do germline atm mutations play a role in familial and sporadic breast cancers

báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps

Ngày tải lên : 11/08/2014, 11:21

... by asterisk) and showed absolutely no staining (Figure 3J and 3K) These mitochondria appeared to have dramatically degraded cristae and nearly indistinguishable membranes via TEM imaging and also ... gradient within a window stage lace plant leaf The three-part differentiation of an areole within a stage 2, or window stage leaf A) A detached stage 2, or “window” stage leaf Note the green and ... stages (M1M4) based on their location in a window stage leaf areole Our findings also indicate that within a single areole of a stage (window stage) leaf a gradient of TUNEL-positive nuclei staining...

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Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt

Ngày tải lên : 23/03/2014, 21:20

... REGULATED PHOSPHORYLATION In higher animals – mammals and insects (at least in Drosophila) – eIF4E is a phosphoprotein It is phosphorylated by the MAP-kinase signal-integrating kinases Mnk1 and ... 5357 an anabolic stimulus, may largely induce increased translation across the board of mRNAs that are already actively being translated How could increased phosphorylation of eIF4E actually inhibit ... phosphorylation in mRNA translation, bearing in mind that the main mechanism governing the actual availability of eIF4E for translation is not its phosphorylation (which probably does not affect its binding...

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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt

Ngày tải lên : 12/08/2014, 04:20

... colocalized predominantly with marker proteins for TGN (TGN46, γ-adaptin and δ-adaptin), and partially with marker proteins for Golgi complex proteins (Golgi58K and GM130) and early endosomes (EEA1) ... AP-1 [41]; δ-adaptin, a marker for AP-3 [42] Both AP-1 and AP-3 localizes to TGN and endosomes, with AP-3 localizes more to endosomes [43] UL56 colocalized with both γadaptin and δ-adaptin, albeit ... analysis and review of the manuscript YN performed project planning, participated in the data analysis and helped to draft the manuscript All authors read and approved the final manuscript Weissman AM:...

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báo cáo khoa học: " Co-expression and promoter content analyses assign a role in biotic and abiotic stress responses to plant natriuretic peptides" pptx

Ngày tải lên : 12/08/2014, 05:20

... physiological role of AtPNP -A in A thaliana a T-DNA insertion mutant, that is available from SALK, could be used Phenotyping this mutant in response to SA-inducing abiotic and biotic stresses as well as ... Kamiya A, Nakajima M, Enju A, Sakurai T, Satou M, Akiyama K, YamaguchiShinozaki K, Carninci P, Kawai J, Hayashizaki Y, Shinozaki K: Monitoring the expression pattern of around 7,000 Arabidopsis genes ... evidence documenting induction of AtPNP -A expression in SA-mediated natural developmental and stress activated processes which both culminate in cell death indicating that AtPNP -A may be involved in...

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báo cáo hóa học:" Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review" pot

Ngày tải lên : 20/06/2014, 04:20

... contributed in acquisition of data, revising the manuscript critically and given the final approval, JYH has contributed in acquisition of data and analysis and interpretation of data; and KPV and NM have ... differential pressure loading on the growth plate [31] Eular’s Law of viscoelastic buckling of a spine in the coronal and transverse planes Page of leading to a lateral bend and axial rotation/torsional ... of data, drafting the manuscript and revising it critically, SWS has contributed in conception and design of data, drafting the manuscript and given the final approval of manuscript, JHY has contributed...

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Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf

Ngày tải lên : 09/08/2014, 06:22

... states beyond atherogenesis Sparrow and colleagues demonstrated that simvastatin had a comparable antiinflammatory effect to that of indomethacin in the carrageenan-induced foot pad oedema inflammatory ... reductions in inflammatory cell infiltrate and eosinophilia in bronchoalveolar lavage fluid were observed with both oral and intraperitoneal administration of simvastatin [36] Continuing studies are addressing ... 26 Mason JC, Ahmed Z, Mankoff R, Lidington EA, Ahmad S, Bhatia V, Kinderlerer A, Randi AM, Haskard DO: Statin-induced expression of decay-accelerating factor protects vascular endothelium against...

