cocaine as a local anesthetic mechanism of action

Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

Ngày tải lên : 22/02/2014, 04:20

... us k XaÀTFPI;VIIaÀTF ¼ k XaÀTFPI;VIIaÀTF þ k XaÀTFPI;VIIaÀTF Appara app a a1 ent values of k XaÀTFPI;VIIaÀTF and k TFPIÀXaÀVIIaÀTF are rather a d low So we assumed the true rate constants of the ... factor X activation in the absence of factor Xa at the initiation point of the reaction Yet this mechanism based on the hypothesis of the interaction between TFPI and Xa–VIIa–TF cannot explain ... though it is clear that the apparent values of kcat and Km may have a more sophisticated interpretation than the constants in the classical scheme of Michaelis This approach was used in the present...

16
415
0

Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf

Ngày tải lên : 12/08/2014, 23:21

... Jersey, USA) DNA oligonucleotide primers D19 (5'-GTCCCTGTTCGGGCGCCAC), D25 (5'-CTGAGACAACATCTGCTGAGGTAGG), and D26 (5'-CTGAGACAACATCTG CTGAGGTA GGA), and templates D3 6A (3'-CGAAAGTCCAGGGA CA AGCCCGCGGTG ... concentration for each compound was fixed at 3–4 fold above the individual drug IC50 value Isobologram analysis The isobologram analysis is a graphical approach that can be traced back to as early as the ... biochemical assays FM and DG carried out the cell-based drug combination assays KLW and ESS participated in the study design, data analysis, and manuscript preparation KBE and MDM participated in...

16
377
0

Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

Ngày tải lên : 26/10/2012, 09:39

... Levantesi G, Gavazzi L, Valagussa F Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data Lipids 2001; 36: S53–S63 67 Cuzzocrea S, Riley DP, Caputi ... mellitus, cardiovascular disease, such as hypertension, and delayed wound healing have a common important basic pathogenesis, which is related to imbalance between free radical production and removal ... Introduction Diabetes mellitus and cardiovascular diseases are challenging medical and social problems Patients with diabetes mellitus are at a higher risk of developing vascular dysfunction and hypertension...

7
813
0

Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

Ngày tải lên : 19/02/2014, 07:20

... of both plasma and inner membranes Experimental procedures Analysis of the fungicidal effect of viscotoxin A3 Biological materials Fusarium solani f sp eumartii, isolate 3122 (EEA-INTA, Balcarce, ... excitation and emission slits at nm Complete release was achieved by adding to the cuvette Triton X-100 to a final concentration of 0.1% (w ⁄ w) Leakage was quantified on a percentage basis according ... fluorescence value after addition of Triton X-100 Light scattering measurements The ability of VtA3 to change large unilamellar vesicle scattering was used as an indicator of liposome integrity Right-angle...

12
530
0

Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

Ngày tải lên : 19/02/2014, 16:20

... MDH was added and the absorbance after reaching the equilibrium was taken as A2 Citrate synthase was added and the reaction was monitored until no further change in absorbance was visible (A3 ) Concentrations ... sample and water to a ﬁnal volume of mL The reaction was started by addition of enzyme sample and decrease in absorbance at 340 nm was monitored One unit of enzyme activity was deﬁned as the amount ... wild-type strain was A2 6 and DmcsA was RYQ11 Succinyl-CoA > acetate, succinyl-CoA:acetate CoA-transferase; Succinyl-CoA > propionate, succinyl-CoA:propionate CoA-transferase; Propionyl-CoA > acetate,...

15
678
0

Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc

Ngày tải lên : 30/03/2014, 11:20

... calculate body fat and lean mass This has been shown to detect a range of 5–30% body fat mass with a correlation of 0.98 to values obtained by chemical analysis [49] The machine was calibrated before ... from adipose tissue during weight loss [7–9] The amount of pollutant released was positively associated with a lower relative metabolic rate as well as decreased oxidative capacity in muscle We also ... stopped after 14 days of treatment The body weight of animals housed in pairs was monitored on a daily basis at 09.00, i.e immediately after the dark cycle Results are shown as the average weight gain...

11
424
0

báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx

Ngày tải lên : 18/06/2014, 15:20

... expression of β-actin mRNA and AMACR mRNA in prostate cancer line LNCaP, but only very weak expression of AMACR mRNA was observed in normal adult liver and pancreas (Figure 1A) In contrast, the AMACR ... One week after the 4th stimulation, cytotoxic activity of the CTL was measured by 51Cr release assay Cytotoxicity Assay The cytotoxic activities of CTLs were measured by 51Crrelease assay as described ... Clontech, Palo Alto, CA) were used as a template of normal tissue cDNA Total RNA was extracted using an RNeasy kit (Qiagen, Hilden, Germany) A cDNA mixture was synthesized from μg of total RNA by reverse...

