... the advantage of specificity of action Nonetheless, in order to confirm the role of α7 nAChRs in the treatment of schizophrenia, a randomised double-blind, placebo -controlled study of the selective ... 2), provided that patients were receiving stable doses of all of these medications in the weeks preceding the trial and throughout the entire duration of the study In all, 10 patients in the placebo ... (for example, the number of cigarettes) in the smoking patients (n = 4) Discussion The major findings of this double-blind, placebo -controlled study are that administration of tropisetron, but not...
... stimulation of the needle, achievement of deqi, number of points, number of sessions and duration of sessions Out of the 47 included trials, two trials employed the sham intervention that consisted of ... and (c) whether trials using different types of sham yielded different results [10] They included 47 randomised controlledtrials published in English or German in which trial patients received ... use of switched-off laser acupuncture devices) Dincer and Linde also examined whether the 'true' and sham interventions differed in terms of points chosen, penetration of the skin, depths of needling,...
... shortage of randomized controlledtrials on this topic is a limitation, and larger randomized controlledtrials are needed to better understand the role of CYC in the care of these patients In ... Patients with severe lung involvement (defined as FVC < 55% and DLCO < 40% of predicted) have a worse prognosis, with a mortality of 42% within 10 years of the onset of disease [5] A number of ... reported in 33% ofpatients with limited scleroderma and in 40% ofpatients with diffuse SSc [5] High-resolution computed tomography detects ILD changes in 90% to 100% of SSc patients [2,5] ILD...
... lack of blinding The numbers and reasons for withdrawal/ dropout were reported in detail across trials None of the trials had extreme imbalances at baseline or was stopped early Thus, the trials ... evidence of heterogeneity (OR 1.32, 95% CI 1.07 to 1.64, P = 0.011, P of heterogeneity = 0.236, I = 24.2%; Figure 3) Subgroup analyses Three trials [22,25,26] that included a total of 373 patients ... had higher magnitudes of gastric colonization than did patients receiving sucralfate (OR 2.03, 95% CI 1.29 to 3.19) Importantly, in spite of evidence of heterogeneity among trials, the heterogeneity...
... the C series of the Official Journal of the EuropeanUnion CHAPTER IV IMPORTS AND EXPORTS Article 10 Imports As regards the hygiene of imported food, the relevant requirements of food law referred ... (b) Regulation (EC) No /2004 of the European Parliament and of the Council of laying down specific rules for the organisation of official controls on products of animal origin intended for ... (EC) No /2004 of the European Parliament and of the Council of laying down specific hygiene rules for food of animal origin lays down these rules (7) The principal objective of the new general...
... Supreme Audit Institutions of the Member States of the EuropeanUnion and the European Court of Auditors, during the Meeting on 6-7 December 2004 in Luxembourg, took note of and discussed the “Guidelines ... conflicts of interest or other impediments to the fair and objective appraisal of the subject of the audit In some SAIs of the “court of audit” type, independence and even-handed behaviour of staff ... above resolution *** The Presidents of the Supreme Audit Institutions of the Central and Eastern European Countries, Cyprus, Malta, Turkey and the European Court of Auditors, meeting in Riga (Latvia)...
... Introduction The EuropeanUnion has signed a number of treaties and conventions and developed a major body of legislation aimed at achieving gender equality.1 For the EuropeanUnion (EU), “Equality ... the existence of swamps The Pampa of the South of Brazil, in the State of Rio Grande Sul (RS) borders another two countries of the Pampa: Uruguay and Argentina Due to a number of factors, including ... implications of the expansion of monocultures of alien trees to the environment as a whole As a result of the situation, mobilizations and resistances of sul-rio-grandense ecological entities, unions...
... Importance of the Developments of the Nineteenth Century important European jurists, regardless of their nationality There is a distinct sense in many of the works of this time that the European ... 139 Decisions and Reports ofEuropean Commission of Human Rights and European Court of Human Rights Austria v Italy (Pfunders case) Application no 788/60 report of 30 March 1963 (1963) YB 740 ... inquisitorial In Part One, this understanding ofEuropean criminal proceedings is challenged by an examination of the work of various important European jurists of the nineteenth century It is argued...
... contract is in the form of an interstate or intergovernmental agreement or covenant, is the agreement of the Executive Office of the Chief Medical Officer The CMO’s Executive Office shall deny its ... currently working on a system of registration for the bodies acting in the field of donation/storage of egg cells and sperm SI Article 10 of the Law governing the status of reproductive cell donation ... treated as patients, patient legislation applies Although the Act of Status and Rights ofPatients requires that mutual understanding be a requisite for patient treatment, explicit consent of the...
... overview of socioeconomic inequalities in health in Europe 63 B Literature review of effects of health on economic outcomes 93 C The impact of health on economic outcomes: analysis of the European ... pertinent comments on the pre-final version of this report Of key importance to this report are the results of the extensive analyses of data of the European Community Household Panel (presented ... upper 50% of the population On the basis of currently observed patterns of mortality by educational level, the number of deaths that can be attributed to health inequalities in the European Union...
