control of cell migration
Control of Cell Proliferation and Growth byMyc Proteins
Ngày tải lên :
25/10/2013, 21:20
... the balance of expression of members of the Myc/Max/Mad network of proteins (see Fig 1) may dictate the response to loss of Myc (Walker et al 2005) In mice, the effects of deletion of the c-myc ... excision of c-myc (de Alboran et al 2001) Importantly, deletion of the mnt gene, which encodes a member of the Mad family of antagonists of Myc, restores proliferation to c-myc deleted cells, suggesting ... neuronal precursor cells leads to a dramatic loss of proliferative capacity of such cells (Knoepfler et al 2002) As long as questions of redundancy between different members of the myc gene family...
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Báo cáo hóa học: " Research Article A Robust Structural PGN Model for Control of Cell-Cycle Progression Stabilized by Negative Feedbacks" pdf
Ngày tải lên :
22/06/2014, 19:20
... that controls function, cell division cycle, and programmed cell death In that network, the level of expression of each gene depends on both its own expression value and the expression values of ... cell- cycle process is an ordered sequence of events by which the cell grows and divides in two daughter cells It is organized in four phases: G1 (the cell progressively grows and by the end of ... behavior (waves of control signals, stability to changes in the input signal, robustness to some kinds of noise, etc.) similar to those observed in real cell- cycle control systems During cell- cycle...
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Protein s nitrosylation and its relevance to redox control of cell signaling
Ngày tải lên :
09/09/2015, 17:56
... vi Summary Discovery of the function of oxidants as signaling molecules marks the beginning of the field of redox control of cell signaling Understanding the mechanism of how free radicals regulate ... Associate Professor Marie-Véronique Clément, Department of Biochemistry, for introducing me into the field of “Redox Control of Cell Signaling”, and guiding me along the arduous journey of my Ph.D ... significance of these events is not fully understood 1.4 MECHANISMS OF REDOX-BASED REGULATION OF CELL SIGNALING: FUNCTIONAL CONSEQUENCES OF OXIDATION OF “REACTIVE CYSTEINE” The notion of ROS/RNS...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc
Ngày tải lên :
15/03/2014, 09:20
... expected on the basis of our definition of RP as a fraction of the cell division cycle The control coefficient of reaction step x on RP is the percentage change in the fraction of the cell cycle length ... for control of normal animal cell proliferation Proc Natl Acad Sci USA 71, 1286–1290 Planas-Silva MD, Weinberg RA (1997) The restriction point and control of cell proliferation Current Opin Cell ... description of the method is provided elsewhere [17] Results and Discussion Control of the RP We used a perturbation method to quantify the control of the respective reaction steps in a mammalian cell...
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Báo cáo khoa học: E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes pot
Ngày tải lên :
16/03/2014, 04:20
... et al A Fine control of pre-mature B -cell apoptosis by E2A B C Fig Analyses of apoptosis in E2A)/) (A) Effects of PMA/ionomycin and etoposide treatments on cell- cycle distributions of DT40 and ... participation of B cell- specific factors in pre-mature B -cell apoptosis mediated by BCR stimulation by analyzing the E2A-deficient DT40 mutant E2A)/), we clarified the impact of E2A on apoptotic cell death of ... 1420 cell- cycle progression and proliferation of DT40 and E2A)/) cells Cells cultured in the presence of PMA/ ionomycin for 24 h or etoposide for h were analyzed by fluorescence-activated cell...
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Báo cáo khoa học: A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration doc
Ngày tải lên :
22/03/2014, 21:20
... because of increased frequency of leukocyte transmigration Cell transmigration is also involved in processes such as cancer cell metastasis and stem cell homing, and although the steps of cancer cell ... they also may take a transcellular route through the body of the cell; see Carman and Springer [100] for a recent review of transcellular migration of cells Both transmigration paths are available ... characterization of cells has been performed using single cells, for which cell substrate interactions are most important However, in the case Biophysical view of transendothelial migration of the endothelium,...
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Báo cáo khoa học: Stage-specific activation of MIG-17⁄ADAMTS controls cell migration in Caenorhabditis elegans docx
Ngày tải lên :
30/03/2014, 04:20
... Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans EMBO J 26, 2607– 2620 18 Kimble JE & White JG (1981) On the control of germ cell development in Caenorhabditis ... Regulated activation of MIG-17 ⁄ ADAMTS S Ihara and K Nishiwaki staining of cross-sections of L3 larvae with antibody to GFP revealed signals in the cytoplasm of muscle cells, the source of MIG-17 expression, ... of body wall muscle cells (E) Coimmunostaining of anti-prodomain (pink) and Monoclonal (green) Overlap of the two antibody stains appears white (F) Schematic presentation of a cross-section of...
