complement pathways and oxidative stress in models of age related macular degeneration
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence of PTP in situ has not gained wide acceptance among investigators and results published in the literature ... buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca2+]c, probably coincides with the cleavage of the exchanger (but see [164]) Therefore, inhibition of the, ... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22];...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... indomethacin plus vitamin Effect of1 brain oxidative stress E supplementation on Effect of indomethacin plus vitamin E supplementation on markers of brain oxidative stress Total cerebral cortex homogenates ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis Page of (page number not for citation purposes) Journal of Neuroinflammation 2004, 1:21 http://www.jneuroinflammation.com/content/1/1/21 ... that oxidative stress and inflammation represent important but distinct therapeutic targets in AD-like amyloidosis We conclude that a combination of therapeutic agents target- Page of (page number...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... acute and sustained beneficial effects on oxidative markers of damage in SSc patients [17] The aim of our study was, first, to investigate serum endothelial cell markers of adhesion (sVCAM-1) and ... Friedlander M, Capelliere-Blandin C, NguyenKhoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B: Advanced oxidation protein products as a novel marker of oxidative stress in uremia Kidney Int...
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Báo cáo khoa hoc:" Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan" ppsx
... to oxidative damage, we intend to further investigate the possible link between oxidative stress and mtDNA mutations mtDNA deletions/insertions and base changes mainly involve purine transitions, ... have increased blood levels of oxidative stress biomarkers and an increased mtDNA copy number in peripheral leukocytes Since mitochondria are a major source of ROS and are highly susceptible to oxidative ... Mix containing μmol (final concentration 0.4 μM) of forward and reverse primers in a final volume of 20 μl PCR reactions were conducted as follows: initially at 50°C for min, 95°C for min, 40 cycles...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... cationic amino acid transporter-2, and NOS in activated murine microglial cells (19) and co-induction of inducible NOS and arginine recycling enzymes in cytokine-stimulated PC12 cells and high ... earlier findings of NO involvement in pathophysiology of hypobaric hypoxia in brain (42-43) In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form In inflammatory ... continuous supply of arginine at the site of synthesis Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circulating arginine and (b) recycling...
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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt
... shown that selected sigma-2 ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animal models of cancer including pancreas cancer [12,13,15] ... obtained from Bryan Clary (Duke University) and maintained in supplemented RPMI 1640 containing glutamine (2 mmol/L), pyruvate (1 mmol/L), penicillin (100 IU/ mL), streptomycin (100 IU/mL), and ... pancreatic adenocarcinoma cell lines (Panc-1, AsPC-1, and CFPAC-1) were obtained from ATCC (Bethesda, MD) and maintained in Dulbecco's modified eagle's medium (DMEM) containing glutamine (2 mmol/L),...
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Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
... the percentage relative to the respective control cells maintained in RGM **P < 0.01 and ***P < 0.001 relative to cells maintained in RGM Bars = mean ± standard deviation Page of 11 (page number ... and other situations involving impaired glu- Page 10 of 11 (page number not for citation purposes) Goldring MB: Update on the biology of the chondrocyte and new approaches to treating cartilage ... dependence of 2-DG influx into normal and OA chondrocytes fitted to the Michaelis–Menten model to determine the affinity and maximal velocity Each value is the mean ± standard deviation of five independent...
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AGE RELATED MACULAR DEGENERATION – THE RECENT ADVANCES IN BASIC RESEARCH AND CLINICAL CARE potx
... nucleotide-binding oligomerization domain (NOD)-like receptor NLRP3 (NOD-, LRRand pyrin domain-containing 3) and the PYHIN (pyrin and HIN200 domain-containing) family protein AIM2 (absent in melanoma ... development of AMD Protecting retinal cells by neutralizing DAMPs and Pathogenic Roles of Sterile Inflammation in Etiology of Age- Related Macular Degeneration 39 inhibiting DAMP-initiated inflammatory ... signaling pathways, including NF-κB, phosphoinositide 3-kinase and MAPK signalling pathways, thereby producing inflammatory cytokines (Hofmann et al., 1999) Cellular expression of RAGE increases...
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Báo cáo y học: " Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration" pot
... acuity of patients randomized to treatment in the Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular Age- Related Macular degeneration (MARINA), ... probabilities of gaining 15 letters or of losing 0, 15 or 30 letters in the second year and solving the resulting equations The transition probabilities were assumed to be independent of the number of letters ... the mid-point of the relevant 5-year age groups, and detailed results are presented for a 67-year old woman Age- related macular degeneration occurs in people aged 65 years and over, and a new,...
