... techniques of internal fixation This unusual case of delayed union ofthe femur fracture associated with Paget 'sdiseaseofthe bone for which functional bracing was ultimately successful illustrates ... biological osteosynthesis has gained a reputation in fracture treatment Minimally invasive plate osteosynthesis (MIPO) techniques minimize the extent of soft tissue trauma to the injury zone, theoretically ... involving the entire femur ofthe fracture (Figure 5), the patient is able to walk unaided with a single T-cane Discussion Although Paget 'sdiseaseofthe bone is a relatively common disease in Australia,...
... nuclei [1,2] The pathogenesis of Paget sdisease is still a subject of debate with two main hypotheses The epidermotropic hypothesis proposes that Paget s cells originate from ductal epithelium, ... where they migrate towards the epidermis This hypothesis is supported by the association between Paget s and an underlying breast carcinoma in the majority of patients The second hypothesis, the ... Paget sdiseaseofthe right nipple with no evidence of underlying invasive ductal carcinoma, ductal carcinoma in situ ofthe breast tissue or lymph node invasion Discussion Paget sdisease is an...
... age, late stage Page of disease, and a poor performance status, as well as delay and contraindication of chemotherapy The prognosis of synchronous primary lymphoma in thesmall and large bowel correlates ... possibly adverse effect on prognosis The lack of specific complaints and the rarity of intestinal obstruction probably account for the delays in diagnosis Early diagnosis and systemic chemotherapy ... al have also found T cell lymphomas in patients with a long history of celiac disease in thesmallbowel and ulcerative colitis in the colon [12] The colon itself is an uncommon site of involvement...
... metastatic polypoid melanoma ofthesmallbowel Discussion Barbette [3] was the first person to refer to intussusception in 1674 The first successful operation to a child with intussusception was ... arrived at the hospital with bowel obstruction and in the first case the diagnosis of intussusception was established intra-operatively, while in the second case the diagnosis was based on abdominal ... findings Thus, in 50% of intussusception cases in adults, the causes are benign lesions such as fibromas, lipomas, adenomas and Meckel s diverticula [2,8,9] In the remaining 50% the causes are...
... alendronate seemed to be more suitable for the treatment of Japanese patients since the dose of alendronate used for the treatment of osteoporosis in Japanese patients (5 mg per day) was half of that used ... other sclerosing bone dysplasia [2,3] To monitor disease activity and the effects of treatment, we measured T-ALP and uNTX levels of our patients every three to six months and assessed their ... throughout the five-year follow-up Recently, several studies have indicated the possibility that long-term or high-dose bisphosphonate therapy could cause severe side effects, including osteonecrosis of...
... Photograph ofthe penile lesion Photograph ofthe penile lesion Figure H&E stain ofthe resected specimen showing a clear margin H&E stain ofthe resected specimen showing a clear margin Discussion ... planus, psoriasis and seborrheic dermatitis This can result in delayed presentation as was the case with our patient In order to make the correct diagnosis, a high index of suspicion is required The ... CKs, have consistently been proven to be the most useful diagnostic markers [2] This observation was confirmed in our case A recent classification based on the origin ofthe Paget 's cells has...
... Paget 'sdisease is to control disease activity with bisphosphonates This is the first reported case of Paget 'sdisease affecting pituitary gland function by involvement ofthe sphenoid bone In this ... function Discussion Erectile dysfunction is a common disorder and is an important health-care issue as it acts as a surrogate marker of other diseases of more concern, such as diabetes mellitus and ... fossa The hypothesis was that the hyperprolactinaemia may have been consequent upon the increased vascularity and blood flow through the sphenoid secondary to the activity ofthe Paget 's disease...
... atoms, and the ions were accelerated through 10 KeV Argon was used as the collision gas RESULTS AND DISCUSSION Analysis of LPS As shown in Fig 1, a ladder-like pattern was observed in the SDS/PAGE ... was further analyzed as the main component of lipid A The structure ofthe lipid A component was established by NMR and MS The 1H NMR signals ofthe isolated lipid A were assigned using DQF-COSY ... analysis As no other O-substituted sugar was observed in the methylation analysis, OPS had a linear structure Thus, the nonsubstituted Rha was estimated to be located at the nonreducing terminus of...
... patients with Crohn'sdisease We also show, using immunohistochemistry, that the CSF1R protein is expressed in the superficial epithelium ofthe ileum and colon *This SNP occurs 2033 base pairs from ... case-control study, we have shown that a SNP in an intron of this gene is associated with Crohn'sdisease Whether this SNP is in close proximity to another disease- causing SNP in the same (or a ... NC) Page of (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines 2004, Results Association ofthe T allele ofthe A2033T SNP with Crohn'sdisease especially...
... immunomodulatory drugs for at least months before screening and stable doses of prednisone for at least weeks before the screening visit Patients were allowed to decrease the steroid dose during the study period ... Two patients had ileocolonic disease and two others had gastrocolonic disease None had a fistula Median duration ofCrohnsdisease was years (range, 1–5) All patients were taking prednisone at ... inactive disease (Fig 2) In three patients, it was possible to taper the dose of steroids while they were receiving LGG Average reduction in steroid dose in these patients was 50% at 12 weeks The...
