cytokines chemokines and adhesion molecules in systemic vasculitis
Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt
Ngày tải lên :
13/08/2014, 05:21
... NF-κB and AP1 These findings suggest that Tax protein could induce the transcription of cytokines, chemokines and cell adhesion molecules in lung epithelial cells in a manner similar to that in ... resulted in infection with HTLV-I Figure of expression of cytokines, chemokines and cell adhesion molecule in A549 cells cocultured with MT-2 cells Induction Induction of expression of cytokines, chemokines ... sentinel system against pathogens The pathogenic significance of aberrant production of inflammatory cytokines and chemokines in the lung has been given increasing attention and a variety of cytokines...
- 10
- 215
- 0
Báo cáo y học: "Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients" docx
Ngày tải lên :
09/08/2014, 13:22
... chemokine ligand; CXCL, C-X-C chemokine ligand; IFIG, IFN-inducible gene; IFIT, interferon-induced protein with tetratricopeptide repeats; IL, interleukin; IP-10, interferon-inducible protein 10; ... finding that IFN-inducible chemokines may serve as a biomarker in active SLE requires verification in a larger cohort of patients, as well as in patients from different races and backgrounds In ... IFN-inducible chemokines and IFIGs, the transcriptional levels of a total of seven IFN-inducible chemokine genes (RANTES, MCP-1, MIG, IP-10, C-X-C chemokine ligand [CXCL]11, IL-8, and CC chemokine ligand...
- 10
- 471
- 0
Báo cáo y học: " Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung" pot
Ngày tải lên :
12/08/2014, 14:20
... BALT T cells and B cells for the expression of L-selectin, which binds to PNAd; α4 integrin, which is a subunit of α4β1 integrin (which binds mainly to VCAM-1) and α4β7 integrin (which binds to MAdCAM-1); ... minutes (min), rinsed in PBS, and incubated with peroxidase-streptavidin for 30 After a final PBS wash, slides were incubated with Vector AEC substrate (per manufacturer's instructions), stained ... cells in adhesion molecule expression Lselectin, which binds to PNAd, was expressed on 20% of T cells and almost all B cells in BALT α4 integrin, which is a subunit of α4β1 integrin that binds...
- 11
- 234
- 0
Báo cáo khoa học: "Changes in some Blood Micronutrients, Leukocytes and Neutrophil Expression of Adhesion Molecules in Periparturient Dairy Cows" ppt
Ngày tải lên :
12/08/2014, 15:20
... collected in the morning, using Vacutainer® tubes (Becton Dickinson Vacutainer Systems, Meylan, France), one month before estimated calving, at calving (within 24 hours after calving) and one month ... immunostaining of CD18 and CD62L adhesion molecules, and for total and differential white blood cell counts Leukocyte counts Total and differential leukocyte counts were determined within h using ... significant increase in the numbers of WBC at calving This was mainly due to an increase in the numbers of circulating neutrophils, and to a less extent, an increase in monocytes At calving, the...
- 12
- 283
- 0
Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
Ngày tải lên :
12/08/2014, 18:20
... Agati JM, Yeagley D, Quinn PG: Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of Page of ... kinase was increased in the presence of insulin after 15 of incubation and remained increased after 16 hours Rapamycin abolished the phosphorylation of Thr389 in both control and insulin-treated ... p44/42 mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI 3-kinase) pathway [8] Insulin initially binds to the insulin receptor causing autophosphorylation of...
- 10
- 281
- 0
Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" doc
Ngày tải lên :
12/08/2014, 18:20
... found to be increased in BALF in the early phase of ARDS, including endotoxin-binding proteins, tumour necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, chemokines, adhesive molecules as ... finding of this study is that the serum levels of the measured cytokines and adhesion molecules can predict survival Indeed, and in contrast to BALF values, serum levels of IL-1 and adhesion molecules ... Discussion We investigated two categories of soluble molecules that might be involved in the pathogenesis of ARDS: proinflammatory cytokines and adhesion molecules We studied these molecules within the...
