do we have better alternatives for the treatment of cardiogenic shock
Báo cáo y học: "Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients" pps
... more strongly with NF-κB signaling Therefore, the proteasome is likely a better target for anti-NF-κB intervention than the IKK cascade for treatment of septic shock Clinically, our findings may ... to the cytoplasmic domain of the receptor [10] Subsequently, TRAF6 interacts with UBC13/UEV1A, a heterodimer that catalyzes the synthesis of polyubiquitin chains assembled through linkage of the ... potentiate the symptoms of endotoxic shock Since K48- and K63-linked chains assemble early in the NF-κB pathway, one could speculate that transgenic animals expressing mutant isoforms of ubiquitin...
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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
... in the study who had large body mass index values were given double the dose of Apatone by doubling the number of capsules in the previous regimen Results Of thirty-three patients approached for ... alone, or a placebo.14 The 7day courses of treatment occurred during the first and fourth week of the study with two weeks of follow up after each treatment period For the vitamin combination, ... 0.008 suggesting the 76 % response we observed, was unlikely due to chance The “non-responders” each 64 volunteered to have their dose of Apatone doubled following the trial There were no adverse...
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Báo cáo khoa học: "Pulse oximeter as a sensor of fluid responsiveness: do we have our finger on the best solution" pot
... catheter The strength of the study is that it takes into account the variation in the ‘pulse’ wave rather than that in the peak of the wave By reflecting the pulsatile changes in absorption of ... changes in absorption of infrared light between the light source and the photo detector of the pulse oximeter, the ‘pulse’ wave is assumed to be the result of the beat-to-beat changes in stroke volume ... good correlation between respiratory variation in the amplitude of the ‘pulse’ wave (peak–nadir) calculated from variations in the POP waveform (called ∆POP by the authors) and the respiratory variation...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... received permanent relief Of the 114 lumbar facet patients, 26 underwent radiofrequency lesioning of the dorsal rami nerves prior to considering the endoscopic surgery option Of these 26 patients, 14 ... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar...
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Báo cáo y học: "Endoscopic thoracic laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 case"
... central or foraminal stenosis treated with endoscopic laminoforaminoplasty via a small incision, of less than one inch Materials and Methods Twelve patients were treated with endoscopic laminoforaminoplasty ... less invasive, such as endoscopic laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia ... [6] In the current study, no adverse events occurred and all patients were discharged the day of surgery Additionally, there was no need for thoracotomy, unlike other surgical approaches At the...
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Behavior of Nitrite Oxidizers in the Nitrification/Denitrification Process for the Treatment of Simulated Coke-Oven Wastewater
... extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the preliminary step to nawwor down the species of NOB, the primer ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... each of the samples were divided into two One of them was for DNA extraction and was washed with TE buffer at pH8.0, and stored at -20oC Another was for FISH analysis and was stored at -80oC The...
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Contact-Adsorption-Regeneration-Stabilization Process for the Treatment of Municipal Wastewater
... respectively The adsorption tank had an inflow of 10 L/h Domestic wastewater was collected with a central sewerage network for the preparation of the influent wastewater The composition of the influent ... al., 2004), the present study showed that the Freundlich isotherm equation (Fig 7) also matched the experimental results well The obtained values of the constant characteristics for the two models ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated The removal efficiency...
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Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... exercising their clinical judgement The guidance does not, however, override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual ... per maintenance dose, equating to a cost of £955.50 for the loading dose and £682.50 for each maintenance dose Patients in the key registration trial received an average of 16.8 doses, equating...
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Hydroxyurea for the Treatment of Sickle Cell Disease docx
... reliability of the instruments used A pair of reviewers each performed the quality assessment independently In the case of the RCTs, a third reviewer reconciled the results of the first two reviewers; for ... for the other study designs, the results of the two reviewers were averaged The overall score was the percentage of the maximum possible score, ranging from to 100 percent The results for RCTs were ... as well as questions to assess the potential for confounding, which could bias the estimates of the treatment effect 30-32 For our assessment of the quality of the qualitative studies we reviewed,...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the metals ... Fe, Zn is redox-silent, and therefore does not contribute directly to redox reactions Its role within the brain, however, is essential nonetheless It is required for the activity of enzymes such ... studies have shown that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore...
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Báo cáo khoa học: A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer ppt
... altering the rate of internalization of the receptor or influencing the intracellular trafficking The proteome of the target cell also influences the pathway We have observed large differences in the ... treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of cancer, and striking responses have been observed ... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues...
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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc
... is the evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The ... exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy for SUI ... effective for the treatment of SUI The other studies in the review were considered for the generalisability of their findings to clinical practice by identifying the patient populations from which the...