... DA in the absence of neuronal degeneration [6] The CSF levels of TIQs increase in early PD and decrease as thedisease progresses [12] TH inhibition by endogenous TIQs may therefore be most prominent ... kinases, which phosphorylate TH at serine residues ofthe N-terminal domain [22,23,28] Phosphorylation by protein kinase A (PKA) at Ser40, the most prominent of these regulatory sites, increases ... [10,27,39,45], leading to loss of TH activity [46,47] Second, thermal stability ofthe enzyme increases and its resistance to proteolysis improves [33] TH preparations from animal tissues are inevitably...
... though the presence ofthe M404V mutation could not be assessed in patient III-6, these hypotheses strongly support the need for further investigation into the possible role ofthe p62 protein in the ... cases with a mis-sense mutation in the p62/SQSTM1 gene These results should be confirmed in other PDB patients of Italian and other ancestries Moreover, the value of a pre-symptomatic gene test ... was not performed on this subject; the skeletal extent of PDB is on the basis of X-ray evaluations bone biopsy showed the presence of an osteogenic sarcoma on the Pagetic bone already metastasized...
... on these mucosal stem cells The aim of this study was to study thebowel damage caused by radiation, 5-FU or oxaliplatin as well as combinations thereof by using a microcolony survival assay ... its clonogenic stem cells which are located in thesmallbowel crypts Therefore, the survival of these clonogens is likely to be a decisive factor in the repair ofthebowel after cytotoxic therapy ... further decrease in D0 when combining both drugs with radiotherapy The basis for this clonogenic assay is that the regeneration ofthebowel mucosa is dependent on its clonogenic stem cells Therefore,...
... ileocecal fistula, and a pelvic abscess increased the suspicion for Crohnsdisease Endorectal ultrasound findings were more consistent with the appearance of a complicated abscess rather than ... reports of patients with Meckel s diverticulum masquerading as Crohnsdisease are rare [12], but cases of patients with Meckel s diverticulum associated with confirmed Crohnsdisease are not ... fine-needle aspirate ofthe abscess fluid also lacked malignant cytology Endoscopically, there were no ulcerations or gross findings to support a diagnosis of IBD, and rectal biopsy specimens did not show...
... ileocecal fistula, and a pelvic abscess increased the suspicion for Crohnsdisease Endorectal ultrasound findings were more consistent with the appearance of a complicated abscess rather than ... reports of patients with Meckel s diverticulum masquerading as Crohnsdisease are rare [12], but cases of patients with Meckel s diverticulum associated with confirmed Crohnsdisease are not ... fine-needle aspirate ofthe abscess fluid also lacked malignant cytology Endoscopically, there were no ulcerations or gross findings to support a diagnosis of IBD, and rectal biopsy specimens did not show...
... patient 's lip before the diagnosis ofCrohn'sdisease Multilayer squamous epithelium covering the tissue specimen, scattered clusters of lymphocytes and histiocytes resembling non-caseating granulomas, ... tissue specimen, scattered clusters of lymphocytes and histiocytes resembling noncaseating granulomas, as well as infiltration ofthesmall vessel walls ofthe underlying connective tissue by ... CD as was suggested previously In the absence of mechanical irritation or other mucosal disease, the oral lesions in CD could be attributed to the inflammatory boweldisease itself It is of interest...
... Evidence of spillover effects • Small business support: o o Survival rates for SBIR supported firms o • Small business share of agency R&D funding Growth and success measures for SBIR vs non-SBIR ... the numerical small business size standard for its industry SBA has established a size standard for most industries in the U .S economy The most common size standards are 500 employees for most ... some analysis; NSF also has some internal assessments These agency reports must be assessed for accuracy and comprehensiveness, as an early-stage priority under Phase II ofthe NRC study.51 Annex...
... national, state, and local levels in support ofthe SATS deployment? The committee interprets the first question as a request for an assessment of whether thesmall aircraft transportation system envisioned ... much ofthe factual information and many ofthe statistics are referenced in later analyses oftheSmall Aircraft Transportation System (SATS) concept Inasmuch as the SATS vision postulates a ... characteristics ofthe pilots that fly them is provided Much ofthe discussion is background, helpful for understanding the terminology and issues presented in subsequent sections ofthe report...
... COMPASS, COMPASS English as a Second Language (ESL), ASSET, and “Combined English Language Skills Assessment” (CELSA).4 The COMPASS ESL and CELSA tests were used only for ESL students The CELSA ... under this subpart of (1) The test taken by the student; (2) The date ofthe test; and (3) The student 's scores as reported by the test publisher, assessment center, or State Students Ineligible ... 16 students, the assessment center manually scored the tests For five of those eight students, the assessment center did not ensure that the tests were administered by certified test administrators...