- 9
- 310
- 0
Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:21
... with TA-cloning vector pCRII, and transformed into IFN-αF cells (Invitrogen, Paisley, UK) and cloned Immunohistochemical staining of tissue sections Frozen sections were stained using mouse monoclonal ... from a patient with systemic lupus erythematosus (a) Anti-FDC (follicular dendritic cell) staining within the area known as germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two ... within close proximity, but B-cell staining shows no clear demarcation (c) Anti-FDC staining for GC B (d) staining with anti-CD20 Panels (a) and (b) are consecutive sections, as are (c) and (d)...
- 8
- 378
- 0
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... mg nifedipine per day (SSc )in conIndividualand (n = 20) and patients with systemic concentrations 20) trol subjects (n = 20) and patients with systemic sclerosis (SSc) at baseline and after treatment ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1 Endothelium injury is critical in SSc and is suspected ... factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation...
- 6
- 518
- 0
Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc
Ngày tải lên :
09/08/2014, 06:22
... Organization standards for any human and murine cytokine, including murine endostatin The minimum detectable concentration of endostatin was less than 12 pg/ml, and the interassay and intra-assay ... hypoxia inducible factor [31] In addition, a variety of cytokines (e.g interleukin-1, transforming growth factor beta and platelet-derived growth factor) known to be upregulated in SSc induce ... Arthritis Research Vol No Distler et al inducers and inhibitors are balanced and angiogenesis does not occur in healthy tissues In a hypoxic environment and in inflammatory states such as rheumatoid...
- 10
- 432
- 0
Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 08:22
... For annexin-V/PI staining × 106 cells were resuspended in 50 µl binding buffer (Roche Diagnostics, Lewes, UK) and incubated with annexin-V/FITC (Roche) and annexin-V/PI (Roche) for 15 minutes at ... TGF-β1 activation during blood clotting in patients and control individuals, and examined whether TGF-β1 activation was associated with clinical phenotype, in particular inflammatory disease ... difference in the type of LDL present in patients and control individuals may explain our observation of an inverse correlation of TGF-β1 AI and LDL in SLE patients, which was not seen in control individuals...
- 7
- 347
- 0
Báo cáo y học: "Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis" ppsx
Ngày tải lên :
09/08/2014, 10:23
... release proinflammatory cytokines and chemokines, causing local tissue damage and stimulating hypertrophy of smooth muscle cells in the artery wall Inflammation is also expanded by the influx Page ... horizontal lines in each box indicate median values Note that inflammatory indices are higher in SLE patients than in healthy controls or RA patients and are higher in RA patients than in healthy ... chemokines, and to the pro-oxidative molecules that arise, also accelerates clinical disease [87] Furthermore, at the adventitial side of the artery, lipokines, cytokines, and chemokines promote inflammation...
- 12
- 323
- 0
Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... pharmaceutical industry realized the unmet medical need for new therapeutics in lupus and has made a considerable investment in bringing new candidates to the clinic The result of this investment ... production in SLE and these cytokines are rather interrelated rather than independently enhanced Interestingly, one-half of lupus patients show enhanced serum BAFF levels, whereas the remaining patients ... soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis J Clin Immunol 1988, 8:447-452 Wolf RE, Brelsford WG: Soluble interleukin-2 receptors in systemic...
- 7
- 387
- 0
Báo cáo y học: " Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus" doc
Ngày tải lên :
12/08/2014, 12:20
... IL-17 producing T cells, including CD4 + and DN T cells, have been found in lupus nephritis In addition, IL17 gene expression was detected in T cells infiltrating the kidneys and in urine sediments ... with SLE than in healthy subjects, suggesting the possible involvement of this cytokine in enhancing the Th17-cell response we observed In line with this finding, increased circulating levels of ... Th17-driving cytokines and IL-10 in patients with SLE and healthy controls Plasma levels of Th17-polarizing cytokinesg(IL-1b, IL-6, IL-21, TGF-b, and IL-23) and IL-10 were measured in patients...
- 10
- 443
- 0
Báo cáo y học: " Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study" pptx
Ngày tải lên :
12/08/2014, 14:22
... TC, SBP, and DBP were included in the analysis Patients attending the University of Toronto lupus clinic are followed up at 2- to 6-month intervals, and clinical and laboratory data obtained at ... risk factors in SLE Second, identifying correlates of TC and BP in SLE aids in the selection of covariates and interaction terms for inclusion in multivariate models when the outcome of interest ... again points to the link between hypercholesterolemia and hypertension in SLE Further support for this link was manifest in the association between lipid-lowering therapy and both reduced TC and...
