clinical implications and therapeutic potential

Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target

Ngày tải lên : 16/10/2015, 15:38

... in Hepatology and Gastroenterology research laboratory for all their helps and guidance I would also like to take this opportunity to thank my parents and friends for their loves and supports ... (Bharadwaj and Yu, 2004) PLK1 may directly regulate these components such as BubR1 (Matsumura et al., 2007) and possibly Mad2 (Eckerdt and Strebhardt, 2006) in order to prevent APC/C inhibition and ... cell cycle dependent kinases and their associated cyclins Potential PLKs’ downstream substrates and upstream regulators discovery will further enhance our understanding in the molecular mechanism...

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Tài liệu SLEEP-RELATED BREATHING DISORDERS EXPERIMENTAL MODELS AND THERAPEUTIC POTENTIAL docx

Ngày tải lên : 14/02/2014, 17:20

... Zapol and K J Falke 25 Gas Mixing and Distribution in the Lung, edited by L A Engel and M Paiva 26 High-Frequency Ventilation in Intensive Care and During Surgery, edited by G Carlon and W S Howland ... Roussos and P T Macklem 30 The Pleura in Health and Disease, edited by J Chrétien, J Bignon, and A Hirsch 31 Drug Therapy for Asthma: Research and Clinical Practice, edited by J W Jenne and S Murphy ... Robertson and H W Taeusch 85 The Thorax: Second Edition, Revised and Expanded (in three parts), edited by C Roussos 86 Severe Asthma: Pathogenesis and Clinical Management, edited by S J Szefler and...

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Stem Cells in Human Reproduction Basic Science and Therapeutic Potential Second Edition pot

Ngày tải lên : 22/03/2014, 20:21

... 226 ¨rn Bjo Heindryckx, Petra De Sutter, and Jan Gerris 21 Derivation and Banking of Human Embryonic Stem Cells for Potential Clinical Use 243 Ana Krtolica and Olga Genbacev Index 251 208 Contributors ... Science and Therapeutic Potential, second edition, useful as a reference and a valuable tool for the improvement of reproductive medicine from the cell biology perspective ´n Carlos Simo and Antonio ... characterize and understand the mechanisms of these phases of embryonic-cellular regulation, as their implications in defining and predicting stem cell behaviors are fundamental OOGENESIS AND EARLY...

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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf

Ngày tải lên : 18/06/2014, 22:20

... DH: Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I CNS Neurol Disord Drug Targets 2009, 8:1-6 Cribbs DH, Agadjanyan MG: Active and passive ... potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease Journal of Translational Medicine 2011 9:127 Submit your next manuscript to BioMed Central and ... significantly higher than that elicited by WSN-WT Anti-Ab and anti-influenza antibodies are therapeutically potent To show the therapeutic potential of dual chimeric vaccine we first analyzed binding...

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Báo cáo toán học: "Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells" ppsx

Ngày tải lên : 08/08/2014, 17:20

... may limit the therapeutic potential of adult NSCs in vivo and ex vivo On the other hand, it may interact with the neurogenic niches to promote the regenerative potential in vivo, and the integration ... has the potential for self-repair and that newborn neuronal cells may contribute to the functioning, and physioand pathology of the CNS [36] However, adult NSCs remain elusive cells and to be ... promote regeneration and repair in vivo and ex vivo Therapeutic strategies for promoting the potential of adult NSCs in vivo and ex vivo may involve pro- and anti-inflammatory treatments Future...

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Báo cáo khoa học: "Clinical features and therapeutic management of patients admitted to Italian acute hospital psychiatric units: the PERSEO (psychiatric emergency study and epidemiology) survey" pot

Ngày tải lên : 08/08/2014, 23:20

... admission, referring structure, clinical and psychometric evaluations, concomitant diseases, previous and ongoing psychiatric treatment, admission and discharge diagnoses, and treatments administered ... the sociodemographic and clinical characteristics of patients, their pathways to psychiatric admission, and describing their behaviour, subjective wellbeing, management and attitude towards treatment ... conventional and atypical antipsychotics at admission, the combination was confirmed during hospital stay and/ or at discharge Similarly, 64.5% and 60.6% of the patients who were taking only atypical and...

