in neurodegenerative...
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báo cáo hóa học: " Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways" pdf
Ngày tải lên :
20/06/2014, 00:20
... Alteration in expression of connexins may be involved in the expression of neoplastic phenotype [79] and changes in the phosphorylation pattern of connexins are also associated with GJIC inhibition by ... blocked GJIC through MAPK and PI3K pathways To study the involvement of protein kinase C (PKC) in the inhibition of GJIC by TPTC, an inhibitor of PKC, GF109203X (bisindolylmaleimide 1) was utilized ... mechanism involved in the apoptotic effects [48] The mitogen-activated protein kinase (MAPK) pathway has been shown to be involved in the inhibition of GJIC by TPA [49-54] Its role in the TPTC-induced...
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Báo cáo hóa học: " Inhibition of foot-and-mouth disease virus replication in vitro and in vivo by small interfering RNA" pot
Ngày tải lên :
20/06/2014, 01:20
... neck with 50–100 ug of plasmids dissolved in 100 ul of saline Mice of the control group were subcutaneously injected with saline After h, the suckling mice were challenged with and 20 LD50 of the ... saline-injected mice (n _ 10 mice per group) died within 69 h, with most mice dying within 48 h, after the viral challenge Only of mice pretreated with pSi-FMD2 and of 10 mice pretreated with ... died within 69 h, with most mice dying within 48 h, after the viral challenge Only of 9–10 mice pretreated with pSi-FMD2 and of 10 mice pretreated with pSiFMD3, survived a viral challenge of LD50...
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Báo cáo y học: "Assessment of the emotional responses produced by exposure to real food, virtual food and photographs of food in patients affected by eating disorders" ppsx
Ngày tải lên :
08/08/2014, 23:21
... designing the study, and drafting and editing the manuscript AP participated in acquisition, analysis and interpretation of data and was involved in drafting the manuscript GR participated in drafting ... was involved in drafting the manuscript, analyzing the data, and revising the text critically for intellectual content and was also involved in training the data collectors EG participated in ... and brain injury or trauma Consensus diagnoses, according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria, were obtained by two clinicians who independently...
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Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
Ngày tải lên :
09/08/2014, 07:20
... L, Li ZW, Greten FR, Kagnoff MF, Karin M: The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion ... Among them, IL-6 and IL-8 are mainly produced by endothelial cells and are critical players in the initiation phases of immunity and inflammation Besides its active role in inflammation, it has ... http://arthritis-research.com/content/8/1/R32 αvβ3 integrin-positive cells, including angiogenic endothelial cells, macrophages in spleen and liver, and macrophage subsets in the intestines [32] and also fibroblasts and macrophages...
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Báo cáo y học: "Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts" pdf
Ngày tải lên :
09/08/2014, 08:22
... cultured with µM lovastatin then induced with IL-1; 3L, TNF, cells cultured with µM lovastatin then induced with TNF-α (b-d) Bands were quantified by UN-SCAN-IT and corrected for loading by actin (b) ... from RA synovial fibroblasts grown in increasing concentrations of lovastatin contained increasing amounts of histone bound DNA fragments, suggesting the induction of apoptosis (Figure 6a) Histone-bound ... by statins has been attributed to a lowering of intracellular FPP and GGPP concentrations [25] This concept was examined in FLS by evaluating the ability of exogenously added FPP and GGPP in the...
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báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx
Ngày tải lên :
10/08/2014, 10:21
... concentration of fluvastatin achieved with high dose were ≤ μM [19] These findings indicate that μM and 2.5 μM of fluvastatin and simvastatin, respectively, are within the peak plasma values of fluvastatin ... fluvastatin and simvastatin decrease the activation of ERK1/2 Akt [4] These findings are in agreement with the results of the present study and indicate that statins induce apoptosis via suppression of ... mevastatin, fluvastatin, and simvastatin for 24, 48, and 72 h After incubation, the cells were stained with trypan blue, and the number of stained cells was counted Page of Measurement of caspase-3...
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báo cáo khoa học: "Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP" pptx
Ngày tải lên :
11/08/2014, 00:22
... CH and SA assisted in the design planning of all experiments PP participated in the design of XTT, CAM and Western experiments, assisted in data analysis and interpretation and in writing and ... Mondalek et al., Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP Journal of Nanobiotechnology ... [11,14-17], and acquisition of chemotherapeutic resistance in androgenindependent proliferation of prostate cancer cells [14], and may or may not produced following induction by the presence of VEGF...
