cscs in lung cancer
Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... transcription of TAp73c in lung cancer via highly conserved Sp1-binding sites on the p73 P1 promoter In addition, TAp73c and Sp1 are co-overexpressed both in vitro and in situ in lung cancer Sp1 also ... HNBE and fetal lung fibroblast CCL171 cell lines, whereas it was significantly increased in the lung epithelial anaplastic carcinoma cell line (CALU6), in the squamous lung cancer cell lines (HTB59, ... differential N-terminal domain and C-terminal domain [15] Despite the rarity of p73 mutations, overexpression of p73 isoforms is common in several types of cancer [14,16], including lung cancer [2] Elevated...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... tested in cell lines and tissue specimens representing different steps of lung cancer progression supporting the panel of the tumor suppressor genes selected to be altered in lung cancer In this ... exist within the individual gene promoters for certain genes in lung cancer carcinomas MS-MLPA is only based on a single CpG site compared to an average of 4-6 CpG sites in MS-PCR assays Since only ... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript...
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Báo cáo sinh học: "Elevated expression of CDK4 in lung cancer" pptx
... phosphorylating the retinoblastoma protein Overexpression of CDK4 has been described in many tumors, including lung cancer In this investigation, we analyzed the expression of CDK4 protein in lung cancer ... CDK4 protein in 89 archived paraffin-embedded lung cancer samples and 23 normal lung tissues using immunohistochemical staining (Figure 1A-E) Specific CDK4 protein staining was found in the cytoplasm ... carcinoma [3], pancreatic endocrine tumors [4], lung cancer [5,6], and nasopharyngeal carcinoma [7], suggesting that CDK4 is a key factor in promoting the initiation and development of tumors In...
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báo cáo hóa học:" Elevated expression of CDK4 in lung cancer" ppt
... phosphorylating the retinoblastoma protein Overexpression of CDK4 has been described in many tumors, including lung cancer In this investigation, we analyzed the expression of CDK4 protein in lung cancer ... CDK4 protein in 89 archived paraffin-embedded lung cancer samples and 23 normal lung tissues using immunohistochemical staining (Figure 1A-E) Specific CDK4 protein staining was found in the cytoplasm ... carcinoma [3], pancreatic endocrine tumors [4], lung cancer [5,6], and nasopharyngeal carcinoma [7], suggesting that CDK4 is a key factor in promoting the initiation and development of tumors In...
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Báo cáo khoa học: " The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients" potx
... IL-6 can reflect the inflammatory state of the lung The IL-6 levels frequently increase in patients suffering with several pulmonary diseases, including infectious pneumonia, interstitial pneumonia ... Georgoulias V: High incidence of pulmonary toxicity of weekly docetaxel and gemcitabine in patients with non-small cell lung cancer: results of a dose-finding study Lung cancer 2004, 44:363-368 ... late toxicity in patients with lung cancer ? analysis of RTOG 91-03 Am J Clin Oncol 2007, 30:368-376 Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff...
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Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
... as a minor clone in nonsmall cell lung cancer Cancer Res 2006, 66(16):7854-7858 28 Syvanen AC: From gels to chips: "minisequencing" primer extension for analysis of point mutations and single ... expression are observed in many cancers, including NSCLC, and its expression is correlated with an adverse prognosis [2-4,19] Clinical responsiveness to gefitinib and erlotinib in NSCLC have been ... subtype and smoking history predict sensitivity to gefitinib in advanced non-smallcell lung cancer J Clin Oncol 2004, 22(6):1103-1109 Yang CH, Shih JY, Chen KC, Yu CJ, Yang TY, Lin CP, Su WP, Gow...
