discovery and development of orally active rsv fusion inhibitors
Provision, discovery and development of ubiquitous services and applications
Ngày tải lên :
10/09/2015, 08:36
... layers for the provision, discovery, and development of ubiquitous services and applications As a proof of concept, we demonstrate the use of the framework for the development of an information sharing ... area recently, including the development of embedded system and sensors, the design of system architecture and middleware, and the implementation of software agent and application framework This ... have to rewrite and redeploy the whole application 1.4 Problem Statement In this thesis, we address the problem of the provision, discovery and development of ubiquitous services and applications...
- 208
- 505
- 0
Design and development of major balance of plant components in solid oxide fuel cell system
Ngày tải lên :
05/09/2013, 16:10
... any SOFC system, the performance of the INER SOFC system is dependent not only on the design and operating conditions of the fuel cell stack, but also on the design and operating conditions of ... provided by the anode off-gas given an anode off-gas temperature of less than 650 oC, a cathode off-gas temperature of less than 390 oC, and a flame barrier temperature of less than 700 oC However, ... operation of voltage, current, active area and cell number Figure Flow chart showing GCTool optimization procedure for single stack output power of kW (or more) and electrical conversion efficiency of...
- 12
- 585
- 0
Tài liệu Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins docx
Ngày tải lên :
19/02/2014, 12:20
... Amidation of C-terminus Sulfation of tyrosine Hydroxylation of proline Carboxylation of glutamic acid Cyclization of N-terminal Gln O-Glycosylation Bromination of tryptophan Isomerization of tryptophan ... characterization of native a-conotoxins Analysis of neuronally active a-conotoxins using HPLC and MS, including identification of post-translational modifications Isolation and identification Standard procedures ... spectrometry and the lability of the sulfogroup in mass spectrometry analysis allows recognition of the modification, and differentiation of sulfotyrosine and phosphotyrosine [38] Characterization of the...
- 11
- 554
- 0
Báo cáo khoa học: Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening docx
Ngày tải lên :
07/03/2014, 16:20
... deglycosylation to yield the 40-kDa band The 51-kDa band thus represents the receptor monomer with the exclusive addition of mannose residues The presence of the immunoreactive bands in the lanes relative ... between yeast and mammalian GPCR signaling pathways, this assay enables the quantitative measurement of receptor activity, or alternately the detection of its ligands Using known ligands of I7 OR ... related ligands strongly suggests the authenticity of its ligand binding and the maintenance of the coding ability at the receptor level Consequently this suggests that glycosylation of I7 OR is...
- 14
- 473
- 0
Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii Implications for the disulfide metabolism of anaerobic hyperthermophiles doc
Ngày tải lên :
07/03/2014, 17:20
... Thermostability and thermoactivity of the CoADR phCoADR is stable for months at both )80 °C and )20 °C, and has half-lives of > 100 and 39 h at 85° and 95 °C, respectively Figure shows the dependence of the ... Addition of a second equivalent of NADPH to the EH2 form of phCoADR results in an increase in absorbance in the regions between 507 and 700 nm and 400 and 500 nm There is also an increase and FEBS ... above Thiols were quantified by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the CoA and dephospho CoA peaks, as described previously...
- 12
- 420
- 0
THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT pptx
Ngày tải lên :
08/03/2014, 23:20
... AND DEVELOPMENT OF THE CEREAL PLANT 24 THE WHEAT BOOK THE WHEAT BOOK CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT Tim Setter and ... formation of florets within each spikelet and, later, the regression and death of some florets and spikelets and the death of some tillers This phase is also the time of greatest dry mass increase and ... Mainstem and tillers 26: Mainstem and tillers 27: Mainstem and tillers 28: Mainstem and tillers 29: Mainstem and or more tillers Dough development Kernel no longer watery but still soft and dough-like...
