compounds alone or in combination with anticancer drugs against cancer cells potential future application of the combinatory therapy
Báo cáo y học: "Infliximab in ankylosing spondylitis: alone or in combination with methotrexate? A pharmacokinetic comparative study" ppt
... assistance with the manuscript The University Hospital of Tours, France, received funding from the French Ministry of Health and Sport for this clinical trial within the framework of the ‘Programme ... practice In the present study, we compared the individual exposure to infliximab of AS patients with predominantly axial symptoms receiving infliximab alone or infliximab and MTX combined Materials ... antirheumatic drugs improving the effectiveness of TNF-a antagonist therapy [9] To date, no study has used infliximab exposure as an end point to compare treatment with the combination of infliximab...
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Báo cáo y học: "Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation" ppt
... Utstein-style guidelines for uniform reporting of laboratory CPR research A statement for healthcare professionals from a task force of the American Heart Association, the American College of Emergency ... anti-inflammatory properties have not yet been investigated in the context of post-resuscitation care Thus, a Page of 11 combination of hypothermia and anesthetic post-conditioning with sevoflurane ... Figure Protein concentration of interleukin-1b Protein concentration of interleukin (IL)-1b was determined by a swine specific enzymelinked-immunosorbent assay NT, normothermia; HT, hypothermia;...
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In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... Nanjing, M.sc National University of Singapore) A THESIS SUBMITTED FOR THE DEGREE OF DORCTOR OF PHILOSOPHY DEPARTMENT OF MEDICINE YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE ... The CI values obtained for ABT-869 in combination with Ara-C and Dox employing three sequences are shown in Table To determine whether the combination therapy produce synergism in induction of ... another important pro-survival signaling pathway was involved in combination therapy or not Western blot revealed that the reduction of p-AKT was more obvious in ABT-869 alone than the combination, ...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... This increase in thermogenesis is similar to the increases reported in previous studies involving p-synephrine [17, 18] The increase in RMR between Group 4, the combination of p-synephrine with ... data indicate that increasing the hesperidin from 100 mg to 1,000 mg reversed some of the thermogenic effects of 100 mg hesperidin in combination with 50 mg p-synephrine plus 600 mg naringin It ... in response to p-synephrine or p-synephrine in combination with naringin and hesperidin (Table 2) p-Synephrine differs from ephedrine in that it has a hydroxyl group on the para position of the...
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báo cáo khoa học: "Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer" docx
... (TLK286) in combination with paclitaxel, doxorubicin, carboplatin, oxaliplatin, cisplatin, docetaxel, gemcitabine and iressa in human cancer cells Proceedings of the American Association for Cancer ... study of TLK286 (Telcyta™, a novel glutathione analog) in combination with carboplatin in platinum refractory or resistant (>/= 3rd line) ovarian cancer Proceedings of the AACR-NCI-EORTC International ... antitumor activity of TLK286 in combination with oxaliplatin, carboplatin, doxorubicin, paclitaxel and docetaxel in human colorectal, ovarian and breast cancer cell lines Proceedings of the American...
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Báo cáo y học: " WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE"
... Treg cells might play a negative role in anti-tumor immunotherapy as in this case These data suggested the possible usefulness of treatment for suppressing the function of regulatory T cells in combination ... in the sample tube containing target cells and effector cells) /absolute number of viable target cells in the tube containing target cells only] x 100 Unlabeled target cell-mediated blocking of ... spontaneously thereafter Imatinib was increased to a dose of 600 mg and continued for months, which caused adverse effects such as worsening of anemia and limb pain with increased CK Therefore the dose of...
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Báo cáo " Development of climate change scenarios for small areas in Vietnam by using the MAGICC/SCENGEN software in combination with statistic correction" docx
... consideration In the study, the temperature and rainfall scenarios are built in the monthly form of decades of the 21st century However, within the scope of this paper, we only introduce climate ... city with the highest value in increasing level, followed by Quy Nhon and Can Tho This is quite compatible with the temperature happening in the past (increasing level declined southwards) In addition, ... relative to the baseline period (1980 - 1999) The months with highest increase in temperatures are often December to February in Da Nang with 2.5-4.2 oC of the increase, March to May in Quy Nhon...
