congenital bone marrow failure syndromes
Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 1) ppsx
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07/07/2014, 04:20
... Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 1)
Harrison's Internal Medicine > Chapter 102. Aplastic Anemia,
Myelodysplasia, and Related Bone Marrow Failure Syndromes
Aplastic ... leukemia (AML)
Some acute lymphoid leukemia
Some lymphomas of bone marrow
Pancytopenia with Cellular Bone Marrow
Primary bone marrow diseases
Myelodysplasia
Paroxysmal nocturnal
Secondary ... leukopenias).
Hematopoietic failure syndromes are classified by dominant morphologic
features of the bone marrow (Table 102-1). While practical distinction among
these syndromes usually is clear,...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) ppsx
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07/07/2014, 04:20
... Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 2)
Aplastic Anemia
Definition
Aplastic anemia is pancytopenia with bone marrow hypocellularity.
Acquired aplastic ... bone marrow hypocellularity.
Acquired aplastic anemia is distinguished from iatrogenic marrow aplasia, marrow
hypocellularity after intensive cytotoxic chemotherapy for cancer. Aplastic anemia ... typical physical anomalies and the
development of pancytopenia early in life, can also present as marrow failure in
normal-appearing adults. Acquired aplastic anemia is often stereotypical in its...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 3) pdf
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07/07/2014, 04:20
... Chapter 102. Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 3)
Radiation
Marrow aplasia is a major acute sequela of radiation. Radiation damages ... a notorious cause of bone marrow failure. Vast quantities of
epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute
leukemia, and blood and marrow abnormalities. ... environment. The
association between marrow failure and other chemicals is much less well
substantiated.
Drugs
(Table 102-3) Many chemotherapeutic drugs have marrow suppression as a
major toxicity;...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 4) pptx
Ngày tải lên :
07/07/2014, 04:20
... cooperate in a repair
complex to maintain telomere length. In Shwachman-Diamond syndrome, marrow
failure is seen with pancreatic insufficiency and malabsorption; most patients have
compound ... thrombotic episodes occur in patients with large
PNH clones (>50%). Functional studies of bone marrow from PNH patients, even
those with mainly hemolytic manifestations, show evidence of ... Fanconi's anemia, an autosomal recessive disorder, manifests as congenital
developmental anomalies, progressive pancytopenia, and an increased risk of
malignancy....
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 5) pdf
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07/07/2014, 04:20
...
Related Bone Marrow Failure Syndromes
(Part 5)
Pathophysiology
Bone marrow failure results from severe damage to the hematopoietic cell
compartment. In aplastic anemia, replacement of the bone ...
responsible for benzene-induced tissue injury. Excessive generation of toxic
intermediates or failure to detoxify the intermediates may be genetically
determined and apparent only on specific ... severe damage to the hematopoietic cell
compartment. In aplastic anemia, replacement of the bone marrow by fat is
apparent in the morphology of the biopsy specimen (Fig. 102-1) and MRI of the...
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Báo cáo hóa học: "Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion" doc
Ngày tải lên :
18/06/2014, 16:20
... resurrection after bone- marrow- derived
Anastasiadis et al. Journal of Translational Medicine 2011, 9:12
http://www.translational-medicine.com/content/9/1/12
Page 4 of 5
Chronic ischemic heart failure epidemic. ... al.: Hybrid approach of ventricular
assist device and autologous bone marrow stem cells implantation in
end-stage ischemic heart failure enhances myocardial reperfusion.
Journal of Translational ... Cardiol 2002, 39:1189-1198.
8. McMurray JV, Pfeffer MA: Heart failure. Lancet 2005, 365:1877-1889.
9. Gheorghiade M, Bonow RO: Chronic heart failure in the United States: a
manifestation of coronary...
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Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
Ngày tải lên :
25/10/2012, 11:18
...
http://www.medsci.org
75
searchers have transplanted the bone marrow stem
cells into the necrotic femoral heads, and results show
bone marrow stem cells can remove vascular lesions
and promote ... GFP labeled MSCs were noted in the lungs, liver, bone
marrow and normal and necrotic femoral heads of rabbits, and the number of MSCs in bone
marrow was higher than that in the, femoral head, ... with autologous bone marrow grafting. Indian J
Orthop. 2009 Jan;43(1):40-45
35. Sun Y, Feng Y, Zhang C. The effect of bone marrow mononu-
clear cells on vascularization and bone regeneration in...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
Ngày tải lên :
02/11/2012, 10:19
... All rights reserved
Research paper
Polysaccharides from the root of Angelica sinensis protect bone marrow and
gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
Marco ... hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone
marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on ...
cancer therapeutic regimen.
In the present study, we investigated whether AP
could protect the bone marrow and the gastrointestinal
tissues from the cytotoxicity of CY in mice. We also
profiled...
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Obstructive lung disease in children after allogeneic bone marrow transplantation docx
Ngày tải lên :
22/03/2014, 10:20
... graft-versus-host disease after
bone marrow transplantation. Thorax 39:887,
1984
IO.
Graham J, Muller NL, Miller RR, Shepherd JD: Intrathoracic
complications following allogeneic bone marrow transplantation. ... following pediat-
ric bone marrow transplantation. Society
for
Pediatric Radiology,
Colorado Springs, CO April 29, 1994
15.
Thomas ED, Storb
R,
Clift RA: Bone marrow transplantation. ... air-flow obstruction in marrow
transplant recipients. Am Rev Respir Dis 129541,1984
4. Holland HK, Wingard JR, Beschorner WE, Sara1 R, Santo
GW: Bronchiolitis obliterans in bone marrow transplantation...
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