crt e7 dna vaccine generates long term e7 specific memory cd8 t cell immune responses in vaccinated mice
Báo cáo sinh học: " A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses" potx
... demonstrate that our construct expressing the NC protein synthesised sufficient protein within infected cells to facilitate the formation of VLPs Detection of antibody titer in mice immunized with the ... 5) in mice that received the DNA construct, recombinant NC protein and adjuvant XIAP To confirm the results obtained by intracellular cytokine staining, we performed an IFN-γ ELISPOT assay to ... antigen -specific CD8+ T cells [16,17] Specific CD8+ T- cells play an important role in the control of viral infection [18-20] Activation of specific CD8+ cells results in the secretion of inflammatory cytokines...
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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot
... 63 T0 T1 T2 T3 T4 T5 FPE7 E7 # 72, 73, 74 T0 T1 T2 T3 T4 T5 FPE6 + FPE7 P1 P2 E7 P3 P4 # 80, 81, 82, 83 T0 T1 T2 T3 T4 T5 FPwt P1 P2 P3 P4 # 50, 51, 52, 53 T0 T1 T2 T3 T4 T5 Figure Prime-boost ... Wang TL, Ji H, Hung CF, Pardoll DM, Cheng WF, Ling M, Wu TC: Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene Gene Ther ... (E7GGG), which cannot bind to its p105Rb cellular substrate, could replace the oncogenic E7 counterpart in new constructs and inhibit the E7- expressing TC-1 cell tumour growth in mice [60] These...
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Báo cáo lâm nghiệp: "Long-term evolution of understorey plant species composition after logging in chestnut coppice stands (Cevennes Mountains, southern France)" ppsx
... practiced a chestnut thinning to complete the role of the clearing This thinning was realized in the winter 1998/1999 by removing, in the 15 plots that have been clear-cut years ago, about one third ... the year after clear-cutting and the absence of repetitions Data processing methods adopted took these shortcomings into account We used non-parametric test that allows to work with low size ... However, the ‘control’ plot that had not been cut provided a rather good estimation of the flora and vegetation present in the site as a whole before the clear-cut The 15 plots were clear-cut in winter...
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Báo cáo khoa học: "Long-term effects of culture establishment from shoot-tip explants in micropropagating oak (Quercus robur L)" pdf
... concentration of the cytokinin used (table I) Use of 2iP proved to be ineffective and Z did not allow the culture to initiate elongation; culture evolution stopped at the rosette stage On BA-containing media, ... necrotic within weeks of culture, whatever the type of source-plant On BM Cyt, the reactivity was better Shoot-tip explants enlarged within the first weeks of culture During the third week, the ... culture de riel mature méristèmes / décontamination / multiplication long terme/Quercus robur L/maté/ matériel juvénile INTRODUCTION In vitro culture establishment from shoot- tip explants potentially...
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Báo cáo y học: "Long-term tracking of neurological complications of encephalopathy and myopathy in a patient with nephropathic cystinosis: a case report and review of the literature" ppt
... tolerance test; SSRI, selective serotonin reuptake inhibitor; TSH, thyroid-stimulating hormone Competing interests The authors declare that they have no competing interests Consent Written informed ... Gahl et al demonstrated that cysteamine is able to deplete muscular tissue of cystine In our patient, the myopathy progressed, pointing towards an insufficient effect of the cysteamine therapy to ... for the therapy of cystinosis in 1994 Cysteamine transforms intralysosomal cystine to cysteine, which is able to leave the cell independently of the defective cystine transporter Measuring the...
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Báo cáo y học: "Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain" doc
... monitor long- term antinociceptive effects of HA preparations, namely the repetitive induction of short-lasting pain states in the joint by the injection of bradykinin, combined with prostaglandin ... can be attributed directly to the antinociceptive effects of HA rather than to disease modification Finally, the protocol of repetitive induction of short-lasting pain states limits suffering of ... and 21 after treatment Data were compared with those obtained from animals receiving a single treatment with saline according to NASHA treatment, or intraperitoneal injections of morphine (2.5...
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Báo cáo khoa học: " Long-term outcome and quality of life of patients treated in surgical intensive care: a comparison between sepsis and trauma" doc
... of the patients were admitted after trauma (polytrauma, multiple trauma, head injury, or spinal injury) Gastrointestinal surgery (complications of gastrointestinal surgery, emergency gastrointestinal ... 0.001) Mortality analysis was separated into short -term mortality (surgical ICU and in- hospital mortality) and long- term mortality (post-hospital mortality) Surgical ICU mortality in the sepsis ... mortality than did patients with trauma ICU, intensive care unit In- hospital mortality The Kaplan-Meier survival curve shows that mortality patients with sepsis had higher in- hospital mortality...
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Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf
... Competing interests The authors declare that they have no competing interests What is the key factor that sustains a non-progressive disease course, and what initiates the decline in protective ... against HIV-1 Gag T cell epitopes (identified by responses at intersecting peptide pools) Sequential T cell reactivity (indicated by X) detected by INF- ELISPOT against HIV-1 Gag T cell epitopes ... detected at this epitope, it is likely that the decline in the p24 -specific proliferative response was the key event that contributed to the failure of CTL to control viraemia, as it is understood...
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Báo cáo y học: "Long-term outcome and prognosis of dissociative disorder with onset in childhood or adolescence" pot
... both inpatient and outpatient treatment had a more favourable course In line with this the outcome in our outpatients was better as compared to inpatients A longer duration of illness prior to ... adolescence http://www.capmh.com/content/2/1/19 term or long- term follow up [26] In summary, our results also point to the fact that in a significant proportion of patients improvement during initial treatment ... dissociative disorder, co-morbid symptoms, inpatient versus outpatient treatment, therapeutic strategies; termination of treatment against medical advice, treatment response, gender, speech or motor...
