defining covariate distribution models for clinical trial simulation
Báo cáo khoa học: "Lexically-Triggered Hidden Markov Models for Clinical Document Coding" pot
Ngày tải lên :
07/03/2014, 22:20
... and effective approach for clinical document coding The LT-HMM takes advantage of lexical triggers for clinical codes by operating in two stages: first, a lexical match is performed against a trigger ... application we have chosen the task of assigning ICD-9-CM codes to free-form clinical narratives We use the dataset collected for the 2007 Medical NLP Challenge organized by the Computational Medicine ... research in the area and to assess the current level of performance on the task Forty-four teams participated in the challenge The top-performing system achieved micro-averaged F1-score of 0.8908,...
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Báo cáo y học: "Osteoarthritis subpopulations and implications for clinical trial design" pptx
Ngày tải lên :
12/08/2014, 15:22
... to avoid multiple testing Combining trials for meta-analysis has the potential to search for subgroup effects For reliable subgroup meta-analysis, individual trials have to supply subgroup effects ... factors certain OA subgroups, such as osteotomy for uni om c part ent malaligned knee OA However, to design such m trials for every suspected subgroup for the available treat ments would take many ... retrieved from the authors For a valid interpretation of these results, a stratified randomisation by subgroup factor in the individual trials is needed, or information on the distribution of prognostic...
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Báo cáo y học: "Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment" pdf
Ngày tải lên :
13/08/2014, 13:20
... Primer Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward ... Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Sequence (5'-3') °C Product ... polymerase activation step and continued for 40 cycles at 95°C denaturation for 20 sec, annealing for 30 sec and elongation at 72°C for 30 sec with a final extension for at 72°C Annealing temperatures...
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Exploring Challenges, Progress, and New Models for ENGAGING THE PUBLIC in the CLINICAL RESEARCH ENTERPRISE Clinical Research Roundtable Workshop Summary pot
Ngày tải lên :
29/03/2014, 13:20
... Health Associations (VHAs) inform patients about the availability of clinical trials, recruit patients to trials, sometimes conduct or fund trials, and provide information about research results ... Engaging the public in clinical research is difficult before people actually have a disease and see a trial as a potential last hope Models for engaging the public in the clinical research enterprise ... Contents Foreword ix Workshop Summary 1 Priorities for Engaging the Public in the Clinical Research Enterprise Workshop Introduction, Priorities for Engaging the Public, Key Issues Facing the Clinical...
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Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot
Ngày tải lên :
18/06/2014, 16:20
... initially enrolled in this clinical trial are shown in this table All patients had relatively good performance status (PS) and had previously undergone treatments (Tx), for example surgery (S), ... 5) Discussion A phase I clinical trial was performed using an HLAA*2402-restricted epitope-peptide derived from gp100 to examine its safety as a primary endpoint and clinical and immunological ... very high at the score of 240.0, when the analysis was performed with the computerbased program for molecular analysis section (BIMAS) for HLA peptide binding predictions [26] Thus, gp100in4 might...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
Ngày tải lên :
19/06/2014, 08:20
... randomized control trials [8], they demonstrate the feasibility of the application of VR technology in this clinical field In regard to standing balance, systems based on force platforms are particularly ... efficacy Therefore, we designed eBaViR, a virtual rehabilitation system for balance recovery that provides motivational task oriented exercises specifically designed for ABI people by clinical therapists ... (ANOVAs) with time (before and after rehabilitation) as the within-subjects factor and treatment option (control versus trial) as the between-subjects factor were performed for each of the balance...
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Báo cáo khoa học: "Choosing simplified mixed models for simulations when data have a complex hierarchical organization. An example with some basic properties in Sessile oak wood (Quercus petraea Liebl.)" ppsx
Ngày tải lên :
08/08/2014, 14:20
... system or by enhancing future crop tree growth in high forest regimes) For these reasons, there is an increasing need for integrated simulation models, providing detailed outputs in terms of stand ... equations present the model we have finally obtained for the density Models for the other properties are not presented for overcrowding reasons The model for the density of cube j within the tree i is ... that it theoretically allows comparing kinds of models (nested or not) for a given data set Unfortunately, their properties have been established for a number of observations that tend to infinity...
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Báo cáo y học: "Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosu" ppt
Ngày tải lên :
09/08/2014, 08:22
... patients available for analysis for each body system) Since the first evaluation was scheduled for weeks, the earliest time to improvement is at least 42 days Page of 11 (page number not for citation ... Except for the aforementioned deviations, all patients received post-treatment evaluations at 6, 10, and 18 weeks One patient was lost to follow-up after 18 weeks, while 13 patients returned for ... shorter lasting Therefore, it is very likely that cyclical therapy will be needed to provide long-term benefit for patients with SLE While the immunogenicity of rituximab has not been clinically important...
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Báo cáo y học: "Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy" pptx
Ngày tải lên :
10/08/2014, 10:20
... randomized clinical trial protocol study in humans for the local therapy in CTS: cortisone versus progesterone Recommendations And Methods The study is designed as a monocentric randomized clinical trial ... paragraphs) Patients who are eligible for participation will be informed about the trial by the neurologist If they show interest, they will receive written information about the Milani et al Journal ... information about the trial is also missed to the general practitioner of the patient Clinical criteria Patients with suspected CTS referred to our electrodiagnostic laboratory to confirm clinical...
