... amount of Chinese borrowed words Therefore, it is very rich inthe stock of vocabulary in general and inthe number of words expressing thedeathin particular Borowed words expressing thedeath ... based on the indirect meaning ofthe word, in other words, the authors make use ofthe change of meaning of words as a means to convey the meaning ofdeathIn English, popular verbs in this case ... defined as the individual meaning that each word has inthe system of language This meaning brings together the different forms of one and the same word, whereas the grammartical meaning ditinguishes...
... seriously from the start ofthe project, beginning with the hiring and training ofthe interviewers Candidates were carefully screened for their experiencein working inthe field and being comfortable ... opportunity to interact with the project staff and collaborators This increased their identification with the project, their feeling of being collaborators inthe project, their knowledge ofthe ... provide the occasion for a safety risk for the woman Finally, the collaborators working inthe Latino/Hispanic community were very worried thatthe inclusion of such questions inthe questionnaire...
... word The first can be either offensive or merely humorously deprecating with the second one generally used more often inthe sense of something deliberately offensive The last is used mainly in ... with the topic of death, and the use of metaphor is often inevitable when trying to explain certain facets ofthe human condition, particularly death Metaphor is a way of describing something ... death, and the misfortune would happen, is rooted in their mind deeply Using the way of metaphor to express theDeath is not mentioning it It must be noted thatthe majority of metaphors view death...
... 269) investigate the mechanism behind the DENSPM-induced cell deathinthe L56Br-C1 cells with the further aim of identifying the markers for an apoptotic response to polyamine depletion The L56Br-C1 ... analysis The cells were sonicated in 50 mM Tris/HCl (pH 7.5) containing 0.25 M sucrose The activity of SSAT inthe sonicate was determined by measuring the synthesis of [14C]acetylspermidine after incubation ... interesting in light ofthe fact thatthe tumour inthe patient was highly refractive to various anticancer treatment regimens including chemotherapy and radiotherapy DENSPM and other polyamine...
... for the kainate receptor (a subtype ofthe ionotrophic glutamate receptor) that mimics the effect of glutamate Ofthe 15 rats that received KA injections, five were used for preparation of brain ... protein synthesis, we evaluated the effectiveness ofthe RNA synthesis inhibitor actinomycin D (1 lgÆmL)1) in preventing excitatory neuronal cell death As shown in Fig 4A, addition of actinomycin D ... atypical form of cell death, and that inhibition of BNIP3 by RNA interference (RNAi) and expression of a dominant negative form of BNIP3 that lacks the functional transmembrane domain protected against...
... hypothesized that protons, accumulated by the electron transport chain inthe intermembrane space, principally flow back into the matrix using the basal conductance function of ANT1 Lowering the ... of siRNA inthe presence ofthe protein synthesis inhibitor puromycin As shown in Fig 2F, treatment with puromycin significantly reduced the ANT1 siRNA-mediated effect on ADF cell viability, indicating ... a short FLAG epitope The resulting expression vectors were composed ofthe ORF encoding human ANT1 or ANT2 fused with the FLAG epitope at their COOH terminal position After transformation in competent...
... mtAEQ, which is the recombinant protein developed for measuring [Ca2+] within the mitochondrial matrix and was instrumental in gaining new insight into mitochondrial Ca2+ handling, i.e the topic of ... checkpoint Interestingly, the link between Ca2+ signalling and cell death has been reinforced by the study of an unrelated pro-apoptotic protein, the x-protein ofthe hepatitis B virus (HBx), which ... activity in uences both the local microdomain (hence affecting local inhibitory or activatory effects of Ca2+ itself on the channel) orthe kinetics ofthe diffusion across the cytosol (thus acting...
... initiates a compensatory response The intensity ofthe error signal determines the intensity ofthe compensatory response This is the gain inthe system The gain determines how rapidly the parameter ... event occurs is 1:100 The probability ofdeath for each event is therefore the product of P × Pd, orin 100,000 The probability of both events occurring is the product of their probabilities, orin ... milieuintérieur inthe development of his own ideas Inthe preface to the French edition of his book The Wisdom ofthe Body, Cannon acknowledged that its main tenet, thatthe stability ofthe inner...
... oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% ofthe remaining ofthe initial death) combined with the initial loss exceed the amount ... Boehringer-Mannheim, Indianapolis, IN) or βactin (Sigma, St Louis, MO) antibodies for detection ofthe level of dopaminergic neuronal terminals, and for normalization ofthe loading protein The ... suggests that COX-2 plays an important role inthe secondary activation of microglia, inthe progression ofthe inflammatory response, and inthe progressive loss ofthe dopaminergic neurons in MPTPinduced...
... buying food and buying medicine, the stress of working in temporary and seasonal jobs, the stress of feeling trapped in circumstances of poverty that she cannot control, the stress of living ... so they find themselves caught ever more tightly inthedeath spiral Most ofthe people we met work despite suffering from an assortment of chronic illnesses In addition to the strain of working ... opportunities result in dead- end positions (across the nation, telemarketing—where the employee is invisible—is one ofthe mainstays ofthe working poor, but such jobs rarely offer health insurance),...
... sensitivity of tumor cells to chemotherapy and radiotherapy by increasing the threshold for cell death induction [7] Therefore, the survival kinase Akt attracted major attention for the development of ... low levels of Bcl-2 inthe PC3 cells may explain why the radiation-induced down-modulation of Bcl-2 was of minor importance for the response of PC3-cells to radiotherapy and the combined treatment ... activation of Akt This process is counteracted by the action ofthe tumor suppressor PTEN which is lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of...
... Zampino et al [7] We did not find any genetic abnormality either inthe karyotype orinthe region of CD96 gene, as recently described by Kaname [8] To the best of our knowledge this is the second ... not find vascular malformation or connective tissue anomalies that could have explained death during surgery However, as in Opitz’s patient the cause ofdeath was an unexpected massive bleeding ... unexplained deathinthe operating room: a case report Journal of Medical Case Reports 2011 5:222 surgery may have clinical implications: diagnosing OTCS in trigonocephalic patients before surgery,...
... from the medical record for up to days or until the time ofdeathor extubation, whichever occurred first These data included the etiology of ALI, coexisting medical illnesses, the use of glucocorticoids ... predictors ofdeath on days and of ALI Cooke et al [19] examined predictors of mortality in a cohort of 1,113 patients with ALI and found thatthe change in PaO2/FiO2 ratio between the day of diagnosis ... on the third day of ALI in prior studies [23,24] The major finding of this study was that a low or decreasing respiratory system compliance on the 6th day of mechanical ventilation is an independent...
... been increasingly intense interest inthe effects of GPS A common denominator in many of these in vitro studies has been an overwhelming system for CS administration The practice of cigarette ... not instantly detrimental for the epithelium, orthe tissues surrounding it Instead, chronic smoking results inthe well-documented loss ofthe lung internal structures [27], which is due to the ... structure, which almost uniformly accepts the toxic chemicals per CS inhalation [7,41] These chemicals are in turn diluted inthe existing air volume inthe airways so thatthe resulting toxicity...
... layer, 368 inthe hidden layer and two inthe output layer, the latter indicating death versus survival Ofthe cohort 75% was used to train the network and 25% was used in testing The training criterion ... namely co-morbid conditions and the type of individual biological response, the latter being determined from clinical findings such as vital signs and GCS score The use of ANNs inthe setting of sepsis ... Shock Index and GCS score, the cutoff points for changes inthe probability ofdeath R152 Critical Care April 2005 Vol No Jaimes et al Table Cutoff points on continuous variables for changes in the...
... occurs when the inherent order ofthe atoms that make up the brain are irrevocably destroyed If the atomic structure ofthe brain is disturbed but the structural integrity ofthe brain is maintained, ... brain, including brain stem” constitutes death [18] The guidelines not elucidate how these two standards reflect the same phenomenon; the wording suggests that there are two kinds of death: brain ... B: On the definition and criteria ofdeath Ann Intern Med 1981, 94:389-394 Guidelines for the determination ofdeath Report ofthe medical consultants on the diagnosis ofdeath to the President’s...
... focus in several laboratories, including our own Competing interests The authors declare that they have no competing interests Acknowledgments The authors’ research is funded by the National Institutes ... animal models of critical illness Similarly, the presence ofthe Tie-2 receptor on certain subpopulations of peripheral blood monocytes [4] suggests a larger role for angpt-2 inthe host innate immune ... response Finally, manipulation ofthe angpt/Tie-2 system may be a rational therapeutic strategy for the management of critically ill patients with sepsis and ALI All of these questions remain an...