clinical studies of carorx™ an antistreptococcus mutans siga to prevent dental caries
Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx
... the recipient of a senior grant FIS 99/3091 and Ana Villagrá is the recipient of a training grant FIS 01/F015 19 Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein ... important determinant of cell wounding [13] Mechanotransduction is the conversion of mechanical stimuli, such as cell deformation, into biochemical and biomolecular alterations How mechanical ... T R, Marshall J, Ranieri V, Slutsky A: Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome...
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Báo cáo khoa học: "Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis" docx
... Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C: Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis Am J ... sepsis and restricted to meta-analyses of human studies, of which nine were specific to severe sepsis From the initial publication list and review of the references from identified meta-analyses, ... anti-inflammatory and/or anticoagulant properties Discussion Recent publications and editorials have suggested that one possible explanation for the discordance between the preclinical efficacy and subsequent...
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An overview of the clinical management of spasticity
... relief of the spasticity in the biceps may not lead to Restriction of the range of movement is not always simply due to increase of tone and spasticity in the relevant muscles The surrounding soft ... soft tissue contracture In practical terms there is often a mixture of neural and biomechanical hypertonia, and it is very difficult clinically to determine the relative contribution of each of ... the leg and involve extension of the hip and knee with plantar flexion and usually inversion of the ankle Once again, such spasms can be triggered by a variety of stimuli and sometimes can be so...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... structural importance of the nature of the amino acid at position 81 of the encephalitogenic sequence 74–85 of guinea MBP: replacement of Asp81 with an alanine seems to break a chain of electrostatic ... Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water ... (epitopes) of the integral protein and in a number of post-translational modifications relevant to multiple sclerosis, such as the reduction in cationicity of MBP, especially due to conversion of...
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Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot
... changes of C393 to G and C1629 to T that not lead to amino acid changes, nucleotide changes of A378 to T and G481 to A lead to amino acid substitutions of R126S and G161R, respectively Two human ... camptothecin Inhibitors of the human TDP might potentiate or synergize the cytotoxic effect of Topo I inhibitors used as cancer therapeutic agents The identification of manganese as a cofactor ... Generation of expression constructs to produce wildtype and mutant human TDP Full-length human TDP cDNA and PCR products of the human TDP deletion mutants were ligated into pBAD/ Thio-TOPO vector separately...
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Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... best chance to define an optimal biologic dose (OBD) to establish proofof-concept anti-tumor activity and conditions of safety to normal tissues At this point in time, however, the first studies ... hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies Cancer Treat Res 2002, 110:79-99 Junghans RP, Abedi M, Ma Q, Davies R, Bais ... Therapy of Cancer) Cancer Gene Ther 1998, 5:S1-S2 Junghans RP, Safar M, Huberman MS, Ma Q, Ripley R, Leung S, Beecham EJ: Preclinical and phase I data of anti-CEA "designer T cell" therapy for cancer:...
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báo cáo hóa học: " Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions" pot
... between 1991 and the end of 2001 Sixtynine percent of the patients that had an ICD implant - all of those still alive who were implanted between 1991 and 1999 and a random sample of those still ... acceptance on to the transplant list, implant with a VAD, or Tx, was used Statistical analysis The EQ-5D index and other continuous variables were summarized using the mean and standard deviation and ... transplantation, Angina = data from PMR, TMR and SPiRiT studies, TRTMT = data from all treatments in Angina studies, Heart failure = TxWL and VAD patients, CCS Canadian Cardiovascular Society angina...
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Báo cáo hóa học: " Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study" potx
... California, San Francisco, CA, 94143, USA 2Department of Medicine, University of California, San Francisco, CA, 94143, USA 3Department of Anesthesia, University of California, San Francisco, CA, ... for database management and data analysis MAM was responsible for study design, data analysis, and manuscript preparation KDL contributed to data analysis and manuscript preparation and revision ... cardiac gene expression of BNP [23,24] and decrease lung expression of the NPR-C clearance receptor leading to increased plasma levels of BNP in animal models [25] Transcription of the BNP gene has...
