complement deficiencies in human systemic lupus erythematosus sle and sle nephritis epidemiology and pathogenesis
Báo cáo y học: "Commentary on “Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al" pdf
... animal models of disease in implicating candidate susceptibility regions in humans The 1q41–42 region is homologous to a locus linked to a mouse model of lupus, and linkage in humans was first demonstrated ... for linkage of a candidate chromosome region to human systemic lupus erythematosus J Clin Invest 1997, 99:725-31 Lander ES, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting ... Miller ME, Kearns GM, Messner RP, King RA, Rich SS, Behrens TW: Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair...
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Báo cáo y học: "Association between anti-nucleophosmin and anti-cardiolipin antibodies in (NZW × BXSB)F1 mice and human systemic lupus erythematosus" doc
... nucleolar staining disappeared when sera were preincubated with recombinant NPM (Fig 2f) in lupus mice Correlation between anti-nucleophosmin and anti-cardiolipin antibodies in lupus mice A positive ... activity of 4B7 mAb Binding of rhNPM to cardiolipin and effects of nucleophosmin on cardiolipin-binding activity of 4B7 mAb (a) Cardiolipin was coated on plastic plates and incubated with various ... WB mouse and SLE staining pattern of anti-nucleophosmin-positive Immunofluorescence sera on HEp-2 cells WB mouse and SLE sera on HEp-2 cells An anti-nucleophosmin (antiNPM) mouse mAb and anti-NPM...
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Tài liệu Reproductive health in male systemic lupus erythematosus pdf
... activity and the cumulative damage of SLE were evaluated in all patients at the beginning of the study, using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)20 and Systemic Lupus International ... concentration) and/ or astenozoospermia (low spermatozoid motility) SLEDAI – Systemic Lupus Erythematosus Disease Activity Index, SLICC/ACR-DI – Systemic Lupus International Collaborating Clinics/ACR ... et al The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus Arthritis...
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Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility" pptx
... processing in patients with systemic lupus erythematosus In vivo imaging and clearance studies J Clin Invest 1992, 90:2075-2083 Sullivan KE, Wooten C, Goldman D, Petri M: Mannose-binding protein ... studied in 143 patients with SLE and 200 healthy blood donors DR3 represents the haplotype DR3-DQ2-C4AQ0 donors F, phenylalanine; H, histidine; Int, intermediate; MBL, mannan-binding lectin; R, arginine; ... the pathogenesis of SLE, a concept that may be instrumental in the analysis of the genetics of SLE as well as providing hypotheses for pathways in the pathogenesis of lupus Available online...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... germinal centre (GC) A (b) Staining for CD20 FDC staining suggests two possible GCs within close proximity, but B-cell staining shows no clear demarcation (c) Anti-FDC staining for GC B (d) staining ... with TA-cloning vector pCRII, and transformed into IFN-αF cells (Invitrogen, Paisley, UK) and cloned Immunohistochemical staining of tissue sections Frozen sections were stained using mouse monoclonal ... distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions Very few T cells could be seen within GC A and B, and no plasma cells could be seen at all within...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... Takeda T, Inoue T: Serum levels of interferons in patients with systemic lupus erythematosus Clin Exp Immunol 1987, 70:562-569 Hooks JJ, Moutsopoulos HM, Notkins AL: Circulating interferon in human ... MAPK and NFB signaling pathways in a network, and consequently contribute to SLE Indeed, it has been shown that FcRIIb is a gene susceptible to SLE both in humans and mice [24] Means and Luster...
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Báo cáo y học: "Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies" pdf
... The Mexican Systemic Lupus Erythematosus Disease Activity Index and the Systemic Lupus International Collaborating Clinics/American Collage of Rheumatology Damage Indexes at the beginning of the ... cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics aInformation for treatment was available in 19 patients in this ... (Invitrogen, Carlsbad, CA, USA) and then into pDEST17 vector The recombinant protein was expressed in Escherichia coli and purified via nickel affinity column Screening of autoantibodies in human...
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Báo cáo y học: "Cytokines in systemic lupus erythematosus, London, UK" ppt
... of interleukin-10 and interleukin-12 on the in- vitro production of antidouble-stranded DNA antibodies from patients with systemic lupus erythematosus Clin Exp Immunol 2001, 124:18-125 13 Leandro ... against C1q are correlated with nephritis, hypocomplementaemia and dsDNA antibodies in systemic lupus erythematosus J Rheumatol 1991, 18:230234 Lawman S, Ehrenstein MR: Many paths lead to lupus ... meeting showed the breadth of interest in the role played by different cytokines in SLE A large amount of work in mice, and a smaller body of evidence on the effects of anticytokine antibodies in...