- 86
- 709
- 0
Antibiotic Discovery and Development pptx
Ngày tải lên :
14/03/2014, 10:20
... antibiotic discovery and development process and provide the reader with a sense of how it is done and where things stand in 2011 The book begins with a solid historical review of the early years of ... potential leads, and the use of cell-based screens to identify inhibitors The role of both NMR and X-ray structure techniques in identifying inhibitors, mechanism of action studies, and their utility ... consisting of three components: Isolation and cultivation of novel producer organisms Screening of cultures for activity Purification and identification of the active metabolites 1.4.1 Isolation of Novel...
- 1.1K
- 12.2K
- 0
Báo cáo khoa học: Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains pdf
Ngày tải lên :
16/03/2014, 18:20
... availability of a large number of genomic sequences has significantly increased the number of identifiable analogs of E coli Lon and prompted a reanalysis of the active sites of this family of proteases ... definition of the domains The locations and sequences of the Walker A and B motifs (AAA+ module) and of fragments of the proteolytic domains including catalytically active serine (S*) and lysine ... analysis of the amino acid sequences of the majority of the currently known Lon proteases The results of site-directed mutagenesis of E coli Lon protease and insights from the crystal structure of...
- 7
- 487
- 0
Báo cáo Y học: Expression and purification of the recombinant subunits of toluene/ o-xylene monooxygenase and reconstitution of the active complex potx
Ngày tải lên :
17/03/2014, 10:20
... in Materials and methods Quantitative analysis of bound FAD yielded the value of 1.1–1.2 mol of FAD per mole of protein The iron content of Tomo F was 1.8–2.1 molÆmol)1 of protein, and the acid-labile ... using mixtures of Tomo H, F, C and D, and changing the concentration of each single component Figure shows the effects on the rate of reaction of increasing ratios of Tomo F, Tomo C and Tomo D with ... presence of constant amounts of the other components A linear relationship is obtained at low ratios of Tomo C and D followed by a sharp break at about 1.6 mol of Tomo C per mol of Tomo H and mol of...
- 11
- 478
- 0
Origin and Development of Commercial and Islamic Banking Operations pot
Ngày tải lên :
22/03/2014, 21:20
... BC) of Lydia They were of electrum Origin and Development of Commercial and Islamic Banking Operations (a mixture of gold and silver) This must have encouraged the emergence and practices of banking ... ups and downs depending on the political and military conditions of the Republic In time of wars and disorder, inflation, financial stagnation and bankruptcy prevail and in times of peace and ... Bin Salih and above all two Jewish merchants and bankers: Yusuf Bin Finkhas and Harun Bin Imran of Baghdad who were appointed to the office of jahbadh of the Persian province Ahwaz and later...
- 23
- 372
- 0
Báo cáo khoa học: Cleavage site analysis of a serralysin-like protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate pdf
Ngày tải lên :
23/03/2014, 09:20
... conjugation of the quencher and the fluorophore influenced neither the rate nor the site of hydrolysis of the peptide Sensitivity and selectivity of the Dabcyl– EVYAVES–Edans substrate and the activity of ... the development of such a substrate based on analysis of PrtA cleavage site specificity, and kinetic characterization of PrtA activity on the new substrate Results and Discussion Identification of ... samples For an exploration of the proteolytic system of PrtA, and an understanding of its role in the infection process of Photorhabdus, we needed a highly sensitive and specific substrate to selectively...
- 11
- 424
- 0
ORIGIN AND DEVELOPMENT OF FORM AND ORNAMENT IN CERAMIC ART pptx
Ngày tải lên :
28/03/2014, 20:20
... painted upon pottery 463 488.—Theoretical development of fret work 464 489.—Theoretical development of scroll work 465 [Pg 443] ORIGIN AND DEVELOPMENT OF FORM AND ORNAMENT IN CERAMIC ART By William ... the shape of the vessels employed at the time of the introduction of the art, and these depend, to a great extent, upon the kind and grade of culture of the people acquiring the art and upon the ... with the use of clay and a capacity in handling it that, with advancing culture, brought all nature within the reach of the potter and made it assist in the processes of variation and development...
