delivery bioavailability of medicinal drugs
Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs
... solubilizer, bioavailability enhancer of hydrophobic drugs (Traber et al., 1994) TPGS can also enhance the oral bioavailability of anticancer drugs by improving the solubilization or emulsification of ... Approaches for delivery of peptide/protein drugs 2.2.3.1 Parenteral delivery Due to the poor absorption and low bioavailability by all non-parenteral routes for effective systemic delivery of peptide/protein ... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS BY LEE SIE HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF MASTER...
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Detection of Antiviral Drugs Oseltamivir Phosphate and Oseltamivir Carboxylate in Neya River, Osaka, Japan
... periods may result to the development of oseltamivir-resistant influenza viruses Furthermore, Japan is at the top of the list of countries for per capita consumption of Oseltamivir (Soderstrom et al., ... drastic increase in antiviral drugs consumption It is therefore worthy to monitor the drugs in surface waters in the winter season to get more insight of whether the drugs really exist in alarming ... ST-2 from the 34th week of 2009 to the 7th week of 2010 period were obtained from Osaka Prefectural Institute of Public Health (2010) An index value gives the total number of influenza cases (average)...
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Risks Associated with Overcollection of Medicinal Plants in Natural Habitats
... excess of auxin will often result in a proliferation of roots, while an excess of cytokinin may yield shoots A balance of both auxin and cytokinin will often produce an unorganized growth of cells ... and Sell Heirloom Seeds of Rare and Endangered Medicinal and Other Plants Because of the loss of crop diversity with the advent of the green revolution and the breeding of crop varieties grown ... over the future of the resource 15.2.2 Organizations Involved in Conservation of Medicinal Plants and Their Ecosystems The important topic of ethnobotany and the sustainable use of plant resources...
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Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx
... chemical instability of DNA To protect the vital genetic information from the deleterious effects of DNA injury a network of genome care-taking mechanisms has evolved of which a set of DNA repair systems ... hyperplasia was observed as a significant increase of splenic B-cells Furthermore, loss of Ung also causes a reduction of T-helper cells, and 50% of the young Ung–/– mice investigated have no detectable ... major mechanism for repair of oxidative DNA damage Xeroderma pigmentosum (XP) C is involved in the recognition of a variety of bulky DNA distorting lesions in NER of the genome overall We show...
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Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States pdf
... Mode of Delivery to Reduce Perinatal Transmission of HIV .G-8 Table Recommended Neonatal Dosing for Prevention of Mother-to-Child Transmission of HIV H-12 Recommendations for Use of ... (HHS) Panel on Treatment of HIVInfected Pregnant Women and Prevention of Perinatal Transmission (a Working Group of the Office of AIDS Research Advisory Council) Members of the Panel Erika Aaron, ... States The Department of Health and Human Services Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission, a working group of the Office of AIDS Research Advisory...
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Programmatic update Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants pptx
... optimize the use of ARVs and standardize the first-line treatment regimen (8,9); •• reassuring data on the safety of efavirenz in pregnancy (10); and •• the decreasing cost of ARV drugs (11,12) ... changing, and a number of high-burden countries are considering moving from Option A to Option B or B+ Costs The cost of ARV drugs was a major determinant in countries’ choice of a PMTCT option In ... ARV drug cost of Option B was three to five times higher than the cost of Option A (depending on regimen and assuming the provision of both ART and prophylaxis) However, by the end of 2011, this...
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On 2001 survey of medicinal plants in bavi national park
... frequency of occurrence of Important Medicinal Species in each of six classi®cation groups, and modal abundance of individuals per 0.05 transect is given below Three other Important Medicinal ... observations on the use of medicinal plants from primary and secondary growth by the Runa of eastern lowland Ecuador Journal of Ethnobiology 12, 141±152 Le, T C (1997) Conservation of Medicinal Plants ... complete set of reference specimens is lodged with the Herbarium of the Hanoi College of Pharmacy (HNP) Throughout the paper, reference is made to a subset of MPs, the Important Medicinal Plant...
