cover letter examples in response to job posting
WRITING IN RESPONSE TO LITERATURE
Ngày tải lên :
25/10/2013, 17:20
... action.
1. Find the line or lines which tell us that Hamlet is thinking about being dead.
2. Find the line or lines which suggest that he views dying as the easy way out of a problem.
3. Find the line ... addicted. Indeed, quitting heroin is easier than quitting tobacco. Yet big
tobacco’s big lie doesn’t stop them from producing cigarettes and marketing them to young consumers all
the while denying ... sleep in those beds,
No bargainers’ bargains by day—no brokers or speculators—would they continue?
Would the talkers be talking? Would the singer attempt to sing?
Would the lawyer rise in the...
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Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf
Ngày tải lên :
18/02/2014, 16:20
... additional insights into this
interesting question.
Conclusions
In summary, we have identified a novel metabolic
gene switch (decrease in fatty acid utilization,
increase in glucose utilization) in the ... the prosurvival serine-threonine
protein kinase, Akt (also known as protein kinase B)
[2]. In agreement with this, elevated levels of activated
Akt in female hearts are linked to improved cardiac
cell ... is limiting, this gene program may be a crucial component that
enhances tolerance to oxygen deprivation in female hearts.
Abbreviations
Akt, serine-threonine protein kinase (protein kinase B);...
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Tài liệu Báo cáo khoa học: Analyzing changes of chromatin-bound replication proteins occurring in response to and after release from a hypoxic block of replicon initiation in T24 cells pptx
Ngày tải lên :
21/02/2014, 00:20
... denoted according to the proteins
they contain. Fraction 1 includes all ‘non-nuclear proteins’,
i.e. cytosolic proteins separated during hypotonic prepar-
ation of nuclei, fraction 2 contains ‘soluble ... staining is colocated with the BrdU
staining and this again signifies that PCNA is only bound to
chromatin portions where actively replicating DNA is
present.
Recruitment of proteins involved in ... nucleosolic proteins.
The remaining pellet contains all DNA and structure bound
proteins and is further referred to as chromatin-fraction.
Electrophoresis of proteins and Western blotting
Cytosolic and...
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Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc
Ngày tải lên :
07/03/2014, 10:20
... loops for sensing [2]. In
addition to the N-terminal input domain, SKs contain
a C-terminal portion representing the transmitter mod-
ule, with several blocks of amino acid residues being
conserved ... buffer W contain-
ing 2.5 m
M desthiobiotin (lane 3). SenS
C
H199A was purified in the
same manner (lane 4). To obtain SenR, a cytoplasmic protein
extract (lane 5) containing SenR obtained from E. ... histidine autokinase in vitro
SenS
c
exhibited time-dependent autophosphorylation
during incubation with [
32
P]ATP[cP]. The highest sig-
nal intensity was already achieved after 5 min of incu-
bation...
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Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx
Ngày tải lên :
07/03/2014, 15:20
... creatine kinase, glycogen syn-
thase, phosphofructokinase 2, ceramide synthesis, glucose
uptake, apoptosis, insulin receptor substrate 1, mammalian
target of rapamycin kinase (mTOR), mitogen-activated
protein ... phosphatidylinositol 3-kinase inhibitor
wortmannin, no other details of this insulin process are
known. A novel and physiologically interesting observation
of the present study was that palmitate totally ... previous finding that
palmitate overrode the effect of insulin to increase malo-
nyl-CoA content in the heart [15,24]. It could also explain
why Sakamoto et al. [66] observed no effect of insulin on
heart...
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Can’t Shake that Feeling: Event-Related fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed Individuals pptx
Ngày tải lên :
07/03/2014, 17:20
... activity in response
to processing negative features of information. This study
examined whether brain activity in response to emotional
stimuli was sustained in depressed individuals, even fol-
lowing ... with
subscales for thinking about depressive affect in relation to a
negative event [MRQ-Emots], thinking about what can be done
in response to it [MRQ-Inst], and searching for meaning in the
event [MRQ-Srch]; ... in response to all emotional stimuli in
depressed individuals who displayed increased amygdala
activity. 4) The clinical relevance of sustained amygdalar
processing can be inferred by examining...
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Báo cáo khoa học: Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana ppt
Ngày tải lên :
07/03/2014, 21:20
... equilibrated with the
urea-binding buffer. After washing the cartridge with the
urea-binding buffer, the luminal domain of At SEL-1L
was eluted with the urea-binding buffer containing 1 m
imidazole, and ... phosphorylating the specific serine resi-
due of eIF2a [51] to protect cells from the stress.
P58
IPK
inhibits PKR-mediated translational arrest by
inactivating the kinase by binding to the domain of
PKR ... participate in the folding of proteins in the ER.