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Best Practice Policy Statement on Cryosurgery for the Treatment of Localized Prostate Cancer pptx
... Cryosurgery for the Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized ... potential of thermal injury to this muscle The thermosensor is introduced through the perineal skin and advanced until the impression of the tip of the thermocouple can be seen in the sphincter The placement ... Activation of the heating mode in the CN/P does not affect the thaw rate of the distal edges of the gland Probe heating affects only the frozen tissue mass juxtaposed to the CN/P and not the distally...
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SYNTHESIZE AND INVESTIGATE THE CATALYTIC ACTIVITY OF THREE-WAY CATALYSTS BASED ON MIXED METAL OXIDES FOR THE TREATMENT OF EXHAUST GASES FROM INTERNAL COMBUSTION ENGINE
... choice and loading of the NM is a compromise between the required efficiency of the converter and the market price of the NM However, the application of noble metals for the treatment of exhaust gas ... are formed in adsorption of reactant molecules on the semi-conducting surface; the formation of these is a function of the electronic properties of the solid, and the structure and kind of bonds ... mechanism of exhaust treatment The aims of this thesis will be then proposed The second chapter introduces basic principles of the physico-chemical methods used in the thesis, catalyst synthesis,...
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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf
... intraperitoneal delivery of the drug Despite being a well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account for the vast majority of tumorassociated ... cellular viability throughout the assay, an aliquot of untreated VLCs were maintained in culture for the duration of the experiment These untreated VLCs were stained for Annexin-V/PI in parallel ... subcutaneously into the flanks of C57BL6 mice and the tumors were allowed to grow for two weeks The animals were then treated twice weekly with μg of anti-CD52-saporin immunotoxin, or rat-IgG-saporin...
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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx
... glioma model we have found that one dose of the Gd-G5-doxorubicin dendrimer is significantly more effective than one dose of free doxorubicin at inhibiting the growth of RG-2 gliomas for approximately ... include the administration of drugs intra-arterially to maximize first-pass drug delivery across the BBTB [44-46], and the temporary opening of the junctions between endothelial cells of the BBTB ... [84-86], we have found that in the physiologic state in vivo there is a fairly well-defined upper limit of pore size, which is approximately 12 nm, independent of whether the location of the malignant...
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Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis" doc
... to reduce the observed variation between the two groups of subjects caused not by the treatment itself but by variation of the clinical scale at the beginning of the therapy To test the overall ... trials However, no one did, and in fact the task was well tolerated Furthermore, there was no degradation of performance at the end of the adaptation phase as compared to the final portion of the ... overall effect of adaptive training, we compared the primary outcome measures (change in the clinical scores) between the baseline (T0) and the end of the treatment (T3), irrespective of the training...
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báo cáo hóa học:" Is tension band wiring technique the "gold standard" for the treatment of olecranon fractures? A long term functional outcome study" docx
... Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2008, 3:9 Statistics The microsoft excel program was used for the creation of the graphs and the SPSS ... nearly half of men with olecranon fractures were between 21 to 40 years of age and 40% of women between 61 and 80 years old Regarding the side of injury, 56.4% of fractures in our series were located ... minimal loss of physical capacity The technique remains the "gold standard" for the treatment of displaced and minimally comminuted olecranon fractures despite the introduction of new Page of (page...
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báo cáo hóa học:" Long-term follow-up on the use of vascularized fibular graft for the treatment of congenital pseudarthrosis of the tibia" pdf
... one was for the initial trial of VFG, and the other was for the second trial of VFG after failure of bone consolidation in ipsilateral VFG Patients The mean age of the patients at the time of VFG ... performed before VFG in patients in other institutions prior to attending our hospital We have reported these patients in a study of short-term follow-up [3] For these patients, the number of ... to 8, the average number being 3.4 The previous surgical treatments were all utilizing intramedullary nails with/without bone grafting The other patients were added for the purpose of the current...
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báo cáo hóa học:" Two levels above and one level below pedicle screw fixation for the treatment of unstable thoracolumbar fracture with partial or intact neurology" pot
... protocol in our clinic for the treatment of osteoporosis The patients were followed with serial physical examinations and radiographs With the use of lateral radiographs centered over the fracture level, ... fixation (SSPF) is the most common and simple treatment, offering the advantage of incorporating fewer motion segments in the fusion [14-17] A review of the literature showed that SSPF alone ... Biomechanical and clinical studies, however, have shown that when there is loss of more than 50% of the vertebral body height or angulations of the thoracolumbar junction of more than 20° [8], acute spinal...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25