11
531
0

báo cáo hóa học: " Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration" docx

Ngày tải lên : 19/06/2014, 22:20

... oxidases in Alzheimer's disease and other types of dementia? IUBMB Life 2003, 55:307-313 Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, ... was added to the supernatant and then mM sulfanilamide and mM N-1 (1-naphthyl)ethylenediamine (NEDA) were added Absorbance at a wavelength of 548 nm was measured by plate reader (BMG, Fluostar ... hours after LPS/IFN-γ addition Assessment of glial activation Activation of glia in the neuronal-glial culture was assessed by NADPH diaphorase staining and measurements of nitrite in the medium...

15
382
0

báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx

Ngày tải lên : 10/08/2014, 22:20

... http://www.jhoonline.org/content/2/1/36 CLL patients are also elevated and exhibit a significant decrease as early as days after lenalidomide treatment These reductions correlate with cytoreduction suggesting a casual relationship ... action of lenalidomide Mechanism of action of lenalidomide Various mechanisms by which lenalidomide achieves clinical efficacy in hematological malignancies Page of 10 (page number not for citation ... vascularization was decreased, supporting the notion that lenalidomide may uncouple angiogenesis from the effect of VEGF[30] Apart from alteration in the levels of VEGF, analysis of signal transduction...

10
301
0

Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt

Ngày tải lên : 11/08/2014, 03:20

... Benoit-Vical F, Abena AA: Analgesic and anti-inflammatory effects of Cassia siamea Lam Stem bark extracts J Ethnopharmacol 2010, 127:198-111 25 Blain EJ, Ali AY, Duance VC: Boswellia frereana (frankincense) ... amastigotes of Leishmania amazonensis, a causal agent of cutaneous leshmaniasis Moreover, this latex also increased NO and TNF-alpha and decreased transforming growth factor-beta (TGF-beta) production ... inflamed mouse paw, in the carrageenan-induced edema model Materials and methods Preparation and chemical characterization of lupeol acetate (LA) The H drasticus latex was collected at the “Chapada...

11
367
0

Báo cáo y học: " Laugh syncope as a rare sub-type of the situational syncopes: a case report" potx

Ngày tải lên : 11/08/2014, 21:22

... etiology One populationbased study found that cardiac and neurologic syncope were associated with an increased risk of death from any cause and an increased risk of cardiovascular events and stroke, ... embolism, aortic dissection, myocardial infarction, left atrial myxoma, cardiac tamponade, atrioventricular block, sick sinus syndrome, tachyarrhythmia, bradyarrhythmia Neurally mediated (reflex mechanisms) ... Bragg MJ: Fall about laughing: a case of laughter syncope Emerg Med Australas 2006, 18:518-519 Arthur W, Kaye GC: Important points in the clinical evaluation of patients with syncope Postgrad...

4
190
0

báo cáo khoa học:" Fanconi anemia manifesting as a squamous cell carcinoma of the hard palate: a case report" pptx

Ngày tải lên : 11/08/2014, 23:22

... mucosa to the soft palate mucosa The nasopharynx appeared normal (Figure 2) No significant cervical lymphadenopathy was seen on the images An incisional biopsy performed under local anaesthesia ... International Fanconi Anaemia Registry (3%) had HNSCC [11] In the same year Bremer presented two cases of HNSCC [15], but in international literature no article has reported a hard palate localization ... surface was erythematous and smooth, with some telangiectasias Clinical examination showed no regional lymphadenopathy CT and MR imaging showed a hard and soft tissue mass extending from molar region...

5
245
0

Báo cáo y học: " Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD" pot

Ngày tải lên : 12/08/2014, 15:20

... acquisition of data, analysis and interpretation of data, and drafting of the manuscript KA participated in the analysis and interpretation of data, technical support, and critical revision of ... heart catheterization A balloontipped pulmonary arterial catheter was advanced to the pulmonary artery for measurement of pulmonary arterial pressure (PAP) and PWP In addition, a plastic catheter ... considered adequate if the patient was able to expectorate at least mL of sputum Statistical analysis All values are presented as mean (SD) Multiple comparisons were performed by one-way analysis of variance...