- 34
- 489
- 0
DESIGN AND DEVELOPMENT OF MEDICAL ELECTRONIC INSTRUMENTATION A Practical Perspective of the Design, Construction, and Test of Medical Devices docx
Ngày tải lên :
29/03/2014, 11:20
... DESIGN AND DEVELOPMENT OF MEDICAL ELECTRONIC INSTRUMENTATION DESIGN AND DEVELOPMENT OF MEDICAL ELECTRONIC INSTRUMENTATION A Practical Perspective of the Design, Construction, and Test of Medical ... responsibility for the use of these circuits and/ or software or of systems incorporating these circuits and/ or software lies with the reader, who must apply for any and all approvals and certifications ... provide an assortment of desired passband and gain characteristics selection and preparation of electrode placement on the subject, and by keeping the bandpass characteristics of the biopotential...
- 478
- 522
- 2
báo cáo hóa học:" Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells" pptx
Ngày tải lên :
18/06/2014, 15:20
... activity of LXR modulator compounds in target organs Several candidate biomarkers of LXR agonist exposure and activity have been identified in peripheral blood, and two of these (ABCA1 and ABCG1) ... elevation of ABCA1 and ABCG1 mRNAs reflected the potency of agonists to activate LXR receptors, rats were treated with a range of doses of GW3965 (Figure 2D) or LXR-623 (Figure 2E) Since the potency of ... with 0, 15 and 50 mpk/day of LXR-623 for days (n = per dose group) Blood was collected on day of dosing, and RNA was prepared from whole blood for gene expression analysis of ABCA1 and ABCG1 qPCR...
- 15
- 623
- 0
Báo cáo hóa học: " On the understanding and development of modern physical neurorehabilitation methods: robotics and non-invasive brain stimulation" pdf
Ngày tải lên :
19/06/2014, 08:20
... optimally promote development and retention of motor skills and translate into long-term reduction in disability Also supporting a quantitative scientific understanding of mechanisms of post-stroke ... extend beyond orthopaedic, and impact recovery of motor control, we know that therapies cannot be passive and patients must be engaged Perhaps part of the 'magic' in the hands of the individual therapist ... world-war and polio survivors The branch of medicine devoted to active rehabilitation was formed, and a shift from 'do nothing' to 'do something' occurred This was based on the understanding of neurological...
- 4
- 452
- 0
Opal''''s Site Organization and Development of Russian Business_1 docx
Ngày tải lên :
20/06/2014, 20:20
... analysis of probability to obtain financial and organizational support from the state authorities Utility of business associations and their contribution to the establishment of standards and rules of ... impacts of business integration via the formation of holding companies and other types of business groups upon corporate governance and firm performance of affiliated firms; and (c) the role and ... and nonmembers of business associations Indicators of financial standing of joint-stock companies and membership in business associations Types of support rendered to authorities and aid through...
- 23
- 266
- 0
Opal''''s Site Organization and Development of Russian Business_2 pptx
Ngày tải lên :
20/06/2014, 20:20
... by studies of economic transition and company behavior in transition economies, with the participation of leading economists of the world, including Andrei Shleifer, Gerard Roland, and Josef Stiglitz ... were related to the compilation and approval of five-year plans and implementation of investment projects came within the competence of higher levels of government); and (c) managers were involved ... planned target volumes and resources allocated to the enterprise and with suppliers and customers on product mix and other terms of supply This pattern of behavior was typical of enterprises in all...
- 23
- 286
- 0
Opal''''s Site Organization and Development of Russian Business_3 pdf
Ngày tải lên :
20/06/2014, 20:20
... Organization and Development of Russian Business Less than 25% of shares 13% More than 50% of shares + absence of a counterbalance 48% From 25% to 50% of shares 18% More than 50% of shares + presence of ... in lack of capacity, lower wages and profitability, and a higher risk of loss Moreover, the authors produced evidence (in a small sample of companies) of the positive role of the size of shareholding ... fact of corporate reality is the non-transparency and complexity of ownership rights and the concealment of true owners behind a multilevel chain (5–8 levels) of affiliated individuals and companies,...
- 23
- 344
- 0