do atm mutations play a role in common cancers

báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps

Ngày tải lên : 11/08/2014, 11:21

... gradient within a window stage lace plant leaf The three-part differentiation of an areole within a stage 2, or window stage leaf A) A detached stage 2, or “window” stage leaf Note the green and ... stages (M1M4) based on their location in a window stage leaf areole Our findings also indicate that within a single areole of a stage (window stage) leaf a gradient of TUNEL-positive nuclei staining ... significant decrease in perforation formation within the lace plant via CsA application indirectly indicates that the PTP pathway may play a role in cellular death within this system Although the involvement...

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Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt

Ngày tải lên : 23/03/2014, 21:20

... 5357 an anabolic stimulus, may largely induce increased translation across the board of mRNAs that are already actively being translated How could increased phosphorylation of eIF4E actually inhibit ... phosphorylation in mRNA translation, bearing in mind that the main mechanism governing the actual availability of eIF4E for translation is not its phosphorylation (which probably does not affect its binding ... REGULATED PHOSPHORYLATION In higher animals – mammals and insects (at least in Drosophila) – eIF4E is a phosphoprotein It is phosphorylated by the MAP-kinase signal-integrating kinases Mnk1 and...

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báo cáo hóa học:" Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review" pot

Ngày tải lên : 20/06/2014, 04:20

... contributed in acquisition of data, revising the manuscript critically and given the final approval, JYH has contributed in acquisition of data and analysis and interpretation of data; and KPV and NM have ... differential pressure loading on the growth plate [31] Eular’s Law of viscoelastic buckling of a spine in the coronal and transverse planes Page of leading to a lateral bend and axial rotation/torsional ... balance the spine by their inherent “balancing or tuning mechanism” for a short period of time till it stabilizes into a single pattern This spinal balancing mechanism might result in a wavy pattern...

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Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf

Ngày tải lên : 09/08/2014, 06:22

... states beyond atherogenesis Sparrow and colleagues demonstrated that simvastatin had a comparable antiinflammatory effect to that of indomethacin in the carrageenan-induced foot pad oedema inflammatory ... 26 Mason JC, Ahmed Z, Mankoff R, Lidington EA, Ahmad S, Bhatia V, Kinderlerer A, Randi AM, Haskard DO: Statin-induced expression of decay-accelerating factor protects vascular endothelium against ... reductions in inflammatory cell infiltrate and eosinophilia in bronchoalveolar lavage fluid were observed with both oral and intraperitoneal administration of simvastatin [36] Continuing studies are addressing...

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Báo cáo khoa học: "Do statins have a role in preventing or treating sepsis" pptx

Ngày tải lên : 12/08/2014, 23:21

... statins may also ameliorate sepsis-induced coagulopathy [5,8,9] Another novel pathway may play an important role in attenuating sepsis-induced endothelial dysfunction Heme oxygenase (HO)-1 is an ... comorbidities and dissipated when the medication was discontinued There is growing interest among clinicians in the role that statins may play in preventing and treating serious infections If such an effect ... using various models indicate that statins profoundly affect NO availability [5,12-14] Specifically, in a rat pretreatment model simvastatin decreased NO overproduction and reverted the impaired...

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Báo cáo y học: "Migration events play significant role in genetic differentiation: A microsatellite-based study on Sikkim settlers" ppt

Ngày tải lên : 14/08/2014, 14:21

... that migratory events have played a significant role in the differentiation of mongoloids of India Background The origin, dispersal and antiquity of Homo sapiens in the Asian peninsula have attained ... population and exhibit a high level of diversity In India, mongoloids contribute approximately 3% of the total population, mainly inhabiting the hills and adjoining plains of Northeast and Central ... of ancient mongoloid migrations Genetics 1992, 130: 139-152 Saha N, Bhattacaryya SP, Mukhopadhyay B, Bhattacharyya SK, Gupta R, Basu A: A genetic study among the Lepchas of the Darjeeling area...

