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OReilly hadoop the definitive guide 4th edition 2015 3
Ngày tải lên :
13/09/2016, 11:24
... numerous articles for oreilly.com, java.net, and IBM’s developerWorks, and speaks regularly about Hadoop at industry conferences US $49.99 Twitter: @oreillymedia facebook.com/oreilly White PROGR AMMING ... analyze the whole dataset in a batch fashion, particularly for ad hoc analysis An RDBMS is good for point queries or updates, where the dataset has been indexed to deliver low-latency retrieval ... http://www.oreilly.com Find us on Facebook: http://facebook.com/oreilly Follow us on Twitter: http://twitter.com/oreillymedia Watch us on YouTube: http://www.youtube.com/oreillymedia Acknowledgments...
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Tài liệu Tips for turning everyday activities into learning activities pptx
Ngày tải lên :
24/02/2014, 18:20
... Family Network 1001 Eastern Ave., Second Floor Baltimore, MD 21202 Phone: 410-659-7701 Email: info@marylandfamilynetwork.org Website: www.marylandfamilynetwork.org Copyright 2010 Maryland Family ... services are available for military families, families of children with special needs, and Spanishspeaking families LOCATE: Child Care is a free service provided by Maryland Family Network and ... Milestones: Is my child developing normally? Parents may wonder if their child is developing at a normal, healthy pace Maybe he seems late starting to talk or early starting to crawl What’s normal...
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DNA, RNA and proteins
Ngày tải lên :
13/03/2014, 16:38
... Synthesis DNA and Protein Synthesis • Codon: three bases code for a specific protein: ex: AAA = Lysine • The codons code for 20 amino acids • Just like the alphabet has 26 letters to make all ... Add just one letter (E): THE DOE GBI TTH ECA T Cells have “proof reading” proteins that constantly check the DNA and fix errors, so most are corrected Protein Synthesis- you try it! DNA transcription...
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Turning Many Projects into Few Priorities with TOC pot
Ngày tải lên :
16/03/2014, 01:20
... project [See Exhibit 2] could systematically both provide clear priorities and In the real world, we expect time variation in the minimize the queue, then the devastating impact of execution of tasks—Murphy’s ... and, more importantly, on repealed (Patrick) Buffers are used to absorb that organizational performance would be minimized variation without distraction to the resource Applying the management ... projects individually without proactively dealing with the interactions between them is not sufficient to assure the attainment of the goals of the organization The system that really needs to be...
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Báo cáo khoa học: Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins docx
Ngày tải lên :
16/03/2014, 22:20
... protein production levels, because a highly specific staining method is available [14] Finally, DOPA is produced naturally in humans by tyrosinase-catalysed oxidation of tyrosine in melanocytes ... (Ala, Cys, Ile, Leu, Met, Phe, Pro, Trp, Val), yellow; positively (Arg, His, Lys) and negatively (Asp, Glu) charged residues, blue and red, respectively; hydrophilic residues (Asn, Gln, Ser, ... staining by Coomassie Brilliant Blue, and only newly synthesized proteins were detected, including some minor species presumed to have been produced by proteolysis and ⁄ or premature termination of...
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báo cáo khoa học: "Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening" doc
Ngày tải lên :
10/08/2014, 10:21
... de-identified and processed within 24 hours to isolate lymphocytes Lymphocytes were separated by density gradient centrifugation using Lymphoprep Briefly, blood samples were diluted 2-fold with PBS, ... MMR proteins, lymphocytes were stimulated with a mitogen, PHA Cell lysates were then prepared For optimized expression of MLH1 and MSH2 proteins, fresh blood lymphocytes were routinely stimulated ... detectable in fresh lymphocytes (Figure 2A) MLH1 and MSH2 levels increased equally after stimulation by PHA (Figure 2B) MLH1 and MSH2 were readily detectable in immortalized lymphocytes and PHA treatment...
