da krishna gg and narins rg the role of the anion gap in detecting and managing mixed metabolic acid base disorders clin endocrinol metab 1984 jul 13 2 333 49
Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches The first approach involved measuring the level of mitochondrial ... CYPs in yeast cells 20 21 22 23 24 25 26 27 28 29 30 31 32 membrane into the matrix J Biol Chem 27 3, 20 941– 20 950 Sepuri NB, Schulke N & Pain D (1998) GTP hydrolysis is essential for protein import ... cells [23 ] The precise nature of CYP proteins targeted to mitochondria and the conservation of targeting mechanism is important for understanding the evolution and regulation of bimodal targeting...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... structure of activated bleomycin: oxygen 4358 P Hlavica (Eur J Biochem 27 1) 24 2 24 3 24 4 24 5 24 6 24 7 24 8 24 9 25 0 25 1 25 2 25 3 25 4 25 5 25 6 25 7 intermediates in heme versus non-heme iron J Am Chem Soc 122 , ... A.M., Mandon, D & Veeger, C (20 02) The nature of the intermediates in the reactions of Fe(III)- and Mn(III)-microperoxidase-8 with H2O2: a rapid kinetics study J Am Chem Soc 124 , 121 4 122 1 196 ... 2cat] 43 23 -25 .5 -27 .9 Scheme 10 Potential energy surface for ethene epoxidation The energies for the low- and high-spin states (2, 4TS1), the corresponding transition intermediates (2, 42) and epoxide...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... opportunities Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice ... Knowledge and Sources of Innovation Indirect Impact: Operations Purchasing and Procurement Activities Preservation of Economic Infrastructure Stable and Larger Tax Base Indirect Impact: Outreach Business...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... (Table 2) Some single VH domains of anti-protein IgG, including HyHEL-10 and D1.3, were known to retain the specificity and affinity to antigen in itself [7 ,20 ] At least for these antibodies, the role ... and the VH ⁄ VL interaction strength determined, five clones in the H39Q group showed both high antigenbinding affinity and strong VH ⁄ VL interaction In FEBS Journal 27 3 (20 06) 21 84 21 94 ª 20 06 The ... While no interchain hydrogen bonds originating from H39 lysine are observed in the crystal FEBS Journal 27 3 (20 06) 21 84 21 94 ª 20 06 The Authors Journal compilation ª 20 06 FEBS 21 89 VH ⁄ VL interaction...
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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... “Gift giving in Hongkong and the continuum of social ties”, Journal of Consumer Research, 28 , 20 01, p 23 9 -25 6 2 Banks, S.K., “Gift-giving: A review and an Interactive Paradigm”, Advances in Consumer ... giving in Hongkong and the continuum of social ties”, Journal of Consumer Research , Vol 28 , 20 01, p .23 9 -25 5 18 Krugman, Herbert E., The impact of television advertising: learning without involvement ... Vol.19, 19 92, p.4 82- 487 23 Otnes, Julie A.Ruth, and Constance C Milbourne, The pleasure and pain of being close: men’s mixed feelings about participation in Valentine’s Day”, Advances in consumer...
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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... and E Hovy 20 04 Determining the sentiment of opinions In Proc of COLING, pages 136 7 137 3 M Koppel and J Schler 20 05 Using neutral examples for learning polarity In Proc of IJCAI (poster) D Lin ... knowledge In Proc of Intelligent User Interfaces (IUI), pages 125 1 32 S Morinaga, K Yamanishi, K Tateishi, and T Fukushima 20 02 Mining product reputations on the web In Proc of KDD, pages 341– 349 T ... (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... bridging the A’ and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... measure the elongation of b-strands A’ and G for unfolding the I27 protein in D2O The pulling coordinate for the separating b-strands is defined as the distance between the first amino acid of strand ... the b-strands A’ and G of the I27 protein showing the protein backbone only for simplicity C) Snapshot of the bstrands A’ and G of the I27 protein showing D2O molecules bridging the protein backbone...
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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
... in microdomains of the plasma membrane, the topology of purinergic receptors is important for modulating signalling triggered by P2X receptors, and also for its integration with other purinergic ... stimuli and the size of the domains containing those clusters has been estimated In summary, multiple lines of evidence have helped to argue in favour of the existence of lipid rafts in cell ... localization of the P2X7 receptors in lipid rafts regarding the regulation of intracellular signalling pathways Interestingly, the P2X7 receptor is a substrate for ART 2. 2, a glycosylphosphatidylinositol-anchored...
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Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf
... site of the N-terminal lobe of human and bovine lactotransferrins Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal lobes in the stability of the ... Nibbering, P.H (20 02) Large scale production of recombinant human lactoferrin in the milk of transgenic cows Nat Biotechnol 20 , 484–487 23 Brines, R.D & Brock, J.H (1983) The effect of trypsin and ... (1994) Lactoferrin is a lipid A-binding protein Infect Immun 62, 26 28 26 32 Lee, W.J., Farmer, J.L., Hilty, M & Kim, Y.B (1998) The protective effects of lactoferrin feeding against endotoxin lethal...
