diversity of extracellular enzymes
Báo cáo khoa học: Structural diversity of angiotensin-converting enzyme Insights from structure–activity comparisons of two Drosophila enzymes docx
... effect of Cl– on enzyme activity, and inhibition by new domain-selective inhibitors of human ACE A model of the structure of ACER has been generated, which provides explanations for some of these ... Hydrolysis of AI The effect of NaCl on the conversion of AI into AII by ANCE was determined at two pH values At pH 7, increasing the concentration of NaCl resulted in a faster rate of conversion, ... generated by the sequential cleavage of Arg-Arg and Ser-Pro MKRSRGPSPRR was a strong inhibitor of the hydrolysis of Abz-YRK(Dnp)P with a Ki of 185 nm for the inhibition of ANCE (Fig 1B) In contrast,...
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Tài liệu Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling pptx
... sustained activation of Rac by overexpression of the Rac-specific activator, Tiam1, or overexpression of V12-Rac1, strongly induces transcriptional upregulation of tissue inhibitor of metalloproteinase ... four different isoforms Of these, the prototype member of the TIMP family, TIMP-1, is of particular interest, because in addition to its classic role as a broad specific inhibitor of active matrix ... well-established roles of (a) AP-1 in regulating the transcription of numerous genes, and (b) of TIMP-1 as an inhibitor of tumor invasion and metastasis as well as a regulator of cell proliferation...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... Activities of the enzymes The specific activities of ALP I, Sendai and the mutant enzymes were measured with casein and Suc-Ala-Ala-ProPhe-MCA as substrates The values of the mutant enzymes were ... ACKNOWLEDGEMENTS We thank Prof Takeshi Uozumi of the Department of Biotechnology, Tokyo University, for the permission to use B subtilis KN2, and Prof Koji Takahashi of the Department of Applied Biochemical ... promoter region of subtilisin NAT (NAT) from B subtilis (natto) was used for expression The open reading frame of the ALP I gene, aprQ, was ligated of the downstream of the promoter region of the Ó...
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Tài liệu Báo cáo Y học: Evolution of the enzymes of the citric acid cycle and the glyoxylate cycle of higher plants pdf
... evolution of all of the enzymes of the pathway (Fig 4), it is clear that only about half of the enzymes of the tricarboxylic acid cycle, the major pathway of carbon metabolism in mitochondria of oxygen-respiring ... insights into the origin of its individual enzymes However, the study of the enzymes of the tricarboxylic acid cycle necessarily also entails the study of the several enzymes involved in the glyoxylate ... relatedness of several of the enzymes investigated to other enzyme families (Table 1) Higher-plant tricarboxylic acid cycle and glyoxylate cycle: eubacterial enzymes All of the plant enzymes surveyed...
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A Diversity Of Creatures By Rudyard Kiping pdf
... given, but he gathered unofficially from the Mayor of Chicago that the District complained of ‘crowd‐making and invasion of privacy.ʹ As a matter of fact, it is of no importance whether Northern Illinois ... or out of planetary circuit; as a matter of policy, any complaint of invasion of privacy needs immediate investigation, lest worse follow. By 9‐45 A.M. De Forest, Dragomiroff (Russia), Takahira (Japan), and ... now you can take hold of the situation.ʹ 17 A Diversity of Creatures ‘Any chance of their quieting down?ʹ De Forest asked. ‘You can try,ʹ said the Mayor. De Forest raised his voice in the face of the reviving Crowd that had ...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... in an increase in the number of binding sites and a decrease of the affinity of the uPAR [38,39] The quantification of uPAR expression by measurement of the amount of uPA bound is thus not ideal ... Ó FEBS 2002 uPA and uPAR possibly through suppression of upstream targets of ERK Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulating uPAR It ... dose-dependent inhibition of 50 and 70% of the uPAR mRNA level at concentrations of 0.1 and lM, Ó FEBS 2002 3948 H Kobayashi et al (Eur J Biochem 269) Fig Induction of uPAR mRNA by PMA in tumor...
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Báo cáo khoa học: Viral entry mechanisms: the increasing diversity of paramyxovirus entry doc
... increased greatly with the elucidation of the crystal structures of the prefusion form of the PIV5 F protein [89] and of the postulated postfusion forms of the NDV and hPIV3 F proteins [90–92] ... conservation of a number of structural elements suggests a similar mechanism of fusion Membrane fusion is considered to be driven by very large conformational changes [13] following the triggering of the ... to sit on top of a membrane-proximal stalk domain The globular head is composed of four identical monomers arranged with four-fold symmetry, with each of the monomers consisting of a six-blade...
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Báo cáo khoa học: Diversity of human U2AF splicing factors Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest pptx
... patterns of candidates for putative novel protein (accessions) Table Predicted number of mRNA isoforms generated by alternative splicing of U2AF genes An alternatively spliced mRNA isoform was ... exon For the predicted patterns of splicing, there is redundance in the number of accessions shown because of the fragmented nature of ESTs and some mRNAs U2AF diversity I Mollet et al FEBS Journal ... ortholog of Murr1 is located on chromosome and there are no U2AF1-related genes on human chromosome Indeed, the phylogenetic analysis of this family of genes indicates independent events of retrotransposition...
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Báo cáo khoa học: MAP2 prevents protein aggregation and facilitates reactivation of unfolded enzymes ppt
... results of investigation of chaperone-like activity of MAP2 using dithiothreitol-induced aggregation of insulin at 25 °C Here, the inhibition of aggregation is about 70% in the presence of 0.1 ... mgÆmL)1 Fig Effect of MAP2 and tubulin on the reactivation of different substrate enzymes (A) Time course of reactivation of 0.05 lM LDH: Self-folding (trace 1, j); in presence of 0.05 lM MAP2 (trace ... presence of 0.4 lM tubulin (trace 3, d) (B) Time course of reactivation of 0.06 lM a-glucosidase: Self-folding (trace 1, j); in presence of 0.05 lM MAP2 (trace 2, m); and in presence of 0.5 lM of tubulin...