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Báo cáo y học: "Relationship among Dexamethasone Suppression Test, personality disorders and stressful life events in clinical subtypes of major depression: An exploratory study" pot
... supposed to be the result of an increased serotonin (5-HT) or Ach activity, or of a disturbance of the feedback to the hippocampus [7] and the hypothalamus A debate still holds, whether some forms of ... the onset of the symptomatology The mg Dexamethasone Suppression Test (DST) protocol demands the administration of mg dexamethasone per os at 23.00 of the first day, and determination of cortisol ... non-suppression) fail to respond properly [27] According to Tazi et al [26], behavioral analogues of the defensive mechanism of displacement seem to suppress this procedure and in this way contribute to the...
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Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
... 225 150 to 375 75 to 225 75 to 200 75 to 225 25, 50 to 75, 150 to 200 100 to 200 75, 150, 200 100 to 150, 175 to 225 75 to 225 75, 150 200 to 375 150 to 375 37.5 to 300 37.5 to 300 Outpatient ... Fixed ranges Flexible Fixed Flexible Flexible Flexible Flexible 75, 150, 225 75, 150, 225 37.5 to 375 75, 150 to 225, 300 to 375 150 to 375 IR: 75 to 150; ER: 75 to 150 75 to 225 75 to 225 150 to ... terms of baseline depression severity and duration of treatment; these analyses evaluated treatment effects with a variety of antidepressants, including tricyclic antidepressants, selective serotonin...
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Báo cáo y học: " Clinical utility of tibial motor and sensory nerve conduction studies with motor recording from the flexor hallucis brevis: a methodological and reliability study" pptx
... plantar sensory amplitude revealed variability ranging up to 45% between participants and 44% within participants and an ICC value of 0.2 (P = 0.002) Tibial motor FHB velocity coefficients of ... some movement of electrodes to achieve the best waveform, a significant deviation was Page of not needed in the majority of participants The mean distance from the motor and medial plantar sensory ... orthodromic medial and lateral plantar sensory studies The American Association of Neuromuscular and Electrodiagnostic Medicine recommends both motor and sensory studies for the evaluation of posterior...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
... Lmdd exposures Anti-vector and anti-HIV Gag antibody responses To test for the presence of anti-Lm antibodies, an ELISA was employed using whole bacteria (Lm strain 12443) or recombinant LLO as described ... ubiquitous, the incidence of exposure to Lm can be from moderate to high within many populations [24], and therefore may pose an obstacle to Lm vaccine development However, the attenuated vector ... to R.M.R, National Institutes of Health Grant AI078779 to F.R.F and National Institutes of Health Grant AI054558 to J.L., F.R.F and R.M.R Author details Division of Viral Pathogenesis, Beth Israel...
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Báo cáo y học: "The terrorist bomb explosions in Madrid, Spain – an analysis of the logistics, injuries sustained and clinical management of casualties treated at the closest hospital" potx
... disasters is to understand the patterns of injuries and logistical problems that result A retrospective analysis of implemented organization and clinical management can identify helpful decisions and ... specific mortality, and tube thoracostomy and laparotomy can be applied on the basis of clinical findings alone [2] In this respect, two of our seven laparotomies were negative and another one was ... GMUGH, 272 of them between 08:00 and 10:30 No secondary transfer of patients was made to or from GMUGH The mean age of victims was 32 years (range 14–63 years) and 59% were males Of the 312 victims,...
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Báo cáo khoa học: "Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies" ppt
... reported in 10 to 20% of patients with MD [34] In our sample about 54% (50 of 92) of adult MD patients and 79% (71 of 90) of pediatric MD patients also had signs and symptoms of PF, although ... subgroups of patients, it is often helpful to pool experience across studies Purpura fulminans (PF), with its attendant consumptive coagulopathy, and meningitis (MEN), with its attendant risk of intracranial ... affords an opportunity to improve our understanding of patients presenting with clinical signs and symptoms of PF, MEN, or MD Here we report the baseline characteristics, mortality outcomes, and...