7
257
0

Discovery and mechanism of action study of anti viral compounds for dengue virus

Ngày tải lên : 10/09/2015, 15:51

... (Sampath et al 2006; Xu et al 2005) This led to the debate as to whether the screening of inhibitors based on helicase assay is a wiser choice over NTPase assay or RNA binding assay Co-crystal ... replication (Kapadia and Chisari 2005) Fatty acids are also important for the post-translational modification of proteins These fatty-acylated proteins are synthesized by acyltransferases that utilize ... collaboration with Walter Reed Army Institute of Research, developed a dengue vaccine based on a different strategy: their vaccine candidate is a cocktail of individual monovalent vaccine against...

175
512
0

Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway

Ngày tải lên : 11/09/2015, 09:08

... superfamily The hexokinase superfamily members represent a class of enzymes that possess an ATPase domain with same basic fold and active site as actin and Hsp70 of the heat shock proteins There are ... seleno-L-methionine TP Triose phosphate Amino acids Ala (A) Alanine Arg (R) Arginine Asn (N) Asparagine Asp (D) aspartic acid Cys (C) Cysteine Gln (Q) Glutamine Glu (E) glutamic acid Gly (G) Glycine His ... gluconokinase, xylulokinase, glycerol kinase, fructokinase, rhamnokinase and fucokinases 1.11.2 Galactokinase superfamily The galactokinase superfamily is still structurally uncharacterized However,...

136
309
0

Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques

Ngày tải lên : 11/09/2015, 09:18

... acute promyelocytic leukemia (APL), a subtype of AML (M3 and variant) has become a reality In the case of ATRA therapy, the strategy involves early addition of chemotherapy such as ara-C to ATRA ... RAD001) and the possibility of using it as therapy for certain cancers are underway (Galanis, et al., 2005; Chan, et al., 2005; Agarwala and Case, 2010) 1.4.2 Rapamycin as an immunosuppressant ... in C.albicans (Wong, et al., 1998; Cruz, et al., 2001) 1.4.4 Mechanism of action of rapa Rapamycin is a known inhibitor of the mammalian Target Of Rapamycin (mTOR) pathway The mechanism of this...

202
319
0

The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta

Ngày tải lên : 14/09/2015, 14:06

... to mammalian Grb2, and Gap1, a Ras GTPase-activating protein, two components of the Ras-ERK pathway This data adds strength to the argument that dSpry acts as a negative feedback inhibitor of ... that 28 associates with the inner leaflet of the plasma membrane (Casci et al., 1999) A similar localization pattern has been observed for the mammalian isoforms of Spry (Lim et al., 2000; Impagnatiello ... activity of GTPases is very inefficient, thus necessitating the assistance of GTPase activating proteins (GAPs) such as RasGAP The relative amounts of the two states of Ras, and hence its activity,...

209
984
0

Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics

Ngày tải lên : 16/09/2015, 17:10

... reasonable since some potential substrates of CK2 are localized in the matrix of mitochondria (Meggio and Pinna, 2003) CK2 has been identified as an endoplasmic reticulum (ER)-associated kinase ... 16 mediating the interaction of synaptic vesicles with the presynaptic plasma membrane Syntaxin, as a neuronal protein at the synaptic sites, appears to mediate the interaction of synaptotagmin ... neurofilaments and the phosphorylation is required in maintaining axonal morphology Cdk5 was originally isolated from the brain as a neurofilament kinase to catalyze the KSP phosphorylation at...

182
480
0

Understanding the mechanism of action of protein synthesis inhibitors against mycobacterium

Ngày tải lên : 13/10/2015, 16:41

... B5 $A 56481 BD8E1 5BCA1 4F68DBA1 BCA1 A 4B1 B41 A D78DBA1 BCA1 78AD A 1 CA A 4 A 1 E4 A6 1 75 1 D A1 5 AEB61 EAA 7A7 1 B41 4F$DB1 B5 $A 56481 CA15AEB1B57145 A 14E 1A D65DB8E ... 4"1 A 8BDE A1 DBBAE1 A 8BA1CD8E 1D14FF4E1BD AB1CA A1 3A1 48 7A1 A87AE A1 BCDB1 BCA1 FACDE8F1 41 A 8BDE A1 41 68EA:46871 DE71 D6EAF568E1 6A5 4F5B868E1 7A 8DB8 A 1 D A1 78 A AEB1DE718E 7A AE7AEB1C815BCA1AECDE A 1BCA148$868B14158E ... 4E A E1 / A 1 AD1 4 A 1 01 F86684E1 EA31 B5 $A 56481 D A 1DE71121F86684E17ADBC1 A6 DBA71B41B5 $A 56481D A1 A 4BA71CA 1A& 8BAE A1 41F56B8" 75 A 8BDEB1 DE71 A& BAE8 A6 1 75 " A 8BDEB1...

92
131
0