clinical trials of gmp products in the gene therapy field
Tài liệu CONSUMER PREFERENCE AND CONSUMPTION OF ORGANIC PRODUCTS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA docx
Ngày tải lên :
14/02/2014, 03:20
... are marked increases in the future demand of all organic products This augurs well for the growth of the organic industry in the Eastern Cape and in South Africa in general The findings of this ... 2% of the respondents in the Transkei and 1% in the Ciskei bought their food from the farm gate This finding is consistent with information that has established the decline of agriculture generally ... group of people as part of its ways, aids in the cohesion of this group, helps that particular group maintain its identity in the face of others, and therefore creates a feeling of "belonging"...
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báo cáo hóa học: " Clinical implications of gait analysis in the rehabilitation of adult patients with "Prader-Willi" Syndrome: a cross-sectional comparative study ("Prader-Willi" Syndrome vs matched obese patients and healthy subjects)" docx
Ngày tải lên :
19/06/2014, 10:20
... rotation of the foot (external/internal rotation) in respect to the walking direction and is defined as the angle formed with the line of progression and the segment connecting the marker on the V ... sole of the foot [24] in young obese patients during standing and walking, revealed a relevant increase in the foot surface in contact with the ground This would predispose to the development of ... comprised in the clinical assessment that all the ambulant patients have during the hospitalization The Lab was Page of (page number not for citation purposes) Journal of NeuroEngineering and Rehabilitation...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
Ngày tải lên :
19/02/2014, 16:20
... iPLA2c gene are shown in scale (kb) The 13 exons of the iPLA2c gene are indicated as boxes Spaces between the exons represent the relative sizes of the 12 introns contained within the iPLA2c gene ... which regulates the flow of the Gibbs free energy inherent in C–C bonds in fatty acids into the production of either chemical energy or heat by directing the flow of iPLA2c into either the peroxisomal ... sequence The significance of this sequence homology in the context of exons within the iPLA2c gene remains unknown Thus, the second draft of the iPLA2c genomic map contains 13 exons, the first four of...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... assay (EMSA) using the Ets consensus site at )133 As the involvement of the Ets consensus binding site at )133 in the promoter activity of the mouse a3 integrin gene was suggested by the luciferase ... triplicate, and the error bars indicate the standard deviation attempted to introduce mutations into these sequences As shown in Fig 8, the introduction of mutation into one of the Ets-binding sequences ... a3b1 integrin plays essential roles in multiple processes during embryogenesis The promoter should thus contain elements directing the expression of this integrin in the kidney, lung, and skin...
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Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf
Ngày tải lên :
23/03/2014, 04:21
... mutated amino acids are indicated in red; and the position of the last amino acid before the frameshift is shown in black The interacting partners of the mutated residues are shown in yellow and the ... Although the imidazole group in the 2110 ˚ The amide nitrogen of Arg173 forms a 2.7 A hydrogen bond with the carboxyl oxygen of the propionic acid side chain of the C1 ring of the cofactor (Fig ... N-terminal and central domains and the dipyrromethane cofactor is covalently linked to Cys261 The interaction of the cofactor with the enzyme side chains is well understood The position of the...
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Báo cáo sinh học: " Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort" pot
Ngày tải lên :
18/06/2014, 18:20
... present in most of the time points (or all of the time points for donor A) within the respective individual but were not seen in any other individual Overall, despite differences in HIV-1 genetic variability ... participates in the binding of Tat to TAR and is involved in the nuclear localisation of Tat [18,19] The strong or total suppression of transactivation abilities observed in many of the recipient ... recipient C Interestingly, none of the amino acid mutations identified in the donor were observed in either of the recipients, who share more nonsynonymous mutations between them compared to their...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
Ngày tải lên :
19/06/2014, 22:20
... effects of pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... evaluation of intracerebral cytokine profiles in these mice (2) In the 2nd part of the experimental study, mice of the C57BL/6 strain (n = 10 per group) were treated by stereotactic intracerebroventricular...
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Báo cáo hóa học: " Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort" pot
Ngày tải lên :
20/06/2014, 01:20
... present in most of the time points (or all of the time points for donor A) within the respective individual but were not seen in any other individual Overall, despite differences in HIV-1 genetic variability ... participates in the binding of Tat to TAR and is involved in the nuclear localisation of Tat [18,19] The strong or total suppression of transactivation abilities observed in many of the recipient ... recipient C Interestingly, none of the amino acid mutations identified in the donor were observed in either of the recipients, who share more nonsynonymous mutations between them compared to their...
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Báo cáo hóa học: " Changes in the gene expression profile of Arabidopsis thaliana after infection with Tobacco etch virus" potx
Ngày tải lên :
20/06/2014, 01:20
... At5g59780), the ninth one (At5g59430) corresponds to the telomeric repeat-binding protein (TRP1), which also contains the typical MYB motifs [26] Eight out of these nine genes were also included in the ... alterations in TEV inoculated plants The classification of these genes into functional categories and their putative role in disease progress will be discussed Finally, the overlapping between these ... the ratio between the intersection and the union of genes from presents in both sets Finally, the statistical significance of this overlap statistic was assessed by bootstrapping the vector of...