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Báo cáo y học: "Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins" doc
Ngày tải lên :
14/08/2014, 16:21
... closely related to a novel family of fungal proteins than the Nnf1 family The human kinetochore protein CENP-H is more closely related to a novel family of fungal proteins than the Nnf1 family ... RY GTDRT GYFTN STRF LLHKQ WT LYSLT P L YKF SYSN- - L KEY SR L L NA FIVAE KQ K G LAVE V LLHKQ WT IYSLT P L YKF SYSN- - L KDY SR L L SA FIVAE KQ K G VAVE V LLSKQ WT LYSVT P MH KF SYTN- - L KEY ... amongst fungi, metazoa and plantae EIKSGVAKLESLL LLENSVDKNFD FDKLELYVLRN RNVLRIPEE EIKSGVAKLESLL LLENSVDKNFD FDKLELYVLRN RNILSIPSD EIEIGMGKLESLL LLESTIDKNFD FELYVLRN FDKFE RNIFRIPKE EIEIGTAKMETLL...
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Turning Data into Information
Ngày tải lên :
03/10/2013, 00:20
... especially useful with the Count function; it counts only the number of rows that have a non-NULL value for the passed column name If all the column values are NULL, or if there are no rows to apply ... to rows, and the removal of rows, respectively Any attempt to carry out a prohibited action throws an exception These limitations apply only to the view, not to the underlying table If you set ... aggregation For example, if you take the average of a table column with 10 rows, but of those rows contain NULL values in the column being averaged, the function will average only the non-NULL values This...
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
Ngày tải lên :
19/02/2014, 05:20
... cisplatin Nucleic Acids Res 32, 5546–5552 33 Fojta M, Pivonkova H, Brazdova M, Kovarova L, Palecek E, Pospisilova S, Vojtesek B, Kasparkova J & Brabec V (2003) Recognition of DNA modified by antitumor ... damage of ovarian cells Oncol Res 10, 151–161 36 Wetzel CC & Berberich SJ (2001) p53 binds to cisplatin-damaged DNA Biochim Biophys Acta 1517, 392– 397 37 Stehlikova K, Kasparkova J, Novakova O, Martinez ... protein kinase C is abolished by protein kinase CK2 Biochem J 378, 939–947 15 Selivanova G, Iotsova V, Kiseleva E, Strom M, Bakalkin G, Grafstrom RC & Wiman KG (1996) The single-stranded DNA...
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Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx
Ngày tải lên :
20/02/2014, 01:20
... meta-analysis suggested that glutamine supplementation in critically ill patients may be associated with a decrease in complications and mortality rate, particularly when delivered parenterally at ... Uptake of apically and basolaterally administered glutamine was significantly different at every time point, for each concentration used Basolateral exposure of the monolayers to glutamine-containing ... decrease, for, respectively, 0.1, 2.0 and 8.0 mm basolateral glutamine, and only a 1.3 ± 0.2, 1.1 ± 0.2 and 1.3 ± 0.2-fold decrease for apical glutamine Time course of glutamine uptake in Caco-2...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
Ngày tải lên :
21/02/2014, 15:20
... similar to those of disordered poly(Lglutamic acid) at high pH and poly(L-lysine) at low pH [18,19] Accordingly, the ROA spectra of disordered poly(Llysine) and poly(L-glutamic acid) are reproduced ... ROA spectra of disordered poly(L-glutamic acid) (top pair) and poly(L-lysine) (middle pair) in aqueous solution at pH 3.0 and 12.6, respectively, and of native human lysozyme at pH 5.4 (bottom ... proteins to remain natively unfolded [1] may be especially pertinent here One possible example of the signi®cance of charge is the observation that removal of the highly charged anionic C-terminal...
