diabetes in vivo study
Báo cáo khoa học: "The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer" pdf
... a single dose Gy× at 60min intervals 2.57 Gy×7 at 10min intervals Gy× at 30min intervals 2.57 Gy×7 at 5min intervals control 18 Gy as a single dose Gy× at 60min intervals 2.57 Gy×7 at 10min intervals ... implanted in C57BL mice was studied in order to investigate the effect of intermittent radiation exposure compared with that of continuous radiation exposure in vivo The results of this in vivo study ... effect of prolonged delivery time in vivo, Sugie et al conducted a study In this study they used EMT6 and SCCVII tumors approximately cm in diameter growing in the hind legs of syngeneic mice Mice...
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báo cáo khoa học: " Osseointegration of zirconia implants compared with titanium: an in vivo study" ppsx
... conditions in a veterinary operating theatre The animals were sedated by an intramuscular injection (10 mg/kg) of ketamine (Ketavet®, Pfizer, Karlsruhe, Germany), ml atropine (Atropinsulfat Braun®, ... using continuous external sterile saline irrigation to minimize bone damage caused by overheating At the surgical site, the skin and the fascia-periosteum were closed in separate layers with single ... (right) implants inserted into the tibia of minipigs after 12 weeks of healing time Radiograph Radiograph showing titanium (left) and zirconia (right) implants inserted into the tibia of minipigs after...
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Báo cáo y học: " Sodium nitroprusside and peroxynitrite effect on hepatic DNases: an in vitro and in vivo study" potx
... changes monitored by using Beckman DU 530 spectrophotometer Protein carbonyls and protein nitrotyrosine were measured in plasma proteins and the remaining protein pellet according to the method of ... endonuclease activity in the culture of neuronal cells In our in vivo study (Table 2), the activity of alkaline DNase increased within 24 h after exposure to SNP (achieving approximately a similar ... assisted during in vivo and in vitro experiments and did the graphical presentation DS performed statistical analysis and assisted during in vivo experiments DP and RK assisted during in vitro experiments...
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In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole Disease...
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In vitro and in vivo study of vitamin e TPGs coated immunoliposomes for sustained and targeted delivery of docetaxel
... tubulin in the microtubules rather than to tubulin dimers The binding site to tubulin differs from the one of vinca-alkaloids and podophyllotoxins While vincas inhibit polymerization and increase ... as vindesine and vinorelbine can inhibit the assembly of microtubule by reducing the rate of tubulin addition, taxanes have the opposite effect, inhibiting the disassembly of microtubules during ... present in physiological system is the high probability of binding to endogenous proteins in the circulatory system The high-binding affinity of most commercial formulations to plasma proteins reduces...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in various cancer types, including CLL, breast cancer, ... of essential proteins responsible for accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes ... RNA-binding-domain protein that is a homologue of the HIV transactivating response RNA-binding protein (TRBP) The functional strand of the miRNA duplex guides the RNA-induced silencing complex (RISC)...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... Production of in vivo mature miRNA23 was detected in three cell lines using the Gaussia luciferase reporter vector containing three tandem repeat regions of miRNA23 binding sequence (reprinted with ... imaging information about miRNA biogenesis in cellular developments and disease In summary, molecular imaging techniques can be used to monitor the in vivo dynamics of miRNAs noninvasively, including ... of miRNAs, including miRNA221, 21 and 142, are involved in multiple oncogene targets in cancer cells, which are thought to originate from two main basic mechanisms, that is, functioning as either...
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Báo cáo y học: "Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study" ppt
... frequencies of in vivo joint loading Conclusion We conclude that cyclical in vivo joint loading increases the proteoglycan content of the cartilage deep zone via signal transduction stimulated by increased ... matrix proteins were not measured Nonetheless, using our in vivo joint loading model, we will be able to test different loading patterns to determine thresholds of healthy and damaging loading These ... matrix proteins Matrix Biol 1999, 18:391-399 15 King KB, Opel CF, Rempel DM: Cyclical articular joint loading leads to cartilage thinning and osteopontin production in a novel in vivo rabbit...
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Báo cáo y học: "The instantaneous helical axis of the subtalar and talocrural joints: a non-invasive in vivo dynamic study" ppsx
... kinematics lack information in regards to in vivo joint motion during volitional activity More importantly, no studies have provided a complete kinematic definition of the FHA for either joint ... products in order to ensure a dextral orthogonal coordinate system The tibial origin (To) was defined as the point that bisected the line connecting the most lateral and medial tibial points in the ... talocrural and subtalar kinematics: A non-invasive 3D dynamic MRI study Foot Ankle Int 2007, 28:323-335 Sheehan FT, Zajac FE, Drace JE: In vivo tracking of the human patella using cine phase contrast...
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báo cáo khoa học: " Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes" ppsx
... assessment (HOMA)) Plasma was obtained by drawing blood samples into glass tubes containing EDTA and serum was obtained by drawing blood into glass tubes containing a clot-inducing plug The tubes were ... or 5% bovine serum albumin (BSA) in TBST Incubation with primary antibody anti-PTBP1 (Polypyri midine tract-binding protein 1; Proteintech Group Inc (Chicago, Illinois, USA) at 1:1,000 in 5% skimmed ... microarray studies examining insulin resistance in skeletal muscle paint a remarkably similar picture - one of no striking change in protein coding mRNA abundance In the Patti et al study [2], muscle...
