closing the loop feedback and stability
Tài liệu Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer docx
Ngày tải lên :
14/02/2014, 21:20
... stakeholders and the general public about the significance of cancer in the AYA population and the unique needs and issues of AYA patients related to their age and stage of life Until now, the AYA ... acknowledge and extend special thanks to the following groups and individuals: • The many scientists, clinicians, advocates, and other professionals who generously gave of their time and knowledge ... from diverse disciplines across the research enterprise, the cancer control continuum, and the advocacy and survivor communities Further, the PRG leadership sought the input of individuals whose...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
Ngày tải lên :
14/02/2014, 22:20
... of ApeSOD The line reflects the best fit of the data and indicates that the apparent molecular mass is 96 265 Da The deviation between empirical data and the fitted line is plotted in the upper ... which, together with the OD2 of Asp165, the NE2 of His79 and the NE2 of His169, formed an equatorial plane (Fig 3B) The metal ion and the addi˚ tional water oxygen were only 0.03 and 0.04 A, ... ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions The manga˚ nese was only 0.06 A out of the equatorial plane (Table 3) The angles around the...
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Tài liệu Closing the gap between research and practice: Foundations for the acquisition of literacy pptx
Ngày tải lên :
17/02/2014, 06:20
... has termed the Matthew effect, with the better readers reading more and therefore increasing their exposure to print, and consequently their word recognition skills and their fluency and speed ... whom had received their research funding from the ARC, to discuss and review their work in the reading area As noted by Pratt and Coltheart7, the issues covered and the emphases of the different ... administrators and the public These concerns include the social factors related to the development of literacy, including the early development of literacy in the home and preschool environment, and the...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
Ngày tải lên :
18/02/2014, 08:20
... in the vicinity of the S1 pocket [11,34], in the rst part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areas that are stabilized by TF [9,25,26] The ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active ... [25], and may thus coincide with a need to restrict the exibility of the unusually long 170 loop of FVIIa It is also the only possible backbone interaction between activation loop and the 170 loop...
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Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
Ngày tải lên :
19/02/2014, 12:20
... dissociation and denaturation To further confirm the urea-induced changes in secondary structure, we analyzed the UV CD spectra of MS2 and the ts mutants in the presence and absence of 4.5 M urea, the ... middle of the central b-strand of the coat protein dimer and its side-chain projects into the protein’s interior (Figs 1B and 8) The two Met88 residues are in close proximity to one another at the ... area of the residue (% 59 A2) and in the interactions occurring there (corresponding to the b-sheet) is smaller An appealing interpretation for these findings is that the lower stability of the coat...
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Đề tài " The strong Macdonald conjecture and Hodge theory on the loop Grassmannian " docx
Ngày tải lên :
06/03/2014, 08:21
... here, the first term is the sum of the first terms in (A.13) and (A.14), the second and third incorporate the second and third terms in (A.13) and the < m < p, resp the p < m < p + n portions of the ... E∞ THE STRONG MACDONALD CONJECTURE 185 The Laplacian on the Koszul complex In preparation for the proof of Theorem B, we now study the Koszul complex for the pair (g[z, s], g) and establish the ... To keep the statements straightforward, G will be simple and simply connected Dolbeault cohomology of the loop Grassmannian (5.1) The loop Grassmannian By the loop group LG of G we mean the group...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
Ngày tải lên :
07/03/2014, 12:20
... release without folding to a Tyr110 -loop- out conformation On the other hand, the 20 ps simulations on the Tyr110 -loop region of the loop- out structure (i.e a ligand-free experimental 1W27) (Fig ... (C) at 300 K and (D) at 370 K These simulations led to a hypothesis that the active state of the parsley PAL is a Tyr110 -loop- in conformation and opening ⁄ closing the entrance to the active site ... the PALbased models Merging the MIO portions to the monomers and building the ‘Tyr -loop- out’ tetrameric models (PlPALout and SmPALout) was achieved in the same way as described for the ‘Tyr -loop- in’...