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Báo cáo hóa học: " Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect® test kit in diagnosis of ami within 12 hours of onset of chest pain in the emergency department" pptx
Ngày tải lên :
20/06/2014, 23:20
... AMI in patients presenting with chest pain in the ED setting General objectives The diagnostic indices and clinical utility of qualitative Cardio Detect® test kit in the diagnosis of AMI in the ... pain (categorical) as in the inclusion criteria, including the timing of onset (numerical) of chest pain The dependent variables included the qualitative (positive or negative) outcome of the ... http://www.intjem.com/content/4/1/67 Page of Figure Flow chart of the study 24 h of onset of chest pain Figure shows the initial ECG findings in the ED The majority of patients (72.5%) in this study...
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Báo cáo lâm nghiệp: "Evaluation of squared timber and log products in the Hyrcanian Forests of Iran" doc
Ngày tải lên :
07/08/2014, 10:21
... northern part of the Alborz Mountains and extend from Astara in the west of Gilan Province to Giledarreh in the east of Golestan province, and are about 800 km in length and 20 to 70 km in width (Fig ... timber products in the three provinces of study for the first 10 years of study were approximately close to each other while in the second 10 years of study they were quite different from the first ... products at the three sites under study during the last 20 years shows that in the first decade (1989–1998) there was not a large difference in the volumes of products, however, during the second...
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Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
Ngày tải lên :
08/08/2014, 23:21
... variety of antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors [5,6] The trials in this analysis all included ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials Int Clin Psychopharmacol 2002, 17:281-285 ... Relative sensitivity of the Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials: a replication...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
Ngày tải lên :
09/08/2014, 06:22
... dosing In trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of ... medications, than in clinical trials Using company clinical trial reports removes some of the problems of selective reporting in published papers due to strict word limitations Here the company clinical ... provided the mainstay of pain therapy, particularly in the early stages of disease, but are often associated with clinically relevant adverse events Common events such as nausea or dizziness, often...
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Báo cáo y học: "Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (International Cartilage Repair Society grade)" pptx
Ngày tải lên :
09/08/2014, 10:23
... cartilage The greater degree of hydration in the grade cartilage affects the interval between signals Information such as the macroscopic findings of cartilage degeneration is therefore helpful to interpret ... and an increase of water content induces the decrease of the speed of sound [25] The water content increases with the swelling of the tissue [27-29] Swelling in fibrillated cartilage [27] with ... depth of 500 μm [18] The signal intensity therefore provides information on the superficial collagen integrity of cartilage The decrease in signal intensity in site C cartilage (Figure 3b) and the...
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Báo cáo y học: " Clinical and economic ramifications of switching antipsychotics in the treatment of schizophreniab" pptx
Ngày tải lên :
11/08/2014, 17:20
... which they were initially randomized at any time during the study and initiated therapy with a different antipsychotic within 14 days of discontinuation of the initial therapy Data on the occurrence ... assessment of the findings within patient groups based on prior therapy By design, clinical data were gathered only at specific assessment points throughout the year, limiting our abil- ity to assess clinical ... that the increased use of acute-care services occurred around the time of antipsychotic medication switching [20] Taken together, findings from the present study and others suggest that switching...
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báo cáo khoa học:"The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation" docx
Ngày tải lên :
11/08/2014, 23:23
... but three of the items were reworded; only the items dealing with feelings of being punished, thoughts about suicide and interest in sex remained the same Finally, respondents rate how they have ... full form PTGI, and the reliability of the total score was generally in the range of 90 across a variety of samples [42] In the present study, the Italian translation of the PTGY-SF 10 items ... is scheduled, the results of this trial will contribute to the evidence-based knowledge on the application of the expressive writing procedure for clinical purposes in clinical settings [52] Author...
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Báo cáo y học: " The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial" potx
Ngày tải lên :
12/08/2014, 13:22
... exploratory manner using a 5% change in VC as indices, evaluated the coincidence of the ratings based on 5% change in VC between months and 12, and examined the usefulness and significance of the 5% change ... change in VC in the comparison of efficacy among treatment groups, and the clinical significance of the 5% decline in VC at month 3, we performed following analyses Significance level of tests ... Coincidence of the improvement ratings based on 5% change in VC at months and 12, in terms of positive and negative predictive values In order to examine the coincidence of the improvement ratings at...
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Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx
Ngày tải lên :
12/08/2014, 18:21
... Finally, intensivists are strongly motivated by the ‘rule of rescue’ Intensivists feel obliged to offer some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the ... especially in the early phase of illness [3] Disappointingly, however, in the only randomized, controlled study of proning yet published, hours of prone positioning did not influence mortality in the ... common in the group whose position was varied than in the group that remained continuously supine Con: prone positioning is not useful in the management of ARDS patients Gordon Rubenfeld Imagine the...
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Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
Ngày tải lên :
12/08/2014, 18:21
... useful in the management of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years Two metaanalyses in ... to guide clinical practice We therefore not advocate use of steroids in this clinically improving patient without another indication We must be cautious in our enthusiasm to try new therapies ... newer, yet preliminary, The patient described in the present scenario is improving in all aspects of organ failure, but remains catecholamine dependent A thorough examination and review of his management...
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