c— bile acid transport cholehepatic circulation
Tài liệu Báo cáo khoa học: Disulfide bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt
... of bile acids EMBO J 25, 1419–1425 Chawla A, Saez E & Evans RM (2000) Don’t know much bile- ology Cell 103, 1–4 Thomas C, Pellicciari R, Pruzanski M, Auwerx J & Schoonjans K (2008) Targeting bile- acid ... NMRbased modeling and binding studies of a ternary complex between chicken liver bile acid binding protein and bile acids Proteins 69, 177–191 6022 ` Pedo M, D’Onofrio M, Ferranti P, Molinari H ... Molinari H & Ragona L (2008) Conformational and dynamics changes induced by bile acids binding to chicken liver bile acid binding protein Proteins 71, 1889–1898 11 Liu J, Chenyun G, Yihe Y & Donghai...
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Báo cáo khoa học: Novel c-carboxyglutamic acid-containing peptides from the venom of Conus textile docx
... propeptide and postpeptide amino acid sequences Amino acids forming the consensus sequence are boxed and their positions highlighted by an asterisk Basic amino acids are shown in bold Shaded residues ... hydrophobic amino acids located in the propeptide region form an important structural element of the c-carboxylation recognition site [16] Similarly, a synthetic substrate based on amino acids + to ... amino acids + to + 18 of mature Gla(1)–TxVI (lacking any potential propeptide) was a 2782 Discussion The marine cone snail remains the sole invertebrate in which the vitamin K-dependent amino acid...
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Tài liệu Vitamin C (Acid ascorbic) ppt
... Acid ascorbic có khả hoàn nguyên chất, thân bị oxy hoá sang dạng acid dchydroascorbic hoạt tính vitamin Do đặc điểm nên việc bảo ... Ngoài biến chứng đường tiêu hoá (giảm dịch vị độ acid) , tim nhiều rối loạn chuyển hoá đường lipid, protein thể + Vai trò sinh hoá học chủ yếu acid ascorbic tham gia trình oxy hoá hoàn nguyên, ... trình oxy hoá hoàn nguyên chất glutation (C10H17N3SO6) + Acid ascorbic xúc tác vận chuyển hydrogen NAD.H2 FAD.H2 với hệ thống cytocrom + Acid ascothic có tác dụng kích thích hoạt động enzym aconitase...
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Tài liệu RETURN-LOADS BUREAUS TO SAVE WASTE IN TRANSPORTATION HIGHWAYS TRANSPORT COMMITTEE COUNCIL OF NATIONAL DEFENSE WASHINGTON, D. C. RESOLUTION PASSED docx
... patriotic service to our country by increasing its transportation facilities at a time when the safety of the Nation depends absolutely upon transportation Shortage of railroad cars and locomotives ... United States, Riggs Building, Washington, D C.) MOTOR-TRUCK TRANSPORTATION RETURN-LOAD BUREAU The motor truck is a part of the transportation equipment in every community Its use more nearly ... Project Gutenberg EBook of Highway Transport Commitee Council of National Defence, Bulletins 1, by US Government *** END OF THIS PROJECT GUTENBERG EBOOK HIGHWAY TRANSPORT COMMITEE *** ***** This...
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Tài liệu Báo cáo khoa học: Purification and characterization of a sialic acid specific lectin from the hemolymph of the freshwater crab Paratelphusa jacquemontii pdf
... N-glycolylneuraminic acid, N-acetyl 9-O-acetylneuraminic acid and, 8,9-di-O-acetylneuraminic acid [6] and proved to be a potent inhibitor On the other hand PSM, which contains 90% (v/v) N-glycolylneuraninic acid, ... sialic acid specificity Inhibition studies with glycoproteins and sugars were helpful in deriving the binding affinity of the humoral agglutinin BSM contains the sialic acids, N-acetylneuraminic acid, ... hemagglutinatin study The lectin is unique from that of other sialic acidspecific lectins O-Acetyl sialic acid- specific lectin was Ó FEBS 2003 A sialic acid specific lectin from P jacquemontii (Eur J Biochem...