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báo cáo khoa học: " Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells" ppsx
... twice with cold PBS, resuspended in 250 μl of binding buffer, and stained with staining solution containing Annexin V/FITC and PI After incubation in the dark for 30 min, cells were analyzed by FACSCalibur ... Sparks CA, Guertin DA: Targeting mTOR: prospects for mTOR complex inhibitors in cancer therapy Oncogene 2010, 29:3733-3744 Guertin DA, Sabatini DM: Defining the role of mTOR in cancer Cancer Cell ... rapamycin are the same for all four cancer cell lines, suggesting rapamycin may act on some targets/pathways common in all of them Figure Rapamycin exerts growth inhibitory effects in four lung cancer...
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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx
... procured locally Cell line and culture conditions The human lung cancer cell line A549 was obtained from the China Center for Type Culture Collection (Wuhan, China) and maintained in RPMI-1640 supplemented ... Cdc2/Cyclin B1, Bcl-2 protein and up-regulated Bax in our study In summary, these results indicated that Osthole induced G2/M arrest and apoptosis possibly by down-regulating Akt signaling in human lung ... against Bcl-2related proteins in breast cancer cells Breast Cancer Res 2005, 7:R940-52 33 Luo J, Manning BD, Cantley LC: Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer...
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Báo cáo y học: " Genomic approaches to research in lung cancer Edward Gabrielson" docx
... overexpression The future of genomics in lung cancer research In the next few years, a considerable effort will be made to classify lung cancers, to discover genes involved in lung cancer pathogenesis, and ... of differentiating lymphoma from carcinoma, or small cell carcinoma from non-small cell carcinoma in the evaluation of a lung tumor However, our inability to subclassify lung cancer further is ... allow investigators to measure the expression of thousands of genes in a single experiment Experiments using such approaches are leading to additional discoveries of genes involved in cancer...
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Báo cáo y học: "Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough" potx
... of findings Lung cancer patients, N = trials from Cochrane systematic review in cancer [12]** Brachytherapy in addition to EBRT resulted in higher improvements in cough at doses of 15 Gy in fractions; ... cell lung cancer Respiratory Medicine 2005, 99:298-307 29 Thatcher N, Jayson G, Bradley B, Ranson M, Anderson H: Gemcitabine: symptomatic benefit in advanced non-small cell lung cancer Seminars in ... randomised study comparing cisplatin-vindesine to gemcitabine Lung Cancer 2003, 40:191-9 31 Lester JF, Macbeth FR, Toy E, Coles B: Palliative radiotherapy regimens for non-small cell lung cancer Cochrane...
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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... increase in lung cancer risk Although the summary risk for developing lung cancer in individuals of each genotype may not be large, lung cancer is such a common malignancy that even a small increase ... binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase the repair rate of certain DNA adducts, including ... provides information on the T19007C polymorphism and lung cancer risk in histologic types There was no difference Int J Med Sci 2007, in risk estimates according to the histological type of lung cancer...
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Too Many Cases, Too Many Deaths: Lung Cancer in African Americans potx
... lung cancer deaths per year in the United States, making it the leading cause of lung cancer in nonsmokers, and the second leading cause of lung cancer overall.10 Other recognized causes of lung ... attributed primarily to smoking.40 Radon is the leading cause of lung cancer in non-smokers and the second leading cause of lung cancer overall Information is lacking that could link household radon ... focusing increased attention on eliminating health disparities of all kinds And lung cancer advocacy groups are becoming more vocal about reducing the toll of this dreaded disease Much remains...
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The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust pptx
... development of lung cancer than the German miners because diesel technology was introduced earlier in the US study mines (1947–1967) than in the German mines (1969) Finally, in this study, an intensive ... 6) This finding mirrors a recent observation from a study in Xuanwei, China (21), where lung cancer rates are high because of unvented indoor burning of coal for heating and cooking in homes ... [years]) Final models also included terms for potential confounding factors These included a variable that combined cigarette smoking status and smoking intensity with location worked because initial...
