computational model for the regulation of extracellular atp and adenosine in airway epithelia

Báo cáo khoa học: "A Unified Statistical Model for the Identification of English BaseNP" pptx

Ngày tải lên : 08/03/2014, 05:20

... (2) and (4) in the following way: In the experiments, the training and testing sets are derived from the 25 sections of Wall Street Journal distributed with the Penn Treebank II, and the definition ... Figure -7 summarize the outcomes of our statistical model on various size of the training data, x-coordinate denotes the size of the training set, where "1" indicates that the training set is from ... POS tagging can benefit from baseNP information Whether or not the baseNP information can improve the precision of POS tagging in our approach is determined by the identifier assignment of the baseNP...

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Báo cáo " A numerical model for the simulation of wave dynamics in the surf zone and near coastal structures " pot

Ngày tải lên : 28/03/2014, 15:20

... part of the lost wave energy is transformed into turbulence energy. At the beginning of the wave breaking process, the turbulence is confined into a small portion of the breaking ... Fig. 1. The coordinate system and method for the evaluation of a wetting and drying boundary. The procedure for determining the cell side wetted function and the cell area wetted function in the numerical ... within first five meshes from the lateral boundaries, and then increases linearly with the distances from the boundaries towards the ends of the wave absorbing zones. Finally, at the ends of ...

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Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx

Ngày tải lên : 20/06/2014, 01:20

... were inoculated with × 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the ... HSV-1 infection of mice Female mice of the strains specified in Table were inoculated with HSV-1 at 6- to 10-weeks of age and were handled in accordance with the NIH Guide for the Care and Use of ... gene regulation On the other hand, the need for an improved in vivo model is clear A model is needed which identifies the host and/ or viral factors that can influence whether HSV-1 infection of...

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Báo cáo khoa học: " A predictive model for the level of sIgA based on IgG levels following the oral administration of antigens expressed in Sacchromyces cerevisiae" pdf

Ngày tải lên : 07/08/2014, 18:21

... ,ytisrevinU lanoitaN luoeS( slamina yrotarobal fo esu dna erac eht rof snoitaluger dna ycilop gniwollof yduts siht tuohguorht desu erew )aeroK ,ytisrevinU lanoitaN luoeS ,retneC laminA yrotarobaL( ecim ... erew stnatanrepuS Co4 ta nim 01 rof g 000,21 ta noitagufirtnec a yb dewollof ,thginrevo Co4 ta derots erew selpmas ehT )ASU ,acitameniK ;0003TP nortyloP( noitazinegomoh MPR 000,01 a yb enitsetni ... noisrev( margorp 2002 lecxE gnisu noisserger raenil rof ecnairav fo sisylana yb ecnacifingis lacitsitats rof denimaxe erew selpmas deriap rof 001 × 2r noitanimreted fo tneiciffeoc dna r tneiciffeoc...

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Báo cáo y học: "γ A novel mechanism for the regulation of IFN-γ inducible protein-10 expression in rheumatoid arthritis" ppsx

Ngày tải lên : 09/08/2014, 01:21

... ligand, may be expressed in the inflamed synovium of RA, and appears to play an important role in the recruitment of Th1-type cells into the joint Thus, the aim of the present study was to examine ... FLSs, indicating that the major cellular sources of IP-10 are probably either monocytes or PMNs during coculture Involvement of integrin–ICAM-1 ligand interactions in the upregulation of IP-10 ... molecules, including the ICAM-1–integrin pathway [19,29] The potential role of these molecules in FLS–leukocyte interactions was investigated by assessing the capacity of specific antibodies to inhibit...

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Báo cáo y học: "In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage" pptx

Ngày tải lên : 09/08/2014, 01:22

... network to the main elements of interest The focus of the model was the representation of initial cartilage destruction, thereby reflecting the main features of early matrix degradation in RA under ... experiments and participated in writing the manuscript SW established the initial form of the in vitro destruction model and described it in his diploma thesis RWK contributed to the design of the study ... of the new model for the analysis of the mechanisms of cartilage destruction by SFB Both MMP-1, capable of cleaving intact collagen [44], and MMP-3, responsible for the cleavage of other extracellular...