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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

Ngày tải lên : 18/02/2014, 04:20

... with a full-length furin cDNA, were permeabilized and stained with polyclonal antibodies against furin and GRASP55 Arrows show examples of membrane compartment containing GRASP55 and furin Scale ... colleagues [35] GRASP55F in pCDNA3.1 Zeo+ contained a C-terminal FLAG tag Full-length GRASP55, GRASP55 PDZ1 (amino acids 1–107), GRASP55 PDZ2 (amino acids 84–172) and GRASP55 region (amino acids ... were annealed and inserted upstream of EYFP in pEYFP-N1 (Clontech-Takara Bio Europe, Saint-Germain-en-Laye, France) DNA coding for MT1-MMP hinge, hemopexin, stalk, transmembrane and cytoplasmic domains...

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Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx

Ngày tải lên : 20/02/2014, 01:20

... Glutamine incorporation in Caco-2 proteins determining the relative uptake of glutamine; (b) by searching for changes in the intestinal proteome; and (c) by examining glutamine incorporation into ... cytoplasmic proteins that can bind to the membrane surface in response to elevations in intracellular calcium [45] Annexin A2 is an F-actin binding protein and participates in the formation of ... the alpha-actinin protein family, alpha-actinin 1, has been shown to be involved in cadherin-mediated cell–cell adhesion via alpha-catenins in adherens junctions of epithelial cells [53] The fact...

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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx

Ngày tải lên : 05/03/2014, 17:20

... determine that a putative signal peptide and a cleavage site exist in ePAD and AAH53724 (an egg and embryo abundant peptidylarginine deiminase), indicating they are likely secreted proteins (Fig arrow) ... cortical granules contain PAD To ascertain if mouse cortical granules contain PAD, antibodies made against mouse ePAD and human recombinant PAD V (anti-PAD V (N)) were used to label in vivo matured ... and LCA All anti-PAD V labeling is shown in green, except in A where it is red DNA stain in A is green ABL2 labeling is green and LCA labeling is red in all figures (A) Cytospin preparations...

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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx

Ngày tải lên : 23/03/2014, 17:21

... rat by another group in collaboration with Hamlyn [21] by means of two independent assays, a radioimmunoassay using an anti-ouabain Ig and an enzymatic assay using ouabain-sensitive Na+/K+ATPase ... larger changes in intracellular Na+ and Ca2+ may thus be the result of a ouabain interaction with subpopulations of Na+/K+ATPase [27] An overall increase in intracellular Na+ was seen in the experiments ... latter may have a sublocalization critical for the observations looking at ouabain as a signal-transducer Experiments pointing to a pivotal role of ouabain in signal-transduction In the following,...

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Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx

Ngày tải lên : 18/06/2014, 16:20

... treatment significantly attenuated some alterations (i.e increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, ... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases ... The role of cytokines in hepatocellular carcinoma J Leukoc Biol 2006, 80(6):1197-213 51 Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato...

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báo cáo hóa học:" Triple-Nucleoside Analog Antiretroviral Therapy: Is There Still a Role in Clinical Practice? A Review" docx

Ngày tải lên : 20/06/2014, 08:20

... Montaner J, et al.: Abacavir-lamivudinezidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial JAMA 2001, 285:1155-1163 Abstract ... 27 Ruane P, Mendonca J, Timerman A, et al.: Kaletra vs nelfinavir in antiretroviral-naive subjects: Week 60 comparison in a phase III, blinded, randomized clinical trial Program and abstracts ... interaction Nonthymidine-Containing ("TAM-Sparing") t-NRTI Regimens as Initial ART Clinical trials that have investigated the use of TDF as part of the NRTI backbone of an ART regimen among treatment-naive...