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Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt
... on finding such a delivery system Applying novel delivery systems to RDO transfer Fig RDO delivery systems and transfer barriers decreased to 40% of normal, showing the effect of RDO conversion ... DIRECTIONS: OPTIMIZING RDO DELIVERY SYSTEMS An ideal RDO delivery system should have little or no toxicity and high efficiency It should be an all-round delivery system that can pass delivery barriers ... improves the relative efficiency of RDOs However, these modified delivery systems are not ideal, because of instability in serum or toxicity to cells Recently, several novel delivery systems have been...
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creating optimal service delivery strategy of long-term service agreements from risk management perspective
... 68 4.1 Flow chart of a simulation of a deterioration process of a system 87 4.2 The confidence interval of the expected total cost of OP T when the range of threshold values of the system is ... part of the service delivery The rigorous framework for the service delivery of LTSAs provides a new understanding of the criticality and the importance of the interactions between the fields of ... nature and the risks of the service delivery Risks of the service delivery pertain to adverse events that might affect the provider’s service delivery Without total comprehension of challenges and...
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báo cáo hóa học: " Uniform comparison of several drugs which provide protection from noise induced hearing loss" docx
... drug group The results of these experiments can lead to possible treatment strategies and, in addition, based on knowledge of the presumed mode of action of the different drugs, it was hoped that ... due to the protective effect (conditioning) of the restraint and injection of the animals [13] Differences in the degree of effectiveness of these drugs in the present study, compared to those ... already been shown that the injection of these drugs at the doses used, not produce a permanent hearing loss, i.e they are not ototoxic [5,9,10] Since some of the drugs were in saline solution and...
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Báo cáo hóa học: " Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors" docx
... Briefly, 100 µl of liposome sample was mixed with 225 µl of cold methanol and 125 µl of chloroform Phase separation was achieved by adding 125 µl of 0.1 M HCl and 125 µl of chloroform After mixing ... The challenge of drug delivery is the liberation of adequate doses of therapeutic agents to a specific target site at the right time in a safe and reproducible manner [11] A number of mechanisms ... of these have been designed for specificity Taking into account the peculiarities of pRBCs, lipid-based nanocarriers have been one of the most promising approaches for the targeted delivery of...
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The Constituents of Medicinal Plants potx
... CONSTITUENTS OF MEDICINAL PLANTS Functional groups Another feature of organic compounds is the presence of functional groups These are groups of atoms attached to carbon chains or rings which are often ... Flavonoids offer the advantage of a high margin of safety and lack of side effects such as ulcerogenicity over the classical antiinflammatory drugs Diseases associated with increased permeability of ... genistein—an isoflavone 38 • THE CONSTITUENTS OF MEDICINAL PLANTS Clinical trials have supported the efficacy of isoflavones such as genistein, found in soymilk and other soy products, in prevention of breast...
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synthesis of commercial drugs 2011 - 12
... SYNTHESIS OF TAMIFLU (oseltamivir phosphate) Oseltamivir : structure design Goal of the design : establishment of a competitive inhibitor of the sialic acid preparation of an analogue of the transition ... SYNTHESIS OF LIPITOR (atorvastatin calcium) The enantioselective synthesis of atorvastatin calcium: the solution Synthesis of Paal-Knorr precursor Synthesis of Paal-Knorr precursor 14 SYNTHESIS OF LIPITOR ... LIPITOR (atorvastatin calcium) The story of statins drugs Potent inhibitors of HMG-CoA reductase 11 SYNTHESIS OF LIPITOR (atorvastatin calcium) The synthesis of atorvastatin lactone Me O O Cl O F...
