determination of neurotransmitter levels in models of parkinson s disease by hplc ecd

báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc

Ngày tải lên : 19/06/2014, 10:20

... variability increases in SOD1 G93A mice as the disease progresses Our findings suggest, however, that gait variability is not increased in the early stages of motor neuron disease Differences in gait ... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several ... cycle timing in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability...

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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

Ngày tải lên : 15/02/2014, 01:20

... discussions References Thomas B & Beal MF (2007) Parkinson s disease Hum Mol Genet 16 Spec No 2, R183–R194 Devine MJ & Lewis PA (2008) Emerging pathways in genetic Parkinson s disease: tangles, ... a-syn, proteins that displayed increased (›) or decreased (ﬂ) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors Hum Mol...

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Báo cáo hóa học: " Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study" doc

Ngày tải lên : 19/06/2014, 08:20

... Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism ... freezing of gait in parkinsonism, proposed working definition, and setting the stage Mov Disord 2008, 23(2) :S4 23-425 Backer JH: The symptom experience of patients with Parkinson s disease J Neurosci ... clinician-rated measures assessing frequency and severity of FOG, as well as situations that elicit freezing, such as walking through narrow spaces and turning, since very few freezing events...

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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx

Ngày tải lên : 19/06/2014, 08:20

... assessment of falls in Parkinson' s disease Journal of Neurology 2001, 248:950-958 Gray P, Hildebrand K: Fall risk factors in Parkinson' s disease J Neurosci Nurs 2000, 32:222-228 Ashburn A, Stack ... (60 seconds) is accomplished Best value is registered Time is registered in seconds, and gaitspeed is calculated as meters per second (m /s) A digital stopwatch is used In the study by Smithson ... minutes in- between the tests (eyes open, eyes closed) The same test order was maintained during the DBS OFF and ON measurements In every test situation, spontaneous sway was recorded for 30 seconds...

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báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx

Ngày tải lên : 19/06/2014, 22:20

... Hirsch EC: FADD: A link between TNF family receptors and caspases in Parkinson' s disease Neurology 2002, 58:308-310 Knott C, Stern G, Wilkin GP: Inflammatory regulators in Parkinson' s disease: iNOS, ... tracersdays measured6-OHDA lesion of dopamine terminal loss and inflammaA) Using A) Using micro-PET and selective radioactive tracers we measured in vivo the extent of dopamine terminal loss and inflammatory ... on selected sections that verified the specificity of staining After immunostaining, floating tissue sections were mounted on glass slides and counterstained with cresyl violet before dehydrating,...

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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx

Ngày tải lên : 19/06/2014, 22:20

... attenuates MPTP-induced loss of THpositive neurons and neuronal terminals in the nigrostriatal system Because of possible unintended confounding effects associated with oral administration of COX-2 inhibitors ... loss instead of a loss of TH expression To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, ... reducing the risk of neurodegenerative disease such as Alzheimer 's disease [8,18] and PD [19] In the present study, we tested the hypothesis that excessive COX-2 aggravates MPTP-induced toxicity by...

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báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot

Ngày tải lên : 19/06/2014, 22:20

... model of prion disease [70] All of these findings suggest that CD200CD200R signalling plays an important role in the pathogenesis of neurological disorders, including PD Previously, we always used ... Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University School of medicine, 225 South Chong Qing Road, ... idiopathic parkinsonism Neurosci Lett 2008, 441:158-162 Nagatsu T, Sawada M: Biochemistry of postmortem brains in Parkinson s disease: historical overview and future prospects J Neural Transm Suppl...

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Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt

Ngày tải lên : 10/08/2014, 05:21

... pathogenesis of gait hypokinesia in Parkinson' s disease Brain 1994, 117(Pt 5):1169-1181 Morris ME, Iansek R, Matyas TA, Summers JJ: Stride length regulation in Parkinson' s disease Normalization strategies ... Performance scoring system in the analysis of Parkinson gait NeuroRehabilitation 2002, 17:255-262 Paquet JM, Auvinet B, Chaleil D, Barrey E: Analysis of gait disorders in Parkinson' s disease assessed ... CatWalk system, has been used to detect footfall patterns, as well as selected time and distance measurements of persons with early-stage Parkinson' s disease [41] The GaitRite system comprises an...

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Báo cáo khoa hoc:" Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson''''s disease in two European populations" pps

Ngày tải lên : 11/08/2014, 08:20

... epidemiology of Parkinson' s disease in the county of Rogaland, Norway Movement Disorders 1995, 10:541-549 Larsen JP, Dupont E, Tandberg E: Clinical diagnosis of Parkinson' s disease Proposal of diagnostic ... patients and controls were determinated by using DHPLC analyses (WAVE® system, Cheshire, UK, using software Wavemaker 4.1) according to established procedures Statistical analyses SNP frequencies ... mutation of the PINK1 in our cohorts composed of patients suffering from late-onset form of PD The risk to miss potential mutations was minimized by a well established and optimized SSCP analyses The...

