development of sensory testing
Sensory evaluation techniques
... the sensory literature, e.g., Journal of Sensory Studies and Sensory Forum (the newsletter of the Sensory Evaluation Division, Institute of Food Technologists [IFT]) Exhibitions at meetings of sensory ... Table of Contents CHAPTER Introduction to Sensory Techniques I Introduction II Development of Sensory Testing III Human Subjects as Instruments IV Conducting a Sensory Study References CHAPTER Sensory ... of Merit for studies of compounds that affect beer flavor He is founder and past president of the Hop Research Council of the U.S., and is past chairman of the Scientific Advisory Committee of...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... total amount of pravastatin entrapped in 0.1 ml of the final packed erythrocytes Efficiency of entrapment The percentage of the loaded amount of pravastatin to the total amount of that added ... ml eppendorff tubes, 400 µl of suspension are added to 400 µl of PBS containing the known concentration of the drug and 2.5 mmol of ATP, 2.5 mmol MgCl2 and 2.5 mmol of CaCl2, gently mixing to ... against lysis as a result of the osmotic pressure changes of their surrounding media was evaluated Twenty five l of erythrocyte sample was added to each of a series of 2.5 ml saline solutions...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough E coli, but the rate of oxidation in the presence of the LPS of smooth E ... fast phase of the reaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA A comparison of rough and smooth LPSs of E coli and S minnesota in the presence of EDTA ... the LPS of rough E coli (Fig 1) The effect of the LPSs of smooth and rough S minnesota on the oxidation rate of Hb A0 was compared (Fig 5) In Fig Comparison of the effects of the LPSs of rough...
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Financial Relationships and Interests in Research Involving Human Subjects: Guidance for Human Subject Protection pdf
... from the effects of conflicts of interest (http://www.georgetown.edu/research/nrcbl/nbac/human/overvol1.pdf) * The HHS Office of the Inspector General (OIG) has issued a series of reports examining ... conflict of interest be managed? Would the rights and welfare of human subjects be better protected by any or a combination of the following: • reduction of the financial interest? • disclosure of ... modification of role(s) of particular research staff or changes in location for certain research activities, e.g., a change of the person who seeks consent, or a change of investigator? • elimination of...
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BELMONT REPORT: ETHICAL PRINCIPLES AND GUIDELINES FOR THE PROTECTION OF HUMAN SUBJECTS OF RESEARCH ppt
... Associate Professor of Law, Georgetown University Law Center Karen Lebacqz, Ph.D., Associate Professor of Christian Ethics, Pacific School of Religion *David W Louisell, J D., Professor of Law, University ... of California at Berkeley Donald W Seldin, M.D., Professor and Chairman, Department of Internal Medicine, University of Texas at Dallas Eliot Stellar, Ph.D., Provost of the University and Professor ... research and the accepted and routine practice of medicine, (ii) the role of assessment of risk-benefit criteria in the determination of the appropriateness of research involving human subjects, (iii)...
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Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... evaluation of the possible consequences of use of hiPSCs for drug screening, as disease models and for medical purposes Conclusions The use of stem cells for the treatment of human diseases is one of ... of blood vessels and of red blood corpuscles as seen in the living blastoderm of chicks during the second day of incubation Contrib Embryol 9, 214 Murray PDF (1932) The development in vitro of ... hematopoietic differentiation of hESCs Expression of CD34 was found in all cases from day and peaked at day 18, matching the peak of activity of colony-forming cells Co-culture of hESCs with primary...
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ETHICAL AND LEGAL ASPECTS OF HUMAN SUBJECTS RESEARCH ON THE INTERNET docx
... can occur with the invasion of subjects’ privacy and the violation of confidentiality Invasions of privacy happen when research participants lose control of the types of personal information revealed ... integrity and autonomy of the individual Invasions of privacy can increase the likelihood of harm because they deprive the individual of that protection 18 Violations of confidentiality occur ... research, application of the principle of justice is inextricably linked to fair distribution of the burdens and rewards of research This bears directly on the selection and recruitment of participants,...