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Báo cáo y học: " Treatment of forefoot problems in older people: study protocol for a randomised clinical trial comparing podiatric treatment to standardised shoe advi" potx
Ngày tải lên :
10/08/2014, 21:24
... care treatments for forefoot problems, ensuring a high external validity of this trial Trial registration: Netherlands Trial Register (NTR): NTR2212 Background Pain and discomfort due to foot ... older with disabling forefoot pain The secondary objective is to conduct a process evaluation of the podiatric treatment provided for forefoot pain in this trial Method Trial design This study ... are no evidence-based estimates for clinically important change in assessing forefoot pain or for Page of clinically relevant differences between interventions for chronic foot pain In a previous...
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Báo cáo y học: "Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia" potx
Ngày tải lên :
11/08/2014, 15:22
... their authorized representatives signed written informed consent prior to participation in the trial (F1D-MCHGJZ; NCT00088478; http://clinicaltrials.gov/ct2/show/ NCT00088478?term=olanzapine+depot&rank=3) ... assess for differences between Early Responder and Early Non-responder groups, baseline characteristics for each group were compared using Fisher’s exact test for categorical variables and t-test for ... study discontinuation for any reason were higher for Early Non-responders than for Early Responders (25.0% versus 17.5%, p=.007) LS mean change from baseline in PANSS Total score for patients identified...
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Báo cáo y học: " A randomized, controlled clinical trial: The effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized trial" pdf
Ngày tải lên :
11/08/2014, 16:21
... randomized, controlled clinical trial including 9-month post-treatment follow-up is proposed Participants screened positive using the Structure Clinical Interview for DSM-IV (SCID) for general anxiety ... way that group intervention can be delivered and inform future research Unique Trail Number (assigned by Centre for Clinical Trails, Clinical Trials registry, The Chinese University of Hong Kong): ... randomized, controlled clinical trial: The effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized trial Samuel YS Wong1§,...
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Báo cáo y học: " Future oriented group training for suicidal patients: a randomized clinical trial" pot
Ngày tải lên :
11/08/2014, 17:20
... manual for the Outcome Questionnaire (OQ-45.2) Stevenson, MD: American Professional Credentialing Services; 1996 Everitt B, Wessely S: Clinical Trials in Psychiatry Oxford University Press: Oxford; ... provided information about the different aspects and dynamics of suicidal thinking and behavior, but only a few interventions for suicidal patients have been evaluated in randomized clinical trials ... in the Netherlands, but they all are developed for specialized settings and specific patient groups A reason for us to develop an intervention for a broad group of patients with suicidal thoughts...
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báo cáo khoa học:"The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation" docx
Ngày tải lên :
11/08/2014, 23:23
... (1th level) coded as for the first (immediately before discharge from hospital) follow-up, as for the second (3month) follow-up, as for the third (6-month) follow-up and as for the fourth (12-month) ... appointments for other problems, such as flu symptoms) will be combined for analysis Covariates CVD-related past and actual perceived stress Along with the collection of demographic and clinical ... opportunities for emotional expression in their social environments [36] Methods Study design A four-arm randomized controlled clinical trial with four follow-up assessments (immediately before discharge...
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Báo cáo y học: "High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial" pptx
Ngày tải lên :
12/08/2014, 14:20
... phase II clinical trial (Chest Wall Oscillation for Asthma and COPD ExacerbaTions [COAT] Trial) was therefore to evaluate the use of HFCWO early in the treatment of adults hospitalized for acute ... asthma and COPD, so no formal sample size calculations were performed Results of this study were intended to provide the information needed for sample size calculations for subsequent studies ... used to inform the design of larger-scale, more definitive trials testing the efficacy of HFCWO on clinical endpoints (e.g., feasibility of using HFCWO for acute asthma or COPD, need for a sham-control,...
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Báo cáo y học: "Amount of health care and self-care following a randomized clinical trial comparing flexion-distraction with exercise program for chronic low back pain" pptx
Ngày tải lên :
13/08/2014, 14:20
... in a clinical trial on low back pain Mayer et al completed a randomized clinical trial com- http://www.chiroandosteo.com/content/14/1/19 paring a rehabilitation and pain management program for ... care utilized outside of a clinical trial However, no investigator has determined the amount of health care utilized for back pain after participation in a clinical trial on chiropractic care ... different However, no statistical analyses were performed on these measures to determine significance Various clinical trials on chiropractic care for low back pain have tracked the use or non-use...
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Báo cáo y học: "Neuro Emotional Technique for the treatment of trigger point sensitivity in chronic neck pain sufferers: A controlled clinical trial" ppsx
Ngày tải lên :
13/08/2014, 14:20
... (pre-post for VAS scores and post-pre for PGA measurements We used GenStat (Payne et al, 2008) for these analyses, with the package testing for treatment variances automatically before testing for ... Randomised controlled trials are the gold standard in evidence based research for efficacy and causal relationship, whilst quasi-experimental studies provide evidence for clinical effectiveness ... the amount of pressure the patient could sustain before the patient registered the pressure as being painful These assessments were performed before and after the intervention The pain threshold...
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Báo cáo y học: "Chiropractic and self-care for back-related leg pain: design of a randomized clinical trial" docx
Ngày tải lên :
13/08/2014, 15:21
... subgroup analyses of two trials of SMT for chronic LBP (including BRLP) performed by the investigators of this trial [35,36] Both trials observed medium to large effect sizes for pain reduction in ... minimization for allocation to clinical trials a review Control Clin Trials 2002, 23:662-674 53 Bronfort G, Evans R, Nelson B, Aker P, Goldsmith C, Vernon H: A randomized clinical trial of exercise and ... case review meetings for clinical eligibility determination A webbased form, designed to prevent errors in eligibility determination, is completed for each patient The web form confirms patient...
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