considerations in the production of vaccines for use in phase 1 clinical trials and preparation of the manufacturer s protocol
Báo cáo y học: " Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa" doc
... reviews the patient s clinical and social history and understanding of the pre-ART counselling as assessed by the counsellor Statistical analysis All HIV infected patients aged 15 years or older assessed ... sensitivity of WHO clinical staging in assessing patient s eligibility for ART [17 ,18 ], our data suggest that it is an important clinical assessment tool and we therefore advocate for the development of ... All statistical analyses were done with STATA release 11 .1 software (STATA Corp, USA) and statistical significance defined as a p-value of less than 0.05 (2-sided) Results Baseline characteristics...
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Báo cáo y học: "What should be the core outcomes in chronic pain clinical trials" ppt
... assessment of core domains with a standard set of measures, the design and conduct of such cooperative trials would be facilitated Finally, having a standardized set of outcome domains would simplify ... Competing interests None declared Acknowledgement This paper is based on the consensus meeting of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) held in ... distinguish global ratings from other measures, and such ratings provide sufficient unique information to warrant inclusion in all clinical trials of treatments for chronic pain Symptoms and adverse...
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Báo cáo y học: " Lack of adaptation to human tetherin in HIV-1 Group O and P" pot
... this consistent observation, the use of a virus release assay that is based on the ratio of p24reacting proteins in the supernatant versus cell lysates, allows us to control for such effects and ... release was measured as the ratio of p24-reacting bands in the supernatants versus cell lysates following Western blot analysis, and made relative to the baseline level in the absence of Vpu, for ... pCMO2.5 Nef protein against the panel of tetherin proteins (Figure 3A) We also included Nef proteins from HIV -1 O isolates ANT70 and MVP 518 0, since the Vpu proteins from these viruses also lacked activity...
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Báo cáo y học: " Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects" pptx
... occurring steroid and possesses both endocrine and immunomodulatory effects Interestingly, serum levels of DHEA are decreased in SLE patients [19 ] Several clinical studies have thus investigated the ... publications describing the successful use of new therapeutic agents in murine models support their further evaluation as therapies for SLE In lupus, therefore, the Page of 10 (page number not for citation ... the p21Waf/Cip1 mimic [40] As the expression of the cyclin-dependent kinase inhibitor p21Waf/Cip1 is decreased in lymphocytes of lupus patients [ 41] , the use of such inhibitors could represent...
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Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target
... importance in species survival Structures and Domains of Polo-like Kinases As mentioned, Polo-like kinases contain two highly conserved structural features, the kinase domains and the polo-box domains ... (PLK1) plays important roles in the progression of cell cycle, especially for cells to transit from anaphase to telophase during mitosis PLK1 is overexpressed in various cancers and has significant ... Analysis Statistical analysis was carried out using Microsoft Excel or SPSS p value of less than 0.05 was deemed significant All data was expressed as mean ± standard error of the means (SEM)...
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The Use of Plant Cell Biotechnology for the Production of Phytochemicals
... fieldcultivated sources In using a plant strategy, major issues are that these plants need a seasonal period of growth before harvesting is possible Other issues here include a relatively short growing seasons ... expression of a number of genes or physiological reactions Continuing efforts of scientists have resulted in engineering of plants resistant to high temperatures, low temperatures, and excess salinity ... approach has four known steps in general The first step consists of gathering various high-throughput data sets in addition to legacy data sets All of these data are then used in the second step to...
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Development of a Regional Risk Management Framework for APEC Economies for use in the Control and Prevention of Introduced Marine Pests
... to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to identify ... Conclusions, including the results of the November 20 01 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC and the MRCWG have a role in liaising ... APEC Fisheries and Transportation Working Groups Presentations from many perspectives - Economies, shipping industry, aquaculture, research institutions, government resource managers and environmental...
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Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States pdf
... manufacturers of ARV drugs or diagnostics used for management of HIV infections A list of the latest disclosures is available on the AIDSinfo website (http://aidsinfo.nih.gov) Users of the guidelines Providers ... Infants) The implications of initiating therapy before conception solely for prevention of sexual and/ or perinatal transmission should be discussed with patients These issues include willingness and ... Women and Their Infants) Results from preclinical and animal studies and available clinical information about use of the various agents during pregnancy also should be discussed (see Supplement: Safety...
