... to men EQUAL He refused the request for help of his friend GRATE He’s terribly absent – minded He even sometimes _ the number of his children COUNT The weather was so terrible that we ... SOLUTION On such a hot day, the sea was RESIST 10 It’s an antique vase It’s the only one of its kind worth thousands of pounds REPLACE Exercise She hates the taste of cigarette She must choose ... felt UNDERSTAND Jack was given an unpleasant insight into the in his behaviour SINCERE It’s _ of you not to prepare students for their exams RESPONSIBLE There are so many _ mysterious...
... to men EQUAL He refused the request for help of his friend GRATE He’s terribly absent – minded He even sometimes _ the number of his children COUNT The weather was so terrible that we ... SOLUTION On such a hot day, the sea was RESIST 10 It’s an antique vase It’s the only one of its kind worth thousands of pounds REPLACE Exercise She hates the taste of cigarette She must choose ... felt UNDERSTAND Jack was given an unpleasant insight into the in his behaviour SINCERE It’s _ of you not to prepare students for their exams RESPONSIBLE There are so many _ mysterious...
... SOLUTION On such a hot day, the sea was RESIST 10 It’s an antique vase It’s the only one of its kind worth thousands of pounds REPLACE Exercise She hates the taste of cigarette She must choose ... absent – minded He even sometimes _ the number of his children COUNT The weather was so terrible that we had an _ holiday PLEASE 10 In my opinion, weather forecasting is an EXACT Exercise ... felt UNDERSTAND Jack was given an unpleasant insight into the in his behaviour SINCERE It’s _ of you not to prepare students for their exams RESPONSIBLE There are so many _ mysterious...
... Furthermore, the pro-peptide of GDF-8 impairs interaction ofthe mature part with its receptors [16] In the case of BMP-9, the pro-peptide appears not to alter significantly the activity ofthe ... implications of our findings, the interaction of proBMP-2 with BMPR-IA and noggin allows indirect conclusions about the position ofthe pro-peptide with respect to the mature part As neither the interaction ... non-covalent complex ofthe pro-peptide and BMP-9 can bind to the type I receptor Alk1 [17], the latencyassociated polypeptide of TGFb inhibits the interaction of TGFb isoforms with type II and III...
... anomeric carbon of fructose The leaving group is carboxylate of Asp54 Dimerization The asymmetric units ofthe crystals of both the apo and complexed formofthe enzyme consist of dimers with noncrystallographic ... In the first step ofthe enzymatic reaction, a nucleophilic attack is performed on the anomeric carbon ofthe sugar substrate by the carboxylate ofthe Asp54 acting as the primary nucleophile, forming ... apo formofthe enzyme runs along the axis ofthe b-propeller through the whole domain and is only blocked by Cys236 in the area ofthe subsite )1 binding the fructose molecule A number of structures...
... coprecipitated only the slowly migrating formof RNA pol II (Fig 1) This suggested that Pol e associates withthe RNA pol IIO isoform To characterize further the phosphorylation status ofthe RNA pol ... isoform IIO that exhibits reduced electrophoretic mobility compared withthe IIA isoform Whereas the polyclonal antiRNA pol II antibody precipitated both the fast and slowly migrating forms of ... corresponding to that of isoform IIA The isoform IIO was also lost from RNA pol II precipitates after phosphatase treatment Thus, Pol e could interact specifically with hyperphosphorylated isoform RNA pol...
... a snake.were / wouldn't want 14 My brother managed to kill the snake just at the time when I (be) almost exhausted If he (be) a little late, I (kill) by the snake.was / had been / would have ... a snake 14 My brother managed to kill the snake just at the time when I (be) had been almost exhausted If he (be) had been a little late, I (kill) would have been killed by the snake 15 Had I ... in a snake 14 My brother managed to kill the snake just at the time when I were almost exhausted If he had beena little late, I would have killed by the snake 15 Had I know you were ill, I (visit)would...
... regulation ofthe PKI and PKI isoforms ofthe inhibitor protein ofthe cAMP-dependent protein kinase J Biol Chem 272, 20011–20020 Byler, D.M & Susi, H (1986) Examination ofthe secondary structure of ... 2) The assay of its activity demonstrated that the purified PKIb inhibited the catalytic subunit of cAPK withthe specific activity of 6.0 · 104 unitÆmg)1 (Fig 3A) .The Ki value determined from the ... (Fig 3B) The experimental molecular mass (8468.0 Da) obtained by electrospray MS was in complete accordance withthe theoretical mass ofthe human PKIb (8468.2 Da) [11] The identification ofthe gene...
... that of its unglycosylated form, though the DV and DGP values were almost the same The Pm value of proCPY was higher than that of its unglycosylated form This is due to the higher DV value ofthe ... that the precursor form was less thermally stable than the mature form, regardless ofthe carbohydrate moiety After the temperature was lowered from the highest temperature tested to 25 °C, the ... (Fig 1A), indicating that the thermal unfolding process ofthe precursor form follows a two-state transition The ratio ofthe unfolding enthalpy (DHcal) to the van’t Hoff enthalpy (DHv) was 1.05...
