clinical implications of epigenetic alterations in human thoracic malignancies epigenetic alterations in lung cancer
báo cáo hóa học: " Clinical implications of gait analysis in the rehabilitation of adult patients with "Prader-Willi" Syndrome: a cross-sectional comparative study ("Prader-Willi" Syndrome vs matched obese patients and healthy subjects)" docx
... minimum (MIN) of the curve of joint movement Beside this, the mean values of MAX and MIN were considered For ankle joint, in addition to ROM on sagittal plane, peak of plantarflexion, peak of ... displacement of the center of gravity creating instability during standing and walking Morbility and mortality of PWS are mainly related to severe obesity Hypothalamic dysfunction is a recognized cause of ... kinetic data were collected and comparing the different plots of kinematic and kinetics were extracted three trials able to evidence the same gait pattern (from kinematics and kinetics point of...
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Báo cáo khoa học: "Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size" ppsx
... Yano S, HIraoka M: Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in fractions for primary lung cancer using a stereotactic body frame Int J Radiat Oncol Biol ... diagnosis of NSCLC could not be confirmed with transbronchial lung biopsy or CT-guided biopsy, such cases were included in the study if FDG-PET findings were positive and the tumor increased in size ... normal breathing, and with breath holding during the expiratory and inspiratory phases The clinical target volume (CTV) was defined as the visible gross tumor volume (GTV) The CTV on CT during the...
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Báo cáo khoa học: "Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma" ppt
... one known point mutations in the EGFR-TK domain in MPM patients All mutations are clustered and reside near the ATPbinding cleft of the tyrosine kinase domain Presence of each mutation in heterozygous ... in study design, coordination, clinical tissue extraction and analysis resulting in the identification of the EGFR mutations PS participated in clinical tissue extraction and analysis resulting ... their binding sites through mutant EGFR proteins These mutation add to the list of previously identified mutations within the kinase domain of the EGFR gene, and also extends the spectrum of malignancies...
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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... polyarthritis that resembles human RA in many clinical and pathological respects This surprising finding induced intense research into the pathophysiology of arthritis in the K/B×N mice Autoantibodies ... dilution (1:50) in the serum of 64% of RA patients but not in control individuals However, a number of other investigators did not find increased levels of α-G6PI antibodies in the serum of patients ... preparation used in the initial study was found to be contaminated with other proteins, and RA sera contained antibodies against some of these other proteins [81] Taken together, these findings indicate...
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Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx
... high lung volumes Those investigators showed that, after RMs, PEEP set at cmH2O above the lower inflection point was more effective in maintaining gas exchange and minimizing inflammation and lung ... expression of many cytokines involved in the pathogenesis of VILI [14] It is unknown whether a single stimulus such as RMs applied during MV can trigger the above-mentioned pathways of lung injury, ... demonstrated that RMs can increase oxygenation and lung volume in collapsed prone lungs However, the benefits of RMs in terms of oxygenation and lung recruitment in ARDS patients and in experimental models...
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Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... relevant to the clinical use of tenofovir-containing regimens in HIV-1 infected humans In the current study, intravenous inoculation of the first group of macaques with a high dose of RT-SHIV led ... implications of K70E and K65R viral mutants These data are important and timely, considering (i) the increased use of tenofovir in HAART regimens, and (ii) the ongoing clinical trials which investigate ... reduced in vitro susceptibility to tenofovir [1,2] Many tenofovir-containing regimens induce strong and longlasting suppression of viremia in the majority of persons, with a low occurrence of the...
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Tài liệu Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients Edited by Mohammed A. Abdelaal ppt
... 2005) (1) A point mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and ... extrapolation of principles of therapy from adult guidelines, limited clinical information from registries, individual case studies and knowledge of current common clinical practice The following is ... and Cancer Patients 2.2 Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins...
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Tài liệu Hypertension - Clinical management of primary hypertension in adults pdf
... hypertension [new 2011] NICE clinical guideline 127 – Hypertension Initiating and monitoring antihypertensive drug treatment, including blood pressure targets Initiating treatment Offer antihypertensive ... hypertension offer to: test for the presence of protein in the urine by sending a urine sample for estimation of the albumin:creatinine ratio and test for haematuria using a reagent strip take a blood sample ... from ‘Medicines adherence’ (NICE clinical guideline 76), published in 2009 [2010] applies to recommendations from ‘Hypertension in pregnancy’ (NICE clinical guideline 107), published in 2010 [new...
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Quantitative Implications of Indexed Bonds in Small Open Economies Ceyhun Bora Durdu potx
... dominates the increase in the covariance of the trade balance with income, which in turn increases consumption volatility.7 To understand the implications of indexed bonds on Sudden Stops, I introduce ... the income uncertainty, and the incompleteness of the insurance market, households’ engage in precautionary savings to hedge away the risk of attaining “catastrophic” levels of income They accomplish ... for precautionary savings against low realizations of income shocks but it might introduce incentives to save against high realizations of income shocks if the degree of indexation is such that...
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Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx
... used [44,47] In line with these studies, we did not detect any increase in phosphorylation of a2 in a2b2c3 complexes by LKB1 or CAMKKb in the presence of increasing concentrations of AMP (Fig ... energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations J Clin Invest 113, 274–284 Kemp BE (2004) Bateman domains and adenosine derivatives form a binding contract ... protein in this tissue [23,25] In addition, it is possible that the antibody binding itself interferes with the AMP-binding properties of c3 Additionally, the low A0.5 value characterizing the...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... detection of metastatic potential of tumors, including lung cancer As the number of genes methylated in cancer is large and increasing, sensitive and robust multiplexed methods for detecting of aberrant ... participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... tested in cell lines and tissue specimens representing different steps of lung cancer progression supporting the panel of the tumor suppressor genes selected to be altered in lung cancer In this...
