... insights arise Computer Applicationsin Bioprocessing 119 3.2 Monitoring and Control of Bioprocesses Instrumentation in a chemical plant brings to mind the control room of a petroleum refinery with ... and Teaching with Computers All areas of science and engineering make use of e-mail, fax machines, and the Internet Information today flows at much faster rates than in the past and in huge amounts ... smart terminals that were fed their programs from a server Very soon my research required a computerin the laboratory because we focused on dynamics and control For ComputerApplicationsin Bioprocessing...
... Combinatorial Mixture Screening / 103 In Vivo Drug Screening / 106 Pharmacokinetics / 109 In Vitro Drug Screening / 115 Metabolic Stability Screening / 118 Membrane Permeability / 119 Drug- Drug Interaction ... analysis of drugs and drug- related compounds OVERVIEW This book focuses on LC/MS applicationsindrug development It examines the role of LC/MS in the pharmaceutical industry during the past ... end points and benchmarks that aim at increasing productivity The strategy is based on introducing more lead compounds into the pipeline to obtain more NDA/MAA filings The logic is highly intuitive;...
... therapeutics, including drug targets, drug chemicals, natural products and biomarkers The drug and target information stored in TTD was updated constantly to include recent approvals into clinical trials ... showed promising future A tremendous amount of money, time and human resources have been injected into drug discovery, in the hope of finding new drugs Statistics show that R&D expenditures in pharmaceutical ... chemical space than individual-target agents For instance, known dual kinase inhibitors of selected kinase pairs are typically 10-fold smaller in numbers than the known individual kinase inhibitors (23)...
... files are in Windows installation directory (usually named \Windows or \Winnt) and are “Winmine.exe” and “Winmine.ini” We know that the exe file is the executable (or main program) and the ini file ... attending the HSSP course “C-01B Reverse Engineering inComputerApplications taught during Spring 2001 at the Massachusetts Institute of Technology The information presented hereby is on an “as-is” ... follow the instruction provided (officially) in his Operating System’s user manual, in the section titled “Copying files” Also, he can use a program without paying it in whole 13 Chapter 1: Introduction...
... so fast" (Rozin 176)? It has nothing to with what sport it is, drugs can have a major effect on it Though the use of drugs seems to be getting greater, the control of them is getting stronger ... stronger too This past summer, in Atlanta, the Olympic Games held its biggest drug crackdown in history In the National Football League, random drug testing is becoming effective There are officials ... one from the beginning"( qtd inVerducci 22) Cocaine took many valued things away from Strawberry: his wives, children, family, baseball, and, of course, money Strawberry has since come clean...
... Aloimonos examine the problem of instantaneous finding of objects moving independently in a video obtained by a moving camera with a restricted field of view In this problem, the image motion is caused ... in recent years As we can see, since Turing’s pioneering 1950 work on determining whether machines are intelligent, the development of computers for enhanced intelligence has undergone great ... recovered analytically from some matching points across m views In general, the homography tensors are useful for recovering linear models under linear uncertainty In Chapter 12 Abhijit Ogale, Cornelia...
... specialists interested in specific topics of this field At the beginning of each chapter, the introduction provides insight on the corresponding developed topic In some cases, the different introductions ... correspond to proteins with O-phosphoserine and O-phosphotreonine groups, which are probably used to link the inorganic mineral component and the organic matrix Phosphoproteins are arranged in the collagen ... new concepts in materials science and engineering.17 Biomineralisation studies the mineral formation processes in living entities It encompasses the whole animal kingdom, from single-cell species...
... Note 10 MATLAB for Engineers – Applicationsin Control, Electrical Engineering, IT and Robotics that controller design in R MS using the feedback system as in Fig results in infinite spectrum of ... characteristic entire function Algebraic controller design in the R MS ring introduced in Section results in a controller owning the transfer function GR ( s ) containing a finite number of unknown (free, ... scientific computing, data processing and math work Its strength lies in toolboxes for Control and Electrical Engineering This book presents interesting topics from the area of control theory,...
... Note 10 MATLAB for Engineers – Applicationsin Control, Electrical Engineering, IT and Robotics that controller design in R MS using the feedback system as in Fig results in infinite spectrum of ... characteristic entire function Algebraic controller design in the R MS ring introduced in Section results in a controller owning the transfer function GR ( s ) containing a finite number of unknown (free, ... scientific computing, data processing and math work Its strength lies in toolboxes for Control and Electrical Engineering This book presents interesting topics from the area of control theory,...
... concerns the use of computers in molecular design and in the lead discovery process The present series “Methods and Principles in Medicinal Chemistry” compiles the progress made in medicinal chemistry ... as being equivalent to computer- assisted molecular design (CAMD) In Fig a schematic representation of the main building blocks used in computerassisted methods in medicinal chemistry is given ... Chemometric Methods in Molecular Design (Methods and Principles in Medicinal Chemistry, Vol 2), VCH, Weinheim, 1994 [7] Kubinyi, H., (ed.), QSAR inDrug Design Theory, Methods and Applications, Escom,...