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báo cáo khoa học: " A new model for the characterization of infection risk in gunshot injuries:Technology, principal consideration and clinical implementation" pptx

Ngày tải lên : 11/08/2014, 20:21

... differences in the diameter of the cavity between the two projectiles were found 6.0-10.0 cm behind the point Page of of impact of the projectile on the gelatin block In this area, the gelatin blocks ... within the ruptures of a temporary cavity in the gelatin block revealed a deposition of particles along the entire bullet path for both types of projectiles examined In the case of the soft point ... and reproducible method of systematic examination in the field of terminal ballistics The model permits the infiltration depth of exogenous particles leading to contamination in relation to the...

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Báo cáo y học: "A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy" pptx

Ngày tải lên : 12/08/2014, 15:20

... covered the clinical part EV was involved in the design of the study and histomorphological evaluation TG conceived the study and was involved in the evaluation of the data as well as the writing of ... 8:43 the potential of the chemotherapeutic drugs to induce reduction of proliferation and induction of apoptosis within the chosen conditions To further validate the STST model, induction of caspase-3 ... responsible for the surgical part of the investigation CM and ARR carried out the LIFE/DEAD-assay and 2-photon microscopy PZ was involved in the design of the study, evaluation of the results and covered...

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Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx

Ngày tải lên : 12/08/2014, 16:20

... of the experiments, was involved in HASMC culture, performed in vitro cAMP studies and helped in the manuscript preparation LB participated in the design of the experiments and was involved in ... reference force of g and the level of pre-contraction induced by carbachol 10-6M were similar in all experimental conditions Furthermore, the relaxant responses to either theophylline [26] or forskolin ... treatments with the PKA inhibitor H89 or forskolin The hypothesis that the LTD4-PKC pathway may also be involved for allergen-induced β2-AR desensitization was tested by assessing the effects of montelukast...

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Báo cáo y học: "A health economic model for evaluating a vaccine for the prevention of herpes zoster and post-herpetic neuralgia in the UK" ppsx

Ngày tải lên : 13/08/2014, 11:22

... testing the applied point estimate and duration of vaccine efficacy The lower and upper limit of the 95% confidence interval of the vaccine efficacy obtained from the Oxman trial were tested in the ... duration of the model, adjusting for their mortality, the likelihood of contracting HZ and PHN and the efficacy of the vaccine Though it was assumed that the vaccine would have lifetime duration of ... further improve the accuracy of the model Continued validation of the duration of efficacy of the vaccine, as mentioned above, remains one of the key areas for research Conclusions The main results...

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Báo cáo y học: " Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test" doc

Ngày tải lên : 13/08/2014, 16:20

... characteristic of the studied subjects along with the descriptives of the 1/HOMA-IR and HOMA2 indices and of the two insulin-sensitivity indices KxgI and SIin the Full Sample and in the Sub-sample (not including ... that: The index of insulin sensitivity is easily derived from this model by applying the same definition as for the Minimal Model [11], i.e (3) and coincides therefore with one of the model structural ... descriptives of the 1/HOMA-IR and HOMA2 indices and of the two insulin-sensitivity indices KxgI and SIin the Full Sample and in the Sub-sample (not including extreme SIvalues) (Continued) Sub-Sample...

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Báo cáo y học: " A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms" pps

Ngày tải lên : 13/08/2014, 16:21

... generator (B) Model interpretation of A showing the delay (τ) and nonlinearity in the protein production cascade, the nonlinear negative feedback, and mRNA and protein production (rM, rP) and degradation ... (Σ) of phenotypic values for traits y and z can be structured in terms of φy, φz, ψy, ψz and Σε(t) by a bivariate SAD(1) model [15,16] Also, the closed forms for the determinant and inverse of ... difference between the peak and trough values; its phase, defined as the timing of a reference point in the cycle (e.g the peak) relative to a fixed event (e.g begin- mined in the ranges of empirical...

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Báo cáo y học: " A statistical model for the identification of genes governing the incidence of cancer with age" pptx

Ngày tải lên : 13/08/2014, 16:21

... are integrated into a QTL mapping framework (reviewed in [16]) The basic principle of these models, called functional mapping, is to characterize the genetic effects of QTLs on the formation and ... closed form for the EM algorithm to obtain the maximum likelihood estimates (MLEs) of the haplotype frequencies, and therefore the allele frequencies and linkage disequilibrium contained in Ω Because ... algorithm to obtain the MLEs of parameters contained in Θ and Ψ Hypothesis Testing One of the most significant advantages of functional mapping is that it can ask and address biologically meaningful questions...