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Báo cáo khoa học: " Pharmacokinetics and bioavailability of doxycycline in ostriches (Struthio camelus) at two different dose rates" potx
... nevig saw dna gurd eht gniretsinimda erofeb h 21 rof dlehhtiw saw dooF ebut hcamots a hguorht yllaro nevig saw dna ,ylevitcepser ,noitartsinimda MI dna VI rof elcsum ciretnahcortoili dna niev laihcarb ... sisylana gurD )CLPH( hpargotamorhc diuqil ecnamrofrep hgih eht otni yltcerid detcejni saw tnatanrepus raelc ehT g 0001× ta nim rof degufirtnec dna s 03 rof dexetrov saw erutxim ehT elpmas dradnats ... scitenikocamrahP .seiceps lamina rehto morf deniatbo erew nosirapmoc rof desu sCIM eht ,eroferehT sehcirtso ni smsinagroorcim elbitpecsus rof sCIM enilcycyxod eht no stroper on era erehT ]41[ )lm/gµ 23-8(...
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Báo cáo khoa học: "Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats" pdf
... demrofrep LA1050-PV rof alumrof eninala dica onima eht yb ytilibaliavaoib fo tnemevorpmi ehT etadidnac gurdorp wen a rof yrotcafsitas erew amsalp ni noitartnecnoc fo ecnanetniam eht dna ,mrof ... noitartsinimda laro eht roF esod eht si D dna noitartnecnoc amsalp eht si C erehw ,t · lek-pxe · dV/D = )t(C saw noitcejni suonevartni rof amsalp ni noitartnecnoc eht rof alumrof ehT noitaterpretni ... fo esod a ta noitcejni suonevartni gniwollof amsalp eht ni dnuof ylidaer saw ti ,revewoH gk/gm 001 fo etar esod a ta star ot noitartsinimda laro gniwollof amsalp eht ni detceted ton saw 2050-PV...
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Báo cáo y học: "Primary care use of antipsychotic drugs: an audit and intervention study" ppt
... recent study of one sixth of the population of Italy reported that one in 50 elderly people were prescribed antipsychotic drugs during a single year, two-thirds being conventional drugs [21] In ... a significant burden of motor side effects Our patients' experience of worsening of symptoms and antipsychotic withdrawal syndromes is of particular concern Re-emergence of symptoms for which ... the lack of tolerability and poor efficacy of carbamazepine compared to valproate semi-sodium, its induction of enzymes reducing antipsychotic levels, the mutually antagonistic effects of risperidone...
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Báo cáo y học: "Indigenous knowledge of medicinal plants used by Saperas community of Khetawas, Jhajjar District, Haryana, India" doc
... of the present study was to document and analyze medicinal plants knowledge of the Saperas ethnic group, which they use for the treatment of snakebite and other type of diseases Description of ... plant medicine as dilutant The mixing of oil of these four plants for preparation of drugs was also reported in Kani tribals of Tamil Nadu [27] Healers of Saperas community also mix sugar in ... little knowledge of medicinal plants Similarly, literate person of the area were found to have less knowledge of medicinal plants as compared to illiterate ones due to lack of their interest...
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Báo cáo y học: "An ethnobotanical survey of medicinal plants in Babungo, Northwest Region, Cameroo" docx
... in the list of medicinal plants is the Asteraceae with 12.1% of the medicinal plants species followed by Lamiaceae and Poaceae with 5.6% each Herbs made up 57% of the total number of medicinal ... the help of the traditional ruler and some of the elders of the tribe A total of 17 TMP’s were interviewed amongst whom were literate Their ages range from 28 to 70 years with more of them in ... located in the grassland Simbo Journal of Ethnobiology and Ethnomedicine 2010, 6:8 http://www.ethnobiomed.com/content/6/1/8 Page of Table Non medicinal uses of medicinal plants in Babungo Scientific...
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Báo cáo y học: "The use of medicinal plants in the transhimalayan arid zone of Mustang district, Nepal" pps
... other medicinal plants of the Himalaya A paste of the roots is applied for allergy, boils, cuts, wounds and edema after mixing with other medicinal plants Page of 11 Different categories of use ... great depth of knowledge on the subject of medicinal plants Medicinal plants still play a pivotal role in the primary healthcare of the local people in the study area Due to the lack of Western ... effective monitoring of the local community resources will be the fundamental ingredient of in situ conservation of medicinal plants in Mustang Over-harvested populations of medicinal plants from...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25