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Báo cáo y học: "Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus" potx
... may explain why TNF blockade can induce increases in antinuclear antibodies and at the same time rapidly reduce inflammation and prevent inflammation-induced damage, also observed in SLE patients ... expression in different tissues is usually for: inflammation and consecutive tissue injury As in experimental lupus, TNF is highly expressed in glomeruli in all forms of lupus nephritis [76–79], and ... of TNF in apoptosis and in immune regulation, its powerful proinflammatory effects are unequivocal and have been numerously reviewed [65] In this regard, murine and human data on systemic lupus...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Kong TQ, Kellum RE, Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 1962, ... Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 1998, 15: 42-52 El-Magadmi M, Ahmad Y, Wajed J, Bruce IN: The bimodal mortality pattern in systemic lupus erythematosus ... and medications Progress will only be made as basic science brings an understanding of the mechanisms of accelerated atherosclerosis in SLE and as clinical studies address both the efficacy and...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... protein autoantibody; CRP, C-reactive protein; mSLEDAI, modified systemic lupus erythematosus disease activity index; n.s., not significant; SLEDAI, systemic lupus erythematosus disease activity index ... Vigushin DM, Pepys MB, Hawkins PN: Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease J Clin Invest 1993, 91:1351-1357 35 Sturfelt G, Sjöholm AG: Complement ... complement system and to bind to apoptotic cells [4,17] Phosphocholine and antigens, for instance chromatin, histones and small nuclear ribonucleoproteins (snRNPs), that are targeted during systemic...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... Wang GR, Lin KT, Chuang CY, Chen CY: The study of anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of Chinese patients with systemic lupus erythematosus and central ... Alarcon-Segovia D: Interleukin-1 and interleukin-6 activities are increased in the cerebrospinal fluid of patients with CNS lupus erythematosus and correlate with local late T-cell activation markers Lupus ... valuable in detecting even minor lesions caused by CNS lupus and correlated to CNS manifestations in SLE [8] Pleocytosis and elevated protein levels are found in some but not all patients with CNS lupus...
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Báo cáo y học: "Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood" pps
... dH20 SLE 13 SLE 12 SLE 11 SLE 10 SLE SLE SLE SLE SLE SLE SLE SLE SLE Type (c) Type Type systemic lupus erythematosus (SLE) in mouthwash samples Epstein–Barr virus (EBV) typing of normal individuals ... virus in systemic lupus erythematosus Lancet 1971, 1:167-168 29 Rothfield NF, Evans AS, Niederman JC: Clinical and laboratory aspects of raised virus antibody titers in systemic lupus erythematosus ... hypothesis that EBV infection could trigger at least some SLE cases Hence, clarifying the precise status of an EBV infection in patients would be valuable in improving our understanding of the role...
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Báo cáo y học: "Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies" docx
... AECA and psychiatric disorders in patients with SLE In 1999, the ACR nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and ... involvement in endothelial dysfunction and a pathogenic role of AECA in SLE [30-34] Interestingly, some in vitro and in vivo reports have demonstrated an increased expression of adhesion molecules on human ... in the pathogenesis of NPSLE should be clarified by prospective studies with both intrathecal and serum determination Finally, anxiety and depression are frequently detected in SLE patients and...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... iodide staining, according to the method of Nicoletti and colleagues [19], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer ... 4°C and then soaked in balanced salt solution (Sigma) for 30 at 25°C Cells were then incubated for 30 at 25°C in the blocking buffer (2% bovine serum albumin in PBS, containing 5% glycerol and ... design of the study and in analysis of data and helped to draft the manuscript FD carried out the cloning and sequencing of cDNA and protein expression and contributed in the interpretation of...
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Báo cáo y học: "B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels" ppsx
... 20:829-833 Ginsburg WW, Finkelman FD, Lipsky PE: Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus Clin Exp Immunol 1979, 35:76-88 Klinman DM, ... interpretation of the results and in writing the final version of the manuscript DMH assisted in the design in the study, in the interpretation of the results, and in writing the final version of the manuscript ... assays and assisted in the interpretation of the results and in writing the final version of the manuscript TSM performed the plasma BLyS protein and anti-BLyS assays and assisted in the interpretation...
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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx
... participated in acquisition of data and helped in drafting and revising the manuscript SJ have been involved in drafting and revising the manuscript for important intellectual content and have given final ... Deficient gamma-interferon production in patients with systemic lupus erythematosus Arthritis Rheum 1986, 29:1210-1215 Kelley VR, Wuthrich RP: Cytokines in the pathogenesis of systemic lupus erythematosus ... polymorphism and many non-skeletal diseases [20] Although SLE has features consistent with Th2-type cytokine predominance, both Th1 and Th2 cytokine may be involved in the pathogenesis of SLE [21]...
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Báo cáo y học: "Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production" pot
... SA12 (broken line), or biotinylated JMAb23 (human IgG2; thin line) and streptavidin-FITC, and then analyzed using flow cytometry (e) Human ICOS expressing CHO-K1 cells were stained biotinylated SA12 ... (phosphate-buffered saline [PBS] containing 0.1% bovine serum albumin and 0.1% sodium azide) and incubated on ice for five minutes with 10 µg purified human immunoglobulin (Cappel, ICN, Aurora, OH, USA) and/ or ... active SLE was significantly greater than the percentages in inactive SLE and normal control individuals Interestingly, percentages of both CD4+CD45RO+ and CD8+CD45RO+ T cells expressing ICOS in inactive...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the first 12 hours post-injection accompanied by an increase ... of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained by a transgenic ... to DNA in murine systemic lupus erythematosus Scand J Immunol 2003, 57:525-533 Izui S, Lambert PH, Fournie GJ, Turler H, Miescher PA: Features of systemic lupus erythematosus in mice injected...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... For annexin-V/PI staining × 106 cells were resuspended in 50 µl binding buffer (Roche Diagnostics, Lewes, UK) and incubated with annexin-V/FITC (Roche) and annexin-V/PI (Roche) for 15 minutes at ... difference in the type of LDL present in patients and control individuals may explain our observation of an inverse correlation of TGF-β1 AI and LDL in SLE patients, which was not seen in control individuals ... TGF-β1 activation during blood clotting in patients and control individuals, and examined whether TGF-β1 activation was associated with clinical phenotype, in particular inflammatory disease...
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