dendritic cells and their role in linking innate and adaptive immune responses
Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
... (reviewed in [27]) and, in particular, the role of leptin in immune responses and inflammation has lately become increasingly evident Altered leptin production during infection and inflammation ... effects on cells involved in the immune and inflammatory responses However, the connection between leptin, immune responses and inflammation in vivo is complex Indeed, leptin/leptin receptor ... protein inhibitor of activated STAT3; Raf, MEK-kinase; Ras, G-protein; SHP-2, SH2-domain containing protein tyrosine phosphatase; SOCS3, suppressor of cytokine signalling-3 inflammatory and anti-inflammatory...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases Editor ... effective vaccines or immunotherapies requires potent immune activating strategies at the interface of innate and adaptive immunity 2.2 2.2.1 Infection and Innate Immunity Neutrophils In the presence ... protection after infection Obviating the predominant role of TLR’s in initiating innate IL-12 production in the presence of parasite derived molecules TLR2 has been found to be involved in the development...
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Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
... 2009, 6:56 tries [16-19] Both macrophages and DCs perform crucial roles in linking innate and adaptive immunity and augmenting the immune response to HSV-1 infection It was previously shown that ... STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... DCs and macrophages in cultures BM cells were isolated by flushing femurs and tibiae with PBS Pelleted cells were briefly resuspended in water to lyse red blood cells and stabilized by adding...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
... 2009, 6:56 tries [16-19] Both macrophages and DCs perform crucial roles in linking innate and adaptive immunity and augmenting the immune response to HSV-1 infection It was previously shown that ... STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... DCs and macrophages in cultures BM cells were isolated by flushing femurs and tibiae with PBS Pelleted cells were briefly resuspended in water to lyse red blood cells and stabilized by adding...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... resulting in the killing of 39 Chapter 1: Introduction these infected cells Under these circumstances, the dying cells, CD8 T -cells and other APCs such as macrophages and DCs within the inflammatory ... primary instigators of the adaptive immunity as they are vital for detecting, alerting and priming the adaptive immune system to invading pathogens (Banchereau et al., 2000; Banchereau and Steinman, ... early phases of infection (Gazzinelli et al., 1994) It also plays an important role by activating bystander resting T cells and maintaining the antigen specific Th1 response (Kubin et al., 1994)...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... during diabetes, causing protein cross -linking and advanced glycation end-products (AGE), a change engendered by methylglyoxal interaction with lysine and arginine residues [51] Glycation in ... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency ... disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion body construction independent of intermediate fialments [62] Interestingly,...
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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... 20 Fernandez , Martinez and Saurina (2000) study cyclical behaviour of bank loans, loan losses and loan loss provisions in Spain and show that housing prices, asset prices and lending margins have ... are found in the following industries: Agriculture and forestry (code 111) in 1990-1992, Raising of fish (code 051) in 1988-1993, Fishery (code 052) in 1988-1993, Publishing, printing and reproduction...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... overlapping ligand-binding pockets The difference of the binding pocket is easy to understand by looking at the superimposition between PonA and BYI06830 shown in Fig Ligand-binding affinity Typically, ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...
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báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx
... institutional review board obtained) was isolated and maintained in TIL Media I medium with 10% heat-inactivated FCS, mM L-glutamine, 100 U/ml penicillin, and 0.1 mg/ml streptomycin The HCC cells ... assay Methods Cell lines K562 cells (American Type Culture Collection) were maintained in DMEM medium Colorectal carcinoma cell lines (COLP-2 and COLM-6) were maintained in TIL Media I medium ... IFN-γ in both CD4+ and CD8+ T cells and T-cell proliferation; 3) enhanced induction of CEA and/ or WT1-specific CTL responses; and 4) augmented CTL activity against autologous HCC cells in vitro...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... muscle cells, monocytes and T cells via RAGE, resulting in the generation of cytokines and proinflammatory adhesion molecules [24,67,68] Conclusion RAGE and its ligands play essential roles in inflammation,...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are ... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
... laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b -cells and in insulin target cells are associated with ... replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin receptor, and hence, protein ... on insulin signaling and coronary heart disease Insulin and zinc ions have potent stimulatory effects on lipogenesis and glucose uptake Zinc-deficient animals are less sensitive to insulin Zinc...
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Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps
... TLR9-expressing cells) includes myeloid and pDCs, macrophages and MZ-B cells in mice, and pDCs, MZ-B cells and memory B cells in humans, which can respond directly and without priming to both single-stranded ... Surprisingly, chromatin-containing immune complexes in lupus sera were capable of inducing proliferation of rheumatoid factor-specific B cells (AM14-transgenic B cells) and DNA-specific B cells ... switching toward complement-fixing IgG isotypes (e.g IgG2a, IgG2b and IgG3 in mice; IgG1 and IgG3 in humans) This suggests that T cells and BAFF-producing antigen-presenting cells may play an indispensable...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer ... shown Severity scoring was done on sections stained with hematoxylin and eosin Boxes indicate areas that are magnified in BMP2 stainings Arrows indicate BMP2-positive cells in synovium Bars =...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical ... papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous cystadenocarcinoma; F: Maspin expression in mucinous cystadenoma The...
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Báo cáo y học: " Eradication of intractable malignant ascites by abdominocentesis, reinfusion of concentrated ascites, and adoptive immunotherapy with dendritic cells and activated killer cells in a patient with recurrent lung cancer: a case report" pps
... effect in the abdominal cavity Intravenous and intrathoracic inoculation of immune cells causes accumulation of effector cells in the thoracic cavity, but not in the abdominal cavity Intra-abdominal ... protein level was maintained between 5.5 and 6.2 g/dl, notwithstanding the repeated drainage of ascites once a week for months Chills and fever for 20 to 30 minutes beginning soon after the initiation ... 3) Cells from TDL consist mainly of CD8-positive and CD4-positive T cells and CD83-positive dendritic cells TIL consists mainly of CD8positive T cells After the second drainage of ascites, we infused...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising ... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie...
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báo cáo khoa học: " Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism" pdf
... recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of male and ... position -30 in the 5'UTR, (ACAAAAAAGG) position 1083 in the second intron, and (TCAAAAAAGG) position 3052 in intron We detected a single potential LEAFY binding site (CCATTGT) in the second intron ... genes in their native context SpAGAMOUS retains floral organ identity and meristem determinacy functions in spinach A single C class gene has been previously described in Spinacia oleracea and...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins ... sensing Cell 1999, 98: 281–284 Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J, May L, Stern D: Induction of interleukin (IL-6) by hypoxia in vascular cells: central role of the binding...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... Opitz B, Lamping N, Michelsen KS, Zahringer U, Gobel UB, Schumann RR: Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses ... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase in TLR4 signaling came from the study of TRAF6 and NF-κB-inducing kinase dominant-negative (DN) variants, which could...
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