c— sensory axon reflexes in gallbladder ganglia
Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx
... factors, including IFN regulatory factor-3 (IRF-3) and kinases, including the Tank-binding kinase (TBK-1) and inhibitor of jB kinase e (IKK-e) [28–31] Although IRF-3 is located in the cytoplasm in ... glycoproteins This response initiates signaling pathways leading to the induction of protective cellular genes, including type-I interferons [initially interferon (IFN)-b, and then IFNa] and proinflammatory ... clearly induced in PH5CH8 and HuH-7 cells, and TLR3 mRNA was induced only in PH5CH8 cells Moreover, there was no such induction in the other cell lines examined (supplementary Table S1) In M-pIC...
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Tài liệu Báo cáo khoa học: Extended half-life upon binding of destabilized intrabodies allows specific detection of antigen in mammalian cells pdf
... expressed intracellularly This may be due to the reducing conditions existing in cell compartments, which may prevent the formation of intradomain disulfide bonds within the VH and VL domains resulting ... fused to d1-EGFP are maintained in the cells by binding to antigen Generation of soluble binding-defective and cysteine-deleted mutants To demonstrate that the observed intracellular colocalization ... was obtained with scFv 4A-d1-EGFP and 7A-d1-EGFP expressed in parallel Interestingly, in the case of 4A (but not 7A), we found a minor percentage of cells with a faint cytoplasmic staining (arrow)...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... protein–protein interactions [45], because their catalytic domain is homologous to adhesion proteins such as neuroligin [46,47] For example, AChE may be involved in neurite extension during brain ... Mouse AChE binds in vivo to domain IV of laminin-1beta Chem Biol Interact 157 ⁄ 158, 411–413 46 Krejci E, Duval N, Chatonnet A, Vincens P & Massou´ lie J (1991) Cholinesterase-like domains in enzymes ... suggesting a predominant in uence of the catalytic domains on oligomerization This may be due in part to the difference in N-glycosylation of AChE and BChE, which carry four and nine N-glycan chains,...
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Báo cáo khoa học: C fi G base mutations in the CArG box of c-fos serum response element alter its bending flexibility Consequences for core-SRF recognition potx
... the 70° sharp bend induced in the HMG box seems very interesting Indeed, the bend determined by Raman for the free SREfos in solution is roughly similar to that formed in SREfos in the crystal of ... and an increase in the intensity of its 790 cm)1 component, thus expressing changes in the geometry of the phosphodiester group, and ⁄ or in the conformation of deoxycytidine or deoxythymidine, ... duplexes in a temperature region where the premelting is dominant By contrast, V2 is mainly normalized according to melting and weak variations between the three duplexes can be seen during premelting...
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Báo cáo khoa học: Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation pdf
... secondary kinetic isotope effects [19,27–29] The existence of a gem secondary kinetic isotope effect has the effect of attenuating the rate of C-H bond-breaking, so in principle the intrinsic kinetic ... effects are interpreted to mean that the step(s) involving the chemistry of C-H bond cleavage are ratelimiting in the reaction even in liver microsomes, as opposed to steps involving generation ... values of the intramolecular values in Table are reasonable but should be considered lower estimates of the intrinsic kinetic deuterium isotope effects Intermolecular competitive kinetic isotope...
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Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein docx
... NaCl/Pi containing 3% hydrogen peroxide and 10% methanol for 15 min; nonspecific binding with PKCa and PKCe was blocked by incubation for 30 with NaCl/Pi containing 1% BSA Cells were incubated for ... is consistent with data in the literature that indicate PKCe as the only protein kinase isoform involved in the signalling pathway downstream of muscarinic m3 receptors in SK-N-BE(C) neuroblastoma ... reports in the literature indicate that PKCe is equally, if not exclusively, involved Kinouchi et al showed initially that an increased release of sAPPa could be induced by overexpression of PKCe in...