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Báo cáo y học: "Clinical value of an arterial pressure-based cardiac output measurement device." pps
... Care Vol 12 No Lemson and van der Hoeven decisions on cardiac output changes of 10% to 15% likely results in unnecessary hemodynamic manipulation of unknown clinical impact and we would strongly ... for APCO and 95% of the time for CCO using this well accepted technology) Breukers and colleagues [5] found concordance of delta cardiac output in 75% of determinations comparing ICO to APCO APCO ... invasive technology that offers great safety advantages over standard techniques utilizing a pulmonary artery catheter when determination of cardiac output is thought to be important for patient care...
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Báo cáo y học: "Clinical relevance of and risk factors for HSV-related tracheobronchitis or pneumonia: results of an outbreak investigation" doc
... were submitted to direct immunofluorescence staining with antibodies specific for HSV A sample (1–2 ml) of the specimen was added to cell cultures of Hep-2 and Vero cells, and was monitored twice ... 17+, R2 = F, R3 = Kos) ganciclovir prophylaxis as part of a postlung-transplant care regimen, which might have prevented development of a clinically relevant HSV-1 infection and might be the reason ... regression analysis, and we cannot exclude that the interaction between longer duration of ventilation and tracheotomy indicates the severity of disease The most significant risk factor for fatal...
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Báo cáo y học: " Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies" potx
... important in influencing severity to the development of sepsis and MODS in trauma patients by changing the balance of pro-inflammatory and anti-inflammatory cytokines There were no significant ... in relation to the development of sepsis and MODS in trauma patients genetic and clinical aspects of data analyses and revised the manuscript All authors read and approved the final manuscript ... protocol and was involved in the 13 Wang ZG, Jiang JX: An overview of research advances in road traffic trauma in China Traffic Injury Prevention 2003, 4:9-16 Jiang JX: Posttraumatic stress and...
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studies of pathogenesis-related proteins in the strawberry plant partial purification of a chitinase-containing protein complex and analysis of an osmotin-like protein gene
... In many cases, the transgenic plants exhibit enhanced disease resistance For example, over-expression of tobacco osmotin in transgenic potato plants led to enhanced resistance to P infestans, ... co-expression of chitinase and β-1,3-glucanase genes in transgenic plants has been shown to synergistically enhance the resistance of plants against pathogens For example, transgenic tomato plants expressing ... osmotic-related stress Tobacco osmotin and a tomato TLP (NP24) were shown to accumulate in salt stressed tobacco cells and tomato cells, respectively, and were the most abundant protein in the cell...
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Mechanistic studies of anti malarial spiroindolones and synthesis and structure activity relationship studies of an inhibitor of dengue proliferation
... I MECHANISTIC STUDIES OF ANTI-MALARIAL SPIROINDOLONES AND II SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF AN INHIBITOR OF DENGUE PROLIFERATION YAP PEILING ... further into the world of organic and medicinal chemistry I would also like to thank him for his patience and valuable feedback during the preparation of this manuscript I would like to thank Dr ... thanks as well to Peiting and Peiyun for their technical support I would also like to thank Dr Bryan Leung, Dr Zou Bin, Ru Hui, Shi Hua, Melissa, Josephine, Andrea, Wang Gang and the rest of...
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Báo cáo y học: "Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators"
... concept and design, to analysis and interpretation of data and to drafting of the manuscript and critical revision for important intellectual content SM contributed to study concept and design, to analysis ... interpretation of data and to drafting of the manuscript and critical revision for important intellectual content NK contributed to study concept and design, to analysis and interpretation of data and to ... interpretation of data, to drafting of the manuscript and critical revision for important intellectual content and to statistical analysis AQ contributed to study concept and design, to analysis and interpretation...
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