... repeats of a single-stranded DNAbinding protein (hPOT1 in humans), which in turninteracts with other proteins in the core telomerecomplex, notably TPP1, to regulate telomerase action in cancer ... which results in the activation of a DNA damage response and selective inhibition of cellgrowth. Several of these G-quadruplex binding molecules have shownpromising anticancer activity in tumour ... withquadruplexes in the promoter region of the c-kit onco-gene that is disregulated in gastrointestinal cancer cells(inhibiting c-kit expression), and telomeric quadruplexes.The inhibition of c-kit...
... examina-tion of the drug effect after incubation several meth-ods are in use. In the 1970s the method of measuring the thymidine incorporation into cancer cell DNA [28] was developed by one of ... Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET. J Nucl Med. 2009; 50: 106S-121S. 71. Institute of Medicine. Improving the quality of cancer clinical trials: ... a medical point of view a rethinking of the pharmacological strategy of cancer drug therapy seems to be necessary, i.e. the management may include, in cases of the de-tection of broad drug...
... compound begun to increase. Since then several pertinent investigations[5, 14] on the O3-sensing properties of In 2O3have been performed resulting in laboratoryversions of chemoresistive ... as gas sensing elements. In spite of this principle scientific interest we did not find any articles dealing with the electrical transport in granular In 2O3layers for gas sensing and, to ... characterisation of c -In 2O3is reported in Ref. [14], those of rh -In 2O3, in Ref. [27, 28]; the detailed characterisation of the sensing properties of the cordundum-type rh -In 2O3will...
... However, in Japan many view living in nursing homes as positive and may be seen as betterthan living in their own homes (Tsugaruya, 2004).When classifying the level of depression, 66.7% of Korean ... with elder people living in nursingWith the growing elderly population, an interest in physical and psychosocial health of the elderly hasconcomitantly increased.Depression in the elderly is ... community resid-ing Korean elderly (Oh & Choi, 2005). Previousfindings suggest that depression can be associatedwith an increased risk of incidence of dementia andideation of suicide in the elderly...
... ended in 1973. e cohorts of physicians in the beginning of the “all-volunteer” era differed from later cohorts in their modes of accession and background. As noted in Chapter One, procuring ... percent of all Dental This document and trademark(s) contained herein are protected by law as indicated in a notice appearing later in this work. This electronic representation of RAND intellectual ... the share of women in entering cohorts, we subtracted the natural log of the percentage of women in the first year (FY 1976) from the natural log of the percentage of women in the second year...
... process of diagnosing, treat-ing, and preventing disease and traumatic injury, of reliev-ing pain, and of preserving and improving human health,using molecular tools and molecular knowledge of ... prove useful in treating diabetes. Instead of taking an injection of insulin, a patient would use aballpoint-pen-size infrared laser to heat the skin wherethe nanoshell polymer had been injected. ... (CCMV) viral protein cagesurface to allow engineering of surface-exposed functionalgroups. This includes the addition of lamanin peptide 11(a docking site for lamanin-binding protein generouslyexpressed...
... Currentstatus and orientation of residential areas in Quang Xuong district, Thanh Hoa province, Vietnam 1018 Table 3. Comparison ofstatusof land use in residential area in the district ... areas in Quang Thinh, 12 in Quang Dong, 9 in Quang Phu), including 9 residential areas of level 1; 9 residential areas of level 2; and 11 residential areas of level 3 (People’s Committee of ... Following this Resolution, in 2009, the Ministry of Agriculture and Rural Development issued “A Set of National Criteria for Renewing Rural Areas”, including 19 criteria with 5 groups: planning,...
... number of childhooddiseasesIncome, financial means, household crowding, living alone,currently married, number of people in the household, number of children living outside household, number of ... alonedecreases, indicating that health status information contained in the historicalSEIs was mediated through current predictors. The unique information ex-plained by historical SEIs fell to 3.8%using current ... in Barbados Original researchTABLE 3. Distribution (%) ofcurrent socioeconomic indicators among 1 443 elderly persons in study of historical and current predictors of self-reported health status, ...
... high-intensity Lamps in terms of size, weight, "fragility", learning curve and high equipment purchase and running costs. The clinical evidence of lesions with inhomoge-neous melanin ... — Tissue Interactions. In: Cutaneous Laser Surgery. St. Louis, Missouri: Mosby Inc. 1999: 13-18. 8. Kollias N. The spectroscopy of human melanin pigmentation. In: Melanin: Its Role in Human ... contemporary dentistry and soft tissue recontouring with the diode laser. J Indiana Dent Assoc. 2004;83(1):13-5. 12. AdamsTC, Pang PK. Lasers in aesthetic dentistry. Dental Clin-ics of North America...
... 39 2. The method of erosion potential classification in Binh Dinh Province The classification of erosion potential M in Binh Dinh Province is based on the numerical value of the flow energy ... Distribution of flow energy (Y) at river basins in Binh Dinh Province (unit: %) Y level Total in province At Lai River Basin At Kon River Basin At La Tinh River Basin At Ha Thanh River Basin ... result of categorizing communes depending on the erosion potential levels as shown in Table 5. Table 5. The specific collection of disposing convertible land (EP2 and EP3) in Binh Dinh Province...