cytokines and cytokine receptors regulating cell survival proliferation and differentiation in hematopoiesis
báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
Ngày tải lên :
11/08/2014, 12:20
... substrates, including ribosomal S6 kinase (S6K) and 4EIF binding protein (4EBP1) Inhibition of mTORC1 by everolimus leads to G1 cell cycle arrest, autophagy induction and cytostasis of many RCC cell lines ... tyrosine kinase inhibitors sorafenib, sunitinib and pazopanib, which inhibit VEGFRs, and the mTOR inhibitors everolimus and temsirolimus Each of these drugs has shown efficacy in RCC in randomized ... forming a complex with the intracellular protein FKBP12 (FK506 binding protein-12) mTOR is a component of two distinct cellular multiprotein complexes, mTOR complex (mTORC)1 and mTORC2, and only...
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The integration of lean man and 6 sigma
Ngày tải lên :
23/11/2013, 14:22
... eventually reach a point of diminishing returns That is, after re-engineering their operating and supporting systems for improvement by solving major problems and resolving key inefficiencies, further ... alone satisfaction when making management decisions, and a significant investment in education and training in statistics, root cause analysis, and other problem solving methodologies With TQM, ... ten and the average processing time per operation is one minute Like many companies run in this traditional batch -and- queue mode, processing is done in batches since machine setup times and the...
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Báo cáo khoa học: "Diagram Understanding Using Integration of Layout Information and Textual Information" ppt
Ngày tải lên :
17/03/2014, 07:20
... (example) "shinpi no chuou ga sakeru (carpel splits open in its center)" in Figure Diagram understanding is the semantic interpretation of the elements in the diagram As mentioned, in the PBF diagrams, ... Layout Information and Natural Language Information In this section, we describe the process of semantic analysis for the PBF diagrams by using the integration of layout and natural language information ... shape of leaf Diagram Understanding P B F D i a g r a m Understanding 2.1 A diagram in the PBF consists of its title and elements A title shows the subject of the diagram and it is generally located...
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Báo cáo hóa học: " Research Article Binocular Image Sequence Analysis: Integration of Stereo Disparity and Optic Flow for Improved Obstacle Detection and Tracking" pptx
Ngày tải lên :
21/06/2014, 22:20
... colour discontinuity occurs in the same object indicating mismatching points By introducing optic flows as extra constraints, we are defining multiple measures for stereo matching As well as the normalized ... measure Applying the epipolar line constraint, we can search the correspondence point in the same row For a seed point at position (il , j) in the left edge image and a candidate point at position ... constant The tracking results of the longitudinal distance and relative speed are shown in Figures 5(a) and 5(b) The lateral and vertical relative speeds are shown in Figures 5(c) and 5(d) In the figures,...
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INTERNATIONAL ASSIGNMENTS An Integration of Strategy, Research, and Practice ppt
Ngày tải lên :
28/06/2014, 09:20
... succession planning and leadership development; in coordination and control; and in technology, innovation, and information exchange and dissemination Leadership Development and Global Assignments ... Appraising: Determining if People Are Doing the Right Things 144 Rewarding: Compensation and Pay 171 IV AFTER THE ASSIGNMENT 187 Repatriating: Helping People Readjust and Perform 189 10 Retaining: ... newsletters and intracompany conferences are ways of facilitating information sharing and exchange Increasingly, the Internet and e-mail are being used for this purpose Nevertheless, the most valuable information...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
Ngày tải lên :
06/08/2014, 18:21
... -catenin into the nucleus [1] Regulation of -catenin stability is mediated via a complex of proteins including Axin, glycogen synthase kinase (GSK3), GSK3-binding protein (GBP) and casein kinase ... release of intra-cellular Ca2+ in a process mediated through heterotrimeric G-proteins and involving numerous other molecules, including phospholipase C (PLC), calcium-calmodulin-dependent kinase ... signaling through the Frizzled (Fz) and LRP5/6 receptor complex induces the stabilization of -catenin via the DIX and PDZ domains of Dishevelled (Dsh) and a number of factors including Axin, glycogen...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
Ngày tải lên :
10/08/2014, 10:21
... immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and VEGF-C were scored in this study The intensity of NF-B, Notch1, podoplanin, and/ or VEGFC staining was score ... conserved proteins regulate “decisions” involved in cell- fate determination, including those involved in mammalian vascular development [15] The finding that genes of the Notch signaling cascade ... an inverse relationship between Notch1 and NF-B signaling and tumor-induced lymphangiogenesis Taken together, our findings imply that Notch1 and NF-B signaling have counter-acting roles in...