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Long term effects of zinc oxide nanoparticles on wastewater treatment in a membrane bioreactor (MBR) process
... evaluate whether or not ZnO-NPs exhibit toxicity to wastewater sludge to the extent that it affects the wastewater treatment efficiency significantly It remains to be seen whether bacteria in the ... detail Lastly, it is also important to study the changes in bacteria community structure due to longterm exposure of ZnO-NPs in order to gain more insight into the microbialNPs interaction in ... occur in wastewater and the potential toxicity, if any In view of these issues, it is important that the fate and transformation of ZnO-NPs during the wastewater treatment process be examined in...
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Long term comparison of four techniques for obtaining nasal symmetry in unilateral complete cleft lip patients a single surgeons experience
... was most comparable with the noncleft side Group I had the lowest nostril height (Tables and 2) This indicated that overcorrection was necessary to maintain the nostril height over the long term ... nostril height: this vertical line was drawn on the medial one-quarter part of the nostril width The distance between the horizontal reference line and the intersection with the upper-inner nostril ... used in this study A horizontal reference line was constructed by connecting the most inward point at the outer lateral borders of the cleft and noncleft nostrils All vertical measurements were...
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Báo cáo y học: "Long Term Persistence of IgE Anti-Influenza Virus Antibodies in Pediatric and Adult Serum Post Vaccination with Influenza Virus Vaccine"
... dependent cell mediated cytotoxicity against cancer cells in vitro These responses were not correlated with total serum IgE levels We therefore speculate that it is not the total IgE levels that are ... cytokines were detected in serum of vaccinated compared with non vaccinated subjects (p>0.05), as well as between vaccinated adults compared with vaccinated children, compared with non vaccinated ... morbidity and mortality in the United States [23] All age groups can be infected with Influenza virus, but children have the highest infection rates [24] In the United States, vaccination is...
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Báo cáo sinh học: " Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage" pptx
... from the National Heart, Lung, and Blood Institute; by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Eye Institute; by the ... in the statistical tests of association of phenotype and genotypes in a GWA study GWA Statistical Genotype QC The results of the GWA statistical genotype QC analysis are summarized in Table The ... QC test of the suitability of the isolated DNA for single SNP genotyping Failure in this step indicates that the DNA quality is unlikely to be sufficient for highly multiplexed GWA genotyping...
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báo cáo hóa học:" Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage" doc
... from the National Heart, Lung, and Blood Institute; by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Eye Institute; by the ... in the statistical tests of association of phenotype and genotypes in a GWA study GWA Statistical Genotype QC The results of the GWA statistical genotype QC analysis are summarized in Table The ... QC test of the suitability of the isolated DNA for single SNP genotyping Failure in this step indicates that the DNA quality is unlikely to be sufficient for highly multiplexed GWA genotyping...
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báo cáo khoa học: "Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy" doc
... reason to attempt AFTV rather than chemotherapy Even in the present time, there is no clinically appropriate estimating system of antitumor cellular immune reactivity for the particular patient Since ... Since DTH testing is commonly used to measure specific antitumor cellular immune reactivity we used it to evaluate antitumor cellular immune status in the different timing as just before, complete, ... were injected intradermally three times every two weeks as AFTV Delayed-type hypersensitivity (DTH) testing both before the first injection and 48 hours later was negative DTH two weeks after the...
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Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
... association between initial DNA damage and RIA in relation to radiation-induced toxicity in the set of LABC patients treated with high dose HF radical RT with long- term follow-up where this association ... used to classify the toxicity of patients Acute toxicity was evaluated during and at the end of RT Late cutaneous and subcutaneous toxicity was evaluated every three months during the first two ... Apoptosis is initiated following DSB through an ATM-directed pathway [50] This could explain the fact that patients affected by the Ataxia-Telangiectasia syndrome show the lowest rates of RIA In...
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báo cáo khoa học: "DNA aneuploidy as a topographic malignant transformation pattern in a pleomorphic adenoma of long-term evolution: a case report" docx
... magnification) Conclusion There is little information in the literature regarding topographic malignant transformation patterns of PA This study revealed that deep tumor compartments may be involved in ... at a faster rate [17] Other studies described that, although the myoepithelial component predominates in most PAs, the genetic changes leading to malignant transformation occur more frequently ... involved in the initial stages of malignant transformation The authors of the present study suggest that deep areas in long- term evolution PAs should be carefully assessed by serial sectioning to document...
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Working paper series the phillips curve and long-term unemployment
... that the estimation is only capturing the indirect impact of institutions on weights through their impact on long- term unemployment That is, the institutions affect long- term unemployment but have ... to see that most of the unemployment growth in Europe can be attributed to the striking growth in long- term unemployment Its rate quickly jumped from about percent in 1976 to almost percent in ... expectations of its shape and with estimates in other studies In this section I will test the sensitivity of α, the weight on short -term unemployment, to alternative values of the 25 32 Complete tables...
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Báo cáo khoa học: " Effect of the medical emergency team on long-term mortality following major surgery"
... as they may introduce new pathogens into an intensive care unit • Psychoemotional intervention alleviated severe posttraumatic stress response Competing interests The authors declare that they ... which the victims were hit and swept away by the wave Antiinfective therapy Our intial choice of anti-infective therapy was a combination of a potent quinolone combined with clindamycin This strategy ... respiratory isolation until their microbial flora is identified as they present a threat for introducing new pathogens into an intensive care unit Initial anti-infective therapy using quinolones...
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