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báo cáo hóa học:" Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma" doc
Ngày tải lên :
18/06/2014, 15:20
... the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule ... and subsequently the inserts of individual colonies subjected to sequence analysis Results Correlation of the UCHL1 expression level in RCC cell lines of the clear cell type with the promoter ... silencing of UCHL1 in RCC cell lines Methylation of UCHL1 in human primary RCC lesions, but not of corresponding normal kidney epithelium Since an impaired UCHL1 expression was not only found in RCC cell...
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Báo cáo sinh học: "Growth control of the eukaryote cell: a systems biology study in yeas" ppt
Ngày tải lên :
06/08/2014, 18:21
... major controller of eukaryotic cell growth) is not subject to growth-rate regulation Moreover, integrative studies reveal the extent and importance of post-transcriptional control, patterns of control ... S12 and S13) and 4) TOR control of cell growth at the transcriptional level The TOR signal transduction pathway is a central controller of the eukaryotic cell, sensing cellular environment and ... regulation of cell growth [24,64,65] (see also the section on translational control, below) As an example, many genes reported to be involved in control of cell size or coordination between cell growth...
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Báo cáo y học: "E3 ubiquitin ligases and their control of T cell autoreactivity" potx
Ngày tải lên :
09/08/2014, 07:20
... cellular processes controlled by ubiquitin modification [2] Different patterns of covalent attachment of ubiquitin to target proteins provide a further level of specificity to regulation of cellular ... ability of over-expressed SOCS3 to inhibit nuclear factor of activated T cells (NF-AT) activation and Il2 gene transcription [21,22] Consistent with this, the depletion of SOCS3 enhances T cell ... the activation of CD25– T cells through an activation of a TGFβ receptor-Smad2 pathway [55] The activation of Smurf1 E3 ligase activity leads to a ubiquitination and degradation of both Smad proteins...
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báo cáo khoa học: " Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?" pps
Ngày tải lên :
11/08/2014, 12:21
... new era in adoptive T -cell therapy because of the increase in the amount and survival of infused T cells found with this system Their system for the control of mammalian T -cell proliferation is ... enhancing the persistence of transferred T cells include ablation of all white blood cells (myeloablative methods), such as total body irradiation and administration of toxic levels of interleukin (IL)-2 ... that limit the use of adoptive T -cell therapy for cancer For example, the failure of adoptive immuno therapy against cancers lies in the absence of tumorspecific sources of T cells [6] If such...
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Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf
Ngày tải lên :
13/08/2014, 05:21
... stable CD4 T cell counts >500 cells/μl, and no history of ART [27,28] Subsequently, loss of LTNP status was defined by any of the following events: a consistent decline in CD4 T cell counts below ... frequency of nonprogression in this TAHIV cohort after 20 years of infection [7] Early studies on this cohort of TAHIV patients led to the identification of the Sydney Blood Bank Cohort (SBBC) of long-term ... predictive of loss of LTNP status and/or disease progression in of 8, and differentiated slow progressors from elite LTNP who retained potent virological control Sustained immunological suppression of...
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Báo cáo y học: "Directed cell migration in the presence of obstacles" doc
Ngày tải lên :
13/08/2014, 16:21
... path cell with2a non-absorbing center of mass of a placed in its Typical trajectories of theobject of unit radius chemotactic Typical trajectories of the center of mass of a chemotactic cell ... object of unit radius placed Typical trajectories of the center of mass of a chemotacticin Typical trajectories of the center of mass of a chemotactic cell with a perfectly absorbing object of unit ... via various types of cell adhesion molecules The strength of this adhesion depends sensitively on the specific type of cells and the obstacles under consideration The dynamics of cell movement very...
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the role of wasp family members in dictyostelium discoideum cell migration
Ngày tải lên :
22/12/2014, 18:48
... and cell migration Actin plays a critical role in all cell motility Co-ordinated cycles of actin polymerisation and depolymerisation induce the changes in cell shape that drive cell migration Cells ... many of the same cellular behaviours as higher eukaryotic cells such as those found in mammals Examples include cell motility and cell division, both of which are more comparable to mammalian cells ... The role of WASP family members in Dictyostelium discoideum cell migration By Andrew J Davidson Submitted in fulfillment of the requirements for the degree of Doctor of Philosophy The...
