cooperative competitive regulation of rem sleep with nrem sleep and wakefulness

Báo cáo hóa học: " Research Article Throughput of Cellular Systems with Conferencing Mobiles and Cooperative Base Stations" pot

Ngày tải lên : 21/06/2014, 22:20

... amplifyand-forward in [13, 15], respectively, and decode-andforward in [14], and the respective merits of multicell processing and MS cooperative transmission technologies, and combinations thereof, ... Y Bar-Ness, and U Spagnolini, “Low-SNR analysis of cellular systems with cooperative base stations and mobiles,” in Proceedings of the 14th Asilomar Conference on Signals, Systems and Computers ... Wyner model with inter-cell conferencing and intra-cell TDMA studied in Section Nm are Gaussian with independent real and imaginary parts that each have zero mean and variance 1/2, and we write...

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Báo cáo y học: "Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss" pdf

Ngày tải lên : 10/08/2014, 09:20

... much more REM compared to adults, as human infants typically enter REM sleep directly after the initial onset of sleep and spend approximately 50% of their total sleep time in REM [15] And we also ... involve REM sleep deprivation and/ or the use of medication to inhibit REM sleep with manipulation of independent variables Importantly, age matched subjects who simply lie down and not sleep (having ... aspects of recuperation during sleep in these mammals Could the finding of mammal size and quantity of sleep be related to the size of the vertebrae and related hydraulic recovery? Page of (page...

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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot

Ngày tải lên : 10/08/2014, 10:21

... down -regulation of phosphodiesterase 1A (PDE1A), a modulator of cAMP and cGMP cyclic nucleotides, could be the key event to explain the TQ-induced down -regulation of UHRF1 and the occurrence of ... hemi-methylated strands, UHRF1 is recruited with DNMT1 and/ or likely DNMT3a and DNMT3b, in order to perpetuate gene repression, and particularly that of TSGs in cancer cells Recently, two novel and interesting ... expression The down -regulation of UHRF1 is probably driven by p53 and/ or p53 This is leading to an inhibition of tumor vascularization as a consequence of the down -regulation of the VEGF gene expression...

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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc

Ngày tải lên : 17/02/2014, 11:20

... sponsors of new drugs and license holders of existing drugs The agency’s general policies and procedures for meetings with sponsors are prescribed in statute and regulation and reflect the requirements ... between CBER and ORA; an approach compatible with existing FDA structures and systems; oversight to ensure consistency of decisions and actions; and efficiency and evaluation of new methods of inspection ... Drug Application ORA Office of Regulatory Affairs ORO Office of Regional Operations OSD Office of the Secretary of Defense PB pyridostigmine bromide PEO Program Executive Officer PHSA Public Health...

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Tài liệu Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation pdf

Ngày tải lên : 20/02/2014, 23:20

... demonstrated that hypoxia and iron chelators could block hydroxylation of both the proline and asparagine residues, regulating the association of VHL with the ODD [84–87] and p300 with the CAD [88], ... mechanism of regulation of both domains involves a common iron dependent process [74,75,79] Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... tumours of oxygen and nutrient supply Coupled with previous studies that have provided Ôproof of principleÕ that targeting HIF stability [111] and transactivation [78] can enhance oxygen delivery and...

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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Ngày tải lên : 15/03/2014, 00:20

... and disease MMP-2 degradation of TnI is associated with diminished contractive function of the heart [11], MMP-9 degradation of aB-crystallin with multiple sclerosis [12] and MMP-9 cleavage of ... that interacts with the catalytic zinc is not removed (Fig 2B, steps 1a and 2a) Treatment of proMMP-9 with an excess of HNL also induced a partial activation of the proenzyme with an identical ... MMP-9, all with a : stoichiometric ratio and binding constants in the nanomolar range [26] These SIBLINGs and MMPs are also co-expressed and colocalized in salivary glands of humans and mice [27]...

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Care of the Patient with Retinal Detachment And Related Peripheral Vitreoretinal Disease docx

Ngày tải lên : 22/03/2014, 09:20

... the posterior pole of the eye Biomicroscopy Examination of ocular tissue using a bright focal source of light with a slit of variable width and height and a binocular microscope with variable magnification ... person often is unaware of the loss of an area of peripheral vision) The sudden onset of numerous floaters and the occurrence of flashes of light are hallmarks of a potential retinal tear Significant ... retina and the Common Signs, Symptoms, and Complications Early symptoms of retinal detachment (photopsia and/ or a sudden shower of floaters due to tearing of a retinal blood vessel) are often...