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Coaching Standardized Patients For Use in the Assessment of Clinical Competence pot
... of these coaching skills in the context of training the SPs to work in high-stakes clinical skills examinations, which requires of the SPs the most authentic and precise performance standards ... Training Session Two: Learning to Use the Checklist Principles for Checklist Coaching The Goal of Training Session Two The Training Setting Summary of the Training Activities Reminders Session Two ... procedures for coaches to use in sequence when training their SPs Chapter 11 describes variations on the four training session protocols, suggesting other possibilities for mixing and matching different...
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Use of Alternative Fuels in Cement Manufacture: Analysis of Fuel Characteristics and Feasibility for Use in the Chinese Cement Sector pdf
... timber forest, special use forest, sparse forest timber stand, sparse forest, firewood forest orchard, special use forest, sparse forest timber forest, shrubs timber forest, shrubs, sparse forest, ... stand, shrubs, sparse forest, firewood forests, protected forests timber stand, shrubs, protected forest, sparse forest timber forest orchard, special use forest, timber forest, sparse forest orchard, ... (GJ) of unused forest residues in the ten provinces in China with the greatest forest resources The total annual value of unused forest residues in China is 1. 6x109 GJ The top ten provinces account...
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báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx
... placebo and 54 dosed) individuals where assessed using the internalization assay The assay variability in the placebo data is 15 .5% over the 11 3 days of sampling (day-3 time point included for a ... guidelines established for ligand binding ELISA pharmacokinetic assays [10 ] was used to establish the %CV boundaries A %CV less than 20% was considered an acceptable parameter A 25% CV was used for ... Number SSC SSC-Height 400 600 No AF488MCP -1 1 01 100 CD14 CD14 APC 10 2 50 R5 10 1 10 2 CD45RO PE 10 3 10 4 10 0 CD45RO 10 0 10 1 10 2 10 3 MCP -1 Alexa-488 10 4 Figure Representative histogram of AF488-MCP -1 staining...
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báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... model 11 11 1 211 212 1 2 312 3322 N/A 0.770 0. 515 0.272 0 .15 6 0.962 0.760 0. 517 0.295 0 .13 6 0.9 61 0.754 0.498 0.308 0 .15 5 Discussion The results from this study present a method for analysing existing ... Philips Z, Palmer S: A pilot study on the use of decision theory and value of information analysis as part of the NHS Health Technology Assessment programme Health Technol Assess 2004, 8( 31) :1- 103 ... these terms in total with level λ = acting as a baseline for each dimension Hence for a simple linear model, the intercept (or constant) represents state 11 11 and summing the coefficients of the 'on'...
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báo cáo hóa học:" Assessing normative cut points through differential item functioning analysis: An example from the adaptation of the Middlesex Elderly Assessment of Mental State (MEAMS) for use as a cognitive screening test in Turkey" docx
... men and women, and so on Thus subtests that not yield the same response function for two or more groups display DIF In the case of determining cut points for passing a subtest, as is the case for ... determine the validity of the existing cut points for passing subtests, given the wide range of the level of education in the Turkish population This paper focuses on the methodological issues associated ... grouped into twelve sub-tests each of which has a 'pass score' (Table 2) A screening score of either (fail) or (pass) is assigned to each subtest These subtests are sensitive to the functioning of...
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Cocoa Processing Methods for the Production of High Quality Cocoa in Vietnam ppt
... thanked for their assistance in providing information regarding the cocoa industry in Vietnam and in the establishment of solar driers and fermenting boxes at their demonstration farm sites in Ben ... rise caused by spreading of the beans for two hours, in the sun, prior to placement in fermentation boxes In both 10 cases, the pods had been stored for seven days This demonstrates that this ... down-grading of the cocoa and buyers will pay less for it In many countries, including parts of Vietnam, the major harvest occurs in the wet season and sun drying of cocoa can not be achieved In these...
