... live in a snake.
14. My brother managed to kill the snake just at the time when I were almost exhausted.
Supply thecorrectformofthe verbs
1. Cats could fly if they (have) wings.
2. If Peter ... (not,want) to live in a snake.
14. My brother managed to kill the snake just at the time when I (be) almost exhausted. If
he (be) a little late, I (kill) by the snake.
15. Had I know you were ill, ... snake.
14. My brother managed to kill the snake just at the time when I (be) had been almost
exhausted. If he (be) had been a little late, I (kill) would have been killed by the snake.
15. Had...
... c-octyldeoxynojorimycin
[33]. As a result ofthe very low level of GCase activity
in the L444P fibroblasts, alternative methods were
developed to reduce the amount of IFG in the assay,
thereby increasing the overall sensitivity. ... measures of dis-
ease (e.g. reduced spleen weight, GC and plasma
markers) were observed in only one ofthe 18 patients
who completed the study. The results of this trial pro-
vide preliminary proof -of- concept ... cleared (Fig. 6), and support the
long half-life ofthe enzyme. The inability to detect
IFG in the brain of L444P GCase mice is most prob-
ably a result ofthe dose of IFG tartrate administered
(20...
... mutation of Arg46 had the dual
effect of (a) decreasing agonist affinity and (b) promoting
the agonist-induced active conformation due to the loss of a
stabilizing constraint on the ground state ofthe ... Results
The effect of systematic substitution of Arg46
on agonist binding
The structural requirements ofthe residue at position 46 in
the N-terminus ofthe V
1a
R (Fig. 1) were investigated, with
respect ... compared to the wildtype Arg46, with the
precise value depending on the identity ofthe substituent
amino acid (Fig. 5). These data establish that the mutant
receptors are much less likely than the wildtype...
... on average, with +35.5% in the EU-10 and
+13.8 in the EU-15. This excess supply makes the net trade position ofthe EU-27 stronger
towards the Rest ofthe World. Within the EU there is a quite ... through either the
transfer of an entire farm, the leasing or purchase of quota, or the allocation of quota from a
national reserve. The transfer of milk quota may take place via a variety of administrative ... Impact ofthe Abolition ofthe Milk Quota Regime – Regional
Analysis ofthe Milk Production in the EU" (AGRI-2007-0444). The project aimed at a
thorough policy impact analysis ofthe EU...
... copies ofthe N protein, respectively. (C) The RNA binding efficiency of
N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The ... suppression.
Moreover, phosphorylation ofthe RS motif modulates
the ability ofthe N protein to form SGs.
RS motif deletion induces the N protein to form
large RNP complexes
The SARS-CoV N protein might ... phosphorylation.
Effect of RS motif phosphorylation on
oligomerization ofthe N protein
To better understand the effect of RS motif phosphor-
ylation on the biological function ofthe N protein, we
Fig. 3. The translation...
... between the projection ofthe tilt ofthe z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the
location ofthe rhombic (x, y) axes. The orientation ofthe ... consistent withthe % 10° tilt of the
Fe-CN vector from the heme normal to avoid van der waals
overlap withthe Tyr32(B10) O
g
. The location of the
rhombic axes, j % 50 ± 10°,isinagreementwiththe
expectations ... water molecule. The two
structures of WT metHb and rWT metHbH
2
O, exhibit
significant differences in the interaction ofthe FG loop
with the heme and in the position ofthe B-helix, with
Tyr32(B10)...
... in 7b compared with 7a (Table 1) because ofthe b-
effect ofthe acetylation. Acetylation of 7b was confirmed by
ESI MS data, which gave the expected mass of 3221.4 Da.
The spectra of oligosaccharide ... and showed, in particular, the
configuration of ManNAc to be
D
.
From the combined the data on the structures of the
isolated oligosaccharides, the overall structure of the
P. frisingensis LPS carbohydrate ... methylation. The most
important result obtained from NMR analysis of com-
pound 4 was the determination ofthe anomeric configur-
ation of Kdo D (see above).
Mild acid hydrolysis ofthe LPS with subsequent...
... mixing the
human CPR FMN domain with its FAD/NADPH domain
(% 16-fold) (29). However, the domain mixture still recon-
stituted only % 2% ofthe activity ofthe full length CPR. In
thecaseofNR1,thek
cat
for ... the
reconstituted activity is % 3% of that in full length NR1,
similartotheratioachievedwithCPRdomains.
To explore further the influence ofthe hydride transfer
step on catalytic activity ofthe ... indicates stabilization ofthe FMN semiqui-
none, consistent with (a) a need to transfer electrons from the
FAD/NADPH domain to the FMN domain, and (b) the
thermodynamic properties ofthe FMN domain in...
... LPS)
[5,6]. The serological specificity ofthe bacteria is defined
by the structure ofthe O-specific polysaccharide chain
(O-antigen) ofthe lipopolysaccharide. On the basis of the
O-antigens, the strains ... the
D
configuration (the b effect on C3 of
L
-GlcA
wouldbeclosetozero[27]).
On the basis ofthe data obtained, it was concluded that
the repeating unit ofthe O-polysaccharide of P. myxofac-
iens has the following ... the structure of the
O-polysaccharide of P. myxofaciens and serological pro-
perties ofthe LPS of this strain, including cross-reactivity
with several other Proteus and Providencia strains with
Correspondence...
... amounts ofthe ECDs ofthe non-a sub-
units of human muscle AChR for use as starting material for the determin-
ation ofthe 3D structure ofthe receptor ECDs and for the characterization
of the ... support the presence
of native-like conformational features on all three
recombinant ECDs.
Discussion
In this paper, we describe the expression of soluble
forms ofthe ECDs of non-a subunits ofthe ... con-
tains the major part ofthe binding site for the cho-
linergic ligands. The two sites are nonequivalent, one
being formed at the interface between one a subunit
and the c ⁄ e subunits and the other...
... in the
light of our results. The presence in vitro of a less stable
dimer in the mutant PufXD
2)7
neither affects the photo-
synthetic capability ofthe bacteria nor the efficiency of
exchange of ... an inhibitory effect
on the formation ofthe LH1 complex. This result suggests
that the central core ofthe PufX protein is responsible of the
break in the continuity ofthe LH1 ring in vivo [14], ... the
role ofthe C-terminal amino-acid residues ofthe LH1 a
polypeptide in the organization ofthe LH1–RC complex
[12]. In the present work, we have investigated the
possible involvement of the...
... terms ofthe content and access platforms available to them;
and in terms ofthe extent to which they want to engage with media as both consumers and
producers of information.
While on the surface ... account ofthe increasing failure ofthe news ecosystem to adequately
report on education nationally and locally, with some suggestions for the formation of a non-
profit reporting sector. The third, ... media platforms that embed the
analysis of media systems within the analysis ofthe ways different kinds of local
communities actually function, and the extent to which local community information...
... could have the effect of stabi-
lizing the Env trimers and/or the resulting transmembrane
pore that could then be formed by the LLP-1 and -2
domains. The location ofthe LLP-3 domain on the inner
leaflet ... http://www.virologyj.com/content/4/1/123
Page 9 of 14
(page number not for citation purposes)
Proposed models ofthe C-terminus of TMFigure 5
Proposed models ofthe C-terminus of TM. Proposed models of LLP domains in the context of TM ... association withthe inner leaflet of the
lipid bilayer. On the other hand, the LLP domains may
possess different activities in the different cell types that it
infects, or there may be some as of yet...