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Báo cáo y học: " Bringing metabolic networks to life: integration of kinetic, metabolic, and proteomic data" pptx
Ngày tải lên :
13/08/2014, 16:21
... enzyme kinetic data E Refined parameter sets based on enzyme kinetic and metabolic data Figure Data integration pipeline Data integration pipeline A metabolic network (A) is translated into a kinetic ... By combining both kinds of information, we can obtain a posterior distribution, which describes how plausible certain parameter sets appear, taking into account both the prior information and the ... the resulting probability densities, eval- uated at the original parameter set θkin, increase in both steps: p(θkin)
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integration of fracture, reservoir and geomechanic Modeling for shale gas reservoir development
Ngày tải lên :
04/10/2014, 22:11
... a combination of injection, shut -in and production (as shown in Table 1) Scenario Well Well Well Well Production Injection Injection Production Shut -in Injection Injection Shut -in Shut -in No ... determines the dominant flow regimes in the well to infer fracture-tofracture and well-to-well interference Using information from production data analysis and fracture height, EUR, and drainage ... refracturing of declining wells, infill drilling in maturing regions and steering of fractures away from water producers SPE 164018 Methodology A multidisciplinary approach integrating aspects related...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
Ngày tải lên :
14/09/2015, 14:25
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain such ... hemagglutinin epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase ... resulting in activation of the intracellular kinases of the receptors Upon ligand binding, the activated kinase then phosphorylates the tyrosine residues at the carboxyl-terminus (C-terminus) domain...
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The convergence challenge global survey into the integration of governance, risk and compliance
Ngày tải lên :
06/12/2015, 23:16
... the information they need to understand and respond to the risks facing the business, as well as anticipating and meeting changing stakeholder and regulatory demands The result is an increasingly ... improve agility in decision-making Increased use of outsourcing and offshoring 8% Increased technological complexity 8% Increasing risk incidents More stringent requirements from rating agencies ... improve agility in decision-making Increased use of outsourcing and offshoring 8% Increased technological complexity 8% Increasing risk incidents More stringent requirements from rating agencies...
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The convergence evolution global survey into the integration of governance, risk and compliance
Ngày tải lên :
06/12/2015, 23:16
... organization at managing the following aspects of governance, risk and compliance? 20% Standardizing policies and procedures Assigning clear responsibilities and reporting lines 17% Minimizing duplication ... picking one project initially, and then gradually moving new and existing capabilities over to a central platform “The way forward is not to throw everything out and put something brand new in that’s ... seen an increase in this expense over the past two years, and expect it to increase even further in the next two years And the proportion that thinks the cost is increasing is higher than in last...
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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt
Ngày tải lên :
16/01/2014, 16:33
... 7pm and the activity entailed diverse kinds of work such as brush-making, bookbinding, basketry, shoemaking and repaire-work, needlework, lace-making, and weaving The children’s work partly financed ... learning and fosterage, unite living and learning and train the children to observe and notice This approach was controversial at the time and eventually resulted in the prohibition of Kindergarten ... of reaching compromises in order to maintain differing traditions, languages and attitudes; but to work toward common objectives by maintaining knowledge and experience while developing a new...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... using muscle specific antibodies against smooth muscle actin Cells were maintained in M199 supplemented with 10% fetal bovine serum and antibiotics in a humidified atmosphere containing 5% CO2 in ... GAPDH Ig mediated through various protein kinase and monomeric GTP-binding protein signaling pathways including MAP kinases and Rho GTPases [18,20,31] To determine the signal transduction pathways ... complex and may involve an increase in the levels of c-jun protein and/ or phosphorylation of specific serines (63 and/ or 73) by JNK Stimulation of our cells with S1P, while it induced an increase in...
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Báo cáo sinh học: "Wnt signaling and the developmental fate of lung cells" ppsx
Ngày tải lên :
06/08/2014, 18:21
... obtained other endodermal lineages.” Wnts and differentiation in other cell types Other groups are also finding evidence that Wnt signaling is important for differentiation and lineage switching ... The findings also reveal something of the delicate interplay between the timing and nature of signaling in determining cell fate For example, the absolute levels of expression of Wnt signalling ... quite labile In asthma, for example, you get many epithelial cells turning into mucusproducing cells, but no one understands why What influenced your thinking in this area? As a student in the 1960s...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
Ngày tải lên :
08/08/2014, 21:20
... JK, JP, and LN and KN aiding in obtaining biopsy and blood samples NR and LH were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final ... (GRO-a); interferon-gamma (IFN-g); interferon-inducible protein 10 (IP10); leptin; monocyte chemotactic protein-3 (MCP3); monokine induced by gamma interferon (MIG); macrophage inflammatory protein ... 8-fold increase in the bFGF levels in EoE subjects as compared to HC subjects and a 4-fold increase compared to GERD; b)There was a 6-fold increase in eotaxin-3 comparing EoE subjects to HC and...
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Báo cáo y học: " Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method" pdf
Ngày tải lên :
13/08/2014, 16:21
... β-catenin at Ser675 by PKA attenuates β-catenin degradation, stabilizing β-catenin and enhancing TCF activity in the cells investigated [7] In aspects of pathology, β-catenin has a role in carcinogenesis ... http://www.tbiomed.com/content/6/1/13 -catenin*+ -catenin* -catenin*/APC*/Axin*/GSK3 -catenin/APC*/Axin*/GSK3 wnt DSHI DSHA APC/Axin/GSK3 18 GSK3 APC*/Axin*/GSK3 GSK3 APC/Axin Axin APC/ -catenin -catenin/TCF -cateni APC ... β-catenin and axin with transient wnt signaling Solid line: the original Lee-Heinrich model Other lines: kG parameter was varied Long dashed line: kG = 0.1 min-1 Short dashed line: kG = 0.5 min-1...
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