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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
Ngày tải lên :
07/03/2014, 12:20
... supports the role of the A-chain in affecting the conformation and catalytic properties of the B-chain, particularly in some insertion loops of the enzyme, such as the 60 -loop, as well as in the geometry ... of Trp207 and 29 may significantly affect the intrinsic fluorescence of the DK9 variant, the higher the surface exposure and flexibility of their side-chains to the solvent the smaller the intrinsic ... 22 ± 1.5 and 24 ± 2.6 mM for WT and DK9 thrombin, respectively The vertical bars are the standard errors of the measurements 162 compared with those of the WT form In other words, in the mutant...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
Ngày tải lên :
07/03/2014, 12:20
... space, the GMK2 clone (Table 1) was modified by site-directed mutagenesis to create the mutants YQ and YP, and the T1 ⁄ of their activity was determined (Table 2) These combinations increased the stability ... similar Km values of the native and WT, and the YQ mutant CPU with a synthetic and physiological substrate of CPU There seem to be no major changes in the positioning of the propeptide, as indicated ... to an increased thermostability of the protein itself, we monitored the thermal unfolding of WT and YQ proCPU-CHis Compared with the WT, the midpoint temperature (Tm) of the protein-unfolding...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
Ngày tải lên :
08/03/2014, 08:20
... to locate the catalytic center and predict the shape of the dimeric protein The model reinforced our hypothesis proposed above To further address this hypothesis, we have characterized the protein ... is the final product of the reaction with HisOMe In fact, after min, the spectra of the HisOMe-treated samples had stabilized with the 390-nm peak as the major and final one In the reaction in the ... histidine and the histidineanalogs HisOMe and a-FMH This scheme was built from the major forms for each step mentioned in the text deduced from the previous information ([18,19] and the present...
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Closing the Cancer Divide: A blueprint to expAnd Access in low And middle income countries pdf
Ngày tải lên :
15/03/2014, 00:20
... similar to the support afforded to AIDS, Malaria and TB And second, the realistic prong which recognizes the limitations on the ground and works despite them, through them and around them to reach ... sweet and loving to us and to all to those who knew her Together with my father and brother we lovingly cared for her day and night in the last few months After a long and painful struggle, my mother ... and that there was nothing they could to save my leg They had to amputate it When I heard what they said, I felt lost and confused I didn’t know what to say to them I screamed and yelled at them,...
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Accelerating Equitable Achievement of the MDGs Closing Gaps in Health and Nutrition Outcomes potx
Ngày tải lên :
16/03/2014, 05:20
... MDGs in Asia and the Pacific: where we stand Asia and the Pacific on the global stage Using the global MDG Database also makes it possible to compare Asia and the Pacific with two other developing ... between the curve and the equal distribution line – expressed as a proportion of the whole area below the equal distribution line The higher the Gini index the greater the disparities Another measure ... how far they lag behind other households either in their own countries or in richer nations halfway around the world.1 These perceptions can undermine national stability and provoke social and political...
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Báo cáo khoa học: Thermodynamic analysis of the unfolding and stability of the dimeric DNA-binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima and its E34D mutant pdf
Ngày tải lên :
23/03/2014, 12:20
... protein -stability graph and has proved to be an important parameter in thermal stability [1,28,32] For example, simulations show that the smaller the DCp,U the wider the DGU(T) curve and thus the ... 3.50 and the °C difference in Tm between the wild-type and the E34D mutant at both pH 4.00 and 3.75 decreases to only °C at pH 3.50 These values, together with the fact that in HUBst, in which the ... concentrations) to the two-state model (Eqn 1) The Tm and DHU,m-values refer to the transition midpoint at the monomer concentration of 120 lM DGU,25 and DDGU,25 stand for the changes in standard Gibbs...