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Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
... proliferation Therefore, at the end of each of the culture schedules, cells were pulsed with BrdU for 30 mins The extent of BrdU incorporation was then measured by flow cytometry In HCT116 cells, there ... treated with drugs separately (Fig 3) Fig Effect of combining CDO with cytotoxic agents in HCT116 and GEO cells The numerical sum of BrdU incorporation into cultures containing CDO or any of the cytotoxic ... Fig The effect of combining CDO with cytotoxic agents in HCT116 and GEO cells Cells were cultured with CDO (C) alone or in combination with 5-FU, SN38 or VP16 There were significant reductions in...
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Báo cáo khoa học: SOX10, in combination with Sp1, regulates the endothelin receptor type B gene in human melanocyte lineage cells pptx
... end-labeled with [c-32P] ATP and used as probes The SOX10-containing lysates were preincubated for 30 on ice with or without a competitor in the absence of a probe and then incubated with the probe for ... transfected with each siRNA against SOX10 or LacZ by LipofectamineTM2000 protocol (Invitrogen) The cells were incubated for days and then each siRNA was transfected again After further days, the cells ... conceivable that the in vitro binding conditions are not suitable for simultaneous binding of the two proteins to the GC1 ⁄ CA2 SOX10 and Sp1 bind to the EDNRB promoter in vivo To investigate whether SOX10...
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Báo cáo khoa học: Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX doc
... transfection with cDNAs coding for GPIba inserted in the pDX vector [20] and GPV inserted in the pZeoSV vector (Invitrogen, San Diego, CA, USA) and selection in the presence of zeocin These cells were ... was obtained by transfection of CHO-DUK cells with GPV cDNA inserted in the pTG2328 vector, selection in the absence of nucleosides and amplification of GPV expression by growing cells in the presence ... of 0.1 M The samples were then incubated with endoglycosidase-H (5 mU per sample) for h at 37 °C in the presence of 1.7 lgÆmL)1 calpain inhibitor and 1· protease inhibitor cocktail In neuraminidase...
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Báo cáo hóa học: " Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice" pptx
... resulting from inclusion of IL-2 in therapy, we determined the relative proportions of activated T cells in tumor-draining lymph nodes This was achieved by determining the ability of T cells, ... orthotopic disease in those settings Other forms of therapy have been demonstrated to impact on orthotopic kidney cancer in mice, including the use of IL-2 in combination with anti-CD40 [20] or IL-12 Westwood ... receptor agonists in combination with anti-CD137 [19] It would be of interest to determine if coadministration of cytokine can enhance therapy against more established subcutaneous disease or orthotopic...
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Báo cáo hóa học: "High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study" pptx
... A and in none in cohort B G1-2 anemia frequently occurred in both cohorts of patients (in and patients respectively) Other minor side effects included nausea-vomiting involving about 50% of patient ... patient in both cohorts, transaminase increase in patient in cohort A, and asthenia in patient in cohort B The median of delivered cycles was (range 1-9) Dose reduction was necessary in patients in ... died for a cerebral hemorrhagic accident arising in the tumor metastasis The other patient is died after 14 months Page of In the Cohort B we reported PR and SD The PR regarded one patient with...
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Báo cáo lâm nghiệp: "Germination response of alder and birch seeds to applied gibberellic acid and priming treatments in combination with chilling" ppt
... of chilling and its interaction with priming and the three-way interaction among MC, chilling and priming were more highly significant for MGT than for germination in both species (Tab V) In the ... However, the seeds of many tree species require chilling to release dormancy before they can germinate [18], so the effect of priming might be expected to vary with dormancy intensity prior to priming ... temperatures for lengthy periods without the risk of premature germination [9, 10] A combination of GA3 and chilling at TMC levels might increase germination potential while reducing the risk of premature...