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Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt
... C-terminally of a single arginine residue or at a multibasic recognition motif by the subtilase furin [11] N GP -2 N GP-C 22 6 23 4 22 4 7 - 22 4 21 6 21 7 24 3 11 316 317 - aa length GP-C 367 375 3 92 397 ... 97 107 90 1 02 113 118 - 121 126 120 - - 169 173 168 - - - 139 168 - 180 - 166 - 178 - 127 - 173 180 - 127 - 176 20 4 - 180 - 128 - 167 - 178 123 134 - 183 - 21 9 oproteins of most other enveloped ... for correct folding and intracellular transport of viral glyco- proteins, as shown for instances for influenza hemagglutinin [19] In order to investigate the importance of the individual N-glycosylation...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... A, Offringa R, de Vries RR, Toes RE: R300 20 21 22 23 24 25 26 27 28 29 30 31 32 33 CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis Arthritis Rheum 20 03, ... blockade of IL -2 binding to CD25 by the PC61 antibody IL -2 or IL -2 signalling via CD25 has been shown to be critical to the regulatory action of Treg cells [22 ,23 ] Also, activation-induced cell ... islets and pancreatic lymph nodes in inflammation-induced diabetes [29 ], in chronically inflamed skin in a Leishmania infection model [30], and in the mucosa and mesenteric lymph nodes in inflammatory...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... domains of Lafferty et al Journal of Inflammation 20 10, 7:57 http://www.journal-inflammation.com/content/7/1/57 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 1 32 133 134 135 136 ... homeostasis in the respiratory tract Nat Rev Immunol 20 08, 8 (2) :1 42- 1 52 Takeda K, Akira S: TLR signaling pathways Semin Immunol 20 04, 16(1):3-9 Page of 14 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ... modulation of intracellular TLR signaling In addition to TLRs, a variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For example, the...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... polymorphisms in MRL-lpr lupus mice and that enhanced expression of α-actinin may determine the extent of antibody deposition [10] These observations, together with the demonstration that α-actinin immunization ... an increased binding to α-actinin as compared with patients with no nephritis [ 12] and that pathogenic human anti-dsDNA antibodies bound strongly to α-actinin [ 12 ,13] Moreover, an increase in ... anti-α-actinin antibodies in lupus patients was associated with a 2. 5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin antibodies correlated with those of anti-DNA...
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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc
... [11,17] In addition, binding of SPD to lipoteichoic acid and peptidoglycan [22 ] may suggest a role for SP-D in the prevention of bacterial colonisation of the alveolar epithelium Elimination of these ... pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence of calcium and is thought to enhance mucociliary and phagocytic ... required to further elucidate the role of SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...
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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot
... from a noninfectious model of ALI (intratracheal acid) on the potential role of APC in endothelial permeability Acid- induced lung injury produces damage to the alveolar epithelium and prominent lung ... with small interfering RNA (siRNA) targeting the enzyme responsible for S1P production, sphingosine kinase-1, blocked the barrierenhancing signaling of APC In addition, siRNA targeting the S1P receptor ... summarize the in vitro and in vivo evidence and concentrate on potential mechanisms of endothelial barrier preservation Experimental evidence supports a role for APC in maintaining the integrity of the...
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Báo cáo y học: "The role of transposable element clusters in genome evolution and loss of synteny in the rice blast fungus Magnaporthe oryzae" pdf
... Pyret 25 Pot3 Pot2 20 MGLR3 MGL MAGGY 10 MG-SINE reports Occan 15 Ch-SINE 5 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 22 .5 20 17.5 15 12. 5 deposited ... Genome Biology 20 06, Volume 7, Issue 2, Article R16 Thon et al R16.3 Genes 45 comment 40 35 30 25 20 15 10 5 reviews 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 ... Simple sequence repeats 25 10 7.5 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 refereed research 2. 5 Figure Distribution of sequence features on...
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THE ROLE OF PYRUVATE DEHYDROGENASE KINASE IN GLUCOSE AND KETONE BODY METABOLISM
... are increased in DKO mice .48 12 Fasting induces acidosis in DKO mice .49 13 Deficiency of PDK2, PDK4, and both PDK2 and PDK4 does not increase expression of the other PDK isoforms ... enhanced in the liver and markedly increased in the skeletal muscle of fasted PDK4 KO mice (Table 3) In spite of the absence of any effect of knocking out PDK2, the combined deficiency of PDK2 and ... levels of fatty acids promote the synthesis of diacylglycerol (DAG) and ceramide DAG activates protein kinase C (PKC) which phosphorylates and inhibits tyrosine kinase activation of the insulin receptor...
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THE ROLE OF TRANSFORMATIONAL LEADERSHIP BEHAVIORS IN AFFECTIVE EMPLOYEE ENGAGEMENT AN EMPIRICAL STUDY IN THE TWO INDUSTRIES OF RETAIL AND FINANCIAL SERVICES IN HO CHI MINH CITY
... 320 320 Pearson Correlation IIA Sig (2- tailed) 000 003 000 001 320 320 320 320 20 3** 180** 24 9** 125 * 22 7** 134 * 000 001 000 026 000 017 N 320 320 320 320 320 320 Pearson Correlation 24 7** 23 7** ... collection and In- depth interview 26 3 .2 QUANTITATIVE RESEARCH .27 3 .2. 1 Response rate and sample size 27 3 .2. 2 Data sources and type 29 3 .2. 3 Data gathering instruments ... behaviors and affective employee engagement by surveying the employees The target population of the study included the employees in Ho Chi Minh City currently working in the industry of retailing and...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... which, in the living state in vitro, are continually elongating, retracting, and reorienting themselves, leading to a wide variety of cell shapes (Steinman and Cohn, 1973) Thereafter, the 23 Chapter ... Trinchieri, 20 03) IL-12p70 binds to the IL- 12 receptor which is composed of two chains, the IL-12Rβ1 and IL12R 2 The IL- 12 receptor is expressed by T cells and NK cells (Presky et al., 1996), DCs and ... antigen and is followed by a contraction phase, when 90–95% of the effector cells die in the ensuing days and weeks and the remaining 5–10% become long-lived memory cells (Harty and Badovinac, 20 08;...
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