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Tài liệu Vitamin C làm giảm nồng độ acid uric huyết thanh! ppt
... nồng độ acid ascorbic (vitamin C) acid uric máu.Nồng độ acid uric máu thay đổi tỷ lệ nghịch với nồng độ acid uric máu GFR (mức lọc cầu thận) tăng nhóm vitamin C Vitamin C có tác dụng giảm acid uric ... nồng độ acid ascorbic tăng ý nghĩa Bảng 1: Vitamin E không gây ảnh hưởng đến nồng độ acid uric huyết ảnh hưởng tương tác vitamin C vitamin E Tại thời điểm kết thúc nghiên cứu, nồng độ acid uric ... tăng đào thải acid uric qua niệu, nhiên họ không đánh giá liệu vitamin C có làm giảm nồng độ acid uric máu không Do đó, thực nghiên cứu để đánh giá ảnh hưởng vitamin C tới nồng độ acid uric huyết...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
... and nucleic acid metabolic process Amino acid biosynthetic process Cytoskeleton organization and biogenesis Carbohydrate metabolic process Protein modification process Amino acid transport Protein ... down-regulation of gene expression in response to amino acid starvation Results Amino acid starvation triggers changes in gene expression In order to identify amino acid- regulated genes, mouse embryonic fibroblast ... amino acid availability has been studied extensively in yeast [8] The GCN2 and TOR kinases sense the intracellular concentration of amino acids In addition, yeast cells possess an amino acid sensing...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... residues, primarily glutamic acid and lysine, than their mesophilic equivalents [29] Interactions between aB-crystallin subunits can be inhibited by the replacement of glutamic acid residues in the a-crystallin ... negatively charged glutamic acid residues in the C-terminal extension of Hsp25 FEBS Journal 275 (2008) 5885–5898 ª 2008 The Authors Journal compilation ª 2008 FEBS Glutamic acid mutants of Hsp25 A ... of human Hsp27 contains an aspartic acid residue, that of murine Hsp25 does not (Fig 1) Thus, apart from the C-terminal carboxyl group, the three glutamic acid residues are the only source of...
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Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx
... sulfuric acid and incubated at 95 °C for 1.5 h Then the acid was neutralized with 50 lL of m NaOH The other tube was kept on ice and was used to measure the amount of endogenous malate Polymalic acid ... and deduced amino acid sequences of NKA48 were compared with the GenBank database The results indicated a high degree of identity on the levels of nucleotides (84%) and amino acids (86%) with ... plasmodium-specific, as they were not detected in amoebae Fragment NKA8 contained an ORF encoding 257 amino acids and showed a putative conserved domain in the NCBI data base termed DUF343 (or gnI|CDD|26165...
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Báo cáo khoa học: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2 potx
... glycine L-Alanine L-a-Aminobutyric acid L-Norvaline L-Norleucine Elongation of the backbone b-Alanine c-Aminobutyric acid d-Aminopentanoic acid e-Aminohexanoic acid O-Methyl substitution O-Methyl-glycine ... proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 J Physiol 546, 349–361 Boll, M., Foltz, M., Rubio-Aliaga, I & Daniel, H (2003) A cluster of proton/amino acid transporter ... amino acid transporter rat PAT2 Biochem Biophys Res Comm 304, 747–754 Boll, M., Daniel, H & Gasnier, B (2004) The SLC36 family: proton-coupled transporters for the absorption of selected amino acids...
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The European Environmental Bureau (EEB) The European Federation for Transport and Environment (T&E) Seas At Risk (SAR) The Swedish NGO Secretariat on Acid Rain pot
... instruments for reducing emissions from sea transport Air pollution and climate series No 11 The Swedish NGO Secretariat on Acid Rain, Göteborg, Sweden (www.acidrain.org) MariTerm (2004) Shore-side ... by the Swedish NGO Secretariat on Acid Rain, the European Environmental Bureau, and the European Federation for Transport and Environment, Göteborg, Sweden (www.acidrain.org) – www.ntm.a.se (update ... the development of an EU system of differentiated charges for all modes of transportation A charging scheme for maritime transportation will be part of that framework, and be developed on the basis...
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Báo cáo khoa học: Differential tissue-specific distribution of transcripts for the duplicated fatty acid-binding protein 10 (fabp10) genes in embryos, larvae and adult zebrafish (Danio rerio) docx
... utilization of fatty acids, intracellular targeting of fatty acids to specific organelles and metabolic pathways, and the protection of cellular structures from the detergent effects of fatty acids [10–14] ... heart-type fatty acid binding protein in cardiac fatty acid utilization FASEB J 13, 805–812 Schaap FG, Binas B, Danneberg H, van der Vusse GJ & Glatz JFC (1999) Impaired long-chain fatty acid utilization ... Moerkerk HTB (1993) Fatty acidbinding protein and its relation to fatty acid oxidation Mol Cell Biochem 123, 101–106 15 Glatz JF & van der Vusse GJ (1996) Cellular fatty acidbinding proteins: their...
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Báo cáo khoa học: Plant oxylipins: Plant responses to 12-oxo-phytodienoic acid are governed by its specific structural and functional properties ppt
... divinylether fatty acids, as well as volatile aldehydes and alcohols and the well-established wound hormones jasmonic acid (JA), 12-oxo-phytodienoic acid (OPDA), dinor-OPDA (dnOPDA), traumatic acid and ... introducing molecular oxygen at either the C9 or C13 position of the C18 fatty acids linoleic acid (18:2) and a-linolenic acid (18:3), respectively [10,11] Plants possess a number of different LOX ... polyunsaturated fatty acids, collectively termed oxylipins or octadecanoids, play a crucial role In mammals, oxylipins derive mainly from arachidonic acid, a fourfold unsaturated C20 fatty acid, and have...