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Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx

Ngày tải lên : 22/03/2014, 15:21

... kinase (JAK2) and casein kinase (CK2) are involved in the regulation of ABCA1 activity and stability by apoA-I The interaction of apoA-I with ABCA1 increases the cellular cAMP content and ABCA1 phosphorylation ... Function and regulation of ABCA1 CDC42, a member of the Rho GTPase family, is reported to interact with ABCA1 and the interaction enhances apoA-I-mediated cholesterol efﬂux [47] Palmitoylation of ABCA1 ... calpain On the other hand, phosphorylation of Thr-1286 and Thr-1305 in the PEST sequence (rich in proline, glutamic acid, serine and threonine) (Fig 1) within the cytoplasmic domain of ABCA1 promotes...

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QUASILINEAR CONTROL: Performance Analysis and Design of Feedback Systems with Nonlinear Sensors and Actuators pot

Ngày tải lên : 23/03/2014, 15:20

... turns out, Na and Ns are functions of the standard deviations, σu and σy , of u and y, respectively, that is, ˆ ˆ ˆ ˆ Na = Na (σu ) and Ns = Ns (σy ) Therefore, we refer to the system of Figure 0.2 ... Proofs 225 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Proofs for Chapter Proofs for Chapter Proofs for Chapter Proofs for Chapter Proofs for Chapter Proofs ... various numerical and analytical studies indicate that if the plant, P(s), is low-pass ﬁltering, the approximation is well within 10% in terms of the variances of y and y and u and ˆ u More details...

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báo cáo hóa học:" The experiences of people living with HIV/AIDS and of their direct informal caregivers in a resource-poor setting" doc

Ngày tải lên : 20/06/2014, 08:20

... expression of emotional and psychological distress and ease the burden of living with HIV/AIDS [22,34,35] A system of informal and formal counselling and support must be accessible to PLHIV and their ... health care programmes and increased levels of support for PLHIV and their caregivers will empower thousands of people to cope with HIV/AIDS and its complex psychological and social challenges ... gender issues, and instrumental Due to the debilitating nature of HIV/AIDS, the physical and medical needs of PLHIV are numerous and can be overwhelming [20] PLHIV cope with a variety of physical...

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Báo cáo hóa học: " Real-time detection of musical onsets with linear prediction and sinusoidal modeling" pot

Ngày tải lên : 20/06/2014, 22:20

... extended, creating models of sound based on the separation of the audio signal into a combination of sinusoids and noise [22], and further into combinations of sinusoids, noise and transients [23] ... of the audio signal at a much lower sampling rate The ODF usually consists of one value for every frame of audio, and should give a good indication as to the measure of the unpredictability of ... frame If R(k, n) and j (k, n) are the actual values of the magnitude and phase, respectively, of bin k in frame n, then the deviation between the prediction and the actual measurement is the Euclidean...

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báo cáo hóa học: " Real-time detection of musical onsets with linear prediction and sinusoidal modeling" pptx

Ngày tải lên : 21/06/2014, 00:20

... extended, creating models of sound based on the separation of the audio signal into a combination of sinusoids and noise [22], and further into combinations of sinusoids, noise and transients [23] ... of the audio signal at a much lower sampling rate The ODF usually consists of one value for every frame of audio, and should give a good indication as to the measure of the unpredictability of ... frame If R(k, n) and j (k, n) are the actual values of the magnitude and phase, respectively, of bin k in frame n, then the deviation between the prediction and the actual measurement is the Euclidean...

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Báo cáo hóa học: " Enhancements of thermal conductivities with Cu, CuO, and carbon nanotube nanofluids and application of MWNT/water nanofluid on a water chiller syste" docx

Ngày tải lên : 21/06/2014, 04:20

... conducted with and without the addition of MWNT/water nanofluid The test system included a base fluid loop and a water loop The base fluid could be supplied with either water or with nanofluid; ... enhancements of CuO and MWNT nanofluids increase with the increase of volume fraction of CuO and MWNT The thermal conductivity ratio improvement for CuO nanofluid is approximately linear with the ... increased The viscosity of water and MWNT nanofluid decreases with the increasing of temperature The measured viscosity of tap water is 0.8 cps at 23.5°C and that of MWNT nanofluid is 1.0 cps at...