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Mathematical modeling of circular dorsal ruffles and lamellipodial dynamics in single and collective cell migration
Ngày tải lên :
09/09/2015, 18:51
... epithelial-type cells, to move out of the primary tumour site [208, 88] 1.4.2 Migration of sheets Another area of collective cell migration is the migration of two dimensional (2D) cell sheets, ... collective cell migration 121 24 Cell migration stalls when the cell- substrate adhesion and extent of polarization is low 122 25 v component of cell migration velocity ... above, the cytoplasm of the cell contains a vast array of other proteins and structures which maintain the everyday activities of the cell In cell migration, the skeleton of the cell, known as the...
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Genetic analysis of the role of ARP2 3 complex in border cell migration in drosophila melanogaster
Ngày tải lên :
10/09/2015, 15:48
... complex in border cell migration Lu Ruifeng 2010 I Introduction Arp2/3 complex in border cell migration Lu Ruifeng 2010 1.1 Cell migration Cell migration is a defining feature of animal cells (Pollard ... the studies of border cell migration Lots of efforts have been put into identification of regulators of the border cell migration The first identified mutant that affects border cell migration ... Collective cell migration In several cases of morphogenesis, epithelial cells move in a process termed “collective cell migration Collective motility is characterized by movement of cohorts of cells...
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Role of stat3 in cell migration
Ngày tải lên :
11/09/2015, 16:06
... required to mediate and maintain efficient cell migration 1.11 Cell migration 1.11.1 Process of cell migration Cell migration is essential to a variety of biological events and this process is ... participation in cell migration is highlighted by studies in T cells, whereby activation of Stat3 signaling by IL-6 is required to mediate the migration and recruitment of T cells to the site of inflammation ... of STAT3 in cell migration under physiological conditions 25 1.10.2 Role of Stat3 in cell invasion and metastasis 27 1.10.3 Cytoplasmic role of Stat3 in regulating microtubules 28 1.11 Cell migration...
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Establishment of cell polarity in zebrafish role of staufen and GRB2 in cell migration
Ngày tải lên :
12/09/2015, 08:18
... cell polarity 1.8 Cell polarity: an attribute to cell migration and cell movement Migratory strategies in several cells are similar to amoeboid mode of migration (Fig 1.9 A) This pattern of migration ... understanding of cell polarity in a global perspective This thesis addresses the function of two proteins namely Staufen and Grb2, in controlling the migration of cells 1.2 Cell polarity in unicellular ... 24 The migratory behavior of germ cells differ from that of other kinds of cells, such as fibroblasts, neural crest cells, border cells, and gastrulating cells, all of which show no amoeboid...
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Genetic control of vertebrate muscle cell identity
Ngày tải lên :
14/09/2015, 14:03
... help with proof-reading of the drafts of this thesis i Table of Contents Acknowledgements Page i Table of Contents ii-v Summary vi-vii List of Tables viii List of Figures ix-x List of Abbreviations ... GENETIC CONTROL OF VERTEBRATE MUSCLE CELL IDENTITY LIEW HOE PENG B.Sc (Hons), M.Sc (Env Engg.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY INSTITUTE OF MOLECULAR AND CELL BIOLOGY ... and directional migration of slow myofibres is the result of dynamic reciprocal waves of expression of N- and Mcadherins in the slow and fast myoblasts (Cortes et al., 2003) This migration also...
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Mechanisms of neurodegeneration and stem cell migration a study of molecular signals in the model of axotomy
Ngày tải lên :
16/09/2015, 17:12
... 6.2.3.2 Migration of transplanted neural stem or progenitor cells……… 52 6.2.4 Mechanisms of the migration of neural stem or progenitor cells in the SVZ …………………………………………………………… 53 6.2.4.1 Cell contact-mediating ... stem or progenitor cells in the SVZ………… 50 6.2.3 Migration of endogenous neural stem or progenitor cells……………… 51 6.2.3.1 Migration of endogenous neural stem or progenitor cells in the SVZ……… ... factors……………………………………………………54 6.2.5 Roles of chemokines in the migration of neural stem or progenitor cells 54 Aims of the present study…………………………………………………………… 55 7.1 Molecular analysis of the degeneration of the vagal motoneurons...
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