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Báo cáo hóa học: " Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects" potx
... plated at a concentration of 20000 cells per well in 96 well plates After days of culture, level of cellular ATP was quantified by bio-luminescence The ratio of average values of ATP in growth factor ... existence of various subsets of cells with EPC potential residing outside of the CD34+ KDR+ fraction Further studies are required to elucidate functional importance of the variable kinetics of mobilization, ... feasibility of significant mobilization of cells expressing hematopoietic stem cell and EPC markers and properties The area of nutritional modulation of the stem cell compartment offers significant...
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Báo cáo hóa học: " Are quantum dots ready for in vivo imaging in human subjects?" docx
... study the wide range of diverse molecular and cellular events involved in the pathology of diseases such as cancer Since the first demonstration of the biomedical potential of QDs in 1998 [1, 2], ... [21, 68, 69] One of the most interesting aspects of QDs for use in immunofluorescence techniques is the small number of QDs necessary to generate a detectable signal A number of 123 268 Fig Pseudocolored ... early stages of development while at later stages they mainly resided in cell nuclei The fluorescence signal of QDs could be followed to the tadpole stage with little or no indication of cytotoxicity...
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báo cáo khoa học: " Human subjects protection issues in QUERI implementation research: QUERI Series" pptx
... minimal risk definitions are met, what type of consent mechanisms are appropriate, and how to weigh individual risk of breach of confidentiality (often the primary risk) with potential societal ... clinicians, administrators), and ᭜ Administrators of databases of veterans' records All levels of VHA administrative structure including: ᭜ Central Office, ᭜ regional health networks and administrative ... Stetler Model of Research Utilization and RE-AIM b Plan – Do – Study – Act (PDSA) intervention adaptation cycles PDSA cycles are often a cornerstone of implementation research The nature of PDSA cycles...
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Báo cáo y học: "valuation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine." pps
... minimum of 1350 plaque forming units (PFU) of Oka/Merck varicella virus, approximately 18 mg of sucrose, 8.9 mg of hydrolyzed gelatin, 3.6 mg of urea, 2.3 mg of sodium chloride, 0.36 mg of monosodium ... structure/appearance of a lyophilized vaccine cake [2] The current manufacturing process of hydrolyzed porcine gelatin yields preparations which consist of a mixture of protein fragments of different ... monosodium Lglutamate, 0.33 mg of sodium phosphate basic, 57 mcg of potassium phosphate monobasic, 57 mcg of potassium chloride The product also contains residual components of MRC-5 cells including...
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Báo cáo khoa học: "Bench-to-bedside review: Human subjects research – are more standards needed" ppsx
... the development and conduct of emergency research using exception from informed consent Conflicts of interest COIs can exist on many levels [30] Almost half of faculty IRB members and 25% of all ... injuries was offered in 61% of industry-sponsored protocols In contrast, only 22% of protocols without industry sponsorship offered coverage (mostly limited to emergency bills), and 60% of consent ... the Protection of Human Subjects of Research Washington, DC: US Government Printing Office (DHEW publication); 1979 Rosenbaum JR: Educating researchers: ethics and protection of human research...