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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx

Ngày tải lên : 14/02/2014, 17:20

... in these positive symptoms of PD ANIMAL MODELS OF PARKINSON S DISEASE AND PARKINSONISM Early animal models of PD were based on lesions of midbrain areas in monkeys (Poirier et al., 1975) These ... Interestingly, loss of function mutations in 12 PARKINSON S DISEASE AND PARKINSONISM PINK1 in Drosophila causes male sterility, muscle wasting, dopaminergic neuronal degeneration, and increased ... misfolds, oligomerizes and aggregates, is resistant to UPS-mediated degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES...

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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot

Ngày tải lên : 05/03/2014, 23:20

... this time 3.2 Dyskinetic Disorders In disorders associated with dyskinesias, basal ganglia output is thought to be reduced, resulting in disinhibition of thalamocortical systems and dyskinesias ... explain several key findings in animals and humans with such disorders The most serious shortcoming of the aforementioned scheme of parkinsonian pathophysiology is, perhaps, that changes in the spontaneous ... that of basal ganglia neurons Reports of movement disorders secondary to extrastriatal pathology should therefore come as no surprise 3.1 Parkinson s Disease Early idiopathic Parkinson s disease...

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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf

Ngày tải lên : 14/03/2014, 22:20

... these nuclei may be responsible for the bradykinesia seen in patients with Parkinson' s disease (Figure 2) Parkinson s disease Any discussion of the clinical characteristics of Parkinson' s disease ... progressive Parkinson' s disease Ann Neurol 1994;35:172–80 Parkinsonian syndromes Mark MH, Sage JI, Walters AS, et al Binswanger 's disease presenting as levodopa-responsive parkinsonism: Clinicopathologic ... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement...

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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot

Ngày tải lên : 14/03/2014, 22:20

... PARKINSON S DISEASE Figure Parkinson s disease: substantia nigra showing depletion of tyrosine hydroxylase (immunostained for tyrosine hydroxylase) Courtesy of S. E.Daniel, The Parkinson s Disease ... ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 11 Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist ... disease Any discussion of the clinical characteristics of Parkinson s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical...

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ETIOLOGY AND PATHOPHYSIOLOGY OF PARKINSON''''S DISEASE pot

Ngày tải lên : 27/06/2014, 19:20

... Pathophysiology of Parkinson' s Disease Genetics of Parkinson Disease 19 The classic approaches of linkage analysis and positional cloning have been very successful strategies to identify genes causing the ... Etiology and Pathogenesis of Parkinson s Disease Taku Hatano and Nobutaka Hattori Chapter Genetics of Parkinson Disease 15 Celeste Sassi Chapter Parkin and Parkinson s Disease 47 Shiam-Peng Tay, Grace ... Distruption of the Ca2+ homeostasis has recently been Genetics of Parkinson Disease 31 proposed of a possible cause of selective vulnerability of dopaminergic neurons in PD Associated SNPs in the BST1...

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Báo cáo hóa học: " Audio-Biofeedback training for posture and balance in Patients with Parkinson’s disease" doc

Ngày tải lên : 19/06/2014, 08:20

... net training time of 30-45 minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate the effects of training Balance ... training; this task was trained during the sessions and reflects a training specific change Patients scored less (better) on the GDS (p = 0.05) and PDQ-39 scales, which suggests less depressive symptoms ... rise (5CR) test was used to assess the ability to perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting...

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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx

Ngày tải lên : 19/06/2014, 22:20

... of increased levels of cytokines in the brains of Alzheimer 's disease patients, and in transgenic mouse models of Alzheimer 's disease [10-12] However, all these reports have focused on a small ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page ... GM-CSF Figure Cytokine production by brain slices from transgenic mouse models of AD at 15 months of age Cytokine production by brain slices from transgenic mouse models of AD at 15 months of...

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

Ngày tải lên : 18/02/2014, 14:20

... calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry ... DES, desaturase; GALC, galactosylceramidase; GBA, glucosylceramidase; GCS, glucosylceramide synthase; SMS, sphingomyelin synthase; SMse, sphingomyelinase; SPT, serine palmitoyl transferase Yellow ... intracellular cholesterol trafﬁcking Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher s disease ⁄ Parkinson s disease in heterozygotes Neurodegeneration...

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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Ngày tải lên : 16/03/2014, 11:20

... as salsolinol [23] In line with the suggested role of ADHs and ALDHs in protection against toxic insults, mRNAs encoding these enzymes have previously been identiﬁed in tissues forming a physiological ... Vos RA, Del Bohl J & TK (2006) Gastric alpha-synuclein immunoreactive inclusions in Meissner s and Auerbach s plexuses in cases staged for Parkinson s disease- related brain pathology Neurosci ... the Swedish Parkinson Foundation, Swedish Brain Power, Bjorn ¨ Oscarssons Stiftelse, USPHS grants and Karolinska Institutet Funds The Adh4 knockout mice were kindly provided by Dr Gregg Duester...

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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc

Ngày tải lên : 18/06/2014, 15:20

... References 10 Twelves D, Perkins KS, Counsell C: Systematic review of incidence studies of Parkinson' s disease Movement Disord 2003, 18:19-31 Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin ... release, RPE cells were depolarized with high potassium (56 mM K+) and the buffer was subjected to HPLC assay Figure HPLC analysis of the synthesis and release of DA by RPE cells HPLC analysis of ... used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at p < 0.05 Results RPE-CM protects against rotenone and...

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