The genes of six translocation-related proteins were
found to be induced. In mammalian cells and yeast,
translocon subunit proteins are thought to be induced
to...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
Ngày tải lên :
16/03/2014, 00:20
... [44–46]
It is interesting to note that in all cases MEK inhibi-
tor-induced BIM expression alone was not sufficient to
induce a dramatic increase in cell death; pronounced
increases in apoptosis were ... Pharmacologic
mitogen-activated protein ⁄ extracellular signal-regulated
kinase kinase ⁄ mitogen-activated protein kinase inhibi-
tors interact synergistically with STI571 to induce
apoptosis in Bcr ⁄ ... mutations in the EGFR
tyrosine kinase domain; these primary mutations corre-
late well with clinical responses to the EGFR-specific,
ATP-competitive tyrosine kinase inhibitors gefitinib
and erlotinib, indicating...
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Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot
Ngày tải lên :
16/03/2014, 06:20
... temperatures during winter and
anoxia during summer, in combination with the
changes in salinity, are associated with high mortality
in this species [25–27]. In view of CHH involvement in
response to stress ... ranging from 1 : 5 for Cal. sapidus ,to1 : 8in
Car. maenas ,to1 :10inCan. pagurus [29,30], yielding
peak 2 as the major CHH.
The immunohistochemistry studies show that the
intrinsically staining cells ... exclusive positive staining in
the PO but not in TG (our unpublished observation),
suggesting that the putative cDNA encoding the
PO-CHH type cloned in TG is not translated into a
protein. Similarly,...
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Bank Behavior in Response to Basel III: A Cross-Country Analysis doc
Ngày tải lên :
22/03/2014, 21:20
...
percent increase in the interest expense to total assets ratio between 2006 and 2008 by
increasing lending rates given that credit growth was declining in this period. The higher
interest expense ... in 2008 and recovered to only 1.4
percent in 2009. Consequently, the profitability of these banks was still suffering from the
aftermath of the financial crisis in 2009. Further insight into ... constraint. In this case total capital has a positive option value, and, the bank
will tend to hold more capital than required in order to gain flexibility to increase its supply
of loans in the...
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Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
Ngày tải lên :
23/03/2014, 03:20
... equally into three
sectors, including the front sector between the nucleus and
the leading edge. The Golgi in the front sector was deter-
mined to be in the polarized position. One hundred cells in
ten ... ⁄ 3-containing adaptor protein that interacts with
the LIM-only protein PINCH and components of
growth factor receptor kinase-signaling pathways. Mol
Biol Cell 9, 3367–3382.
34 Miyamoto Y, Yamauchi ... Cdc42 in response to these
environmental changes are key events leading to cell
polarization [5,6].
Cas is a multiadaptor protein that regulates various
signaling pathways in response to extracellular...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot
Ngày tải lên :
23/03/2014, 06:20
... results obtained from exper-
iments using hDlg mutated at different p38c phosphor-
ylation sites or using several kinase inhibitors,
including the general kinase inhibitor staurosporine,
demonstrated ... the concentrations indicated. Cells
were exposed to 0.5
M sorbitol for 60 min, and then incubated for 9 h in sorbitol-free medium (in the continued absence or presence of
inhibitor). Endogenous ... different MAPK pathway
inhibitors to block hDlg phosphorylation [17]. We then
examined hDlg loss in cells treated with inhibitors and
exposed to sorbitol. Both p38MAPK inhibitors,
BIRB0796, which...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf
Ngày tải lên :
23/03/2014, 10:21
... split and
plated in media containing Geneticin to select for cell containing vector DNA. After three weeks, the number of cells was determined by
fixing cells and staining with dye: vector only, p53 ... media containing Geneticin to
select for cell containing vector DNA (as in Fig. 5A,G). After three weeks, the number of cells was determined by fixing cells and staining
with dye. Individual colonies ... cell lines to determine whe-
ther the gene product had protective effects from DCA
damage in vitro.
Cellular stress protein responses play a key role in
minimizing cell injury and maintaining tissue...
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Báo cáo khóa học: Soluble LDL-R are formed by cell surface cleavage in response to phorbol esters pdf
Ngày tải lên :
23/03/2014, 12:20
... cytosolic adaptor proteins
containing phospho-tyrosine binding domains are known to
interact with the NPXY motif. ARH and Disabled 1 are
two cytosolic proteins that have been shown to bind to ... [
35
S]methionine by incubating in methionine/
cysteine-free EMEM/LPDS for 30 min and then for
2 h in methionine/cysteine-free EMEM/LPDS containing
50 lCiặmL
)1
[
35
S]methionine. The medium was changed
to ... Fischer,D.G.,Tal,N.,Novick,D.,Barak,S.&Rubinstein,M.
(1993) An antiviral soluble form of the LDL receptor induced by
interferon. Science 262, 250–253.
41. Klein, B. & Brailly, H. (1995) Cytokine-binding proteins: stimu-
lating...
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