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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf
... [15,17,20], a direct action of this fatty acid on cholesterol transport into the mitochondria cannot be ruled out In this context, a positive action of nonesterified fatty acids on cholesterol metabolism ... 0.85 0.70 None + CHX + NDGA 0.20 0.15 0.10 0.05 0.00 Control Arachidonic acid 22(R)OHcholesterol Oleic Arachidic acid acid Progesterone (ng/mg protein) B a,b 0.25 a a 0.20 0.15 0.10 0.05 0.00 ... where cholesterol transport, ACS4 and PBR play an important role [23–25,47] Experimental procedures Materials Fatty acid- free bovine serum albumin, AA, arachidic and oleic acids, 4-bromophenacyl...
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Báo cáo khoa học: Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression doc
... and mouse (Ms; P02695) CRABPIs Dots indicate amino acid identity and dashes represent gaps Positions of amino acids are marked and numbered Amino acid sequence identity values between the zebrafish ... which codes for a peptide of 138 amino acids with a theoretical molecular mass of 15.68 kDa and a predicted isoelectric point of 5.05 The deduced amino acid sequence of the zebrafish CRABPIa showed ... shown) Comparison of the amino acid sequence of the zebrafish CRABPIa with its mammalian and pufferfish orthologs showed that there is a proline insertion in the amino acid sequence immediately following...
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Báo cáo khoa học: The crystal structure of a xyloglucan-specific endo-b-1,4glucanase from Geotrichum sp. M128 xyloglucanase reveals a key amino acid residue for substrate specificity potx
... bond of unbranched Glc residues, suggesting a difference between the two enzymes in the Key amino acid residue of Geotrichum XEG three-dimensional structures of the active sites In this study, we ... Journal 276 (2009) 5094–5100 ª 2009 The Authors Journal compilation ª 2009 FEBS 5095 Key amino acid residue of Geotrichum XEG K Yaoi et al from the N-domain, blocking one end of the cleft However, ... difference between XEG and OXG-RCBH is at the active site In OXG-RCBH, a loop comprising 11 amino acid residues protrudes 5096 Figure shows a close-up view of the active sites of XEG and OXG-RCBH...
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Báo cáo khoa học: Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport ppt
... that the half-life of this cadmium transporter would be 11.5 ± 1.5 h (see Experimental procedures) ZIP8 has recently been reported to be the major cadmium transporter in cells [22], and its characteristics ... ZIP8 transporters were all rounded and displayed very weak GFP signals, reflecting the enhanced toxic effect of this very low cadmium concentration, owing to the increased number of ZIP8 transporters ... simplest explanation is that PMA has a direct negative effect on cadmium transporter function Thus, independent of the quantity of transporter present in the cell, PMA treatment would always result...
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Báo cáo khoa học: Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system pptx
... electrochemical membrane potential We have shown that some components of this additional electron transport chain are sited on the ‘respiratory contact sites’ [5,6], but endogenous cyto-c, present ... similar to that reported in our paper published at the beginning of 2005 [6] The NADH/cyto-c electron transport system may have the function, in the physio-pathological conditions associated with the ... programme To date, the components identified and involved in the cytosolic NADH/cyto-c electron transport pathway are as follows: NAD-dependent dehydrogenases present in the cytosol; cytosolic...
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TRƯ NGI H C C N THƠKHOA TH Y S NNGUY N TH DI M THÚYB O QU N CÁ TRA PHILÊ B NG CÁCH R A TRONG DUNG D CH ACID LACTIC VÀ Ư P TRONG NƯ C ÁLU N VĂN T T NGHI PIH CNGÀNH CH BI N TH Y S N2009.TRƯ NGI H C C N THƠKHOA TH Y S NNGUY N TH DI M pptx
... vi c thay th chlorine b ng acid lactic, acid acetic, acid citric, E400… K t qu c a nghiên c u cho th y kh c ch vi sinh v t c a acid lactic tương i cao có th ng d ng acid lactic m t cách có hi ... ng Acid lactic c s d ng công nghi p th c ph m m t ch t b o qu n ch t t o mùi v Acid lactic có ho t l c c ch Bacillus coagulans dung d ch cà chua m nh l n lo i acid h u khác acid propionic, acid ... dung môi… Acid lactic c s n xu t b i s t ng h p hóa h c Nhưng s n xu t acid lactic b i s lên men glucose nh ng ch t khác r Acid lactic có hai d ng ng phân quang h c là: Dextro levo Acid lactic...
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Báo cáo khoa học: Structural function of C-terminal amidation of endomorphin Conformational comparison ofl-selective endomorphin-2 with its C-terminal free acid, studied by 1 H-NMR spectroscopy, molecular calculation, and X-ray crystallography pot
... C-terminal free acid [8] Furthermore, the d-opioid receptor selectivity of the l-opioid receptorspecific agonist TIPP-NH2 (Tyr-Tic-Phe-Phe-NH2, where Tic ¼ tetrahydro-3-isoquinoline carboxylic acid) was ... conformer of cis EM2 leads to a labile binding due to the breakage of these interactions 5093 Conformational comparison of endomorphin-2 and its C-terminal free acid Y In et al Fig Stereoscopic ... Conformational comparison of endomorphin-2 and its C-terminal free acid Y In et al amide group makes the peptide structure more flexible and leads to the ensemble of...
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