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báo cáo hóa học:" Clinical report of cervical arthroplasty in management of spondylotic myelopathy in Chinese" pot
... operation result on range of motion (ROM) of replaced level or stability of the prosthesis has been reported either In order to find out the clinical result of CSM of which among Chinese, a prospective ... Goffin : Proceedings of the Annual Meeting of the Spinal Arthroplasty Society, May 2002, Montpellier, France Sekhon LH: Cervical arthroplasty in the management of spondylotic myelopathy J Spinal ... because that abnormal shifting of the center of rotation following spinal arthroplasty has been implicated in recent reports of facet pain associated with prosthesis positioning[13] A functional disc...
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báo cáo hóa học:" Clinical effects of Garcinia kola in knee osteoarthritis" doc
... grouping of subjects Figure The mean time of onset of action of the study medication (minutes) The mean time of onset of action of the study medication (minutes) The mean time (minutes) of onset of ... associated with incapacity and a deteriorating quality of life owing to increased pain, loss of mobility, and the consequent loss of functional independence [4] There is general increase in life expectancy ... clinics of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife (OAUTHC); Nigeria Study medication and blinding At the beginning of the study, no commercial preparation of Garcinia...
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PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF VENOUS THROMBOEMBOLISM IN NEONATES, RENAL DISEASE AND CANCER PATIENTS pdf
... 2005) (1) A point mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and ... extrapolation of principles of therapy from adult guidelines, limited clinical information from registries, individual case studies and knowledge of current common clinical practice The following is ... and Cancer Patients 2.2 Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins...
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Báo cáo y học: " Transdisciplinary unifying implications of circadian findings in the 1950s" doc
... circadian, in keeping with precedents of nomenclature in physics Kleitman? Brevity and ringing bells are the main criteria in coining terms Investigators coming to our laboratory included both ... view of a gliding spectral window of amplitudes of systolic blood pressure, focusing on infradians and circadians in the first 40 days of life of a boy born at term (FW) The prominence of the infradian ... map) of a gliding spectral window of amplitudes of systolic blood pressure, focusing on infradians and circadians in the first 40 days of life of a boy born at term (FW) The prominence of the infradian...
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Báo cáo y học: "Clinical audit of foot problems in patients with rheumatoid arthritis treated at Counties Manukau District Health Board, Auckland, New Zealand" potx
... [5] increasing to 90% as disease duration increases [5,6] This can lead to joint instability, difficulties in walking and limitation in functional ability that restricts activities of daily living ... the main or only cause of walking difficulty in 25% [1] In the foot, joint pain and stiffness is the most common initial presentation, but a range of other features, including tenosynovitis, nodule ... self-managed foot care, including nail clipping and filing, callus filing and daily hygiene and inspection [13] A clinical audit of 139 rheumatoid patients undertaken in the UK reported that...
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báo cáo khoa học:"The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation" docx
... and clinical researchers who, beginning in the 90s and going on until nowadays, have started to use the expressive writing procedure with their patients and to examine its effects empirically in ... appetite All but three of the items were reworded; only the items dealing with feelings of being punished, thoughts about suicide and interest in sex remained the same Finally, respondents rate ... extremely Writing ratings Immediately following the last writing session, participants will be asked to rate sixteen items reflecting some aspects of the writings and of the whole writing experience...
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Báo cáo y học: " The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial" potx
... times by definition of disease progression as death or ≥ 5% relative decline in absolute VC were obtained (In our previous paper, we used ≥ 10% instead of ≥ 5% decline in VC to define PFS times ... with origin at month in groups of patients with and without 5% decline in VC at month Solid line with closed circle: No decline in VC at month 3; broken line with plus: a ≥ decline in VC at month ... effect of additional therapy strategies, such as combination with NAC [22] or BIBF-1120 [27], should be addressed in further clinical trials In order to translate the 5% decline in VC into a clinical...
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Báo cáo y học: "Ethics review: Long-term outcomes and clinical predictors of hospital mortality in very long stay intensive care unit patients: a cohort study" pptx
... determining hospital mortality in very long stay ICU patients Clinical decisions regarding individual very long stay patients clearly require incorporating other individualized clinical information ... obtained using Wilcoxon Rank Sum test; P = 0.02 using χ2 test comparing patients requiring 90 days of ICU care (also see Figure 1) cP value obtained ... obtained using Fisher's exact test dP value obtained using Wilcoxon rank sum test; P = 0.007 using χ2 test comparing patients requiring 90 days of ventilation...
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Báo cáo y học: "Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough" potx
... Overview of findings Lung cancer patients, N = trials from Cochrane systematic review in cancer [12]** Brachytherapy in addition to EBRT resulted in higher improvements in cough at doses of 15 Gy in ... combined with clinical experience in an attempt to provide a sensible approach to the clinician and guide practice in a field with minimal evidence 2.3 Clinical consultation of the guidelines ... Neltenexine-2 trials Sinecod linctus (butamirate) with a similar effect to that of small dose of Codeine-1 trial Overview of findings Asthma (cough often secondary from systematic outcome) review in...
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