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DIVERSITY OF ECOSYSTEMS pot
... Deputy Vice Chancellor and Dean of Faculty of Sciences and Technics (FST), University of Maradi, Maradi Niger Macrofaunistic Diversity in Vallisneria americana Michx in a Tropical Wetland, Southern Gulf of Mexico ... vulnerability in face of the eutrophication of coastal aquatic ecosystems and the declination or disappearance of populations with the resulting loss of biodiversity are a matter of concern (Wigand ... analysis of the spatial and temporal variations of 1) the environmental quality of the water column, 2) the quantitative habitat complexity of V americana, and 3) the abundance and diversity of molluscs,...
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Báo cáo khóa học: Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose ppt
... variant of L-fucokinase consisted of 3270 bp, encoding a protein of 1090 amino acids The sequence of the shorter cDNA was similar to the sequence of the IMAGE clone 4190449, consisting of 3057 ... calculations, expression levels of those enzymes found in mouse liver were assigned a relative expression value of one The expression of both splice variants of L-fucokinase was found to be relatively ... pathway of GDP-L-fucose in mouse (Eur J Biochem 271) 79 Fig Gene structures of the short and the long splice variants of mouse fucokinase (A) and human fucokinase (B) The long splice variant of mouse...
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Báo cáo khoa học: Diversity of metallothioneins in the American oyster, Crassostrea virginica, revealed by transcriptomic and proteomic approaches potx
... a diversity of oyster MTs that has implications for our understanding of the evolution of this gene family and for interpreting structure/function relationships in molluscan MTs Diversity of ... Analysis of cDNA sequences of CvMT-I/II clones, along with the intronic sequence of the CvMT-IA gene, permitted deduction of the series of events that probably led to the generation of genes ... mutation of a lysine codon introduces a stop codon in CvMT-II isoforms (A) Diagram of CvMT-I and -II Ó FEBS 2004 isoform structural diversity, as represented by cDNA (B) Conceptual translation of the...
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Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx
... Ó FEBS 2004 Role of ERK1/2 in neuronal survival (Eur J Biochem 271) 2051 overexpression of mutated elements of the pathway, use of pharmacological inhibitors and genetic ... synaptosomes [8] The interpretation of the data obtained through experimental modulation of ERK1/2 signaling may be hampered by the fact that inhibition of one element of the ERK1/2 signaling network ... activation of ERK1/2 reached levels similar to those observed at the peak of BDNF action [16] Inhibition of ERK1/2 by either pharmacological inhibitors or by a dominant-negative mutant form of MKK1...
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Báo cáo sinh học: " Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source" pptx
... alignments of the V1V2 and V3 regions of Envs cloned from each virus are shown in Fig 7A and 7B, respectively The net charge of the V3 regions of D36E and D36L clones was +6, and the net charge of the ... by identifying distinct phases of HIV-1 env sequence diversity and divergence during the asymptomatic period preceding the development of AIDS [29]; an early phase of variable duration with linear ... late phase characterized by a stabilisation of viral divergence and a continued stability or decline in viral diversity The emergence of X4 HIV-1 variants often coincided with transition between...
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Báo cáo sinh học: " Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pptx
... and of the distribution of viruses the location of the completely location of CMG clones types of viruses well as the localizationinlay map of Tanzania showingsimilar to these clones Map of mapping ... potential source of origin of the family of EACMVs The revealed strain diversity further exemplifies the wealth of this part of Africa with respect to cassava geminiviruses Some of these viruses ... Determination of genetic diversity of EACMV DNA-B using partial sequences The diversity of different CMG isolates was analyzed using a partial DNA-B genomic region spanning the N-terminal region of BC1...
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Báo cáo sinh học: " Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis" docx
... + + + - - - Figure Comparison of the sensitivity of the E2-HVR1 PCR using Taq and HF-2 enzymes Comparison of the sensitivity of the E2-HVR1 PCR using Taq and HF-2 enzymes RNA was extracted from ... of Taq increased the proportion of minor QS variants [31], and we have found that, in general, QS diversity is lower if proof-reading enzymes are used instead of Taq [32] But the question arises ... results in cohort-based studies of HCV QS analyzed by HMA However, the use of proofreading enzymes such as HF-2 is recommended for more accurate characterization of HCV QS in vivo Background HCV...
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báo cáo hóa học:" Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pot
... and of the distribution of viruses the location of the completely location of CMG clones types of viruses well as the localizationinlay map of Tanzania showingsimilar to these clones Map of mapping ... potential source of origin of the family of EACMVs The revealed strain diversity further exemplifies the wealth of this part of Africa with respect to cassava geminiviruses Some of these viruses ... Determination of genetic diversity of EACMV DNA-B using partial sequences The diversity of different CMG isolates was analyzed using a partial DNA-B genomic region spanning the N-terminal region of BC1...
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Báo cáo hóa học: " Research Article Superresolution under Photometric Diversity of Images" ppt
... irradiance of the scene; it requires estimation of the CRF and its inverse explicitly The algorithm derives a specific certainty function using the Taylor series expansion of the inverse of the CRF ... estimation or knowledge of the exposure rates and CRF Spatial registration, lens flare, ghost removal, vignetting correction, compression, and display of HDR images are some of the other challenges ... section, we conclude that nonlinear photometric models should be a part of SR algorithms when there is a possibility of photometric diversity among input images = f α ji f −1 zi + β ji (5) The function...
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