... Percentage of responses Year of primary medical qualification Figure Diagram1showing the year of primary qualification of overseas doctors Diagram showing the year of primary qualification of overseas ... the career paths of many non -European doctors, many of whom have spent a considerable duration of time working and training in the National Health Service of United Kingdom Page of (page number ... total of 239 661 doctors registered with it on June 2006, 22.8% (n = 54 656) obtained their primary medical qualification outside the EuropeanUnion UK government policy towards non -European Union...
... that psoriasis has a broad impact on patients' HRQOL Adalimumab treatment ofpatients with psoriasis improved the physical and psychological health of these patients to levels comparable with or ... involvement, a PASI score of ≥ 12 and a Physician's Global Assessment of at least moderate disease The REVEAL study was conducted in accordance with the principles of the Declaration of Helsinki, and ... REVEAL study patients The MEPS is a nationally repre- Page of (page number not for citation purposes) Health and Quality of Life Outcomes 2008, 6:75 sentative, cross-sectional sample of the non-institutionalized...
... functioning in patients with cardiovascular diseases, requiring the use of acetylosalicylic acid and the relief of these symptoms, independently of the kind of therapy, has improved patients HRQL ... recommendation of a double dose of omeprazole (2 × 20 mg) not only significantly decreased angina-like chest pain occurrence in 17 of the 48 (35%) patients with CAD and the prevalence of some electrocardiographic ... The patients were asked to take capsules for 14 days, twice a day, 30 minutes before a meal from their respective box Patients took the first dose of the recommended substance on the evening of...
... specific problem of the member state - were not given The Republic of Austria appealed against this decision at the European Court of First Instance Page of The Court subscribed to the view of the commission ... L 106/1 of 17 April 2001 Regulation (EC) No 1829/2003 of the European Parliament and the Council of 22 September 2003 on genetically modified food and feed , Official Journal L 268/1 of 18 October ... and Annex II A of Directive 2001/18/EC , Commission Recommendation of 13 July 2010, 2010/C 200/01, O J C 200/1 of 22.07.2010 Proposal for a Regulation of the European Parliament and of the Council...
... creation of a European network - The merging of the different sectorial measures to make the most of synergies - Avoid all polluting effects and protect the environment CONTENT AND MAIN PRINCIPLES OF ... public institutions Each is comprised of a number of groups of players: - For people or associations of people: associations representing an interest (trade unions, trade associations); associations ... activities by way of diversification of activities - The programmes will have a local and endogenous focus to add value to the resources of the regions themselves - The promotion of any innovative...
... number of weeks available), and for the final on-therapy (FOT) visit HAM-D17, MADRS, CGI-S, and CGI-I Table 1: Summary of 22 placebo -controlled clinical trialsof venlafaxine for treatment of major ... placebo -controlled comparison of venlafaxine and fluoxetine treatment in depressed outpatients J Psychiatr Res 2007, 41:351-359 Schatzberg A, Roose S: A double-blind, placebo -controlled study of venlafaxine ... [4-6] The present analysis was undertaken in a large dataset of 22 double-blind, placebo -controlled, clinical studies of venlafaxine in patients with MDD to identify and assess correlations among...
... (2.6) 0.97 Number ofpatients on DMARDS (%) (33%) 13 (81%) 0.05 Number ofpatients on NSAIDs (%) (33%) 12 (75%) 0.09 Mean number of DMARDS (range) 1.3 (0–3) 0.9 (0–2) 0.37 Number ofpatients on prednisone ... was the degree of attrition, with only of 22 patients (32%) completing the study The majority ofpatients who did not complete the 24-week study terminated because of perceived lack of efficacy ... randomized, double-blind, placebocontrolled study of the use of IFN-β-1a (Avonex®) in patients with RA The primary objective of the study was to evaluate the safety of its weekly administration Secondary...
... enough trials some exceptions would be found However, our results are confirmed by many other studies In a study of 61 industry-sponsored trialsof nonsteroidal anti-inflammatory drugs [17], 100% of ... the principle of equipoise Publication bias Results The results from every RCT (45 out of 45) favored the drug of the sponsor (P < 0.0001) Discussion Clearly, the results of these trials could ... were so categorized because of insufficient priority to warrant publication; 81% of positive trials and 70% of negative ones were published, suggesting a publication bias of perhaps 13% [25] Publication...
... tolerability of known side-effects, adherence to treatment, quality -of- life issues) If this is the purpose of phase III trials, then this will mean that different types of design and different numbers of ... that make full use of the ability to alter the assignment ofpatients to arms of the trial in the light of new information can be complex and difficult to analyse, and the choice of prior to reflect ... interested in the relative effectiveness of drug versus surgery for osteoarthritis of the knee, yet they are offered very little evidence on this type of question; patients may be more interested in...