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Báo cáo khoa học: "Do statins have a role in preventing or treating sepsis" pptx

Ngày tải lên : 12/08/2014, 23:21

... statins may also ameliorate sepsis-induced coagulopathy [5,8,9] Another novel pathway may play an important role in attenuating sepsis-induced endothelial dysfunction Heme oxygenase (HO)-1 is an ... comorbidities and dissipated when the medication was discontinued There is growing interest among clinicians in the role that statins may play in preventing and treating serious infections If such an effect ... smooth muscle and endothelial cells both in vitro and in vivo, suggesting that the anti-inflammatory, antiproliferative, and antioxidant effects of simvastatin occur largely through induction of...

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Báo cáo y học: "Migration events play significant role in genetic differentiation: A microsatellite-based study on Sikkim settlers" ppt

Ngày tải lên : 14/08/2014, 14:21

... population and exhibit a high level of diversity In India, mongoloids contribute approximately 3% of the total population, mainly inhabiting the hills and adjoining plains of Northeast and Central ... that migratory events have played a significant role in the differentiation of mongoloids of India Background The origin, dispersal and antiquity of Homo sapiens in the Asian peninsula have attained ... origin and period of migration to Sikkim: (i) A small population of Naga stock from the Garo hills of Assam migrated to Sikkim about 2000 years ago, and (ii) a group from east Asia mainland migrated...

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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

Ngày tải lên : 18/02/2014, 04:20

... with a full-length furin cDNA, were permeabilized and stained with polyclonal antibodies against furin and GRASP55 Arrows show examples of membrane compartment containing GRASP55 and furin Scale ... were annealed and inserted upstream of EYFP in pEYFP-N1 (Clontech-Takara Bio Europe, Saint-Germain-en-Laye, France) DNA coding for MT1-MMP hinge, hemopexin, stalk, transmembrane and cytoplasmic domains ... containing insulin, transferrin and selenium supplements (Sigma-Aldrich) and the cells were incubated at 37 °C for a further 24 h Cell supernatants were harvested and analyzed by gelatin zymography,...

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Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx

Ngày tải lên : 20/02/2014, 01:20

... Glutamine incorporation in Caco-2 proteins determining the relative uptake of glutamine; (b) by searching for changes in the intestinal proteome; and (c) by examining glutamine incorporation into ... bloodstream via their basolateral membranes [14] The endogenous glutamine arises from conversion of glutamate and ammonia by glutamine synthetase [15] However, in human and rat, intestinal glutamine ... cytoplasmic proteins that can bind to the membrane surface in response to elevations in intracellular calcium [45] Annexin A2 is an F-actin binding protein and participates in the formation of...

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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx

Ngày tải lên : 05/03/2014, 17:20

... determine that a putative signal peptide and a cleavage site exist in ePAD and AAH53724 (an egg and embryo abundant peptidylarginine deiminase), indicating they are likely secreted proteins (Fig arrow) ... their assistance in obtaining Figures and 9, and Norton Kitagawa for his invaluable advice in tandem mass spectrometric protein identification Finally, we would like to thank Dr Bradley Hyman and ... cortical granules contain PAD To ascertain if mouse cortical granules contain PAD, antibodies made against mouse ePAD and human recombinant PAD V (anti-PAD V (N)) were used to label in vivo matured...

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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx

Ngày tải lên : 23/03/2014, 17:21

... rat by another group in collaboration with Hamlyn [21] by means of two independent assays, a radioimmunoassay using an anti-ouabain Ig and an enzymatic assay using ouabain-sensitive Na+/K+ATPase ... larger changes in intracellular Na+ and Ca2+ may thus be the result of a ouabain interaction with subpopulations of Na+/K+ATPase [27] An overall increase in intracellular Na+ was seen in the experiments ... glands and tissues of man at all [22] Endogenous ouabain was a theme at the 10th International Conference on Na,K-ATPase and Related Cation Pumps in Elsinore, Denmark, in August 2002 The meeting...

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Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx

Ngày tải lên : 18/06/2014, 16:20

... treatment significantly attenuated some alterations (i.e increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, ... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases ... The role of cytokines in hepatocellular carcinoma J Leukoc Biol 2006, 80(6):1197-213 51 Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato...