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Prophylactic and therapeutic potential of synthetic peptides against enterovirus 71

Ngày tải lên : 12/09/2015, 08:19

... culturing and activation of dendritic cells (DCs) 64 CD4+ T cell selection and proliferation 65 Molecular biology 66 2.3.1 Design and synthesis of EV71-specific primers and probes 66 2.3.2 Design and ... study and their technical advices in tissue culture work and in vitro microneutralization assay Mr Ramasamy Pallan, Mr Goh Ting Kiam, Paul, Jasmine, Li Li and Auntie Zainal for their friendships and ... help in all administrative and technical matters Boon King, Eng Lee, Adrian, Andrew, Boon Eng, Si Ying, Wen Wei, Grace, Li Rui, Wei Xin and Joo Lee for their help and encouragement Thank you...

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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

Ngày tải lên : 26/10/2012, 10:04

... membrane potential induced by D-glucose, thioglycosides I and VII and phlorizin As expected, the maximal effect was observed with D-glucose with FRET values of 5.62 and 2.29 for hSGLT1 and hSGLT2, ... (hSGLT1 and hSGLT2) and to the inhibition exerted by the same concentration of phlorizin, exceptions are thioglycosides I and VII Thioglycoside I inhibited hSGLT2 stronger than hSGLT1 and to a ... Current therapies and emerging targets for the treatment of diabetes Current Pharmaceutical Design 2001; 7: 417-450 Wood IS, and Trayhurn P Glucose transporters (GLUT and SGLT): expanded families...

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Ovarian Cancer – Clinical and Therapeutic Perspectives Edited by Samir A. Farghaly doc

Ngày tải lên : 17/03/2014, 02:20

... carcinoma, and peritoneal carcinoma In: DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology, 9th Edition., DeVita, V.T.; Lawrence, T.S & 12 Ovarian Cancer – Clinical and Therapeutic ... Table Ovarian cancer incidence counts and rates for selected regions and continents worldwide Rates are per 100,000 women and age-standardized to the 1960 world standard population Source: Ferlay ... cancer incidence counts and rates for the United States, U.S Census regions and divisions and individual states Rates are per 100,000 women and age-adjusted to the 2000 U.S standard Data presented...

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THE CARDIOVASCULAR SYSTEM – PHYSIOLOGY, DIAGNOSTICS AND CLINICAL IMPLICATIONS pot

Ngày tải lên : 28/03/2014, 09:20

... CARDIOVASCULAR SYSTEM – PHYSIOLOGY, DIAGNOSTICS AND CLINICAL IMPLICATIONS Edited by David C Gaze The Cardiovascular System – Physiology, Diagnostics and Clinical Implications Edited by David C Gaze Published ... pathophysiology, clinical presentation and implications of cardiovascular diseases The first chapter of this section explores the relationship of cardiovascular health and exercise from both the European and ... factors, the clinical signs and symptoms, and the clinical tools to aid diagnosis The next chapter details the cardiovascular risk factors associated with the development of diabetes mellitus and the...

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Chromosomal Instability and Aging Basic Science and Clinical Implications doc

Ngày tải lên : 29/03/2014, 08:20

... along the way: my parents, Kay and Toshi, my teachers, and my husband, Rusty And to Mr William T Comfort, Jr., and the John A Hartford Foundation, whose kindness and interest in this project were ... Chromosomal Instability and Aging Basic Science and Clinical Implications edited by Fuki M Hisama Sherman M Weissman Yule Universify School ... instability in human diseases and model organisms We intend this book for students, scientists, and physicians interested in the biology of aging and human genetics, and for those studying genomic...

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Báo cáo sinh học: " Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications" docx

Ngày tải lên : 18/06/2014, 19:20

... using BMP7 as a therapeutic agent [250,251] Yet, a valuable and potentially useful piece of knowledge for the clinical handling of CKD is still in the horizon; namely understanding how and why an ... dysfunction and inflammation leading to fibrosis and reduced filtration; (ii) creating hypoperfusion and ischemic scenarios compromising renal blood flow, and tubular and glomerular function; and (iii) ... increase of cytosolic calcium and inositol phosphate, prostaglandin synthesis and cellular contraction and long-term alterations such as proliferation, hypertrophy and ECM production [159] These...

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báo cáo hóa học: " Clinical implications of gait analysis in the rehabilitation of adult patients with "Prader-Willi" Syndrome: a cross-sectional comparative study ("Prader-Willi" Syndrome vs matched obese patients and healthy subjects)" docx

Ngày tải lên : 19/06/2014, 10:20

... were obese and overweight Mean Body Mass Index (BMI) and Standard Deviation (± SD) were 41.3 ± 6.0 kg/m2 (range 29.3–50.1 kg/m2) Standing height was determined by a Harpenden Stadiometer and expressed ... adiposity- structural and functional limitations of obesity and implications for movement Obesity Rev 2002, 3:35-43 Must A, Strauss RS: Risks and consequences of childhood and adolescent obesity ... "Istituto Scientifico Ospedale S Giuseppe" and they underwent clinical assessments and attended a rehabilitation program All patients showed the typical PWS clinical phenotype [16] Cytogenetic analysis...