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Designation: C 465 – 99 - Processing Additions for Use in the Manufacture of Hydraulic Cements1 pdf
... mass, 13 .1. 3 Detailed results of all analyses and tests prescribed by this specification, and the amount of the addition used, as well as other pertinent information required, 13 .1. 4 Comparison ... batch for each round 11 .2 Types of Specimens: 11 .2 .1 Compressive Strength—Compressive strength test specimens shall be cylinders made and cured as prescribed in Practice C 19 2 Cylinders shall ... Processing Additions 7 .1 Test the liquid processing addition, in the form normally marketed, in accordance with the following test methods: 7 .1. 1 Specific Gravity Use Test Methods D 8 91, Test Method...
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Báo cáo y học: "A standardized scoring method for the copy of cube test, developed to be suitable for use in psychiatric populations" pdf
... assess the clinical picture of patients The PANSS assesses psychotic symptoms, the YMRS manic symptoms and the MADRS depressive symptoms Page of 10 Table Frequencies of healthy controls’ performance ... 10 0 17 18 .28 65 20 21. 51 45 12 12 .90 25 8.60 10 2 .15 >5 0.00 0 11 11 .83 10 0 15 16 .13 90 18 19 .35 70 10 10 .75 55 15 16 .13 40 10 10 .75 25 5.38 15 4.30 10 1. 08 3.23 10 1. 08 >10 0.00 Distorted lines ... 11 4 12 7 Total 78 .18 71 149 220 The results of the discriminant function analysis support the usefulness of this new scoring method By using the functions, the SCCT can assist in the differentiation...
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Báo cáo y học: " Assessing medically unexplained symptoms: evaluation of a shortened version of the SOMS for use in primary care" doc
... disorders and not somatization in general This study was designed to validate the Portuguese version of the SOMS-2 for use in PC settings The performance of the screening tool was also tested in the ... and MES when screening somatoform symptoms or disorders using self-report measures, as advocated by some authors [12 ,28] In spite of that, the R-SOMS-2 presents a satisfactory sensitivity and good ... R-SOMS-2 at FCSE, and the corresponding values at self-report are 57.9% and 88.2% for the former, decreasing slightly the sensitivity and increasing the specificity for the R-SOMS-2 symptoms...
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báo cáo khoa học:" Rasch analysis of the Hospital Anxiety and Depression Scale (HADS) for use in motor neurone disease" pot
... GS: Rasch analysis of the scoring scheme of the HADS Depression subscale in Chinese stroke patients Psychiatry Res 2007, 15 0 (1) :97 -10 3 27 Lamberts S, Pallant JF, Girgis A: Rasch analysis of the ... stroke patients, the depression subscale of the HADS displayed adequate fit to the Rasch model [26] The variability of the results of Rasch analyses across a range of diseases suggests that the ... revised cut-off values by clinical diagnostic interview These findings support the use of the modified HADS-D and HADS-A for use with patients with MND within clinics and research, and support the modified...
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báo cáo khoa học:" Measurement properties of physical function scales validated for use in patients with rheumatoid arthritis: A systematic review of the literature" pps
... relevant to the assessment of PF and their respective number of items The consensus based standards for the selection of health status measurement instruments (COSMIN) checklist [19 ] was used to identify ... databases (19 75-2 010 ) in January 2 011 This search strategy consists of four sets of independent searches that are later merged The first search contains various synonyms of the construct of interest ... cases, there was no assessment of the dimensionality of the scales beyond the reporting of item level fit statistics The AIMS2-SF and both versions of the MDHAQ were rated indeterminate because...
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Báo cáo y học: "Evaluation of the psychometric properties of a modified version of the Social Phobia Screening Questionnaire for use in adolescents" pdf
... There are a few psychometrically evaluated self-report instruments for use in the assessment of SAD in children and adolescents The most widely used and well established instruments are the Social ... reliability was assessed using Spearman 's correlation coefficient The internal consistency of the scale was assessed using the Cronbach 's coefficient alpha for the first eight items of the SPSQ-C (data ... language revision MT developed the SPSQ-C, took part in the statistical analyses, discussion of the design and in the preparation of the ms CGS supervised the design and execution of the study and made...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25