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báo cáo sinh học:" The role of nurses and midwives in polio eradication and measles control activities: a survey in Sudan and Zambia" pdf

Ngày tải lên : 18/06/2014, 17:20

... proposal, discussions, data analysis and review of the article SH, ETAES and HM were involved in data collection, discussion and review of article All authors have read and approved the final manuscript ... advocacy, social mobilization, training, implementation, supervision, monitoring and evaluation) and the same proportion was involved in AFP surveillance On the other hand, in Zambia, nurses and ... and 18.1% in Sudan and Zambia, respectively, as an important factor for improving work performance Best practices in SIAs for polio and measles Nurses and midwives reported that they played a...

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báo cáo hóa học:" Triple-Nucleoside Analog Antiretroviral Therapy: Is There Still a Role in Clinical Practice? A Review" docx

Ngày tải lên : 20/06/2014, 08:20

... Montaner J, et al.: Abacavir-lamivudinezidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial JAMA 2001, 285:1155-1163 Abstract ... 27 Ruane P, Mendonca J, Timerman A, et al.: Kaletra vs nelfinavir in antiretroviral-naive subjects: Week 60 comparison in a phase III, blinded, randomized clinical trial Program and abstracts ... interaction Nonthymidine-Containing ("TAM-Sparing") t-NRTI Regimens as Initial ART Clinical trials that have investigated the use of TDF as part of the NRTI backbone of an ART regimen among treatment-naive...

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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx

Ngày tải lên : 28/06/2014, 11:20

... Silveira, Antonio Marcos E Bezerra, Luzia Kalyne A M Leal and Glauce Socorro B Viana Chapter 18 General Introduction on Family Asteracea 375 Maha Aboul Ela, Abdalla El-Lakany and Mohamad Ali Hijazi ... characteristics, analytical challenges in their isolation and characterization, and the undertaking of basic and clinical researches to evaluate their biological activities both in animal and human health ... rutin, naringin , hesperidin and chlorogenic (Fig 4) 2.5 Saponins The term saponin is derived from Saponaria vaccaria (Quillaja saponaria), a plant, which abounds in saponins and was once used as...

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Báo cáo khoa học: "Pim-1 A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis" potx

Ngày tải lên : 07/08/2014, 15:20

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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf

Ngày tải lên : 10/08/2014, 05:21

... Komura M, Komura H, Kanamori Y, Tanaka Y, Suzuki K, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T: An animal model study for tissue-engineered trachea fabricated ... cells that have been used or have a potential to be applied in lung regeneration; and analyze current strategies in tracheal bioengineering and transplantation Endogenous and exogenous stem and progenitor ... engineers should pay special attention to the fabrication of biologically active scaffolds and matrices capable of fulfilling natural properties of the airway ECM, for example, by maintaining and...

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báo cáo khoa học: " A role for neurotransmission and neurodevelopment in attention‑deficit/hyperactivity disorder" ppsx

Ngày tải lên : 11/08/2014, 12:20

... BAIAP2 acting specifically in cases of persistent ADHD BAIAP2 is located at 17q25 and encodes the 53 kDa insulin receptor tyrosine kinase substrate protein (IRSp53), a molecule that participates ... protein (BAIAP2), dapper antagonist of β-catenin homo log 1 (DAPPER1), LIM domain only (LMO4), neurogenic differentiation (NEUROD6), ATPase, Ca++ transporting plasma membrane (ATP2B3) and inhibitor ... inhibitor of DNA binding 2 (ID2) An initial case-control study was con uct d d e in a sample of 587 participants with ADHD (children and adults) and 587 matched control individuals from Spain The results...

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Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf

Ngày tải lên : 12/08/2014, 19:22

... multiple organ failure and death) Watanabe and coworkers [53] prevented endotoxin shock in rabbits by administering a specific monoclonal antibody against CD18 (integrin β2) In a mouse lethal septic ... shock In an experimental study in dogs, an ablated reactive hyperaemia was associated with endotoxaemia-induced impaired oxygen extraction at the level of the gastrointestinal tract [71] Nevière and ... level of the abdominal aorta as early as after several hours following injury and persisted for at least days afterward [6,17] After 21 days we observed that the endothelial surface had recovered...

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