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Báo cáo y học: "Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study" ppt
... other inflammatory cells [12-14] In addition to the inflammatory component described above, more recent studies on the histology of psoriasis and PsA revealed an important role for endothelial cells ... after initiation of infliximab therapy The data are expressed as mean ± standard error of the mean *P ≤ 0.05, **P ≤ 0.02, versus baseline The mechanism by which the number of lesional inflammatory ... initiation of infliximab therapy Original magnification: 400× patients with psoriasis and PsA as compared with normal individuals [46-49] The effect of infliximab on vascularity, as shown in the present...
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báo cáo khoa học: "Aspergilloma in combination with adenocarcinoma of the lung" ppt
... performed the histopathological evaluation and interpretation of the data AA gave final approval for publication All authors read and approved the final manuscript Competing interests The authors ... wall of the cavity and its position is not altered with the patient’s movements [5] and particularly in case of preexisting factor of lung cancer Frozen section examination of a Wedge excision of ... gathered the data and wrote the manuscript M Serraj interpreted the data and revised the manuscript YO acquired the data LC performed the histopathological evaluation and interpretation of the...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... gastric cancer cells, which was mainly due to the decrease in expression of NF-B via inhibited b-ARs Discussion Gastric cancer is one of the major causes of cancer mortalities in the world, and ... induction by isoproterenol or propranolol in combination with irradiation in BGC-823 and SGC-7901 cells There was an increasing rate of apoptosis in gastric cancer cell lines in response to the ... radiotherapy is a standard treatment for gastric cancer patients Taken together, radiotherapy in combination with propranolol can be more useful for patients with a high risk of recurrence in gastric...
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Báo cáo khoa học: "Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series" pptx
... chemotherapy Systemic chemotherapy regimens for these two groups of patients are presented (Table and 2) Of the 32 treatments for cancer (19 with PIs, 13 without PIs), 13 included systemic chemotherapy ... not reveal increased toxicity in patients taking PIs during radiation therapy Our cohort doubles the number of patients in the current literature on the acute safety profile of combining PIs and ... but the data is limited Our study characterizes the safety of radiation therapy combined with the newer generation of PIs in treatment of non-AIDS defining malignancies which are increasingly...
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Báo cáo khoa học: "A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma" doc
... because of the evidence of evolutive disease with a gastric outlet obstruction and in another patient because of persisting inoperability at exploratory laparotomy In the remaining three patients, there ... months, indicating that CRT may play a role in the therapy of borderline resectable or unresectable LAPC Another important field of interest and future research which may lead to a significant clinical ... jeopardise their limited survival by increasing overall treatment time Radiotherapy The dose was prescribed at the centre of the target area or at the intersection of central rays of the beam Highly...
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Báo cáo khoa học: " The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay" pptx
... estimate D0, i.e., the inverse of the slope of the exponential part of the survival curve, for radiotherapy alone and for the combinations of 5-FU and /or oxaliplatin with radiotherapy The Mann-Whitney ... DG: Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared With Either Therapy Alone in Patients With Progressive Colorectal Cancer After Irinotecan and Fluorouracil-Leucovorin: Interim ... crypt survival, neither alone nor in combination with radiotherapy The oxaliplatin doses tested, from to 10 mg/kg, have previously been used in combination with radiotherapy in xenografted mice...
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báo cáo khoa học: "Blunt cerebrovascular trauma causing vertebral arteryd issection in combination with a laryngeal fracture: a case report" ppsx
... bleeding combined with moderate intracranial swelling without any signs of incarceration of the brain stem Evaluation of the vascular status confirmed the initial finding of retrograde filling of ... pontine region and a stable fracture of the arch of the seventh cervical vertebra and fractures of the transverse processes of C5-C7 with involvement of the lateral wall of the transverse foramen ... Written informed consent was obtained from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25