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Tài liệu Báo cáo khoa học: Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins pdf
... embryonic development Histochemical analysis of ovaries from superovulated females showed reduced oil red O staining of lipids in the ovarian copora lutea of SR-BI knock out relative to those of wild-type ... plasma membrane of JAr and Jeg3 cells and to a much lesser degree in the cytoplasma of both cell lines (Fig 4B,C) Omission of the primary antibody (data not shown) or replacement of primary antibodies ... Effect of HDL and ox–LDL on cell association of [3H]CEHDL at 37 °C Choriocarcinoma cells were incubated for h at 37 °C with 10 lgÆmL)1 of [3H]CE-labeled HDL3 in the absence (control) or presence of...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... extent telomere shortening, initially considered to be an essential marker of Fig Schematic of mechanism of action of the telomeric quadruplex ligand BRACO-19 1120 FEBS Journal 277 (2010) 1118–1125 ... Validation of a telomeric quadruplex mode of action involves evidence from a number of assays The most important are: (a) high-affinity in vitro telomeric quadruplex binding, with a Ka value of at ... G-quadruplexes as cancer drug targets S Neidle length of kb, a 24 h cell-doubling time and a subsequent loss of 100 nucleotides per round of replication would reach critical telomere shortening...
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Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... the expression of MT2A was upregulated in Tca8113 ⁄ PYM cells MT2A, as the main isoform of MTs, may closely mediate the resistance of Tca8113 ⁄ PYM cells to PYM BMP2 is a member of the transforming ... because of the methylation of the promoter, and restoration of DKK1 expression can induce apoptosis and suppress colony formation [42] As a suppressor of cancer, the downregulated expression of DKK1 ... therapeutic benefits of PYM can be attenuated in the clinic, because of intrinsic and ⁄ or acquired drug resistance, which is the major limitation of PYM-based chemotherapy The mechanism of cellular resistance...
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Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identification ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt
... pairs of primers, which amplify overlapping 5¢- and 3¢-parts of ZF5 cDNA, were designed using Primer software developed by V Prutkovsky and O Sokur of the Institute of Influenza, Ministry of Health ... (GCC)n-binding protein Fig Identification of p56 polypeptide as Kruppel-like transcription factor ZF5 by MALDI-TOF assay (A) Fragment of MALDI-TOF spectrum of ¨ p56-derived peptides (B) Mascot search ... RT-PCR of ZF5 mRNA (27 cycles); 1, 8, negative control; 2, 9, transfection of HepG2 cells by siRNAZF5 with oligofectamine; 3, 10, transfection of HepG2 cells by control siRNA with oligofectamine;...
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Báo cáo khoa học: Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene pptx
... a member of the NF1 family of transcription factors [15] by trypsin fragment mass analysis using MALDI-TOF MS Out of 13 peptide masses, nine (69%) were matched to different isoforms of NF1 from ... with 0.25 mL of sample The column was eluted at 0.1 mLÆmin)1 Fractions of 0.5 mL were collected after the void volume of the column SDS/PAGE and protein identification by MALDI-TOF MS Samples ... Biochem 271) Ó FEBS 2004 Fig Identification of the Site-2 and Site-3 binding protein as a member of the NF1 family of transcription factors (A) Binding of purified, recombinant NF1 to the Site-2...
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Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
... - hearing loss - unilateral orchitis( inflammation of one or both of the testes) ** These conditions are usually relieved with the treatment of 1% atropine and steroids Epidemiology ... Ethics is defined as motivation based on ideas of right and wrong when dealing with the geographical distribution of animals and plants This concept of can be used to explain the world’s shockingly ... United States, the locality of this virus has become less isolated as the threat of bioterrorism looms large The Ebola virus is now on the “A” list for hopeful vaccination development Experiments...
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Báo cáo khoa học: Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation pptx
... presence of Brij58 Lane 3: supernatant of ETBcHx expression in the presence of Brij78 Lane 4: ETBcHx after Ni–chelate acid chromatography Lane 5: supernatant of ETBStrep expression in the presence of ... cHx cHx A B Fig PAGE analysis of CF-expressed ETB fragments on SDS gels (A) CF expression of ETB fragments in the presence of Brij78; 0.7 lL of supernatant (S) and lL of eluate (E) after Ni–chelate ... cut-off of 25 kDa in an RM volume of 70 lL with an RM ⁄ feeding mixture ratio of : 14 Preparative-scale reactions were carried out in dispodialyzers (Spectrum Laboratories) in an RM volume of...
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