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Báo cáo y học: "ost-effectiveness of smoking cessation to prevent age-related macular degeneration" doc
... data (see Table 1).[2] Incidence of age- related macular degeneration in quitters Through a comprehensive MEDLINE search combining the search terms "smoking" and "macular degeneration" , we identified ... cases of macular degeneration than continuing smokers, leading to 12 fewer cases of blindness, 21 fewer blind-years and 1,611 more QALYs The lifetime macular degeneration -related costs and costeffectiveness ... age- related macular degeneration outcomes Our model predicted gains in QALYs, and savings in the cost of macular degeneration treatment and the cost of care for people with impaired vision Our findings...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... is involved in multiple signaling pathways a wide range of substrates, and it has been suggested to be the integrative point of multiple pathways [3] The MAPK cascade consists of three interlinked ... H2O2 and OÀ accumulation detected by DAB staining and NBT staining, respectively WT, wild-type role of GhMPK2 against oxidative stress was evaluated by testing the tolerance of the plants to MV In ... Analysis of ROS accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses (A) Virus infection-induced H2O2 accumulation detected by DAB staining (B) Abiotic stress- induced...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... densitometer (BioRad) Single strand breakage assay (SSBs assay) using pBR322 DNA To measure PM-induced oxidative DNA damage, single strand DNA breakage assay was performed according to Nampalli et ... remarkable change of expression level in Nrf-2, proteins related with many transcriptional and anti -oxidative stress enzyme, was observed in the groups of three concentration of PM2.5 and PM10 (5, ... suggesting that PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... xation of CO2 by PEPC increased in response to O3 in both groups of seedlings (Figs 5E5H) during the growing season The level of activity decreased in the neoformed ush of the episodic seedlings ... processes of injured leaves [23] However, phenol content of truncated seedlings remained unchanged with increasing O3 and even decreased with increasing O3 for episodic seedlings Large progression of ... immersing the tubes for in boiling water The colorimetric determination of NO2 was done by mixing 0.25 mL of incubation medium with 0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and 0.25 mL of sulfanilamide...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... cartilage from elder donors and in OA cartilage, suggesting the presence of oxidative damage in ageing and degenerative cartilage These findings provide evidence to support the concept that oxidative ... dysfunction and degeneration in cartilage The findings of the present study suggest that cumulative oxidative stress leads to a decrease in antioxidative capacity in articular cartilage, resulting in ... provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere erosion, and chondrocyte...
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Báo cáo y học: "Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinscher" potx
... lymphocytes and pigmented (probably copper) macrophages HE staining (B) Centrolobular accumulation of copper in hepatocytes and band of fibrous tissue with inflammatory cells and copper-laden macrophages ... related signaling molecules Q-PCR was performed on a total of 17 genes involved in oxidative stress and copper metabolism Real-time PCR was based on the high affinity double-stranded DNAbinding ... involved in copper metabolism and oxidative stress in several gradations of hepatic copper toxicosis in Doberman pinschers Results To gain insight into the pathogenesis of copper toxicosis, we first...
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Báo cáo y học: "Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats" potx
... effect was related, at low dosage, to the inhibition of the conversion of citrulline into arginine by eNOS (contraction) and at high dosage by activation of K+ATP channels or due to NO quenching [15] ... effects of the hydrogen sulfide donor Moreover, we did not assess the effects of NaHS on inflammation and oxidative stress in non hemorrhagic rats since the injection of a single dose of 0.2 mg/kg of ... = 10) in the aorta (a) and heart (c) of the two groups of rats (b, d) Western blots revealing iNOS expression in the in the whole lysate of aortas (n = 6) (b) and in hearts (n = 6) (d) of two...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... representing hierarchical clustering of average log signal values of auxin-induced (A) and auxin-repressed (B) genes in various tissues ⁄ organs and developmental stages (mentioned at the top of each ... Transcript profiling of auxin-responsive genes M Jain and J P Khurana responses, which indicates crosstalk between stress and auxin signaling In the recent past, the identification of F-box proteins (TIR1 ... as auxin receptors has been a milestone in our understanding of the molecular mechanisms of auxin signaling pathways These F-box proteins are components of E3 ligase and target Aux ⁄ IAAs, in particular...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... EhADH2, indicating the presence of two catalytically independent domains, the N-terminal domain, displaying ALDH activity, and the C-terminal domain, containing an iron-binding domain, which is involved ... 2010 FEBS 3383 Fermenting enzymes and oxidative stress in Entamoeba E Pineda et al Table Kinetic parameters of EhPFOR at 37 C Figures in parentheses indicate numbers of individual amebal extracts ... FEBS 3385 Fermenting enzymes and oxidative stress in Entamoeba A E Pineda et al in complex with pyruvate as template [25] Because of the high percentage of identity between the amino acid sequences...
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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx
... the molecular basis of oxidative stress response by annexins Materials and methods Purification of recombinant protein Cloning and construction of an N-terminal His4-fusion protein has been described ... are certainly promising for succeeding in determination of a calcium-bound structure of a plant annexin A feature of particular interest in Anx(Gh1) is the occurrence of two adjacent cysteine residues ... fascinating perspective for plant annexin function, since it might well represent the structural basis of the role of annexins in the oxidative stress response Oxy5, an annexin-like protein from...
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