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Báo cáo khoa học: Solution structure and stability of the full-length excisionase from bacteriophage HK022 pot
Ngày tải lên :
23/03/2014, 15:21
... a reverse b-turn T between b-strands and The b-strands (residues Ile30–Phe31) and (residues Val48–Lys49) form the second b-sheet The Ó FEBS 2003 Structure and stability of HK022 excisionase (Eur ... annealed, and the double-stranded X1 was purified by gel filtration in buffer containing 40 mM K2HPO4 and 100 mM NaCl, pH 6.0 The double-stranded X1 DNA was concentrated and equilibrated with the corresponding ... based on the protein structure However, the reasons for Xis instability in vitro and in vivo, as well as the role of the C-terminal tail, remained unclear In order to better understand the functional...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
Ngày tải lên :
24/03/2014, 03:21
... in the wild-type PA c-551 and its quintuple mutant The mutated residues in the quintuple mutant, and the corresponding ones of the wild-type PA c-551 and HT c-552 are colored purple, green, and ... respectively (A) The region around A7/M13 in HT c-552 and the corresponding regions (B) The region around Y34/Y43 in HT c-552 and the corresponding regions (C) The region around I78 and the heme (denoted ... c-552, but not in most of the others at the corresponding positions It is likely that some of them are the residues responsible for stability, and in fact Ala7, Met13, and Tyr43 in HT c-552 have...
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Báo cáo " A combination of the identification algorithm and the modal superposition method for feedback active control of incomplete measured systems " doc
Ngày tải lên :
28/03/2014, 13:20
... identification algorithm The numerical simulations are taken when the sensor is placed at the distances L/4, L/2 and L from the base In Fig 3, the shapes of the 1st mode, the 3rd mode and the 5th mode are ... term The magnitude of the error term depends on the number and the locations of the sensors The numerical simulation is applied to a base excited cantilever beam to illustrate the algorithm The ... measuring the displacement of a certain point of the beam Because the velocity can be calculated from the displacement, the measurement vector contains components: the displacement and the velocity...
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Báo cáo " A combination of the identification algorithm and the modal superposition method for feedback active control of incomplete measured systems" doc
Ngày tải lên :
28/03/2014, 13:20
... identification algorithm The numerical simulations are taken when the sensor is placed at the distances L/4, L/2 and L from the base In Fig 3, the shapes of the 1st mode, the 3rd mode and the 5th mode are ... term The magnitude of the error term depends on the number and the locations of the sensors The numerical simulation is applied to a base excited cantilever beam to illustrate the algorithm The ... measuring the displacement of a certain point of the beam Because the velocity can be calculated from the displacement, the measurement vector contains components: the displacement and the velocity...
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The Future Security Environment in the Middle East - Conflict, Stability, and Political Change pptx
Ngày tải lên :
29/03/2014, 20:20
... the World Trade Center and the Pentagon, the suppression of terrorism rose to the fore of U.S concerns in the Middle East Al Qaeda and other radical Islamist groups draw heavily on the Arab and ... Byman and Jerrold D Green, Political Violence and Stability in the States of the Northern Persian Gulf, Santa Monica, Calif.: RAND, MR-1021OSD, 1999 10 The Future Security Environment in the Middle ... in the Middle East 27 and to a lesser extent in Kuwait, have increased the powers of the legislature while distancing themselves from the day-to-day operations of the government The king is then...
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Báo cáo khoa học: Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 docx
Ngày tải lên :
30/03/2014, 02:20
... the shape of the denaturation curve Complementary to the CD experiments, the thermal denaturation of S100A2-DCys was followed by FT-IR The absorbance change at the amide I (1600– 1700 cm)1) and ... important contributor to the irreversibility of the thermal denaturation The denaturation curves of the above-mentioned structural elements are compatible with the CD results, and further corroborate ... partial tetramerization (Fig S1) Chemical stability of holo and apo S100A2 proteins The conformational stability of S100A2-wt and mutants, in the apo and distinct metallated states, was investigated...
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