... by special-
ized cells in the wall ofthe afferent ar-
teriole ofthe renal glomerulus. These
cells belong to the juxtaglomerular ap-
paratus ofthe nephron, the site of con-
tact between afferent ... membranous
sacs ofthe sarcoplasmic reticulum (SR);
c) Ca
2+
bound to the inside ofthe plas-
malemma. The plasmalemma of cardio-
myocytes extends into the cell interior
in the form of tubular invaginations
(transverse ... conditions of license.
Overview of Modes of Action (A)
1. The pumping capacity ofthe heart is
regulated by sympathetic and parasym-
pathetic nerves (pp. 84, 105). Drugs ca-
pable of interfering...
... intermediate by the unique action ofthe serpin,
whereby the RCL ofthe serpin inserts into the major
A b -sheet causing the protease to be rapidly translo-
cated from the top to the bottom ofthe inhibitor ... polymers of serpins, where the insertion of
another molecule’s RCL takes place [8]. Both of these
result in the irreversible inactivation (generally) of the
serpins, and, in the case ofthe anticoagulant ... many ofthe principal procoagulant compo-
nents ofthesystem are serine proteases, regulation of
thesystem is principally by the action of serine protease
inhibitors. One major class of serine...
... interaction between the ongoing contraction process ofthe
cardiac muscles and the properties ofthe arterial system and is beyond the scope of this lecture.
As the contraction process ofthe cardiac ... arteries, the pulmonary
capillaries and pulmonary veins and the systemic vascular system which contains the left
ventricle, the systemic arteries, the systemic capillaries and the systemic veins. ... anything about the way the
ventricle works. The upper left hand
corner of each loop falls on the ESPVR,
while the bottom right part ofthe loop
falls on the EDPVR. In the panel on the
right,...