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IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANS-FACTORS REQUIRED FOR THE REGULATION OF RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION

Ngày tải lên : 24/08/2014, 12:22

... 2006) ATP- dependent chromatin remodeling ATP- dependent chromatin remodeling involves mobilization and repositioning of nucleosomes by sliding of nucleosomes along the path of the DNA, transfer of ... tens of thousands of base pairs away from the transcription start site Therefore dynamic interplay between the cis-acting elements and DNA binding proteins is needed for proper regulation of these ... contact other proteins in the basal promoter (Bulger and Groudine 2002) In the scanning model, Pol II binds to the enhancer and scans along the DNA until it reaches the promoter (Blackwood and Kadonaga...

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An asthma allergen specific animal model for the study of responses to dust mite allergen induced asthma

Ngày tải lên : 15/09/2015, 21:56

... cytokine in the initiation and maintenance of Th2 inflammation This cytokine is responsible both for the polarization of the T cells into a Th2 phenotype as well as in the suppression of other ... to a variety of PAMPs and DAMPs Activation of epithelial cell PRRs results in the release of cytokines and chemokines and the recruitment of components of both the innate and adaptive immune system ... the structural components of the lung and have shown that, rather than being a passive bystander in the inflammatory process, these components can have a profound influence on the nature of the...

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A model for the prediction of subgrade soil resilient modulus for flexible pavement design

Ngày tải lên : 04/07/2016, 17:20

... “Education is not the taming or domestication of the soul's raw passions not suppressing them or excising them, which would deprive the soul of its energy -but forming and informing them as art.” ... state of development in the western world in road construction is evident in the 15th and 16th centuries under the Aztecs in Mexico, the Maya in Central America and the Incas in South America These ... prime input material property necessary for determining deflection in layered systems, resilient stress, and strains and for analyzing the performance of the system 3.2.1 Determination of Resilient...

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Tài liệu Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom pdf

Ngày tải lên : 12/02/2014, 11:20

... interface includes work on luminal bacteria, biofilms, the epithelial glycocalyx and mucus, epithelial barrier function, epithelial remodelling and immune/epithelial interactions The inflammatory ... IBD in the UK [12] Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom 2.3 Pathogenesis [13] The etiologies of both UC and CD remain unknown The ... presented in this way [7] 44% of patients with CD have no diarrhoea but the majority [72%] complain of abdominal pain Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the...

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Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc

Ngày tải lên : 14/02/2014, 13:20

... importance of achieving a balanced diet reducing the consumption of fats, free sugars and salt, of increasing the intake of fruits, vegetables, legumes, grains and nuts, and of performing moderate ... comparable set of indicators for health status, including in the area of dietary intake, physical activity and obesity IV.4.2 Under the health determinants strand, the Programme is supporting pan-European ... regards in particular advertising for foods high in fat, salt and sugars, such as energy-dense snacks and sugar-sweetened soft drinks, and the marketing of such products in schools26 Industry self regulation...

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Tài liệu APICE: Common Mediterranean strategy and local practical Actions for the mitigation of Port, Industries and Cities Emissions pdf

Ngày tải lên : 17/02/2014, 22:20

... meeting of the APICE project will be held in Venice on 24th 26th January 2012 During the meeting a full day will be devoted to the discussion of the results of the intercomparison campaign held in ... prominent forums for discussing the latest scientific developments, applications and implications for policy and other users An important feature of the conference is that it brings together ... in Marseille in February 2011 In addition, the recent developments of the common approach to the model application and scenarios definition for sustainable development strategies in harbour areas...

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Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx

Ngày tải lên : 18/02/2014, 02:20

... the proffered choice In general, the presence of a reinforcer is incentive (marketing), whereas the withholding of a reinforcer or the onset of a punishment is coercive (backed by the force of law) ... if the target cannot discern the reward in doing so Dickson (1992) discusses the invisible hand of competition that constrains the self-interest of the firm and forces the firm to serve the interests ... that stand in isolation The former are included under marketing and law; the latter are considered education Marketing refers to attempts to manage behavior by offering reinforcing incentives and/ or...

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