- 9
- 394
- 0
Báo cáo y học: " The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus" doc
Ngày tải lên :
12/08/2014, 15:22
... recognizing epitopes of various molecules, including oxidized LDL, and by secreting IFN-γ, which then leads to increased in ammatory cytokine production This chronic production of in ammatory cytokines ... cells and IL-17 in the upregulation of in ammatory mediators and adhesion molecules that contribute to CVD in SLE Future studies should address if, indeed, any of these cytokines play a prominent ... (ICs), such as seen in SLE, and result in upregulation of endothelial adhesion molecules, including E-selectin and VCAM-1 These molecules may enhance neutrophil recruitment and endothelial damage...
- 10
- 299
- 0
Báo cáo y học: " Adhesion molecules in different treatments of acute myocardial infarction" doc
Ngày tải lên :
12/08/2014, 18:21
... decreasing or increasing intra-individual In patients undergoing PTCA, sICAM-1 levels were significantly elevated in comparison with controls and patients with tPA or SK lysis, whereas no intra-individual ... remained significant during the whole observation period No increasing or decreasing intra-individual trends could be observed, either in the tPA group or in the PTCA group SK patients, in contrast, ... several cytokines, notably tumor necrosis factor-α, undergo processing similar to L-selectin, this mode is unique to L-selectin among adhesion molecules of the selectin or immunoglobulin families, and...
- 6
- 233
- 0
Immune memory and activation markers in systemic lupus erythematosus
Ngày tải lên :
09/10/2015, 11:06
... Layout…………………………………………………………….….….…….51 2.4.4 Staining Layout for Extracellular Staining………………………………….….….… 52 2.4.5 Staining Layout for Intracellular Staining………………………………… … …….53 2.4.6 Staining Procedures…………………………………………………………… ... protein, including complements and other mediators of inflammation c) Phagocytes (macrophages, neutrophils) and NK cells d) Cytokines which regulate and coordinate activities of cells of innate ... homeostatic cytokines, anti-apoptotic molecules and effector functions and tissue homing receptors, meanwhile losing the lymph node homing marker, proliferative potential and activating their IL-2...
- 148
- 258
- 0
Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps
Ngày tải lên :
09/08/2014, 14:22
... pathogenesis [8,9] Therefore, both chemokines and In the present investigation, we have determined levels of cytokines and chemokines in BAL fluids (BALF) in an early SSc cohort Furthermore, ... some cytokines/ chemokines, such as CCL2 and CCL3, were increased in idiopathic ILD as well as in SSc-associated ILD, indicating an important, but nonspecific contribution of these chemokines in ... autoantibodies, Th2 cytokines, growth factors, and several other cytokines/ chemokines [42,43] As detected with our first analysis including 17 different cytokines, profibrotic cytokines such as IL-13...
- 11
- 584
- 0
Báo cáo y học: " Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus" potx
Ngày tải lên :
12/08/2014, 15:21
... tyrosine kinase) which is involved in BCR signaling, but also in the regulation of integrin activation [44] Moreover, recent work indicates that Syk is involved in CXCL12- and a4b1 integrin-induced ... a4b7 integrin is regulated in a homeostatic relation with the surface expression of a4b1 integrin on T-cells since high expression of a4b1 integrin resulted in a loss of a4b7 integrin With this in ... baseline and not substantially changed by epratuzumab The data indicate that b1 integrin and b7 integrin expression could be regulated interdependently on CD27 negative B-cells In addition, binding...
- 11
- 389
- 0
THE SIMPLE SENTENCE IN TRADITIONAL GRAMMAR AND THE CLAUSE SIMPLEX IN SYSTEMIC FUNCTIONAL GRAMMAR a COMPARATIVE STUDY
Ngày tải lên :
07/09/2013, 13:48
... commodity (information and goods and services), when taken together, define the four basic speech functions: giving information, demanding information, giving goods -and- services and demanding goods -and- services ... Sayer the participant saying, telling, stating, informing, asking, demanding, offering, threatening, suggesting and so on, The Sayer can be a human or human-like speaker, and also any other symbolic ... giving and demanding Language is used to exchange either the commodity of information or the commodity of goods -and- services Giving and demanding information is concerned with verbal exchange in...
- 59
- 1.1K
- 13