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Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling ppt
... switch serines 73 and 138 and threonine 153 of the HIP/PAP protein for alanines Oligonucleotides cassettes containing the desired mutations were inserted into pcDNA3-HIP/PAPmyc-His as indicated ... HIP/PAP expression in hepatocellular carcinoma, we looked for proteins capable of interacting with this protein by screening a human HCC cDNA expression library in kgt11 using [32P]chimeric HIP/PAP ... overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity FEBS Lett 337, 114–118 Christa, L., Pauloin, A., Simon, M.T., Stinnakre, M.G., Fontaine,...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... repressor protein Ara C Aldehyde dehydrogenase C-terminal tail Increased stability C-terminal tail Increased stability Reference [4] [5] C-terminal tail Increased stability [11] C-terminal tail Increased ... MBP-Pfg27–70K fusion protein marked by an arrow according to manufacturer’s instructions All constructs showed equivalent levels of protein induction but the resulting fusion protein had varying solubilities ... constructs was retained Therefore, the differing protein solubilities were inherent in the constructs and could not be modulated by varying the ambient growth conditions DISCUSSION The routine production...
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Báo cáo Y học: Secretion of egg envelope protein ZPC after C-terminal proteolytic processing in quail granulosa cells doc
... band was also observed during insulin biosynthesis in pancreatic b cells [55], which is regarded as an intermediate of proinsulin to insulin conversion Because the intensity of the 94-kDa band ... indicate that BFA inhibits the secretion of ZPC by inhibiting the conversion of proZPC to 35-kDa ZPC C-terminal sequence of 35-kDa ZPC In order to determine the C-terminal amino acid of 35-kDa ... C-terminal amino acid was determined as Phe by an automated C-terminal protein sequencer Effects of monensin and BFA on proteolytic processing of proZPC Next, we evaluated the effects of monensin...
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Báo cáo khoa học: Specific Ca2+-binding motif in the LH1 complex from photosynthetic bacterium Thermochromatium tepidum as revealed by optical spectroscopy and structural modeling pdf
... structural domain constituting the Ca2+ binding motif is found in a large number of Ca2+-binding proteins, and is also known as the EF hand [16] Proteins containing the EF hand are divided into two ... orange, amino acids of LH1 polypeptides; red, His coordinating to BChl a in LH1 of Tch tepidum; purple, His coordinating to BChl a in the template; yellow, hydrogen atoms coordinating to BChl ... 273 to 323 K The increase in spectral shift or bandwidth in response to the increase in temperature may indicate the involvement of more thermally populated excitonic states in the Qy-state manifold...
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Báo cáo khoa học: Molecular identification and expression study of differentially regulated genes in the Pacific oyster Crassostrea gigas in response to pesticide exposure doc
... b-1,3-Glucan binding protein 3e-6 Putative senescence-associated protein 5e-46 Cavortin 1e-5 Cytoskeleton Tubulin alpha chain 4e-17 Tubulin alpha chain 5e-20 Tubulin beta 1e-50 Actin cytoplasmic ... b-1,3-Glucan binding protein 3e-6 Procathepsin L 1e-12 Meningioma expressed antigen 7e-19 Lipoprotein receptor related protein 2e-24 Fucolectin-1 6e-4 Cytoskeleton Tubulin alpha chain 4e-40 Tubulin beta ... monitoring can be determined Other interesting genes that were identified from our libraries are the lysosomal associated protein and procathepsin L, a protein protease Both are involved in FEBS...
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Báo cáo sinh học: " Transmission of human hepatitis C virus from patients in secondary cells for long term culture" pot
... protein pellet was solubilized into 200– 500 µl of 1% SDS by incubating at 55°C for 10 minutes Any remaining insoluble subcellular particles were removed by centrifugation at 14000 × g for 10 minutes ... analysis of HCV proteins binding to IgG from patient sera Dot blot analysis of HCV proteins binding to IgG from patient sera HCV proteins were obtained from tissue culture fluid Protein preparations ... within an hour of blood drawing Repeat samples were obtained from 77 of the original patients in order to confirm our initial results Thirty-three of these 151 HCV-infected patients were co-infected...