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Báo cáo khoa học: "Pim-1 A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis" potx

Ngày tải lên : 07/08/2014, 15:20

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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf

Ngày tải lên : 10/08/2014, 05:21

... Komura M, Komura H, Kanamori Y, Tanaka Y, Suzuki K, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T: An animal model study for tissue-engineered trachea fabricated ... 82 Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzuka T, Kobayashi K, Nakamura T, Kanemaru S, Yamashita M, Asato R: Clinical application of in situ tissue engineering using a scaffolding technique ... engineers should pay special attention to the fabrication of biologically active scaffolds and matrices capable of fulfilling natural properties of the airway ECM, for example, by maintaining and...

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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt

Ngày tải lên : 12/08/2014, 04:20

... Journal 2009, 6:168 members, is one of the main HECT E3 protein families They are characterized by a unique domain architecture, with an amino-terminal C2 domain, two to four proteinprotein interacting ... AP-1 [41]; δ-adaptin, a marker for AP-3 [42] Both AP-1 and AP-3 localizes to TGN and endosomes, with AP-3 localizes more to endosomes [43] UL56 colocalized with both γadaptin and δ-adaptin, albeit ... EP, Toh BH: EEA1, an early endosome-associated protein EEA1 is a conserved alphahelical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif J Biol...

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báo cáo khoa học: " Co-expression and promoter content analyses assign a role in biotic and abiotic stress responses to plant natriuretic peptides" pptx

Ngày tải lên : 12/08/2014, 05:20

... Kamiya A, Nakajima M, Enju A, Sakurai T, Satou M, Akiyama K, YamaguchiShinozaki K, Carninci P, Kawai J, Hayashizaki Y, Shinozaki K: Monitoring the expression pattern of around 7,000 Arabidopsis genes ... physiological role of AtPNP -A in A thaliana a T-DNA insertion mutant, that is available from SALK, could be used Phenotyping this mutant in response to SA-inducing abiotic and biotic stresses as well as ... evidence documenting induction of AtPNP -A expression in SA-mediated natural developmental and stress activated processes which both culminate in cell death indicating that AtPNP -A may be involved in...

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Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf

Ngày tải lên : 12/08/2014, 19:22

... shock In an experimental study in dogs, an ablated reactive hyperaemia was associated with endotoxaemia-induced impaired oxygen extraction at the level of the gastrointestinal tract [71] Nevière and ... Szymanski LM: The suprapharmacologic dosing of antithrombin concentrate for Staphylococcus aureus-induced disseminated intravascular coagulation in guinea pigs: substantial reduction in mortality ... trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation Chest 1993, 104:882-888 34 Baudo F, Caimi TM, de Cataldo F, Ravizza A, Arlati S, Casella G, Carugo...

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Báo cáo y học: "RNA interference has a role in regulating Drosophila telomeres" potx

Ngày tải lên : 14/08/2014, 16:21

... involved in transcriptional silencing in plants [12], Caenorhabditis elegans [13] and mammals [14], and in genome rearrangements in Tetrahymena [15], suggesting that RNAi is affecting Drosophila telomeres ... example, several aub alleles increased HeT -A expression in only a fraction of the ovaries, or sometimes only in some ovarioles in a single ovary Only in one case was HeT -A expression increased ... HeT -A is significantly more abundant than TART in the genomes of stocks that have been examined (P.G DeBaryshe, personal communication) The predominance of HeT -A has always been puzzling, because...

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Running and adult neurogenesis does septohippocampal sonic hedgehog play a role

Ngày tải lên : 14/09/2015, 14:09

... behavioural act of running causes a striking increase in neurogenesis (van Praag et al., 199 9a; van Praag et al., 1999b) It does not merely facilitate cellular plasticity, it also brings about a ... pyramidal neurones then send axons to the ipsilateral CA1 pyramidal cells via the Schaffer Collateral pathway and contralateral CA3 and CA1 pyramidal cells via the Associational/Commissural fibres ... these findings Running does not increase vascularisation to the DG (van Praag et al., 2007) Running did not bring about a change in vascular permeability in the brain as well, even with the addition...

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