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Báo cáo hóa học: " Characterization of Titania Incorporated with Alumina Nanocrystals and Their Impacts on Electrical Hysteresis and Photoluminescence" pot

Ngày tải lên : 22/06/2014, 00:20

... superposition of the patterns from two pieces of nanocrystals Both of interplanes spacings, whose values are about 0.237 nm and lie at an angle of near to 60°, are of regular parallelogram with a center and ... of China (Grant number of 60576023 and 60636010), the State Key Program for Basic Research of China (2004CB619004), the State Key Program for Science and Technology of China (2009ZX02101-4) and ... proportional to the size of the nanocrystals In order to further understand the nature of the charge carrier trapping, migration and transfer in Ti0.25Al0.75Ox ﬁlms with small nanocrystals and the PL excitation...

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Báo cáo hóa học: " Research Article Three-Dimensional SPIHT Coding of Volume Images with Random Access and Resolution Scalability" doc

Ngày tải lên : 22/06/2014, 00:20

... diﬀerent parts of the image, enabling the possibility of high-quality region of interest (ROI) and the possibility of discarding unused portions of the image An unused portion of the image could ... codestream and includes all headers and required side information This rate is given in terms of bits per pixel per band (bpppb), where band means spectral band for hyperspectral data and axial ... reading the minimum amount of bits spectral dimensions independently and random access decoding These properties are important to ease of access and processing of the data and were not introduced...

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Báo cáo khoa học: " Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows" docx

Ngày tải lên : 07/08/2014, 23:22

... by TYPEDIS and the PARITY by TYPEDIS interactions were important with p-values of 0.04 and 0.02, respectively Namely, 27% of the animals with purulent and fetid discharge and 13% with purulent ... effect of CL, MLo = fixed effect of ML100, TDp = fixed effect of TIMED, Cr = random effect of farm A similar model was fit for the variable ΔBCS Stepwise forward selection was used and the levels of ... associated with the presence of A pyogenes and Escherichia coli, but not with that of Fusobacterium necrophorum or Prevotella melaninogenicus, the synergy of which is important for the pathogenesis of...

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Báo cáo khoa học: "A case of high-grade leiomyosarcoma of the bladder with delayed onset and very poor prognosis" pptx

Ngày tải lên : 09/08/2014, 03:21

... (35 patients, with a diagnosis of LMS of the bladder) showed a years disease-specific survival of 62%, with a 34% recurrence rate at a median follow-up of 38 months, with both local and distant ... resection with 2-3 cm depth free from tumor invasion [15-17,19] Neoadjuvant and adjuvant therapies were used in 21% and 16% of patients at MD Anderson, respectively, and both resulted in a doubling of ... conflicts of interest The authors alone are responsible for the content and writing of the paper Authors' contributions ER conceived of the study, and participated in its design and coordination and...

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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt

Ngày tải lên : 09/08/2014, 14:20

... -7 and 13 are upregulated with increasing degeneration [2,7] and that stimulation of cells in culture with IL-1β results in an upregulation of MMP-3 and -13 as well as ADAM-TS4 and a downregulation ... addition of recombinant IL-1β for 48 hours resulted in a significant upregulation of mRNA of MMP-3, -9 and -13 in both normal and degenerate NP cells (P = 0.05) (Figure 1b) The upregulation of MMP-9 ... expression of aggrecan and type II collagen genes and upregulates mRNA expression of matrix metalloproteinase (MMP)-1, -3 and -13 and ADAM-TS4 (a disintegrin and metalloproteinase with thrombospondin...

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Báo cáo y học: "Analysis of alternative splicing with microarrays: successes and challenges" docx

Ngày tải lên : 09/08/2014, 20:20

... of their distance from an exon junction, their position with the gene, and so on They also described a novel unbiased protocol for amplification and labeling of full-length RNAs, combining random-primed ... random-primed first-strand and second-strand synthesis steps with an amplification strategy that uses both PCR and in vitro transcription The method is reported to sample the entire transcript and thus prevent ... that the probes considered by standard expression-data analysis to be ‘noise’ are actually reproducible signals, indicative of different patterns of regulation of multiple splice forms Recently,...

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báo cáo khoa học: " Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells" docx

Ngày tải lên : 10/08/2014, 10:21

... expression of miR-27a by almost 67% as compared with that of control Cell growth was assayed, and down -regulation of miR-27a significantly inhibited proliferation of MKN45 cells as compared with control ... PCR (Figure 3) and western blot (Figure 4) Down -regulation of miR-27a could significantly decrease the expression of Pglycoprotein and cyclin D1, and up-regulate the expression of p21 To evaluate ... of the cells were detected in soft agar D, tumorigenicity of the cells in BALB/c nu/nu mice was detected The volumes of tumors were monitored at the indicated time results of MTT assay and soft...

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