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Báo cáo y học: " The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu" potx
Ngày tải lên :
12/08/2014, 23:22
... formation of cysteinelinked dimers is not mediated by any one specific cysteine residue in the ectodomain since mutation of each cysteine individually or in combination of two did not affect protein ... cells Blue lines represent BST-2 staining in the absence of Vpu and green lines indicate BST-2 staining in the presence of Vpu Numbers in the boxed legends represent mean fluorescence intensities ... contrast, mutation of all three cysteines in the BST-2 ectodomain abolished its ability to inhibit virus release (Fig 7, bottom panel) Inhibition of virus release by the cysteine mutants of BST-2 was...
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Báo cáo y học: "The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium: correlation with the release of acetylcholine" ppsx
Ngày tải lên :
13/08/2014, 16:21
... (Figure 2) These findings, confirming the previous findings of other investigators, are best explained by invoking a slow association of the nondepolarizing neuromuscular blocking drug with the presynaptic ... application of lidocaine (4%, ml) Anesthesia was maintained with propofol infusion (100–150 μg·kg1·min-1) and 66% N O in oxygen Ventilation was con2 trolled to maintain normocapnia The thumb of one hand ... However, in that report we were interested in the properties of the muscle relaxants in relation to their interaction with the presynaptic receptors (the affinities and the rates of interaction) In...
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The graphs below show the numbers of male and female workers in 1975 and 1995 in several employment sectors of the republic of Freedonia
Ngày tải lên :
04/10/2012, 10:02
... women worked in finance and banking institutions in 1975, the number increased to 450 000 by 1995 The number of men grew only marginally from 425 000 to 480 000 over the same period In defence, ... two decades later The number of men in this sector remained stable over the period, at around 700 000 Women also made gains in both the finance/banking industries and in the defence-related public ... 1975 and 1995 brought significant changes in the representation of women in Freedonia's work force, according to the graphs In 1975, for example, some 300 000 men and 250 000 women worked in the...
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Báo cáo y học: "Management of chest pain: exploring the views and experiences of chiropractors and medical practitioners in a focus group interview"
Ngày tải lên :
25/10/2012, 10:06
... perceptions and interprofessional relationships (5) Best practices and standardization of care Participants reported that standardizing care within professions may facilitate opportunities for interprofessional ... collaborative and interdisciplinary As noted, funding opportunities within chiropractic are limited, yet chiropractors are working in collaboration with medical physicians in a variety of settings Following ... contains only one citation for chest pain, not musculoskeletal [19] The Database of Abstracts of Reviews of Effects (DARE), maintained by the NHS Centres for Reviews and Dissemination and linked...
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Improvement of recruitment and selection process in HKT Consultant Jsc
Ngày tải lên :
24/07/2013, 15:36
... employees with functional departments including Research and Development, Sales, Administration and Human Resources, IT, and Finance and Accounting Now, HKT mainly does business in two fields including ... There are many meanings of human resources People often use the meaning of HR within corporations and businesses which refers to the individuals within the firm, and to the portion of the firm’s organization ... lack of knowledge and insufficient training, and accordingly provide methods in the form of workshops and seminars; developing positive interactions between workers, to ensure collated and constructive...
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MÔ HìNH HOá QUá TRìNH TRAO ĐổI NHIệT ẩM TRONG MáY ấP TRứNG GIA CầM Modeling of heat and mass transfer in chicken egg incubators
Ngày tải lên :
28/08/2013, 08:31
... Modeling Simultaneous Heat and Mass Transfer in Isotropic Sphere, Trans ASEA, pp 31 Husain A., Chen C.S., Clayton J T, Whitney L.F (1972), Mathematical Simulation of Mass and Heat Transfer in High ... Christopher D McDaniel (2004), A Practical Manual for Understanding the Shell Structure of Broiler Hatching Eggs and Measurement of their Quality, Mississipi State University, p 3-5 ... Mathematics of Diffusion, Oxford University Press, Bala, B K (1998), Solar drying systems: Simulations and optimization, Agrotech Publishing Academy, Udaipur, pp 131-133 Haghighi K., Segerlind L.J,...
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Integration of energy and environmental systems in wastewater treatment plants
Ngày tải lên :
05/09/2013, 15:28
... Engineering from North Carolina State University, Master of Engineering in Mechanical Engineering and Master of Business Administration from the University of Hartford, and her doctorate in Engineering ... Professor with the Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology Prior to joining Missouri S&T she was an Assistant Professor in ... Departments of Management and Marketing, Missouri Southern State University and Coordinator of the transportation-logistics program She holds a PhD and an M.S in engineering management, B.S in physics and...
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