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Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc
Ngày tải lên :
07/03/2014, 00:20
... Cox10p (equivalent to human Cox5b, Cox4-1 and Cox6a, respectively) [19] In order to characterize the assembly of nDNAencoded complex IV subunits into the various super6704 Fig BN-PAGE analysis of ... evolutionarily conserved In vitro import of Cox10p has previously been used to analyze complex IV assembly in yeast, but digitonin-solubilized mitochondria were employed and hence only supercomplexes ... subunits was found predominantly in stalled assembly intermediates Therefore, it is possible that newly imported subunits are channeled more efficiently into assembly intermediates in patient mitochondria...
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Báo cáo khoa học: Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins pptx
Ngày tải lên :
08/03/2014, 08:20
... Methylation interference analysis The 3¢ end-labelled D-TERM DNA probe prepared as described above was partially methylated using dimethylsulphate essentially as described by Maxam and Gilbert [28] ... of the AATAAA sequence, respectively, competed slightly differently (Fig 2A, lanes 8–11) from Mut1 with both complexes These results show that the putative polyadenylation signal AATAAA, and also ... the polyadenylation signal sequence (A at 16 282) the remaining two residues lie in the flanking sequences Additionally, two A residues (nucleotides 16 294 and 16 295, respectively), immediately...
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Báo cáo khoa học: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals pdf
Ngày tải lên :
15/03/2014, 11:20
... segment, we observed greatly increased cytoplasmic localization of the fluorescent reporter construct (Fig 4E) This observation indicates that removal of only one positively charged residue in addition ... and its various sequence derivatives Fluorescence microscopy observations show the subcellular distribution of chimeric UDE constructs (A) Wild-type UDE (UDEWT–YFP) was targeted exclusively to ... respectively The relevant motifs, regions and positions of the NLS of dUTPase are indicated by differently shaded boxes (C) The NLS sequence (PAAKKMKID) and its truncated sequence variants (KKMKID...
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Báo cáo khoa học: 3¢- to 5¢ DNA unwinding by TIP49b proteins docx
Ngày tải lên :
15/03/2014, 11:20
... mostly hexamers (Fig 1B, left), whereas fraction mostly contained TIP49b monomers (Fig 1B, right) 2706 440 158 67 43 2000 A kDa 20 Hexamer 15 Monomer mAU 10 0 20 40 mL 60 80 100 B TIP49b: Hexamer ... elucidated, particularly in view of such diverse functions Although ATP hydrolysis is most likely essential for the functions of these proteins [7,8], most biochemical analyses of TIP49 proteins ... Stimulation of ATP hydrolysis by TIP49b was found to be strongly dependent on oligonucleotide length, with a plateau of approximately 75% and 45% for ssM13 and ss115, respectively, indicating a correlation...
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The future of internal audit is now Increasing relevance by turning risk into results pot
Ngày tải lên :
15/03/2014, 23:20
... | July 2012 Evaluate • Assess KPIs against mandate value scorecard • Re-evaluate strategy and audit plan • Employ continuous improvement 1) Leverage the organizational strategy To create value ... efficiently, effectively and timely.” — Auditor survey respondent Employing innovation throughout the audit cycle Q: In our survey, 80% of respondents indicate that they use data analytics for ... a value charter and scorecard to define value The value charter should include a vision statement and commit internal audit to: Developing a value charter enables internal audit to effectively...
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Báo cáo khoa học: DNA mediated disassembly of hRad51 and hRad52 proteins and recruitment of hRad51 to ssDNA by hRad52 pot
Ngày tải lên :
16/03/2014, 14:20
... centrifugation assays (Fig 1B) hRad51 migrated as a highly aggregated form (several hundred kDa complexes) that barely entered into the gel Only a faint signal was detectable at the monomer position ... Monomodal distribution of Rh values (in nm) vs intensity is plotted as histograms where groupings a–d depicts 10–80 nm range distribution (D) Partial proteolysis experiment to analyse DNA induced conformational ... the absence of ssDNA, hRad52 protein appeared to be so highly aggregated that it hardly entered into the gel (lane 5, Fig 2A) and was mostly in the pellet fraction following a centrifugation assay...
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