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Báo cáo hóa học: "Research Article Polarimetric Kronecker Separability of Site-Specific Double-Directional Channel in an Urban Macrocellular Environment" pptx
... explained in detail in [20] Figure shows the measurement map Note that the arrows in the figure show the moving direction of the MS The important parameters are summarized in Table By using a ... marginal PSD models are briefly summarized in Table Their best-fit parameters, which were obtained from fitting the PSD models and their corresponding measured PSDs, were listed in the tables in ... variations in case of existence Obtain the joint angular PSD between the BS and MS according to (22) and (26) Generate random phases Obtain the single channel polarization-pair MIMO channel according...
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Báo cáo lâm nghiệp: "Solar activity, global surface air temperature anomaly and pacific decadal oscillation recorded in urban tree rings" pot
... on urban trees are becoming increasingly important [8,9,31,55,65] In China, tree ring chronologies studies started in the 1930s [34, 64] Since then, research using tree rings has been conducted ... Mountains, located in natural sites (72 km to Shenyang, 0.2181) [8] Qianshan Mountains Chinese pines and Fuling Mausoleum Chinese pines also have stronger responses to local climate than Chinese pines ... H.Y., Wang S.Q., Preliminary research on the reasons of declining and dying of palaeo-Chinese pine in Zhaoling Mausoleum, Shenyang, J Shenyang Agri Univ., 28 (1997) 39–43 (in Chinese with English...
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Báo cáo y học: " EGFR Expression in Gallbladder Carcinoma in North America" doc
... staining in over 10% of tumor cells The staining pattern for EGFR was determined as follows: Score 0= no staining is observed; Score 1+= faint membrane staining in more than 1% of tumor cells in ... intensity of the staining (0negative to 3- strong) was determined (Figure 1a-c) Int J Med Sci 2008, 287 The staining pattern for Her2-neu was determined as follows: Score 0= no staining is observed; ... shown clinical efficacy in colon, [31, 32] and head and neck cancers [31] Small molecules that target EGFR compete with ATP binding to the tyrosine kinase domain, thereby blocking signaling pathways.[32]...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
... higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal objective of this study was to determine the relationship between serum IL-6 and CRP levels and staging ... Kattan MW, Timme TL, Scardino PT, Thompson TC: Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma J Urol 1999, 161:182-187 ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as...
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báo cáo khoa học: " A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro" pptx
... signal that gradually increased in intensity In the tumor center (yellow circle), GBC-SD exhibited spots in which the signal gradually increased in intensity (consistent with the intensity recorded ... Laminin is the only laminin that contains the g2 chain, which following cleavage into promigratory fragments, the domain Ⅲ region, causes increased levels of matrix metalloproteinase-2 (MMP-2), and ... management of gallbladder cancer Surg Oncol Clin N Am 2009, 18:307-324 Hsing AW, Gao YT, Devesa SS, Jin F, Fraumeni JF Jr: Rising incidence of biliary tract cancers in Shanghai, China Int J Cancer...
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báo cáo khoa học: "Multiple etiologies of axonal sensory motor polyneuropathy in a renal transplant recipient: a case report" pot
... The muscle force grading was 3/5 in his proximal upper limbs, 4/5 in his distal upper limbs, 2/5 in his proximal lower limbs and 4/5 in his distal lower limbs Sensory examinations were normal ... patients had demyelinating and axonal damage and all the patients recovered within two months of cyclosporine cessation [9] Terrovitis et al reported cyclosporine-associated axonal degenerative ... discontinuation of the medical therapy, although there have been cases of permanent or even fatal damage [8] Guarino et al observed cyclosporine-induced motor polyneuropathy in four out of nineteen...
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Báo cáo y học: " Hepatitis C virus genotypes circulating in district Swat of Khyber Pakhtoonkhaw, Pakistan" doc
... participated in data analysis SUG, MA, LA and AA helped IU in data analysis All the authors read and approved the final manuscript 20 Competing interests The authors declare that they have no competing interests ... probably got infected over there The mode of contamination was unknown in 40.0% of the infected individuals Results of the multivariate ANOVA showed that the genotype prevalence is independent ... new/resistant virus to become the leading strain, therefore, in order to correctly genotype these newly emerged strains, clinical laboratories may require to up date their genotyping assays as the previously...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25