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Báo cáo khoa học: Perturbation of membrane microdomains in GLC4 multidrug-resistant lung cancer cells ) modification of ABCC1 (MRP1) localization and functionality docx
... flask-shaped invaginations of the plasma membrane that originate from the presence of caveolin family proteins Among the three isoforms, caveolin-1, caveolin-2 and caveolin-3, caveolin-1 is the predominant ... X-100 [12–15] Hinrichs et al [12] found that MRP1 was predominantly located in the Lubrol-based fraction of detergent-insoluble membrane domains in the colchicine-selected cell line HT29-col Although ... 480 nm) after incubation with the cells in a cm quartz cuvette (Fig 2) The decrease in fluorescence occurring during incubation with cells is due to the quenching of fluorescence after intercalation...
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Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer" pdf
... receptor tyrosine kinases, which also includes HER2/neu, HER3, and HER4 [15] Activating mutations in the tyrosine kinase domain, involving mainly exons 19 and 21, play an important role in lung oncogenesis ... previously described [14]: = negative or faint staining in 10% of cancer cells; = moderate staining; = strong staining A score of was considered negative, ... AF: Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors Oncogene 2009, 28(Suppl 1):S24-31 10 Molina-Vila MA,...
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Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt
... in blood circulation may act as a risk marker of lung cancer in Taiwan Cancer 2003, 97:1558-1563 11 Klein F, Amin Kotb WF, Petersen I: Incidence of human papilloma virus in lung cancer Lung Cancer ... lines indicate protein-protein binding interactions, and arrows refer to “acts on” interactions such as proteolysis, expression, and protein-protein interactions Genes up regulated are shown in ... lung cancer [11] HPVs detection rates in lung cancer are highly variable in the different studies published from several countries, ranging from 0% to 79% The mean incidence of HPVs in lung cancer...
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Báo cáo hóa học: "Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization" pot
... now being exploited in cancer, attempting to modulate their expression, reintroducing microRNAs lost in cancer, or inhibiting oncogenic microRNAs by using anti-micro oligonucleotides [38] In a ... semiquantitatively for cytoplasmic staining on computer screen The dominant staining intensity in tumor cells was scored as: = negative; = weak; = intermediate; = strong (Figure 1) In case of disagreement ... contributed in the clinical and demographic database and KAS and SAS in making the TMAs RB and LTB supervised and participated in the study design, result interpretation and in the writing All authors...
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Báo cáo hóa học: "Lung cancer risk among textile workers in Lithuania" docx
... differences in the degree of lung cancer risk which are correlated with differences in working conditions The basic raw materials used in textile production were fibers, obtained from cotton but beginning ... group of textile finishing departments (bleaching, dyeing, printing and other finishing) was characterized by high exposure to chemicals The percentage of the subjects employed in that unit was ... obtained from the Cancer Registry of Institute of Oncology, Vilnius University Cancer cases were identified by record linkage to the cancer register To calculate the standardized lung cancer incidence...
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báo cáo hóa học: " Bayesian bias adjustments of the lung cancer SMR in a cohort of German carbon black production workers" pdf
... above, information on smoking and previous exposures is either lacking or incomplete By including the limited information available on smoking and previous exposures from a case-control study [8] in ... 0.03572) accordingly Secondly, we derived a distribution of the effect of smoking on lung cancer mortality The conditional logistic regression for lung cancer mortality depending on a smoking indicator ... occupational cancer risk due to carbon black exposure is indicated by the occurrence of lung cancer in rats after inhalation or instillation of carbon black and, thus, a working group at the International...
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Báo cáo toán học: "Molecular Predictors of EGFR-TKI Sensitivity in Advanced Non–small Cell Lung Cancer" ppsx
... probably could introduce new insight into clinical practice to assure better clinical outcomes By comparing the gene expression patterns of gefitinib sensitive and gefitinib resistant lung cancer, Balko ... versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens The TAX 320 Non-Small Cell Lung Cancer Study ... adenocarcinomas with acquired resistance to kinase inhibitors Clin Cancer Res 2006; 12(21): 6494-501 Costa DB, Halmos B, Kumar A, et al BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in...
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