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báo cáo hóa học:" Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications" pdf

Ngày tải lên : 20/06/2014, 03:20

... using BMP7 as a therapeutic agent [250,251] Yet, a valuable and potentially useful piece of knowledge for the clinical handling of CKD is still in the horizon; namely understanding how and why an ... dysfunction and inflammation leading to fibrosis and reduced filtration; (ii) creating hypoperfusion and ischemic scenarios compromising renal blood flow, and tubular and glomerular function; and (iii) ... increase of cytosolic calcium and inositol phosphate, prostaglandin synthesis and cellular contraction and long-term alterations such as proliferation, hypertrophy and ECM production [159] These...

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báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx

Ngày tải lên : 20/06/2014, 08:20

... 559 and 1233 patients in the routine clinic database were recorded for severe bacteria pneumonia (81.8% and 96.4%, respectively), herpes zoster (83.3% and 88.8%), oral candidiasis (55.9% and ... (12.2% and 12.2%), Cryptococcus meningitis (+12.5% and 12.5%), and Kaposi’s sarcoma (+16.7% and +150%) Although the same number of patients was identified with Cryptococcus meningitis and Kaposi’s ... analysis BC, PS and TM participated in its design and coordination, and provided comments on the manuscript PJE conceived the study, participated in its design and coordination, and drafted the...

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Báo cáo hóa học: " Ventilator-induced lung injury: historical perspectives and clinical implications" docx

Ngày tải lên : 21/06/2014, 01:20

... mL/kg and PEEP of cmH2O) only 36 h after randomization [62] However, this study was not designed to address whether these decreases were associated with improved clinical endpoints and the clinical ... lung injury; and 3) studies modulating hormonal and metabolic pathways: inhibition of the renin-angiotensin system [92,93] and pretreatment with atorvastatin or simvastatin [94,95] Clinical relevance ... Ventilator-induced lung injury: historical perspectives and clinical implications Annals of Intensive Care 2011 1:28 Submit your manuscript to a journal and beneﬁt from: Convenient online submission Rigorous...

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THE CARDIOVASCULAR SYSTEM – PHYSIOLOGY, DIAGNOSTICS AND CLINICAL IMPLICATIONS pot

Ngày tải lên : 27/06/2014, 09:20

... outstanding person! She was the General Manager of the Company CARDIOCODE-Finland She remains in our memory for ever 22 The Cardiovascular System – Physiology, Diagnostics and Clinical Implications ... positioning and awkward curvature of the aortic arch and a misdirected and elongated ductus arteriosus (Bergwerff et al., 2000) Moreover, expression of endothelial markers such as Flk-1 and VCAM-1 and ... Morphology and Functional Changes of Intestine, Trophology Status and Systemic Inflammation in Patients with Chronic Heart Failure 383 G.P Arutyunov and N.A Bylova Chapter 20 Evaluation and Treatment...

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OVARIAN CANCER – CLINICAL AND THERAPEUTIC PERSPECTIVES potx

Ngày tải lên : 27/06/2014, 11:20

... carcinoma, and peritoneal carcinoma In: DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology, 9th Edition., DeVita, V.T.; Lawrence, T.S & 12 Ovarian Cancer – Clinical and Therapeutic ... Table Ovarian cancer incidence counts and rates for selected regions and continents worldwide Rates are per 100,000 women and age-standardized to the 1960 world standard population Source: Ferlay ... cancer incidence counts and rates for the United States, U.S Census regions and divisions and individual states Rates are per 100,000 women and age-adjusted to the 2000 U.S standard Data presented...

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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:22

... the TCR transgenic K/B×N model and the situation in patients Some of the major clinical and immunological similarities and differences between CIA, the K/B×N model and G6PI-induced arthritis are ... importantly, depletion of CD4+ cell on days 11 and 14 (i.e when clinical symptoms are at their maximum) induces rapid remission of arthritis both clinically and histologically [93] Thus, in G6PI-induced ... provides a reliable and robust model in which the induction, effector phase and modulation of organ-specific disease induced by systemic autoimmunity can be dissected and therapeutically targeted...

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