... between the two proteins (as indicated by the values of DGwater, Cm and Tg) hence arise from the changes in the surface ofthe protein because ofthe interactions ofthe cofactor withthe protein ... unfolding thermodynamic parameters ofthe two forms are given in Tables 13 In the entire experimental regime, it is seen that the holo form presents better stability than the other form (Fig 4C) The ... are comparable, the Tg values ofthe proteins vary slightly; there is a difference of almost C between the Tg values ofthe proteins, the value being higher for the holo form There have been...
... structure ofthe soluble formof CLIC4 the backbone and side chain of Asn34 and the side chain of Lys24 This crystal contact stabilizes the structure ofthe leading side ofthe foot loop The putative ... the side chain of Asn81 The intervening residues ofthe C-terminal extension interact withthe neighboring monomer via hydrophobic contacts Comparison withthe structure ofthe soluble formof ... from the behavior of CLIC1, which forms a noncovalent dimer concomitant withthe formation of an intramolecular disulfide bond between Cys24 and Cys59 5001 Crystal structure ofthe soluble form of...
... speaking, the theories view the kinds of M as forming an upper semilattice of kinds with M at the top This is a "formal" semilattiee in that the union of any two elements of it is a member ofthe semilattice, ... able to formthe name of a kind from a predicate: (# water') is the name ofthe kind water and (# (cheap'(wine')) is the name ofthe kind cheap wine The rules for the relevant portion of our theories ... assigning the same logical form to both theories Nonetheless, the meaning postulates ofthe two theories will differ for these.) In addition to the sorts of examples stated above, both these theories...
... [43] The present study further illustrates the importance ofthe eightpeptide sequence 57–64 in maintaining the inhibitory effect ofthe original 20-peptide aIIb 49–68 The N-terminal region ofthe ... result of their interaction withthe activated formof aIIbb3 To address this question we studied, by FACS analysis, the effect of these peptides on PAC-1 binding to platelets activated with ADP ... described [33] The platelet count of PRP was adjusted to a final platelet concentration of 2.5 · 108ÆmL)1 with homologous platelet-poor plasma The PRP was then preincubated with each ofthe synthetic...
... °C The cells were then washed and reincubated with new medium for up to h at 37 °C The release ofthe 125I-label into the efflux medium from the cells was then assessed (Fig 7) The release of ... examining the uptake ofthe 125I-sMTf or 125I-Tf, the proteins were also saturated with 59Fe by the procedures described above These dual labelling experiments enabled examination ofthe uptake of both ... Kinetic analysis ofthe efflux ofthe 125I-label revealed that after a pre-labelling period of 24 h with 59Fe-125I-Tf or 59Fe-125I-sMTf, the release of 125I from the cell after incubation with sMTf (Fig...
... can’t say with (certain) Travel is said to the mind (broad) Maradona is one ofthe best football in the world (play) The town is situated on the river (attract) How can you imagine theof mathematics ... will never forget theof Europe from the fascists by Allied troops (liberate) He won wide in the field of tropical medicine (recognize) She appeared with a smile (content) They have measures ... is thinking of English (study) Do you like to solve puzzles? (mathematics) The to the problems will be difficult to find (solve) He is the most pupil in our class (intelligence) The company is...
... the highest quintile, otherwise FOLLOW*AGGRESSIVE is the interaction of FOLLOW and AGGRESSIVE TENURE equals the number of years audited by AA with a maximum of 10 AGE is the number of years the ... firms because ofthe monitoring performed by bondholders If debt holders viewed the demise of AA as indicative of quality related problems, then we predict the greater the LEVERAGE the less likely ... positive giventhe significant costs associated with educating an audit team about various geographic segments However, there is no guarantee that the other offices that aided in the audit of the...
... 94% ofthe students agree that the content ofthe test relates to what they have been taught and nearly 90% ofthe teachers think so One ofthe teachers supposes that the topic ofthe text in the ... bank of test items for the school, the reliable items ofthe test would be stored in a file kept in the computer ofthe group at school Another 45 copy ofthe file would be sent to the email ofthe ... trust the results ofthe test: for example, if the same test is given to the same group of students twice within two days; they should get the same results on each occasion In other words, the...
... the country 81 The sudden ( appear) of a security guard caused them to drop the money and run 82 Parent is( condition) upon delivery ofthe goods 83 The sky began to ( dark) .as the ... centuries ago The countryside in the area is ( charm) and most ofthe buildings there ear made from an( attract) of light stone that is particular to the Cotswold’s In the summer, the Cotswold’s ... feel( help) against such abuse 56 His ( inform) were middle- class professional women 57.Only the snores ofthe ( sleep) broke the silence ofthe house 58 His landlady was a kind( home)...