... use method referred to as ‘skin popping’, as in our patient [10] Skin popping is the injection of narcotics, commonly heroin, just under the skin Black tar heroin is used on the west coast of the ... which was previously called Figure Hematoxylin and eosin staining results Hematoxylin and eosin stain of splenic tissue at 40 × magnification showing amyloid around a blood vessel (arrow) Roll ... appears as pink, amorphous, intercellular material in tissue sections stained with hematoxylin and eosin, can be deposited in any tissue, and may be localized or widespread in its deposition The most...
... intended to abstain in the future and those who preferred to continue street druguse We identified five key reasons for street drugusein schizophrenia Drugs were used: • As a identity-defining ... ever gaining employment [30] Loss, rejection and being exploited are experiences that can maintain or escalate druguse [31] Reducing or stopping druguse can be motivated by a change in personal ... for abstinence Our study aimed to elicit factors that maintain illicit druguse However, of the 17 participants reported a current intention to maintain abstinence Reasons included disliking the...
... studies investigated the impact of these events on changes indruguse We here describe time use changes between 2001 and 2004 among injecting drug users (IDUs), other drug users, and non-users We use ... reported among injection drug users in Argentina and in other Latin American countries [30-33] Comparing changes indruguse between 2001 and 2004, the number of IDUs and drug users stayed stable ... Prevention in Injection Drug Users in the Southern Cone of Latin America In 1999 Global Research Network Meeting on HIV Prevention inDrug Using Populations Second Annual Meeting Report, NIDA, Washington;...
... be entered directly into a laptop computerin real time, thus incorporating the database as an intrinsic part of the medical record Selection of areas of interest Once the linkage between cannabis, ... significant role in their adolescent drug initiations, the inquiry was broadened to include those areas A prototype of the standardized clinical interview (SCI) became ready for clinical use by July ... cannabinoid CB1 receptors in mood and anxiety disorders Behav Pharmacol 2005, 16:315 Kandel DB: Stages and pathways of drug involvement In Stages and pathways of drug involvement, Examining the...
... Methamphetamine use is also increasing rapidly, and while usually smoked, it is increasingly used in combination with heroin, acting as a gateway drug to more addictive opiates [16] IDU have been interviewed ... ever injected drugs [23] Patterns of heroin injecting vary from daily or intermittent use for most Nigerian IDU to frequent binging in Dar es Salaam, Tanzania [13,28] Heroin use now occurs in most ... Lawal R: Druguse and HIV infection in Nigeria: A review of recent findings Afr J Drug Alcohol Stud 2006, 5(2):118-129 Dewing S, Pluddemann A, Myers B, Parry C: Review of injection drugusein six...
... of male users residing in the town The lists containing names of women users were the starting point for the snowball sample Snowball sampling has been used in the UK to contact drug users not ... into general street talk [27] Injecting practice Heroin users in Malindi have developed techniques and social protocols of injecting In late 1999, when many users in the town moved from chasing ... within the midst of mainstream society Heroin users in this Kenyan setting use a mixture of Swahili and English loan words to talk about injecting in particular and heroin usein general [10] Most...
... development of interventions The DrugUse Assessment focuses on the nature and extent of druguse – who is injecting drugs and where this occurs, as well as trends in injection druguse over time Finally, ... patients during the Soviet era indicated that the nature of drugusein Vinnitsya has changed dramatically over the past decade In the years following Ukraine's independence, druguse has increased ... International Clinical, Operational and Health Services Research and Training Award IDU – Injection DrugUse IDUs – Injection Drug Users IDU-RAR – Rapid Assessment and Response in Injection DrugUse NEP/SEP...
... Office for DrugControl and Crime Prevention, United Nations Office on AIDS: Baseline study of the relationship between injecting drug use, HIV and hepatitis C among male injecting drug users in Lahore ... buprenorphine, anti-histamine and tranquilizers In Quetta, 58.3% preferred injecting heroin alone, while 41.7% injected heroin in combination with a liquid antihistamine and/or a tranquilizer In both sites, ... of Injection DrugUse Among Drug Users in Pakistan J Urban Health 2003, 80(2):321-329 Strathdee SA, Zafar T, Brahmbhatt H, Baksh A, ul-Hasan S: Rise in needle sharing among injection drug users...
... http://www.capmh.com/content/5/1/17 Introduction European adolescents have increased their alcohol and drug intake during the last decades; in particular binge drinking and cannabis use has grown [1-3] Alcohol and drugusein ... alcohol use and initiation of drug use, as expected [17,19] Conduct problems in early adolescence also appeared to be a major contributor to increased risk for both frequent drinking and drugusein ... of drug habits In accordance with previous findings [19,23,41] our study confirms that early alcohol intoxications or binge drinking substantially increases the odds for frequent alcohol and drug...
... ciprofloxacin resistance in P aeruginosa was significantly higher in medical and interdisciplinary ICUs than in surgical ICUs In contrast, vancomycin resistance in E faecium was significantly higher in ... - the increase in 3GC resistance, which indicates a rise in ESBL-producing bacteria, has been followed by a doubling of carbapenem use that, in turn, might now be followed by an increase in imipenem-resistant ... 15% in 2008 (b) Carbapenem use The pooled mean (solid line) and the median (dotted line) run almost parallel to one another In most ICUs the increase in carbapenem use also starts in 2006 The interquartile...