... that the two-tailed t test comparison of silencing efcacy of the siRNAs with guide strand 5¢ end mismatches versus siRNA 396 was significant at P < 0.05 ‘Control’ and ‘mock’ refer to untreated cells ... exhibited silencing efcacy that was comparable to that of the fully paired 396 In addition, knockdown of Dicer had the greatest impact on the activity of 396-AG Dicer has been shown to prefer adenosine ... S1) [22] However, our goal was to test whether introducing a mismatch to an already asymmetric siRNA would also improve the silencing ef ciency of the siRNA We tested an siRNA targeting position...
... lipopolyamine-induced effect on protein synthesis Interestingly, the degree of saporin sensitization correlated directly with the transfection efcacy of the lipopolyamine By contrast, the three tested lipopolyamines ... is elicited by treatment with the fungal drug brefeldin A [9] Intoxication with several other ER-translocating toxins is effectively blocked by brefeldin A [18] Finally, saporin does not follow ... model cancer cell line to assess the efcacy of anticancer toxin treatments [2,7,8] Both LB6 and LB6 clone 19 cells were used to distinguish general cytotoxic effects from uPAR ⁄ cancer-specific...
... PNU142721 and Efavirenz according to potency The inhibitory efcacy to wild-type RT is within subnanomolar range for all three inhibitors PNU142721 and MSC194 show a 3–10-fold reduction in efcacy for ... reduction in efcacy for the K103N mutant The effect of the mutation is more pronounced for Efavirenz where there is a 200-fold reduction in efcacy compared to wild-type RT This corresponds ... PNU142721 and Efavirenz The more extensive interactions of MSC194 and PNU142721 to the asparagine residue are in agreement with the higher efcacy of these compounds compared to Efavirenz, shown...
... and reliable assay and therefore useful in a preclinical setting to assess the efcacy of inhaled glucocorticoids in vivo Preclinical Model and Side Effects The efcacy data were used to set ... the efcacy observed with inhaled ICS is related to local pulmonary exposure and what portion of the efcacy is from systemic exposure Thus, improved discernment of pulmonary vs systemic efcacy ... ciclesonide nanosuspensions, is a useful tool to demonstrate pulmonary-targeted efcacy and to differentiate the side effects The differentiation in side effect profiles, however, was only observed...
... synthetic efforts have been initiated to increase chemotype solubility [20, 21], and heroic dose formulations of DCU have been used to study its in vivo efcacy as a sEH inhibitor [15] Despite these efforts, ... 1,3-Dicyclohexylurea (DCU) is a potent inhibitor of soluble epoxide hydrolase, or sEH [13] Anti-hypertensive efcacy following a single dose of DCU has been demonstrated in spontaneously hypertensive rats [14, ... no absorption by DCU at the laser line (750 nm) so the complex index of refraction was determined by finding the average refractive index of DCU (1.57) by microscopy Index matching fluids from Cargille...
... Studies on the efcacy of systemic treatment of staphylococcal mastitis are not abundant (Funke 1982, Jarp et al 1989, Pyörälä & Pyörälä 1998), and even less has been published on the effect of combination ... susceptibility on the cure rate was tested using a model where penicillin susceptibility and parity (first or subsequent) were included as factors The effects of treatments were tested separately for the ... ratio test) were dropped from the models The difference between proportion of moderate and severe signs in early (first 14 days post partum) and later lactation was tested using the Chi-square test...
... selected The consumertest was performed on six of the cheeses selected from the total number as described below All the presented cheese samples in the descriptive test and in the consumertest came ... University of Norway The consumers were given the following information about the test during recruiting: ‘‘We seek participants for a consumertest of hard/semi-hard cheese The test implies evaluation ... primarily were sensory-based as we did blind testing of a single food item in a testing situation as opposed to branded testing, meal testing and/or testing under more natural eating conditions...
... standard against which oneself is compared about from out up Reference groups come in several different forms: the reference group refers to those others against whom one would like to compare ... represent what many people would ideally like to be aspirational deferential experiential potential reference groups include people who more realistically represent the individuals' current equals or ... 2 A useful framework of analysis of group influence on the individual is the so-called 'reference group' — the term comes because an individual...
... needed to develop effective selection programs for feed ef ciency in fish In endothermic land vertebrates, residual feed intake (RFI) is generally used to study the determinants of feed ef ciency Calculation ... population, clonei is the random clone effect, tankj is the random tank effect, clonei * tankj is the interaction between the clone and tank effect, and eijk the residual Clone genetic values of BW, ... tank effects showed a strong clone effect on RFI (Tab II) Therefore, when for a 100 g weight gain, the mean CI of the populations was 105 g, the RFI varied between –11.1 g for the most ef cient...
... sai độ lệch bình phương sai số Do đó, tỷ số phương sai nhân tố phương sai sai số gọi giá trị F Ftest Giá trị F biểu thị biến thiên gộp trị trung bình nhân tố quan tâm so với trị trung bình chung...
... permanent C) consumer D) social E) group Answer: C Diff: Page Ref: 136 Skill: Concept Objective: 5-1 5) The starting point of understanding a consumer' s response to various marketing efforts is ... Diff: Page Ref: 151 AACSB: Communication Skill: Concept Objective: 5-2 55) If a consumer' s experience is rewarding, that consumer will probably use the product more and more The consumer' s response ... attention E) perceptual defense Answer: D Diff: Page Ref: 150 AACSB: Reflective Thinking Skill: Application Objective: 5-2 87) Stephanie and Jamal attended a sales seminar Both left the seminar with...
... French since he Ho Chi Minh city in 1990 a has been taught / left b has taught / left c has taught / has left d had taught / left b TEST I Pronunciation a cure a a plow d a enough c a son a ... Kong as soon as he ………… about her wife’s accident a had left / was informed b has left / was informed c leaves / has been informed d left / had been informed > d 24 How are you going to eat ... He always gives advice a useless b use c useful d usefulness a 35 Newspapers should try to printing statements that they cannot check a refuse b neglect c deny d avoid >d 36 She hopes...
... your test book (A) They wrote the check in the bank (B) The trees are by the flowers (C) The hall is very large √ (D) The passengers are on the plane Look at the picture marked number in your test ... your test book (A) The operator pushes a button √ (B) The man is fixing the elevator (C) He's putting a button on his shirt (D) Stocks are going up Look at the picture marked number in your test ... your test book (A) The jewels are in the safe (B) The woman works with her hands √ (C) The optician is grinding lenses (D) The woman saws metal Look at the picture marked number in your test...
... your test book (A) The flags fly from the roof √ (B) The court is in session (C) The ceiling is very low (D) The yard is full of tourists 12 Look at the picture marked number 12 in your test ... room only left on the bus (B) People were trampled at the fair (C) The conductor is wearing a pouch √ (D) The bus stopped at the corner 13 Look at the picture marked number 13 in your test book ... your test book (A) The horses are racing √ (B) The hoarse announcer can't catch up (C) The writer is very fast (D) The jockey has a twin 15 Look at the picture marked number 15 in your test...
... your test book (A) Both players want the puck (B) The athletes rest after the game (C) The tackle is a success (D) A player carries the ball √ Look at the picture marked number in your test book ... in your test book (A) The space is for rent (B) It's a new rocking chair (C) The bird flies through the air (D) The rocket lifts off √ 15 Look at the picture marked number 15 in your test book ... I like to return this coffeemaker It doesn't work M: Of course Would you like a refund, or a replacement? W: A refund, please What did the woman decide? (A) To make coffee (B) To get a replacement...