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báo cáo khoa học: " A cluster randomized trial to improve adherence to evidence-based guidelines on diabetes and reduce clinical inertia in primary care physicians in Belgium: study protocol [NTR 1369]" potx
... opinion leaders and experts in diabetes care [41] Modeling phase In the modeling phase, we delineated the components of our complex intervention and the underlying mechanisms by which they influence ... registry, clinician reminders, facilitated relay of clinical information to clinicians, patient reminder systems, and continuous quality improvement Five interventions are not included in the service ... self-monitoring of blood glucose levels Level two: professional Clinician education Interventions for clinician education include an increased understanding of principles guiding clinical care...
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Báo cáo y học: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study" pps
... containing 1% penicillin, 1% streptomycin, and 1% gentamycin at 37°C in 5% carbon dioxide/air for 16 hours Tissue was then either stimulated with 100 ng/ml LPS (Sigma-Aldrich, UK) or maintained in ... cytokines most reportedly elevated in COPD patients during exacerbations Figure of Severity COPD influences cytokine release Severity of COPD influences cytokine release Using the GOLD guidelines ... is a highly complex inflammatory disease in which many mediators are involved However, the substantial increase in TNFα production following LPS exposure in our model and in vivo exacerbation studies...
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Báo cáo khoa học: "Comparative study on the in vitro and in vivo properties of two bovine herpesvirus-5 reference strains" pptx
... caused by infectious bovine rhinotracheitis virus in calves in Hungary Acta Vet Acad Sci Hung 1969, 19:145-151 Moretti B, Orfei Z, Mondino G, Persechino A: Infectious bovine rhinotracheitis, clinical ... sulfolipocyclodextrin in a squalane -in- water and water -in- mineral oil emulsions for BHV-1 vaccines in cattle Vaccine 2000, 19:132-41 32 Reed CJ, Muench HA: A simple method of estimating fifty per cent end points ... of infection Page of Conclusions The in vitro and in vivo properties of two strains of BoHV-5 belonging to different subtypes were studied Our results show that the A663 strain used in this study...
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Study of biomolecular interactions in vivo by multicolour fluorescence spectroscopy
... are single molecule sensitive optical tools to study mobility, concentrations and interactions Due to their non-invasive nature, they are gaining popularity in studying molecular processes in vivo ... to quantitate protein-protein interactions in vivo The thesis contains six chapters and is structured into the following sections: Chapter introduces the basic principles and instrumentation of ... processes in a cell, protein-protein interactions play an important role in a cell system As a cell functions through a network of protein-protein interactions, it is vital to study these interactions...
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Developing small molecule chemical biology tools for studying cellular phosphorylation events in vivo
... Phenylalanine G Gly Glycine H His Histidine I Ile Isoleucine K Lys Lysine L Leu Leucine M Met Methionine N Asn Asparagine P Pro Proline Q Gln Glutamine R Arg Arginine S Ser Serine T Thr Threonine V ... peptide/protein having an N- terminal cysteine and a peptide/protein containing a C-terminal thioester.[16] In the case of expressed protein ligation (EPL), intein-mediated splicing is used to ... against PTP1B binding peptide 2.3.2 Microplate investigation on the binding of PTP1B-ABDF 54 against c-Src catalytic domains 2.3.3 Microplate investigation on the binding of PTP1B-ABDF 59 against...
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In vivo and in vitro study on potential combination therapy of COL 3 and tamoxifen in breast cancer a pilot study
... Chapter In Vitro Studies 5.1 PROTEIN BINDING STUDY 5.1.1 Introduction The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution throughout the body Protein binding ... COL-3 bind mainly to albumin So protein-binding interaction, where competition for the protein-biding site involves, could be a good reason to explain this phenomenon Some cases of protein displacement ... protein binding of acenocoumarol was reduced at higher concertations of E7070[153] However, in the present study, in vitro protein binding of COL-3 was not altered by tamoxifen, suggesting that interactions...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... characterized by insulin resistance and insulin secretion deficiency At present, there is no a single medication which treats type diabetes by improving both insulin resistance and insulin secretion ... glycine-rich linker is flexible, which allows the specific engineering of hinge regions into proteins to achieve desired functional motions [17] We used a glycine-rich short peptide including 15 amino ... fusion protein in inclusion body was refolded in urea gradient refolding buffer And then, the refolded protein was incubated with enterokinase to remove the His-tag The fusion protein without...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... the loading of pravastatin into erythrocytes was directly proportional with increase of drug concentration in the incubation medium, in the 2-10 mg/ml concentration range This finding is in concurrence ... pravastatin However, the relative impacts of different in vitro findings on the overall in vivo drug delivery efficacy of these cellular carriers remain to be evaluated during the future in vivo ... endocytosis, including vinblastine, chlorpromazine, hydrocortisone, propranolol, tetracaine, retinol, and primaquine [16, 19] The current work aims to study the encapsulation of pravastatin in human carrier...
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Tác dụng kháng viêm in vivo của dẫn chất polyoxychalcon
... anti-inflammatory activity is measured by the model of carrageenin-induced edema in hind paw of the rat Results: 10 Polyoxychalcones were obtained with good yields and the results of in vivo ... affect to the in vivo anti-inflammatory activity of tested chalcones The polyoxychalcone which possessing a hydroxy group at position C2 of A ring and at least one group methoxy in B may be consider ... nhóm methoxy vòng B làm tăng tác dụng kháng viêm in vitro in vivo chalcon - Nhóm 2’-hydroxy có ảnh hưởng định đến tác dụng kháng viêm in vitro in vivo chalcon Tăng tác động kháng viêm cho chalcon...
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